beta-2-microglobulin
B2M Antigen Presentation, Immune Escape, and Biomarker Roles
High B2M expression correlated with worse prognosis. Our results indicate that B2M and HLA-A loss occurs frequently in tumors.
B2M is considered a tumor suppressor gene.
Elevated serum B2M is strongly associated with poor prognosis in: Multiple myeloma, Lymphomas (CLL, NHL), and Some leukemias
Dual Nature: Tumor Suppression vs Disease Severity
Loss of B2M (tumor cell)
→ Immune escape, therapy resistance
High B2M (serum)
→ High tumor burden, inflammation, poor prognosis
β2-Microglobulin is essential for anti-tumor immune recognition.
-Loss of B2M in tumor cells enables immune escape and immunotherapy resistance.
-Elevated circulating B2M reflects tumor burden and poor prognosis, especially in hematologic malignancies.
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