CREB2 (cAMP response element‐binding protein 2) is a member of the CREB/ATF family of transcription factors.
– CREB2 is involved in stress-related signaling pathways and has been implicated in processes like memory consolidation and synaptic plasticity in neuronal cells.
– It helps in the cellular response to environmental and intracellular stresses by modulating the expression of target genes.
– Through regulation of gene expression, CREB2 can influence proliferation, differentiation, and apoptosis in various cell types.
– The balance of CREB2 activity is critical in maintaining normal cellular homeostasis.
– Some studies have reported increased CREB2 expression in certain cancers (e.g., brain tumors, leukemia), while others have noted reduced expression in different tumor types.
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