SHARP1/BHLHE41 is a basic helix-loop-helix (bHLH) transcription factor that regulates gene expression by binding to E-box elements in target gene promoters.
– A suppressor of breast cancer metastasis
– It generally functions as a transcriptional repressor, controlling the expression of genes involved in circadian rhythm, differentiation, and metabolism.
• Circadian Rhythm and Metabolism:
– SHARP1 plays a role in maintaining circadian rhythm by modulating the oscillatory expression of clock genes.
– Through these regulatory networks, it also influences energy metabolism and cell-cycle control.
– Some studies report downregulation of SHARP1 in certain cancers, which may correlate with loss of its differentiation and growth-suppressive functions.
– In other contexts, SHARP1 may be upregulated, potentially reflecting an adaptive response to the altered microenvironment or a compromised circadian program in tumors.
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