NCOA4 (Nuclear Receptor Coactivator 4) is a protein that was initially characterized as a coactivator for nuclear receptors, enhancing transcriptional activity in response to ligands such as hormones.
Beyond transcriptional coactivation, NCOA4 is also known for its role in selective autophagy, particularly in mediating ferritinophagy (the autophagic degradation of ferritin), thus influencing cellular iron homeostasis.
Dysregulation of NCOA4 and its impact on iron metabolism may contribute to tumor progression, where a delicate balance between proliferation and cell death is maintained.
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