Research Edit: by Research Num 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rid		ANTI-Cancer/IllnessPRO-Cancer/Illness

Prod	,2DG,2-DeoxyGlucose3BP,3-bromopyruvate5-FU,5-fluorouracilacet,acetaminophenacetaz,acetazolamideAco,Acoschimperoside P, 2’-acetateAdag,AdagrasibTFdiG,Aflavin-3,3′-digallateATAGJ,Ai-Tong-An-Gao-JiAjoene,Ajoene (compound of Garlic)Akk,AkkermansiaAL,Allicin (mainly Garlic)almon,almonertinibAV,Aloe veraaLinA,alpha Linolenic acidALA,Alpha-Lipoic-AcidAVA,Aminolevulinic acidAMQ,AmodiaquineAnd,AndrographisACNs,AnthocyaninsantiOx,Anti-oxidantsApi,Apigenin (mainly Parsley)AG,ArctigeninART/DHA,ArtemisininAP,Ascorbyl PalmitateAsh,AshwagandhaASA,Aspirin -acetylsalicylic acidAS,AstragalusATV,AtorvastatinAur,AuranofinBa,BaicaleinBA,Baicalinbemp,bempedoic acidBaP,benzo(a)pyreneBBM,BerbamineBB,BerberinebetaCar,beta-caroteneB-Gluc,beta-glucansBA,Betulinic acidBEV,Bevacizumab (brand Avastin)Bical,BicalutamideHCO3,BicarbonateBif,BifidobacteriumBCA,Biochanin ABP,Black phosphorusborn,borneolBor,BoronBTZ,BortezomibBos,Boswellia (frankincense)BML,BromelainBJ,Brucea javanicaBrut,BruteridinBF,BufalinBA,ButyrateCA,Caffeic acidCaff,CaffeineCalc,CalciumCRMs,Calorie Restriction MimeticsCPT,CamptothecinCBC,CannabichromeneCBD,CannabidiolCBDA,cannabidiolic acidcapec,capecitabineCAP,Capsaicincarbop,carboplatinCA,Carnosic acidCAR,CarvacrolCats,Cat’s ClawCatechins,CatechinsCela,CelastrolCEL,CelecoxibCET,cetuximabCDT,chemodynamic therapyChemo,ChemotherapyChit,chitosanCGA,Chlorogenic acidCHL,ChlorophyllinCHOC,ChocolateCH,ChrysinCin,CinnamonCisplatin,CisplatinCitrate,Citric AcidCu,Copper and Cu NanoParticlexCroc,CrocetinCuc,CucurbitacinCUR,CurcuminCUSP9,CUSP9CP,CyclopamineCBC/D,Cynanbungeigenin C (CBC) and D (CBD)DL,D-limoneneDand,Dandelion RootDAS,DasatinibDeg,DeguelinAnamu,dibenzyl trisulphide(DTS) from AnamuDCA,DichloroacetateDAP,Dichloroacetophenone(2,2-)Dicl,DiclofenacdietF,diet Fermented FoodsdietFMD,diet FMD Fasting Mimicking DietdietKeto,diet KetogenicdietMet,diet Methionine-Restricted DietdietP,diet Plant basedDHCA,Dihydrocaffeic AcidDSMO,Dimethyl SulfoxideDipy,Dipyridamoledocx,DocetaxelDHA,Docosahexaenoic AciddoxoR,doxorubicinEch,EchinaceaEGCG,EGCG (Epigallocatechin Gallate)EPA,eicosapentaenoic acidEP,Electrical PulsesEA,Ellagic acidRF,EMFEMD,EmodinMS-275,entinostatEPI,epirubicinerastin,erastinEst,EstrogenEDTA,ethylene diamine tetraacetic acidEDM,EvodiamineEx,ExerciseFenb,FenbendazoleFA,Ferulic acidFer,ferumoxytolFIS,FisetinFlav,flavonoidsFA,Folic AcidForm,FormononetinF,FucoidanGA,Gallic acidGallo,GalloflavinGamB,Gambogic AcidGAR,GarcinolGB,gefitinib, erlotinibGEM,Gemcitabine (Gemzar)GEN,GenisteinGer,GermacranolideGE,GermaniumGI,Ginger/6-Shogaol/GingerolGB,Ginkgo bilobaGins,GinsengGlaB,Glabrescione BGlucDep,glucose deprivationGoldNP,Gold NanoParticlesGos,GossypolGe,Grapeseed extractGra,GraviolaHne,Helleborus niger extracts – Christmas RoseHibSad,Hibiscus sabdariffaHNK,HonokiolHops,Hops (Humulus lupulus)HRT,Hormone replacement therapyH2,Hydrogen GasHCQ,hydroxychloroquineHCAs,Hydroxycinnamic-acidHCA,HydroxyCitric AcidHTyr,HydroxytyrosolHP,HyperosideHPT,HyperthermiaIMA,imatinibimmuno,immunotherapyI3C,Indole-3-carbinolInA,Inoscavin AIns,InositolIP,Inulin Prebioticiod,iodineIP6,IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)lpi,ipilimumabFe,IronisoFl,isoflavonesitraC,itraconazoleIVM,IvermectinJG,JugloneKaempF,KaempferolL-A,L-AlinineL-Orn,L-ornithineLA,LactobacillusLF,LactoferrinLae,Laetrile B17 Amygdalinlamb,lambertianic acidLapC,LapacholLap,LapatinibLas,LasiodinLEC,LecithinLE,Licoricelign,lignansLip,Lipoic acidLDN,low dose naltrexoneLT,LuteolinLyco,LycopeneMg,MagnesiumMFrot,Magnetic Field RotatingMF,Magnetic FieldsMNPs,magnetic nanoparticlesMAG,MagnololMatr,MatrineMCT,MCToilmeben,mebendazoleMEL,MelatoninMel,MelitidinMET,MetforminMTX,methotrexateMeJa,Methyl JasmonateM-Blu,Methylene blueMGO,MethylglyoxalMeSA,methylseleninic acidMSM,MethylsulfonylmethanemetroC,metronomic chemoMT,MistletoeMCP,Modified Citrus PectinMoringa,Moringa oleiferaMushCha,Mushroom ChagamushLions,Mushroom Lion’s ManeMushMait,Mushroom MaitakeMushPL,Mushroom Phellinus. linteusMushReishi,Mushroom ReishiMushShi,Mushroom Shiitake, AHCCmushTT,mushroom Turkey TailMyr,MyricetinMyrrh,MyrrhNarG,NaringinNRF,nelfinavir/ViraceptNCL,Niclosamide (Niclocide)NAD,nicotinamide adenine dinucleotideNimb,NimbolideNIV,nivolumabNos,NoscapineOctr,octreotideOLST,OrlistatOA,Oroxylin AOA,Oroxylin-AOsi,OsimertinibOXA,OxaliplatinOAA,oxaloacetateOxy,Oxygen, HyperbaricPA,Pachymic acidPacT,PaclitaxelPap,papainPart,ParthenolidePawPaw,Paw PawPem,pembrolizumabP,PeppermintpH-AT,pH-Alkalization TherapyPB,PhenylbutyratePDT,Photodynamic TherapyPFB,Physalin F & BPI,PiperinePL,PiperlonguminePIT,PitavastatinPlum,PlumbaginPACs,ProanthocyanidinsProBio,probioticsPBG,Propolis -bee gluePG,Propyl gallatePS,PterostilbenePurp,PurpuronePhen,PXD, phenoxodiolQC,QuercetinRF,Radio FrequencyRad,Radiotherapy/RadiationRalox,raloxifenRAPA,RapamycinRSL3,Ras-selective lethal 3RSQ,ResiquimodRES,ResveratrolRetA,Retinoic AcidRosA,Rosmarinic acidRT,RutinSB,Saccharomyces boulardiiSS,Saikosaponin B1 and DSal,salinomycinSM,Salvia miltiorrhizaSANG,SanguinarineSco,ScoulerineSelenate,SelenateSel,SeleniteSe,SeleniumSeMet,selenomethioninesericin,sericinSK,ShikoninSTF,Short Term FastingGSL,Siegesbeckia glabrescensSB,SilibininSNP,Silver-NanoParticlesSIL,Silymarin (Milk Thistle)SIM,SimvastatinSDT,SonoDynamic Therapy UltraSoundSRF,Sorafenib (brand name Nexavar)Squ,Squalenestatins,statinsSulfas,SulfasalazineSulf,Sulforaphane (mainly Broccoli)SNT,sunitinibSuD,Sutherlandioside DTam,tamoxifenTau,TaurineTMZ,temozolomideTF,TheaflavinTb,TheobromineTV,Thymol-Thymus vulgarisTQ,ThymoquinoneTC,Tinospora CordifoliaTiO2,Titanium DioxideTomatine,TomatineTACE,Transarterial ChemoembolizationTras,TrastuzumabTSA,Trichostatin ATrip,triptolideTu,TulsiTTT,Tumor Treating FieldsUkrain,Ukrainurea,ureaUA,Ursolic acidVem,verapamilVitB12,Vitamin B12VitC,Vitamin C (Ascorbic Acid)VitD3,Vitamin D3VitE,Vitamin EVitK2,Vitamin K2VitB1/Thiamine,VitB1/ThiamineVitK3,VitK3,menadioneSAHA,VorinostatWBV,Whole Body VibrationWog,WogoninWor,Woreninewortm,wortmanninXyl,XylitolZeo,ZeoliteZ,ZincZO,Zinc Oxideβ�Ele,β�Elemeneγ-Toc,γ-Tocotrienol	Syn1	,2DG,2-DeoxyGlucose3BP,3-bromopyruvate5-FU,5-fluorouracilacet,acetaminophenacetaz,acetazolamideAco,Acoschimperoside P, 2’-acetateAdag,AdagrasibTFdiG,Aflavin-3,3′-digallateATAGJ,Ai-Tong-An-Gao-JiAjoene,Ajoene (compound of Garlic)Akk,AkkermansiaAL,Allicin (mainly Garlic)almon,almonertinibAV,Aloe veraaLinA,alpha Linolenic acidALA,Alpha-Lipoic-AcidAVA,Aminolevulinic acidAMQ,AmodiaquineAnd,AndrographisACNs,AnthocyaninsantiOx,Anti-oxidantsApi,Apigenin (mainly Parsley)AG,ArctigeninART/DHA,ArtemisininAP,Ascorbyl PalmitateAsh,AshwagandhaASA,Aspirin -acetylsalicylic acidAS,AstragalusATV,AtorvastatinAur,AuranofinBa,BaicaleinBA,Baicalinbemp,bempedoic acidBaP,benzo(a)pyreneBBM,BerbamineBB,BerberinebetaCar,beta-caroteneB-Gluc,beta-glucansBA,Betulinic acidBEV,Bevacizumab (brand Avastin)Bical,BicalutamideHCO3,BicarbonateBif,BifidobacteriumBCA,Biochanin ABP,Black phosphorusborn,borneolBor,BoronBTZ,BortezomibBos,Boswellia (frankincense)BML,BromelainBJ,Brucea javanicaBrut,BruteridinBF,BufalinBA,ButyrateCA,Caffeic acidCaff,CaffeineCalc,CalciumCRMs,Calorie Restriction MimeticsCPT,CamptothecinCBC,CannabichromeneCBD,CannabidiolCBDA,cannabidiolic acidcapec,capecitabineCAP,Capsaicincarbop,carboplatinCA,Carnosic acidCAR,CarvacrolCats,Cat’s ClawCatechins,CatechinsCela,CelastrolCEL,CelecoxibCET,cetuximabCDT,chemodynamic therapyChemo,ChemotherapyChit,chitosanCGA,Chlorogenic acidCHL,ChlorophyllinCHOC,ChocolateCH,ChrysinCin,CinnamonCisplatin,CisplatinCitrate,Citric AcidCu,Copper and Cu NanoParticlexCroc,CrocetinCuc,CucurbitacinCUR,CurcuminCUSP9,CUSP9CP,CyclopamineCBC/D,Cynanbungeigenin C (CBC) and D (CBD)DL,D-limoneneDand,Dandelion RootDAS,DasatinibDeg,DeguelinAnamu,dibenzyl trisulphide(DTS) from AnamuDCA,DichloroacetateDAP,Dichloroacetophenone(2,2-)Dicl,DiclofenacdietF,diet Fermented FoodsdietFMD,diet FMD Fasting Mimicking DietdietKeto,diet KetogenicdietMet,diet Methionine-Restricted DietdietP,diet Plant basedDHCA,Dihydrocaffeic AcidDSMO,Dimethyl SulfoxideDipy,Dipyridamoledocx,DocetaxelDHA,Docosahexaenoic AciddoxoR,doxorubicinEch,EchinaceaEGCG,EGCG (Epigallocatechin Gallate)EPA,eicosapentaenoic acidEP,Electrical PulsesEA,Ellagic acidRF,EMFEMD,EmodinMS-275,entinostatEPI,epirubicinerastin,erastinEst,EstrogenEDTA,ethylene diamine tetraacetic acidEDM,EvodiamineEx,ExerciseFenb,FenbendazoleFA,Ferulic acidFer,ferumoxytolFIS,FisetinFlav,flavonoidsFA,Folic AcidForm,FormononetinF,FucoidanGA,Gallic acidGallo,GalloflavinGamB,Gambogic AcidGAR,GarcinolGB,gefitinib, erlotinibGEM,Gemcitabine (Gemzar)GEN,GenisteinGer,GermacranolideGE,GermaniumGI,Ginger/6-Shogaol/GingerolGB,Ginkgo bilobaGins,GinsengGlaB,Glabrescione BGlucDep,glucose deprivationGoldNP,Gold NanoParticlesGos,GossypolGe,Grapeseed extractGra,GraviolaHne,Helleborus niger extracts – Christmas RoseHibSad,Hibiscus sabdariffaHNK,HonokiolHops,Hops (Humulus lupulus)HRT,Hormone replacement therapyH2,Hydrogen GasHCQ,hydroxychloroquineHCAs,Hydroxycinnamic-acidHCA,HydroxyCitric AcidHTyr,HydroxytyrosolHP,HyperosideHPT,HyperthermiaIMA,imatinibimmuno,immunotherapyI3C,Indole-3-carbinolInA,Inoscavin AIns,InositolIP,Inulin Prebioticiod,iodineIP6,IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)lpi,ipilimumabFe,IronisoFl,isoflavonesitraC,itraconazoleIVM,IvermectinJG,JugloneKaempF,KaempferolL-A,L-AlinineL-Orn,L-ornithineLA,LactobacillusLF,LactoferrinLae,Laetrile B17 Amygdalinlamb,lambertianic acidLapC,LapacholLap,LapatinibLas,LasiodinLEC,LecithinLE,Licoricelign,lignansLip,Lipoic acidLDN,low dose naltrexoneLT,LuteolinLyco,LycopeneMg,MagnesiumMFrot,Magnetic Field RotatingMF,Magnetic FieldsMNPs,magnetic nanoparticlesMAG,MagnololMatr,MatrineMCT,MCToilmeben,mebendazoleMEL,MelatoninMel,MelitidinMET,MetforminMTX,methotrexateMeJa,Methyl JasmonateM-Blu,Methylene blueMGO,MethylglyoxalMeSA,methylseleninic acidMSM,MethylsulfonylmethanemetroC,metronomic chemoMT,MistletoeMCP,Modified Citrus PectinMoringa,Moringa oleiferaMushCha,Mushroom ChagamushLions,Mushroom Lion’s ManeMushMait,Mushroom MaitakeMushPL,Mushroom Phellinus. linteusMushReishi,Mushroom ReishiMushShi,Mushroom Shiitake, AHCCmushTT,mushroom Turkey TailMyr,MyricetinMyrrh,MyrrhNarG,NaringinNRF,nelfinavir/ViraceptNCL,Niclosamide (Niclocide)NAD,nicotinamide adenine dinucleotideNimb,NimbolideNIV,nivolumabNos,NoscapineOctr,octreotideOLST,OrlistatOA,Oroxylin AOA,Oroxylin-AOsi,OsimertinibOXA,OxaliplatinOAA,oxaloacetateOxy,Oxygen, HyperbaricPA,Pachymic acidPacT,PaclitaxelPap,papainPart,ParthenolidePawPaw,Paw PawPem,pembrolizumabP,PeppermintpH-AT,pH-Alkalization TherapyPB,PhenylbutyratePDT,Photodynamic TherapyPFB,Physalin F & BPI,PiperinePL,PiperlonguminePIT,PitavastatinPlum,PlumbaginPACs,ProanthocyanidinsProBio,probioticsPBG,Propolis -bee gluePG,Propyl gallatePS,PterostilbenePurp,PurpuronePhen,PXD, phenoxodiolQC,QuercetinRF,Radio FrequencyRad,Radiotherapy/RadiationRalox,raloxifenRAPA,RapamycinRSL3,Ras-selective lethal 3RSQ,ResiquimodRES,ResveratrolRetA,Retinoic AcidRosA,Rosmarinic acidRT,RutinSB,Saccharomyces boulardiiSS,Saikosaponin B1 and DSal,salinomycinSM,Salvia miltiorrhizaSANG,SanguinarineSco,ScoulerineSelenate,SelenateSel,SeleniteSe,SeleniumSeMet,selenomethioninesericin,sericinSK,ShikoninSTF,Short Term FastingGSL,Siegesbeckia glabrescensSB,SilibininSNP,Silver-NanoParticlesSIL,Silymarin (Milk Thistle)SIM,SimvastatinSDT,SonoDynamic Therapy UltraSoundSRF,Sorafenib (brand name Nexavar)Squ,Squalenestatins,statinsSulfas,SulfasalazineSulf,Sulforaphane (mainly Broccoli)SNT,sunitinibSuD,Sutherlandioside DTam,tamoxifenTau,TaurineTMZ,temozolomideTF,TheaflavinTb,TheobromineTV,Thymol-Thymus vulgarisTQ,ThymoquinoneTC,Tinospora CordifoliaTiO2,Titanium DioxideTomatine,TomatineTACE,Transarterial ChemoembolizationTras,TrastuzumabTSA,Trichostatin ATrip,triptolideTu,TulsiTTT,Tumor Treating FieldsUkrain,Ukrainurea,ureaUA,Ursolic acidVem,verapamilVitB12,Vitamin B12VitC,Vitamin C (Ascorbic Acid)VitD3,Vitamin D3VitE,Vitamin EVitK2,Vitamin K2VitB1/Thiamine,VitB1/ThiamineVitK3,VitK3,menadioneSAHA,VorinostatWBV,Whole Body VibrationWog,WogoninWor,Woreninewortm,wortmanninXyl,XylitolZeo,ZeoliteZ,ZincZO,Zinc Oxideβ�Ele,β�Elemeneγ-Toc,γ-Tocotrienol
Syn2	,2DG,2-DeoxyGlucose3BP,3-bromopyruvate5-FU,5-fluorouracilacet,acetaminophenacetaz,acetazolamideAco,Acoschimperoside P, 2’-acetateAdag,AdagrasibTFdiG,Aflavin-3,3′-digallateATAGJ,Ai-Tong-An-Gao-JiAjoene,Ajoene (compound of Garlic)Akk,AkkermansiaAL,Allicin (mainly Garlic)almon,almonertinibAV,Aloe veraaLinA,alpha Linolenic acidALA,Alpha-Lipoic-AcidAVA,Aminolevulinic acidAMQ,AmodiaquineAnd,AndrographisACNs,AnthocyaninsantiOx,Anti-oxidantsApi,Apigenin (mainly Parsley)AG,ArctigeninART/DHA,ArtemisininAP,Ascorbyl PalmitateAsh,AshwagandhaASA,Aspirin -acetylsalicylic acidAS,AstragalusATV,AtorvastatinAur,AuranofinBa,BaicaleinBA,Baicalinbemp,bempedoic acidBaP,benzo(a)pyreneBBM,BerbamineBB,BerberinebetaCar,beta-caroteneB-Gluc,beta-glucansBA,Betulinic acidBEV,Bevacizumab (brand Avastin)Bical,BicalutamideHCO3,BicarbonateBif,BifidobacteriumBCA,Biochanin ABP,Black phosphorusborn,borneolBor,BoronBTZ,BortezomibBos,Boswellia (frankincense)BML,BromelainBJ,Brucea javanicaBrut,BruteridinBF,BufalinBA,ButyrateCA,Caffeic acidCaff,CaffeineCalc,CalciumCRMs,Calorie Restriction MimeticsCPT,CamptothecinCBC,CannabichromeneCBD,CannabidiolCBDA,cannabidiolic acidcapec,capecitabineCAP,Capsaicincarbop,carboplatinCA,Carnosic acidCAR,CarvacrolCats,Cat’s ClawCatechins,CatechinsCela,CelastrolCEL,CelecoxibCET,cetuximabCDT,chemodynamic therapyChemo,ChemotherapyChit,chitosanCGA,Chlorogenic acidCHL,ChlorophyllinCHOC,ChocolateCH,ChrysinCin,CinnamonCisplatin,CisplatinCitrate,Citric AcidCu,Copper and Cu NanoParticlexCroc,CrocetinCuc,CucurbitacinCUR,CurcuminCUSP9,CUSP9CP,CyclopamineCBC/D,Cynanbungeigenin C (CBC) and D (CBD)DL,D-limoneneDand,Dandelion RootDAS,DasatinibDeg,DeguelinAnamu,dibenzyl trisulphide(DTS) from AnamuDCA,DichloroacetateDAP,Dichloroacetophenone(2,2-)Dicl,DiclofenacdietF,diet Fermented FoodsdietFMD,diet FMD Fasting Mimicking DietdietKeto,diet KetogenicdietMet,diet Methionine-Restricted DietdietP,diet Plant basedDHCA,Dihydrocaffeic AcidDSMO,Dimethyl SulfoxideDipy,Dipyridamoledocx,DocetaxelDHA,Docosahexaenoic AciddoxoR,doxorubicinEch,EchinaceaEGCG,EGCG (Epigallocatechin Gallate)EPA,eicosapentaenoic acidEP,Electrical PulsesEA,Ellagic acidRF,EMFEMD,EmodinMS-275,entinostatEPI,epirubicinerastin,erastinEst,EstrogenEDTA,ethylene diamine tetraacetic acidEDM,EvodiamineEx,ExerciseFenb,FenbendazoleFA,Ferulic acidFer,ferumoxytolFIS,FisetinFlav,flavonoidsFA,Folic AcidForm,FormononetinF,FucoidanGA,Gallic acidGallo,GalloflavinGamB,Gambogic AcidGAR,GarcinolGB,gefitinib, erlotinibGEM,Gemcitabine (Gemzar)GEN,GenisteinGer,GermacranolideGE,GermaniumGI,Ginger/6-Shogaol/GingerolGB,Ginkgo bilobaGins,GinsengGlaB,Glabrescione BGlucDep,glucose deprivationGoldNP,Gold NanoParticlesGos,GossypolGe,Grapeseed extractGra,GraviolaHne,Helleborus niger extracts – Christmas RoseHibSad,Hibiscus sabdariffaHNK,HonokiolHops,Hops (Humulus lupulus)HRT,Hormone replacement therapyH2,Hydrogen GasHCQ,hydroxychloroquineHCAs,Hydroxycinnamic-acidHCA,HydroxyCitric AcidHTyr,HydroxytyrosolHP,HyperosideHPT,HyperthermiaIMA,imatinibimmuno,immunotherapyI3C,Indole-3-carbinolInA,Inoscavin AIns,InositolIP,Inulin Prebioticiod,iodineIP6,IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)lpi,ipilimumabFe,IronisoFl,isoflavonesitraC,itraconazoleIVM,IvermectinJG,JugloneKaempF,KaempferolL-A,L-AlinineL-Orn,L-ornithineLA,LactobacillusLF,LactoferrinLae,Laetrile B17 Amygdalinlamb,lambertianic acidLapC,LapacholLap,LapatinibLas,LasiodinLEC,LecithinLE,Licoricelign,lignansLip,Lipoic acidLDN,low dose naltrexoneLT,LuteolinLyco,LycopeneMg,MagnesiumMFrot,Magnetic Field RotatingMF,Magnetic FieldsMNPs,magnetic nanoparticlesMAG,MagnololMatr,MatrineMCT,MCToilmeben,mebendazoleMEL,MelatoninMel,MelitidinMET,MetforminMTX,methotrexateMeJa,Methyl JasmonateM-Blu,Methylene blueMGO,MethylglyoxalMeSA,methylseleninic acidMSM,MethylsulfonylmethanemetroC,metronomic chemoMT,MistletoeMCP,Modified Citrus PectinMoringa,Moringa oleiferaMushCha,Mushroom ChagamushLions,Mushroom Lion’s ManeMushMait,Mushroom MaitakeMushPL,Mushroom Phellinus. linteusMushReishi,Mushroom ReishiMushShi,Mushroom Shiitake, AHCCmushTT,mushroom Turkey TailMyr,MyricetinMyrrh,MyrrhNarG,NaringinNRF,nelfinavir/ViraceptNCL,Niclosamide (Niclocide)NAD,nicotinamide adenine dinucleotideNimb,NimbolideNIV,nivolumabNos,NoscapineOctr,octreotideOLST,OrlistatOA,Oroxylin AOA,Oroxylin-AOsi,OsimertinibOXA,OxaliplatinOAA,oxaloacetateOxy,Oxygen, HyperbaricPA,Pachymic acidPacT,PaclitaxelPap,papainPart,ParthenolidePawPaw,Paw PawPem,pembrolizumabP,PeppermintpH-AT,pH-Alkalization TherapyPB,PhenylbutyratePDT,Photodynamic TherapyPFB,Physalin F & BPI,PiperinePL,PiperlonguminePIT,PitavastatinPlum,PlumbaginPACs,ProanthocyanidinsProBio,probioticsPBG,Propolis -bee gluePG,Propyl gallatePS,PterostilbenePurp,PurpuronePhen,PXD, phenoxodiolQC,QuercetinRF,Radio FrequencyRad,Radiotherapy/RadiationRalox,raloxifenRAPA,RapamycinRSL3,Ras-selective lethal 3RSQ,ResiquimodRES,ResveratrolRetA,Retinoic AcidRosA,Rosmarinic acidRT,RutinSB,Saccharomyces boulardiiSS,Saikosaponin B1 and DSal,salinomycinSM,Salvia miltiorrhizaSANG,SanguinarineSco,ScoulerineSelenate,SelenateSel,SeleniteSe,SeleniumSeMet,selenomethioninesericin,sericinSK,ShikoninSTF,Short Term FastingGSL,Siegesbeckia glabrescensSB,SilibininSNP,Silver-NanoParticlesSIL,Silymarin (Milk Thistle)SIM,SimvastatinSDT,SonoDynamic Therapy UltraSoundSRF,Sorafenib (brand name Nexavar)Squ,Squalenestatins,statinsSulfas,SulfasalazineSulf,Sulforaphane (mainly Broccoli)SNT,sunitinibSuD,Sutherlandioside DTam,tamoxifenTau,TaurineTMZ,temozolomideTF,TheaflavinTb,TheobromineTV,Thymol-Thymus vulgarisTQ,ThymoquinoneTC,Tinospora CordifoliaTiO2,Titanium DioxideTomatine,TomatineTACE,Transarterial ChemoembolizationTras,TrastuzumabTSA,Trichostatin ATrip,triptolideTu,TulsiTTT,Tumor Treating FieldsUkrain,Ukrainurea,ureaUA,Ursolic acidVem,verapamilVitB12,Vitamin B12VitC,Vitamin C (Ascorbic Acid)VitD3,Vitamin D3VitE,Vitamin EVitK2,Vitamin K2VitB1/Thiamine,VitB1/ThiamineVitK3,VitK3,menadioneSAHA,VorinostatWBV,Whole Body VibrationWog,WogoninWor,Woreninewortm,wortmanninXyl,XylitolZeo,ZeoliteZ,ZincZO,Zinc Oxideβ�Ele,β�Elemeneγ-Toc,γ-Tocotrienol	Syn3	,2DG,2-DeoxyGlucose3BP,3-bromopyruvate5-FU,5-fluorouracilacet,acetaminophenacetaz,acetazolamideAco,Acoschimperoside P, 2’-acetateAdag,AdagrasibTFdiG,Aflavin-3,3′-digallateATAGJ,Ai-Tong-An-Gao-JiAjoene,Ajoene (compound of Garlic)Akk,AkkermansiaAL,Allicin (mainly Garlic)almon,almonertinibAV,Aloe veraaLinA,alpha Linolenic acidALA,Alpha-Lipoic-AcidAVA,Aminolevulinic acidAMQ,AmodiaquineAnd,AndrographisACNs,AnthocyaninsantiOx,Anti-oxidantsApi,Apigenin (mainly Parsley)AG,ArctigeninART/DHA,ArtemisininAP,Ascorbyl PalmitateAsh,AshwagandhaASA,Aspirin -acetylsalicylic acidAS,AstragalusATV,AtorvastatinAur,AuranofinBa,BaicaleinBA,Baicalinbemp,bempedoic acidBaP,benzo(a)pyreneBBM,BerbamineBB,BerberinebetaCar,beta-caroteneB-Gluc,beta-glucansBA,Betulinic acidBEV,Bevacizumab (brand Avastin)Bical,BicalutamideHCO3,BicarbonateBif,BifidobacteriumBCA,Biochanin ABP,Black phosphorusborn,borneolBor,BoronBTZ,BortezomibBos,Boswellia (frankincense)BML,BromelainBJ,Brucea javanicaBrut,BruteridinBF,BufalinBA,ButyrateCA,Caffeic acidCaff,CaffeineCalc,CalciumCRMs,Calorie Restriction MimeticsCPT,CamptothecinCBC,CannabichromeneCBD,CannabidiolCBDA,cannabidiolic acidcapec,capecitabineCAP,Capsaicincarbop,carboplatinCA,Carnosic acidCAR,CarvacrolCats,Cat’s ClawCatechins,CatechinsCela,CelastrolCEL,CelecoxibCET,cetuximabCDT,chemodynamic therapyChemo,ChemotherapyChit,chitosanCGA,Chlorogenic acidCHL,ChlorophyllinCHOC,ChocolateCH,ChrysinCin,CinnamonCisplatin,CisplatinCitrate,Citric AcidCu,Copper and Cu NanoParticlexCroc,CrocetinCuc,CucurbitacinCUR,CurcuminCUSP9,CUSP9CP,CyclopamineCBC/D,Cynanbungeigenin C (CBC) and D (CBD)DL,D-limoneneDand,Dandelion RootDAS,DasatinibDeg,DeguelinAnamu,dibenzyl trisulphide(DTS) from AnamuDCA,DichloroacetateDAP,Dichloroacetophenone(2,2-)Dicl,DiclofenacdietF,diet Fermented FoodsdietFMD,diet FMD Fasting Mimicking DietdietKeto,diet KetogenicdietMet,diet Methionine-Restricted DietdietP,diet Plant basedDHCA,Dihydrocaffeic AcidDSMO,Dimethyl SulfoxideDipy,Dipyridamoledocx,DocetaxelDHA,Docosahexaenoic AciddoxoR,doxorubicinEch,EchinaceaEGCG,EGCG (Epigallocatechin Gallate)EPA,eicosapentaenoic acidEP,Electrical PulsesEA,Ellagic acidRF,EMFEMD,EmodinMS-275,entinostatEPI,epirubicinerastin,erastinEst,EstrogenEDTA,ethylene diamine tetraacetic acidEDM,EvodiamineEx,ExerciseFenb,FenbendazoleFA,Ferulic acidFer,ferumoxytolFIS,FisetinFlav,flavonoidsFA,Folic AcidForm,FormononetinF,FucoidanGA,Gallic acidGallo,GalloflavinGamB,Gambogic AcidGAR,GarcinolGB,gefitinib, erlotinibGEM,Gemcitabine (Gemzar)GEN,GenisteinGer,GermacranolideGE,GermaniumGI,Ginger/6-Shogaol/GingerolGB,Ginkgo bilobaGins,GinsengGlaB,Glabrescione BGlucDep,glucose deprivationGoldNP,Gold NanoParticlesGos,GossypolGe,Grapeseed extractGra,GraviolaHne,Helleborus niger extracts – Christmas RoseHibSad,Hibiscus sabdariffaHNK,HonokiolHops,Hops (Humulus lupulus)HRT,Hormone replacement therapyH2,Hydrogen GasHCQ,hydroxychloroquineHCAs,Hydroxycinnamic-acidHCA,HydroxyCitric AcidHTyr,HydroxytyrosolHP,HyperosideHPT,HyperthermiaIMA,imatinibimmuno,immunotherapyI3C,Indole-3-carbinolInA,Inoscavin AIns,InositolIP,Inulin Prebioticiod,iodineIP6,IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)lpi,ipilimumabFe,IronisoFl,isoflavonesitraC,itraconazoleIVM,IvermectinJG,JugloneKaempF,KaempferolL-A,L-AlinineL-Orn,L-ornithineLA,LactobacillusLF,LactoferrinLae,Laetrile B17 Amygdalinlamb,lambertianic acidLapC,LapacholLap,LapatinibLas,LasiodinLEC,LecithinLE,Licoricelign,lignansLip,Lipoic acidLDN,low dose naltrexoneLT,LuteolinLyco,LycopeneMg,MagnesiumMFrot,Magnetic Field RotatingMF,Magnetic FieldsMNPs,magnetic nanoparticlesMAG,MagnololMatr,MatrineMCT,MCToilmeben,mebendazoleMEL,MelatoninMel,MelitidinMET,MetforminMTX,methotrexateMeJa,Methyl JasmonateM-Blu,Methylene blueMGO,MethylglyoxalMeSA,methylseleninic acidMSM,MethylsulfonylmethanemetroC,metronomic chemoMT,MistletoeMCP,Modified Citrus PectinMoringa,Moringa oleiferaMushCha,Mushroom ChagamushLions,Mushroom Lion’s ManeMushMait,Mushroom MaitakeMushPL,Mushroom Phellinus. linteusMushReishi,Mushroom ReishiMushShi,Mushroom Shiitake, AHCCmushTT,mushroom Turkey TailMyr,MyricetinMyrrh,MyrrhNarG,NaringinNRF,nelfinavir/ViraceptNCL,Niclosamide (Niclocide)NAD,nicotinamide adenine dinucleotideNimb,NimbolideNIV,nivolumabNos,NoscapineOctr,octreotideOLST,OrlistatOA,Oroxylin AOA,Oroxylin-AOsi,OsimertinibOXA,OxaliplatinOAA,oxaloacetateOxy,Oxygen, HyperbaricPA,Pachymic acidPacT,PaclitaxelPap,papainPart,ParthenolidePawPaw,Paw PawPem,pembrolizumabP,PeppermintpH-AT,pH-Alkalization TherapyPB,PhenylbutyratePDT,Photodynamic TherapyPFB,Physalin F & BPI,PiperinePL,PiperlonguminePIT,PitavastatinPlum,PlumbaginPACs,ProanthocyanidinsProBio,probioticsPBG,Propolis -bee gluePG,Propyl gallatePS,PterostilbenePurp,PurpuronePhen,PXD, phenoxodiolQC,QuercetinRF,Radio FrequencyRad,Radiotherapy/RadiationRalox,raloxifenRAPA,RapamycinRSL3,Ras-selective lethal 3RSQ,ResiquimodRES,ResveratrolRetA,Retinoic AcidRosA,Rosmarinic acidRT,RutinSB,Saccharomyces boulardiiSS,Saikosaponin B1 and DSal,salinomycinSM,Salvia miltiorrhizaSANG,SanguinarineSco,ScoulerineSelenate,SelenateSel,SeleniteSe,SeleniumSeMet,selenomethioninesericin,sericinSK,ShikoninSTF,Short Term FastingGSL,Siegesbeckia glabrescensSB,SilibininSNP,Silver-NanoParticlesSIL,Silymarin (Milk Thistle)SIM,SimvastatinSDT,SonoDynamic Therapy UltraSoundSRF,Sorafenib (brand name Nexavar)Squ,Squalenestatins,statinsSulfas,SulfasalazineSulf,Sulforaphane (mainly Broccoli)SNT,sunitinibSuD,Sutherlandioside DTam,tamoxifenTau,TaurineTMZ,temozolomideTF,TheaflavinTb,TheobromineTV,Thymol-Thymus vulgarisTQ,ThymoquinoneTC,Tinospora CordifoliaTiO2,Titanium DioxideTomatine,TomatineTACE,Transarterial ChemoembolizationTras,TrastuzumabTSA,Trichostatin ATrip,triptolideTu,TulsiTTT,Tumor Treating FieldsUkrain,Ukrainurea,ureaUA,Ursolic acidVem,verapamilVitB12,Vitamin B12VitC,Vitamin C (Ascorbic Acid)VitD3,Vitamin D3VitE,Vitamin EVitK2,Vitamin K2VitB1/Thiamine,VitB1/ThiamineVitK3,VitK3,menadioneSAHA,VorinostatWBV,Whole Body VibrationWog,WogoninWor,Woreninewortm,wortmanninXyl,XylitolZeo,ZeoliteZ,ZincZO,Zinc Oxideβ�Ele,β�Elemeneγ-Toc,γ-Tocotrienol	Syn4	,2DG,2-DeoxyGlucose3BP,3-bromopyruvate5-FU,5-fluorouracilacet,acetaminophenacetaz,acetazolamideAco,Acoschimperoside P, 2’-acetateAdag,AdagrasibTFdiG,Aflavin-3,3′-digallateATAGJ,Ai-Tong-An-Gao-JiAjoene,Ajoene (compound of Garlic)Akk,AkkermansiaAL,Allicin (mainly Garlic)almon,almonertinibAV,Aloe veraaLinA,alpha Linolenic acidALA,Alpha-Lipoic-AcidAVA,Aminolevulinic acidAMQ,AmodiaquineAnd,AndrographisACNs,AnthocyaninsantiOx,Anti-oxidantsApi,Apigenin (mainly Parsley)AG,ArctigeninART/DHA,ArtemisininAP,Ascorbyl PalmitateAsh,AshwagandhaASA,Aspirin -acetylsalicylic acidAS,AstragalusATV,AtorvastatinAur,AuranofinBa,BaicaleinBA,Baicalinbemp,bempedoic acidBaP,benzo(a)pyreneBBM,BerbamineBB,BerberinebetaCar,beta-caroteneB-Gluc,beta-glucansBA,Betulinic acidBEV,Bevacizumab (brand Avastin)Bical,BicalutamideHCO3,BicarbonateBif,BifidobacteriumBCA,Biochanin ABP,Black phosphorusborn,borneolBor,BoronBTZ,BortezomibBos,Boswellia (frankincense)BML,BromelainBJ,Brucea javanicaBrut,BruteridinBF,BufalinBA,ButyrateCA,Caffeic acidCaff,CaffeineCalc,CalciumCRMs,Calorie Restriction MimeticsCPT,CamptothecinCBC,CannabichromeneCBD,CannabidiolCBDA,cannabidiolic acidcapec,capecitabineCAP,Capsaicincarbop,carboplatinCA,Carnosic acidCAR,CarvacrolCats,Cat’s ClawCatechins,CatechinsCela,CelastrolCEL,CelecoxibCET,cetuximabCDT,chemodynamic therapyChemo,ChemotherapyChit,chitosanCGA,Chlorogenic acidCHL,ChlorophyllinCHOC,ChocolateCH,ChrysinCin,CinnamonCisplatin,CisplatinCitrate,Citric AcidCu,Copper and Cu NanoParticlexCroc,CrocetinCuc,CucurbitacinCUR,CurcuminCUSP9,CUSP9CP,CyclopamineCBC/D,Cynanbungeigenin C (CBC) and D (CBD)DL,D-limoneneDand,Dandelion RootDAS,DasatinibDeg,DeguelinAnamu,dibenzyl trisulphide(DTS) from AnamuDCA,DichloroacetateDAP,Dichloroacetophenone(2,2-)Dicl,DiclofenacdietF,diet Fermented FoodsdietFMD,diet FMD Fasting Mimicking DietdietKeto,diet KetogenicdietMet,diet Methionine-Restricted DietdietP,diet Plant basedDHCA,Dihydrocaffeic AcidDSMO,Dimethyl SulfoxideDipy,Dipyridamoledocx,DocetaxelDHA,Docosahexaenoic AciddoxoR,doxorubicinEch,EchinaceaEGCG,EGCG (Epigallocatechin Gallate)EPA,eicosapentaenoic acidEP,Electrical PulsesEA,Ellagic acidRF,EMFEMD,EmodinMS-275,entinostatEPI,epirubicinerastin,erastinEst,EstrogenEDTA,ethylene diamine tetraacetic acidEDM,EvodiamineEx,ExerciseFenb,FenbendazoleFA,Ferulic acidFer,ferumoxytolFIS,FisetinFlav,flavonoidsFA,Folic AcidForm,FormononetinF,FucoidanGA,Gallic acidGallo,GalloflavinGamB,Gambogic AcidGAR,GarcinolGB,gefitinib, erlotinibGEM,Gemcitabine (Gemzar)GEN,GenisteinGer,GermacranolideGE,GermaniumGI,Ginger/6-Shogaol/GingerolGB,Ginkgo bilobaGins,GinsengGlaB,Glabrescione BGlucDep,glucose deprivationGoldNP,Gold NanoParticlesGos,GossypolGe,Grapeseed extractGra,GraviolaHne,Helleborus niger extracts – Christmas RoseHibSad,Hibiscus sabdariffaHNK,HonokiolHops,Hops (Humulus lupulus)HRT,Hormone replacement therapyH2,Hydrogen GasHCQ,hydroxychloroquineHCAs,Hydroxycinnamic-acidHCA,HydroxyCitric AcidHTyr,HydroxytyrosolHP,HyperosideHPT,HyperthermiaIMA,imatinibimmuno,immunotherapyI3C,Indole-3-carbinolInA,Inoscavin AIns,InositolIP,Inulin Prebioticiod,iodineIP6,IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)lpi,ipilimumabFe,IronisoFl,isoflavonesitraC,itraconazoleIVM,IvermectinJG,JugloneKaempF,KaempferolL-A,L-AlinineL-Orn,L-ornithineLA,LactobacillusLF,LactoferrinLae,Laetrile B17 Amygdalinlamb,lambertianic acidLapC,LapacholLap,LapatinibLas,LasiodinLEC,LecithinLE,Licoricelign,lignansLip,Lipoic acidLDN,low dose naltrexoneLT,LuteolinLyco,LycopeneMg,MagnesiumMFrot,Magnetic Field RotatingMF,Magnetic FieldsMNPs,magnetic nanoparticlesMAG,MagnololMatr,MatrineMCT,MCToilmeben,mebendazoleMEL,MelatoninMel,MelitidinMET,MetforminMTX,methotrexateMeJa,Methyl JasmonateM-Blu,Methylene blueMGO,MethylglyoxalMeSA,methylseleninic acidMSM,MethylsulfonylmethanemetroC,metronomic chemoMT,MistletoeMCP,Modified Citrus PectinMoringa,Moringa oleiferaMushCha,Mushroom ChagamushLions,Mushroom Lion’s ManeMushMait,Mushroom MaitakeMushPL,Mushroom Phellinus. linteusMushReishi,Mushroom ReishiMushShi,Mushroom Shiitake, AHCCmushTT,mushroom Turkey TailMyr,MyricetinMyrrh,MyrrhNarG,NaringinNRF,nelfinavir/ViraceptNCL,Niclosamide (Niclocide)NAD,nicotinamide adenine dinucleotideNimb,NimbolideNIV,nivolumabNos,NoscapineOctr,octreotideOLST,OrlistatOA,Oroxylin AOA,Oroxylin-AOsi,OsimertinibOXA,OxaliplatinOAA,oxaloacetateOxy,Oxygen, HyperbaricPA,Pachymic acidPacT,PaclitaxelPap,papainPart,ParthenolidePawPaw,Paw PawPem,pembrolizumabP,PeppermintpH-AT,pH-Alkalization TherapyPB,PhenylbutyratePDT,Photodynamic TherapyPFB,Physalin F & BPI,PiperinePL,PiperlonguminePIT,PitavastatinPlum,PlumbaginPACs,ProanthocyanidinsProBio,probioticsPBG,Propolis -bee gluePG,Propyl gallatePS,PterostilbenePurp,PurpuronePhen,PXD, phenoxodiolQC,QuercetinRF,Radio FrequencyRad,Radiotherapy/RadiationRalox,raloxifenRAPA,RapamycinRSL3,Ras-selective lethal 3RSQ,ResiquimodRES,ResveratrolRetA,Retinoic AcidRosA,Rosmarinic acidRT,RutinSB,Saccharomyces boulardiiSS,Saikosaponin B1 and DSal,salinomycinSM,Salvia miltiorrhizaSANG,SanguinarineSco,ScoulerineSelenate,SelenateSel,SeleniteSe,SeleniumSeMet,selenomethioninesericin,sericinSK,ShikoninSTF,Short Term FastingGSL,Siegesbeckia glabrescensSB,SilibininSNP,Silver-NanoParticlesSIL,Silymarin (Milk Thistle)SIM,SimvastatinSDT,SonoDynamic Therapy UltraSoundSRF,Sorafenib (brand name Nexavar)Squ,Squalenestatins,statinsSulfas,SulfasalazineSulf,Sulforaphane (mainly Broccoli)SNT,sunitinibSuD,Sutherlandioside DTam,tamoxifenTau,TaurineTMZ,temozolomideTF,TheaflavinTb,TheobromineTV,Thymol-Thymus vulgarisTQ,ThymoquinoneTC,Tinospora CordifoliaTiO2,Titanium DioxideTomatine,TomatineTACE,Transarterial ChemoembolizationTras,TrastuzumabTSA,Trichostatin ATrip,triptolideTu,TulsiTTT,Tumor Treating FieldsUkrain,Ukrainurea,ureaUA,Ursolic acidVem,verapamilVitB12,Vitamin B12VitC,Vitamin C (Ascorbic Acid)VitD3,Vitamin D3VitE,Vitamin EVitK2,Vitamin K2VitB1/Thiamine,VitB1/ThiamineVitK3,VitK3,menadioneSAHA,VorinostatWBV,Whole Body VibrationWog,WogoninWor,Woreninewortm,wortmanninXyl,XylitolZeo,ZeoliteZ,ZincZO,Zinc Oxideβ�Ele,β�Elemeneγ-Toc,γ-Tocotrienol

Maintaining cellular redox homeostasis is imperative for the survival and normal functioning of cells. This study describes the role and regulation of MAPKinases in oxidative stress mediated apoptosis. Plumbagin, a vitamin K3 analog and a pro-oxidant, was employed and it induced apoptosis in both mouse and human T-cell lymphoma cell lines via increased oxidative stress, caspase activity and loss of mitochondrial membrane potential. The pro-oxidant and cytotoxic effects of plumbagin were sensitiv ...

PMID	year	Title	Author	Link
25444924	2015	Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)	Rahul Checker	https://pubmed.ncbi.nlm.nih.gov/25444924/	Link

Model	Illness	Cell Line	Dosage	IC50	Notes
NAin-vitroin-vivovitro+vivoHumanAnalysisReviewex-vivoCase ReportTrialStudy	ACC,Adenoid Cysadrenal,adrenalALL,Acute LymphAML,Acute MyeloBC,Breast CanceBCC,Basal Cell Bile,cholangiocBladder,BladderBrCC,bronchial CardioV,CardiovCerv,Cervical CChon,ChondrosarCLL,Chronic LymColon,Colon CanCRC,Colorectal EC,Endometrial Endo,EndometrioEOC,Epithelial ESCC,oesophageafibroS,fibrosarGall,GallbladdeGBM,glioblastomGC,gastric adenGI,GastrointestHCC,HepatocelluHepat,hepatomaHNSCC,Head and Kidney,Kidney (Laryn,LaryngealLiver,Liver CanLung,Lung Cancelymphoma,lymphoMB,medulloblastMelanoma,MelanoMG,malignant glMM,malignant meNA,Not Availablneuroblastoma,nNMSC,Non MelanoNor,Normal HealNPC,nasopharyngNSCLC,Non-smallOral,OralOS,OsteosarcomaOvarian,OvarianPC,pancreatic cPca,Prostate CaPerC,PeritonealRCC,renal cell RPE,retinal pigsarcoma,sarcomaSCC,squamous ceSchw,SchwannomaTesti,TesticulaThyroid,ThyroidTLS,Tumor lysisTong,TongueUEC,uterine endVar,Various CanAD,Alzheimer's AKI,Acute kidneAlcohol,AlcoholArthritis,Arthrasthmatic,asthmCKD,chronic kidCol,colitisCSCs,Cancer SteDiabetic,DiabetHeart,Heart DisIBD,inflammatorInf,InfectionLiverDam,Liver Mal,MalariaMS,Multiple sclObesity,ObesityostP,osteoporosPark,Parkinson'PSA,PsoriasisSepsis,SepsisStroke,CerebralUTI,Urinary TraVit,VitiligoWounds,Wounds	1-,Nor1321N1 ,Nor143B,OS2-,Var22Rv1,Pca3T3,Nor402,lymphoma4T1,BC5637,Bladder769-P,RCC786-O,Kidney8505C,ThyroidA172,GBMA2058,MelanomaA2780S,MelanomaA375,MelanomaA431,MelanomaA498,RCCA549,LungACC-M,adrenalACHN,KidneyAGS,GCAMGM,GBMAMJ13,AMLAML12 ,LiverAN3CA,EndoAPL NB4,AMLARPE-19,NAAsPC-1,PCAU-565,BCB16-BL6,MelanomB16-F10,MelanomBcap37,BCBCPAP,ThyroidBEAS-2B,NorBel-7402,LiverBel7,lymphomaBGC-823,GCBPH1,PCBT20,BCBT474,BCBT549,BCBV2,NorBxpc-3,PCC33A,CervC3H10T1/2,NAC4-2B,PcaC8161,MelanomaCa9-22,SCCCaco-2,ColonCAF,VarCaki-1,KidneyCAL-62,ThyroidCAL27,SCCCAL51,BCCalu-1,LungCalu-6,LungCaOV3,OvarianCapan1,PCCC531,CRCCCD-18Co,NorCCD19,NorCCD841,NorCCl233,LungCD133+,PCCD24+,PcaCD44+,PCCEM,ALLCOLO205,CRCCOLO357,PCcolon26,ColonCRL-7891,LungCT26,ColonCV1,NorCX-1,CRCD407,RPEDAOY,GCDIPG,GBMDLD1,CRCDMS114,LungDU145,PcaE0771,BCE18,NorEAhy926,LungEC9706,ESCCEca109,ESCCEL4,NorEMT6,BCESA+,PCF344,VarF9,TestiFaDu,LarynFaO,HepatFF95,NorFTC-133,ThyroidFTC-133,ThyroidG361,MelanomaGBC-SD,GallGBM,GBMGBM115,GBMGBM8401,GBMGCSCs,GCGES-1,NorGL-15,GBMGL26,GBMglial,NorGM05757 ,NorGP-293,NorH1299,LungH146,LungH157,LungH1650,LungH1792 ,LungH1975,LungH2009,LungH2030,LungH226,SCCH23,LungH2452,MMH292,LungH295R,adrenalH385,LungH4,NorH446,LungH460,LungH4IIE,LiverH6c7,NorH720,BrCCH727,BrCCHaCaT,NorHBE4-E6/E7,NorHBL ,lymphomaHBL-100,NorHC11,NorHCC-38,BCHCC1937,BCHCC827,LungHCC9810,HCCHCCLM3,HCCHCE-2,NorHCEC 1CT,NorHCT-15,ColonHCT116,CRCHCT8,CRCHDFa,NorHEC1B,ECHEI-OC1,NorHEI193,NorHEK293,NorHeLa,CervHEp2,LarynHep3B,LiverHepaRG ,NorHepG2,LiverHepG3,LiverHet-1A,NorhFOB1.19,NorHGC27,GCHK-2,NorHL-60,AMLHL7702,NorHMC3,MelanomaHMEC,NorHMrSV5 ,NorHMVEC-dLy,NorHN30,HNSCCHN5 ,HNSCCHN8,neuroblastoHNK,NAHNPSC,NorHO-8910,OvarianHONE1,NPCHPAECs,NorHPDE-6,NorHPNE,NorHs294T,MelanomaHS587T,BCHS68,NorHs683,GBMHs766t,PCHSC-T6,NorHSC2,OralHSC3,OralHSC4,SCCHT-29,CRCHT1080,IBDHT29,ColonHTB-22,BladderHTB-35,CervHTC15,LiverhTERT-HPNE,NorHTH-83,ThyroidHuCCT1,BileHuH28,BileHUH7,LiverHuT78,lymphomaHUVECs,NorIGROV1,OvarianIHH4,ThyroidIMR90,NAIOSE364,NorIPEC-J2,NorISH,ECJ82,BladderJB6,NorJCA-1,PcaJPL119,lymphomaJurkat,AMLK1,ThyroidK562,AMLKAIMRC1,BCKB,OralKG-1 ,AMLKGN,OvarianKLE,EndoKP2,PCKYSE-510,ESCCKYSE150,SCCKYSE170,ESCCKYSE450,SCCL02,NorL132,LungL428,lymphomaL929,NorLAPC-4,PcaLGR5,NALL/2 (LLC1),LunLLC1,LungLM8,OSLN-18,GBMLN229,GBMLNCaP,PcaLNM35,LungLoVo,CRCLS1034,CRCLS174T,CRCLU99,LungM059K,GBMMBT-2,BladderMC38,ColonMCF-7 ,BCMCF10 ,NorMDA-MB-231,BCMDA-MB-361,BCMDA-MB-435,BCMDA-MB-453,BCMDA-MB-468,BCMDAH-2774,OvariMeT5A,NorMG63,OSMGC803,BCMH-S,NorMHCC-97H,HCCMIA PaCa-2,PCMIHA,NorMKN-28,GCMKN45,GCMM.1S,MelanomaMPC5,NorMRC-5,NorMS-1,PCMSTO-211H,MMNA,NANCI-H441,LungNCI-H929 ,MelanNCIH1299,LungNCM460,NorNG108-15,NorNHEKn ,NorNIH-3T3,NANOZ,GallNRK52E,NorOS-RC-2,NAOV-MZ-6,OvarianOV1369,OvarianOV1946,OvarianOV7 ,OvarianOV90,OvarianOVCAR-3,OvarianPA1,OvarianPanc02,PCPANC1,PCPanCSC,PCPATU-8988,PCPC12,NorPC3,PcaPC9,LungpCSCs ,PcaPECs,NAPEL,lymphomaPHEO ,adrenalPNT1A,NorPrEC,NAPrEC,PcaPWR-1E,NorRAW264.7,NorRCC4 ,RCCREN,RCCRKO,CRCRM-1,PcaRPE-1,NorRPMI-7951,MelanRPMI-8226,MelanRT112,BladderRT4,BladderRWPE-1,NorS180,sarcomaSALTO,BCSaOS2,OSSCC-154,SCCSCC15 ,SCCSCC25,SCCSCC25,TongSCC4,SCCSCC9,TongSCM1,GCSGC-7901,GCSH-SY5Y,neuroblSiHa,CervSK-HEP-1,adrenaSK-LU-1,LungSK-MEL-28,MelanSK-N-BE,PCSK-N-SH,neuroblSkBr3,BCSKM-1,AMLSkMC,NorSKOV3,OvarianSMMC-7721 cell,SNB19,GBMSNU-407,CRCSNU1041,GISNU1076,GISNU5,GCSNU620,GCSUM159,BCSUNE-1,NPCSV-HUC-1,NorSVGp12,NorSW-620,CRCSW1353,ChonSW48,ColonSW480,ColonSW780 ,BladderT24,CRCT47D,BCT84,ColonT98G,GBMTca8113,TongTCAM-2,TestiTCCSUP,BladderTCO1 ,ALLTCO2,ALLTE1,ESCCTF1,AMLTHESCs ,NorTHP1,AMLTIG-1,NorTK6,lymphomaTM4,NorTMK-1,GCTOV-21G,OvarianTPC-1,ThyroidTRAMP-C1,PcaTSCCa,TongTSGH8301,BladdeTUBO,BCU118MG,GBMU1285,SCCU251,GBMU266,MelanomaU2OS,OSU373MG,GBMU87MG,GBMU937,lymphomaUM-SCC-1,HNSCCUMUC3,BladderUTSCC15 ,HNSCCUW-BCC1,NMSCWalker256,BCWI38,NAWM35,MelanomaWM983B,MelanomaWPMY-1,NorWRL68,NorYAMC,NorYPEN-1,PcaZR-75-1,BC			mouse
NAin-vitroin-vivovitro+vivoHumanAnalysisReviewex-vivoCase ReportTrialStudy	ACC,Adenoid Cysadrenal,adrenalALL,Acute LymphAML,Acute MyeloBC,Breast CanceBCC,Basal Cell Bile,cholangiocBladder,BladderBrCC,bronchial CardioV,CardiovCerv,Cervical CChon,ChondrosarCLL,Chronic LymColon,Colon CanCRC,Colorectal EC,Endometrial Endo,EndometrioEOC,Epithelial ESCC,oesophageafibroS,fibrosarGall,GallbladdeGBM,glioblastomGC,gastric adenGI,GastrointestHCC,HepatocelluHepat,hepatomaHNSCC,Head and Kidney,Kidney (Laryn,LaryngealLiver,Liver CanLung,Lung Cancelymphoma,lymphoMB,medulloblastMelanoma,MelanoMG,malignant glMM,malignant meNA,Not Availablneuroblastoma,nNMSC,Non MelanoNor,Normal HealNPC,nasopharyngNSCLC,Non-smallOral,OralOS,OsteosarcomaOvarian,OvarianPC,pancreatic cPca,Prostate CaPerC,PeritonealRCC,renal cell RPE,retinal pigsarcoma,sarcomaSCC,squamous ceSchw,SchwannomaTesti,TesticulaThyroid,ThyroidTLS,Tumor lysisTong,TongueUEC,uterine endVar,Various CanAD,Alzheimer's AKI,Acute kidneAlcohol,AlcoholArthritis,Arthrasthmatic,asthmCKD,chronic kidCol,colitisCSCs,Cancer SteDiabetic,DiabetHeart,Heart DisIBD,inflammatorInf,InfectionLiverDam,Liver Mal,MalariaMS,Multiple sclObesity,ObesityostP,osteoporosPark,Parkinson'PSA,PsoriasisSepsis,SepsisStroke,CerebralUTI,Urinary TraVit,VitiligoWounds,Wounds	1-,Nor1321N1 ,Nor143B,OS2-,Var22Rv1,Pca3T3,Nor402,lymphoma4T1,BC5637,Bladder769-P,RCC786-O,Kidney8505C,ThyroidA172,GBMA2058,MelanomaA2780S,MelanomaA375,MelanomaA431,MelanomaA498,RCCA549,LungACC-M,adrenalACHN,KidneyAGS,GCAMGM,GBMAMJ13,AMLAML12 ,LiverAN3CA,EndoAPL NB4,AMLARPE-19,NAAsPC-1,PCAU-565,BCB16-BL6,MelanomB16-F10,MelanomBcap37,BCBCPAP,ThyroidBEAS-2B,NorBel-7402,LiverBel7,lymphomaBGC-823,GCBPH1,PCBT20,BCBT474,BCBT549,BCBV2,NorBxpc-3,PCC33A,CervC3H10T1/2,NAC4-2B,PcaC8161,MelanomaCa9-22,SCCCaco-2,ColonCAF,VarCaki-1,KidneyCAL-62,ThyroidCAL27,SCCCAL51,BCCalu-1,LungCalu-6,LungCaOV3,OvarianCapan1,PCCC531,CRCCCD-18Co,NorCCD19,NorCCD841,NorCCl233,LungCD133+,PCCD24+,PcaCD44+,PCCEM,ALLCOLO205,CRCCOLO357,PCcolon26,ColonCRL-7891,LungCT26,ColonCV1,NorCX-1,CRCD407,RPEDAOY,GCDIPG,GBMDLD1,CRCDMS114,LungDU145,PcaE0771,BCE18,NorEAhy926,LungEC9706,ESCCEca109,ESCCEL4,NorEMT6,BCESA+,PCF344,VarF9,TestiFaDu,LarynFaO,HepatFF95,NorFTC-133,ThyroidFTC-133,ThyroidG361,MelanomaGBC-SD,GallGBM,GBMGBM115,GBMGBM8401,GBMGCSCs,GCGES-1,NorGL-15,GBMGL26,GBMglial,NorGM05757 ,NorGP-293,NorH1299,LungH146,LungH157,LungH1650,LungH1792 ,LungH1975,LungH2009,LungH2030,LungH226,SCCH23,LungH2452,MMH292,LungH295R,adrenalH385,LungH4,NorH446,LungH460,LungH4IIE,LiverH6c7,NorH720,BrCCH727,BrCCHaCaT,NorHBE4-E6/E7,NorHBL ,lymphomaHBL-100,NorHC11,NorHCC-38,BCHCC1937,BCHCC827,LungHCC9810,HCCHCCLM3,HCCHCE-2,NorHCEC 1CT,NorHCT-15,ColonHCT116,CRCHCT8,CRCHDFa,NorHEC1B,ECHEI-OC1,NorHEI193,NorHEK293,NorHeLa,CervHEp2,LarynHep3B,LiverHepaRG ,NorHepG2,LiverHepG3,LiverHet-1A,NorhFOB1.19,NorHGC27,GCHK-2,NorHL-60,AMLHL7702,NorHMC3,MelanomaHMEC,NorHMrSV5 ,NorHMVEC-dLy,NorHN30,HNSCCHN5 ,HNSCCHN8,neuroblastoHNK,NAHNPSC,NorHO-8910,OvarianHONE1,NPCHPAECs,NorHPDE-6,NorHPNE,NorHs294T,MelanomaHS587T,BCHS68,NorHs683,GBMHs766t,PCHSC-T6,NorHSC2,OralHSC3,OralHSC4,SCCHT-29,CRCHT1080,IBDHT29,ColonHTB-22,BladderHTB-35,CervHTC15,LiverhTERT-HPNE,NorHTH-83,ThyroidHuCCT1,BileHuH28,BileHUH7,LiverHuT78,lymphomaHUVECs,NorIGROV1,OvarianIHH4,ThyroidIMR90,NAIOSE364,NorIPEC-J2,NorISH,ECJ82,BladderJB6,NorJCA-1,PcaJPL119,lymphomaJurkat,AMLK1,ThyroidK562,AMLKAIMRC1,BCKB,OralKG-1 ,AMLKGN,OvarianKLE,EndoKP2,PCKYSE-510,ESCCKYSE150,SCCKYSE170,ESCCKYSE450,SCCL02,NorL132,LungL428,lymphomaL929,NorLAPC-4,PcaLGR5,NALL/2 (LLC1),LunLLC1,LungLM8,OSLN-18,GBMLN229,GBMLNCaP,PcaLNM35,LungLoVo,CRCLS1034,CRCLS174T,CRCLU99,LungM059K,GBMMBT-2,BladderMC38,ColonMCF-7 ,BCMCF10 ,NorMDA-MB-231,BCMDA-MB-361,BCMDA-MB-435,BCMDA-MB-453,BCMDA-MB-468,BCMDAH-2774,OvariMeT5A,NorMG63,OSMGC803,BCMH-S,NorMHCC-97H,HCCMIA PaCa-2,PCMIHA,NorMKN-28,GCMKN45,GCMM.1S,MelanomaMPC5,NorMRC-5,NorMS-1,PCMSTO-211H,MMNA,NANCI-H441,LungNCI-H929 ,MelanNCIH1299,LungNCM460,NorNG108-15,NorNHEKn ,NorNIH-3T3,NANOZ,GallNRK52E,NorOS-RC-2,NAOV-MZ-6,OvarianOV1369,OvarianOV1946,OvarianOV7 ,OvarianOV90,OvarianOVCAR-3,OvarianPA1,OvarianPanc02,PCPANC1,PCPanCSC,PCPATU-8988,PCPC12,NorPC3,PcaPC9,LungpCSCs ,PcaPECs,NAPEL,lymphomaPHEO ,adrenalPNT1A,NorPrEC,NAPrEC,PcaPWR-1E,NorRAW264.7,NorRCC4 ,RCCREN,RCCRKO,CRCRM-1,PcaRPE-1,NorRPMI-7951,MelanRPMI-8226,MelanRT112,BladderRT4,BladderRWPE-1,NorS180,sarcomaSALTO,BCSaOS2,OSSCC-154,SCCSCC15 ,SCCSCC25,SCCSCC25,TongSCC4,SCCSCC9,TongSCM1,GCSGC-7901,GCSH-SY5Y,neuroblSiHa,CervSK-HEP-1,adrenaSK-LU-1,LungSK-MEL-28,MelanSK-N-BE,PCSK-N-SH,neuroblSkBr3,BCSKM-1,AMLSkMC,NorSKOV3,OvarianSMMC-7721 cell,SNB19,GBMSNU-407,CRCSNU1041,GISNU1076,GISNU5,GCSNU620,GCSUM159,BCSUNE-1,NPCSV-HUC-1,NorSVGp12,NorSW-620,CRCSW1353,ChonSW48,ColonSW480,ColonSW780 ,BladderT24,CRCT47D,BCT84,ColonT98G,GBMTca8113,TongTCAM-2,TestiTCCSUP,BladderTCO1 ,ALLTCO2,ALLTE1,ESCCTF1,AMLTHESCs ,NorTHP1,AMLTIG-1,NorTK6,lymphomaTM4,NorTMK-1,GCTOV-21G,OvarianTPC-1,ThyroidTRAMP-C1,PcaTSCCa,TongTSGH8301,BladdeTUBO,BCU118MG,GBMU1285,SCCU251,GBMU266,MelanomaU2OS,OSU373MG,GBMU87MG,GBMU937,lymphomaUM-SCC-1,HNSCCUMUC3,BladderUTSCC15 ,HNSCCUW-BCC1,NMSCWalker256,BCWI38,NAWM35,MelanomaWM983B,MelanomaWPMY-1,NorWRL68,NorYAMC,NorYPEN-1,PcaZR-75-1,BC
NAin-vitroin-vivovitro+vivoHumanAnalysisReviewex-vivoCase ReportTrialStudy	ACC,Adenoid Cysadrenal,adrenalALL,Acute LymphAML,Acute MyeloBC,Breast CanceBCC,Basal Cell Bile,cholangiocBladder,BladderBrCC,bronchial CardioV,CardiovCerv,Cervical CChon,ChondrosarCLL,Chronic LymColon,Colon CanCRC,Colorectal EC,Endometrial Endo,EndometrioEOC,Epithelial ESCC,oesophageafibroS,fibrosarGall,GallbladdeGBM,glioblastomGC,gastric adenGI,GastrointestHCC,HepatocelluHepat,hepatomaHNSCC,Head and Kidney,Kidney (Laryn,LaryngealLiver,Liver CanLung,Lung Cancelymphoma,lymphoMB,medulloblastMelanoma,MelanoMG,malignant glMM,malignant meNA,Not Availablneuroblastoma,nNMSC,Non MelanoNor,Normal HealNPC,nasopharyngNSCLC,Non-smallOral,OralOS,OsteosarcomaOvarian,OvarianPC,pancreatic cPca,Prostate CaPerC,PeritonealRCC,renal cell RPE,retinal pigsarcoma,sarcomaSCC,squamous ceSchw,SchwannomaTesti,TesticulaThyroid,ThyroidTLS,Tumor lysisTong,TongueUEC,uterine endVar,Various CanAD,Alzheimer's AKI,Acute kidneAlcohol,AlcoholArthritis,Arthrasthmatic,asthmCKD,chronic kidCol,colitisCSCs,Cancer SteDiabetic,DiabetHeart,Heart DisIBD,inflammatorInf,InfectionLiverDam,Liver Mal,MalariaMS,Multiple sclObesity,ObesityostP,osteoporosPark,Parkinson'PSA,PsoriasisSepsis,SepsisStroke,CerebralUTI,Urinary TraVit,VitiligoWounds,WoundsNA	1-,Nor1321N1 ,Nor143B,OS2-,Var22Rv1,Pca3T3,Nor402,lymphoma4T1,BC5637,Bladder769-P,RCC786-O,Kidney8505C,ThyroidA172,GBMA2058,MelanomaA2780S,MelanomaA375,MelanomaA431,MelanomaA498,RCCA549,LungACC-M,adrenalACHN,KidneyAGS,GCAMGM,GBMAMJ13,AMLAML12 ,LiverAN3CA,EndoAPL NB4,AMLARPE-19,NAAsPC-1,PCAU-565,BCB16-BL6,MelanomB16-F10,MelanomBcap37,BCBCPAP,ThyroidBEAS-2B,NorBel-7402,LiverBel7,lymphomaBGC-823,GCBPH1,PCBT20,BCBT474,BCBT549,BCBV2,NorBxpc-3,PCC33A,CervC3H10T1/2,NAC4-2B,PcaC8161,MelanomaCa9-22,SCCCaco-2,ColonCAF,VarCaki-1,KidneyCAL-62,ThyroidCAL27,SCCCAL51,BCCalu-1,LungCalu-6,LungCaOV3,OvarianCapan1,PCCC531,CRCCCD-18Co,NorCCD19,NorCCD841,NorCCl233,LungCD133+,PCCD24+,PcaCD44+,PCCEM,ALLCOLO205,CRCCOLO357,PCcolon26,ColonCRL-7891,LungCT26,ColonCV1,NorCX-1,CRCD407,RPEDAOY,GCDIPG,GBMDLD1,CRCDMS114,LungDU145,PcaE0771,BCE18,NorEAhy926,LungEC9706,ESCCEca109,ESCCEL4,NorEMT6,BCESA+,PCF344,VarF9,TestiFaDu,LarynFaO,HepatFF95,NorFTC-133,ThyroidFTC-133,ThyroidG361,MelanomaGBC-SD,GallGBM,GBMGBM115,GBMGBM8401,GBMGCSCs,GCGES-1,NorGL-15,GBMGL26,GBMglial,NorGM05757 ,NorGP-293,NorH1299,LungH146,LungH157,LungH1650,LungH1792 ,LungH1975,LungH2009,LungH2030,LungH226,SCCH23,LungH2452,MMH292,LungH295R,adrenalH385,LungH4,NorH446,LungH460,LungH4IIE,LiverH6c7,NorH720,BrCCH727,BrCCHaCaT,NorHBE4-E6/E7,NorHBL ,lymphomaHBL-100,NorHC11,NorHCC-38,BCHCC1937,BCHCC827,LungHCC9810,HCCHCCLM3,HCCHCE-2,NorHCEC 1CT,NorHCT-15,ColonHCT116,CRCHCT8,CRCHDFa,NorHEC1B,ECHEI-OC1,NorHEI193,NorHEK293,NorHeLa,CervHEp2,LarynHep3B,LiverHepaRG ,NorHepG2,LiverHepG3,LiverHet-1A,NorhFOB1.19,NorHGC27,GCHK-2,NorHL-60,AMLHL7702,NorHMC3,MelanomaHMEC,NorHMrSV5 ,NorHMVEC-dLy,NorHN30,HNSCCHN5 ,HNSCCHN8,neuroblastoHNK,NAHNPSC,NorHO-8910,OvarianHONE1,NPCHPAECs,NorHPDE-6,NorHPNE,NorHs294T,MelanomaHS587T,BCHS68,NorHs683,GBMHs766t,PCHSC-T6,NorHSC2,OralHSC3,OralHSC4,SCCHT-29,CRCHT1080,IBDHT29,ColonHTB-22,BladderHTB-35,CervHTC15,LiverhTERT-HPNE,NorHTH-83,ThyroidHuCCT1,BileHuH28,BileHUH7,LiverHuT78,lymphomaHUVECs,NorIGROV1,OvarianIHH4,ThyroidIMR90,NAIOSE364,NorIPEC-J2,NorISH,ECJ82,BladderJB6,NorJCA-1,PcaJPL119,lymphomaJurkat,AMLK1,ThyroidK562,AMLKAIMRC1,BCKB,OralKG-1 ,AMLKGN,OvarianKLE,EndoKP2,PCKYSE-510,ESCCKYSE150,SCCKYSE170,ESCCKYSE450,SCCL02,NorL132,LungL428,lymphomaL929,NorLAPC-4,PcaLGR5,NALL/2 (LLC1),LunLLC1,LungLM8,OSLN-18,GBMLN229,GBMLNCaP,PcaLNM35,LungLoVo,CRCLS1034,CRCLS174T,CRCLU99,LungM059K,GBMMBT-2,BladderMC38,ColonMCF-7 ,BCMCF10 ,NorMDA-MB-231,BCMDA-MB-361,BCMDA-MB-435,BCMDA-MB-453,BCMDA-MB-468,BCMDAH-2774,OvariMeT5A,NorMG63,OSMGC803,BCMH-S,NorMHCC-97H,HCCMIA PaCa-2,PCMIHA,NorMKN-28,GCMKN45,GCMM.1S,MelanomaMPC5,NorMRC-5,NorMS-1,PCMSTO-211H,MMNA,NANCI-H441,LungNCI-H929 ,MelanNCIH1299,LungNCM460,NorNG108-15,NorNHEKn ,NorNIH-3T3,NANOZ,GallNRK52E,NorOS-RC-2,NAOV-MZ-6,OvarianOV1369,OvarianOV1946,OvarianOV7 ,OvarianOV90,OvarianOVCAR-3,OvarianPA1,OvarianPanc02,PCPANC1,PCPanCSC,PCPATU-8988,PCPC12,NorPC3,PcaPC9,LungpCSCs ,PcaPECs,NAPEL,lymphomaPHEO ,adrenalPNT1A,NorPrEC,NAPrEC,PcaPWR-1E,NorRAW264.7,NorRCC4 ,RCCREN,RCCRKO,CRCRM-1,PcaRPE-1,NorRPMI-7951,MelanRPMI-8226,MelanRT112,BladderRT4,BladderRWPE-1,NorS180,sarcomaSALTO,BCSaOS2,OSSCC-154,SCCSCC15 ,SCCSCC25,SCCSCC25,TongSCC4,SCCSCC9,TongSCM1,GCSGC-7901,GCSH-SY5Y,neuroblSiHa,CervSK-HEP-1,adrenaSK-LU-1,LungSK-MEL-28,MelanSK-N-BE,PCSK-N-SH,neuroblSkBr3,BCSKM-1,AMLSkMC,NorSKOV3,OvarianSMMC-7721 cell,SNB19,GBMSNU-407,CRCSNU1041,GISNU1076,GISNU5,GCSNU620,GCSUM159,BCSUNE-1,NPCSV-HUC-1,NorSVGp12,NorSW-620,CRCSW1353,ChonSW48,ColonSW480,ColonSW780 ,BladderT24,CRCT47D,BCT84,ColonT98G,GBMTca8113,TongTCAM-2,TestiTCCSUP,BladderTCO1 ,ALLTCO2,ALLTE1,ESCCTF1,AMLTHESCs ,NorTHP1,AMLTIG-1,NorTK6,lymphomaTM4,NorTMK-1,GCTOV-21G,OvarianTPC-1,ThyroidTRAMP-C1,PcaTSCCa,TongTSGH8301,BladdeTUBO,BCU118MG,GBMU1285,SCCU251,GBMU266,MelanomaU2OS,OSU373MG,GBMU87MG,GBMU937,lymphomaUM-SCC-1,HNSCCUMUC3,BladderUTSCC15 ,HNSCCUW-BCC1,NMSCWalker256,BCWI38,NAWM35,MelanomaWM983B,MelanomaWPMY-1,NorWRL68,NorYAMC,NorYPEN-1,PcaZR-75-1,BCNA
NAin-vitroin-vivovitro+vivoHumanAnalysisReviewex-vivoCase ReportTrialStudy	ACC,Adenoid Cysadrenal,adrenalALL,Acute LymphAML,Acute MyeloBC,Breast CanceBCC,Basal Cell Bile,cholangiocBladder,BladderBrCC,bronchial CardioV,CardiovCerv,Cervical CChon,ChondrosarCLL,Chronic LymColon,Colon CanCRC,Colorectal EC,Endometrial Endo,EndometrioEOC,Epithelial ESCC,oesophageafibroS,fibrosarGall,GallbladdeGBM,glioblastomGC,gastric adenGI,GastrointestHCC,HepatocelluHepat,hepatomaHNSCC,Head and Kidney,Kidney (Laryn,LaryngealLiver,Liver CanLung,Lung Cancelymphoma,lymphoMB,medulloblastMelanoma,MelanoMG,malignant glMM,malignant meNA,Not Availablneuroblastoma,nNMSC,Non MelanoNor,Normal HealNPC,nasopharyngNSCLC,Non-smallOral,OralOS,OsteosarcomaOvarian,OvarianPC,pancreatic cPca,Prostate CaPerC,PeritonealRCC,renal cell RPE,retinal pigsarcoma,sarcomaSCC,squamous ceSchw,SchwannomaTesti,TesticulaThyroid,ThyroidTLS,Tumor lysisTong,TongueUEC,uterine endVar,Various CanAD,Alzheimer's AKI,Acute kidneAlcohol,AlcoholArthritis,Arthrasthmatic,asthmCKD,chronic kidCol,colitisCSCs,Cancer SteDiabetic,DiabetHeart,Heart DisIBD,inflammatorInf,InfectionLiverDam,Liver Mal,MalariaMS,Multiple sclObesity,ObesityostP,osteoporosPark,Parkinson'PSA,PsoriasisSepsis,SepsisStroke,CerebralUTI,Urinary TraVit,VitiligoWounds,WoundsNA	1-,Nor1321N1 ,Nor143B,OS2-,Var22Rv1,Pca3T3,Nor402,lymphoma4T1,BC5637,Bladder769-P,RCC786-O,Kidney8505C,ThyroidA172,GBMA2058,MelanomaA2780S,MelanomaA375,MelanomaA431,MelanomaA498,RCCA549,LungACC-M,adrenalACHN,KidneyAGS,GCAMGM,GBMAMJ13,AMLAML12 ,LiverAN3CA,EndoAPL NB4,AMLARPE-19,NAAsPC-1,PCAU-565,BCB16-BL6,MelanomB16-F10,MelanomBcap37,BCBCPAP,ThyroidBEAS-2B,NorBel-7402,LiverBel7,lymphomaBGC-823,GCBPH1,PCBT20,BCBT474,BCBT549,BCBV2,NorBxpc-3,PCC33A,CervC3H10T1/2,NAC4-2B,PcaC8161,MelanomaCa9-22,SCCCaco-2,ColonCAF,VarCaki-1,KidneyCAL-62,ThyroidCAL27,SCCCAL51,BCCalu-1,LungCalu-6,LungCaOV3,OvarianCapan1,PCCC531,CRCCCD-18Co,NorCCD19,NorCCD841,NorCCl233,LungCD133+,PCCD24+,PcaCD44+,PCCEM,ALLCOLO205,CRCCOLO357,PCcolon26,ColonCRL-7891,LungCT26,ColonCV1,NorCX-1,CRCD407,RPEDAOY,GCDIPG,GBMDLD1,CRCDMS114,LungDU145,PcaE0771,BCE18,NorEAhy926,LungEC9706,ESCCEca109,ESCCEL4,NorEMT6,BCESA+,PCF344,VarF9,TestiFaDu,LarynFaO,HepatFF95,NorFTC-133,ThyroidFTC-133,ThyroidG361,MelanomaGBC-SD,GallGBM,GBMGBM115,GBMGBM8401,GBMGCSCs,GCGES-1,NorGL-15,GBMGL26,GBMglial,NorGM05757 ,NorGP-293,NorH1299,LungH146,LungH157,LungH1650,LungH1792 ,LungH1975,LungH2009,LungH2030,LungH226,SCCH23,LungH2452,MMH292,LungH295R,adrenalH385,LungH4,NorH446,LungH460,LungH4IIE,LiverH6c7,NorH720,BrCCH727,BrCCHaCaT,NorHBE4-E6/E7,NorHBL ,lymphomaHBL-100,NorHC11,NorHCC-38,BCHCC1937,BCHCC827,LungHCC9810,HCCHCCLM3,HCCHCE-2,NorHCEC 1CT,NorHCT-15,ColonHCT116,CRCHCT8,CRCHDFa,NorHEC1B,ECHEI-OC1,NorHEI193,NorHEK293,NorHeLa,CervHEp2,LarynHep3B,LiverHepaRG ,NorHepG2,LiverHepG3,LiverHet-1A,NorhFOB1.19,NorHGC27,GCHK-2,NorHL-60,AMLHL7702,NorHMC3,MelanomaHMEC,NorHMrSV5 ,NorHMVEC-dLy,NorHN30,HNSCCHN5 ,HNSCCHN8,neuroblastoHNK,NAHNPSC,NorHO-8910,OvarianHONE1,NPCHPAECs,NorHPDE-6,NorHPNE,NorHs294T,MelanomaHS587T,BCHS68,NorHs683,GBMHs766t,PCHSC-T6,NorHSC2,OralHSC3,OralHSC4,SCCHT-29,CRCHT1080,IBDHT29,ColonHTB-22,BladderHTB-35,CervHTC15,LiverhTERT-HPNE,NorHTH-83,ThyroidHuCCT1,BileHuH28,BileHUH7,LiverHuT78,lymphomaHUVECs,NorIGROV1,OvarianIHH4,ThyroidIMR90,NAIOSE364,NorIPEC-J2,NorISH,ECJ82,BladderJB6,NorJCA-1,PcaJPL119,lymphomaJurkat,AMLK1,ThyroidK562,AMLKAIMRC1,BCKB,OralKG-1 ,AMLKGN,OvarianKLE,EndoKP2,PCKYSE-510,ESCCKYSE150,SCCKYSE170,ESCCKYSE450,SCCL02,NorL132,LungL428,lymphomaL929,NorLAPC-4,PcaLGR5,NALL/2 (LLC1),LunLLC1,LungLM8,OSLN-18,GBMLN229,GBMLNCaP,PcaLNM35,LungLoVo,CRCLS1034,CRCLS174T,CRCLU99,LungM059K,GBMMBT-2,BladderMC38,ColonMCF-7 ,BCMCF10 ,NorMDA-MB-231,BCMDA-MB-361,BCMDA-MB-435,BCMDA-MB-453,BCMDA-MB-468,BCMDAH-2774,OvariMeT5A,NorMG63,OSMGC803,BCMH-S,NorMHCC-97H,HCCMIA PaCa-2,PCMIHA,NorMKN-28,GCMKN45,GCMM.1S,MelanomaMPC5,NorMRC-5,NorMS-1,PCMSTO-211H,MMNA,NANCI-H441,LungNCI-H929 ,MelanNCIH1299,LungNCM460,NorNG108-15,NorNHEKn ,NorNIH-3T3,NANOZ,GallNRK52E,NorOS-RC-2,NAOV-MZ-6,OvarianOV1369,OvarianOV1946,OvarianOV7 ,OvarianOV90,OvarianOVCAR-3,OvarianPA1,OvarianPanc02,PCPANC1,PCPanCSC,PCPATU-8988,PCPC12,NorPC3,PcaPC9,LungpCSCs ,PcaPECs,NAPEL,lymphomaPHEO ,adrenalPNT1A,NorPrEC,NAPrEC,PcaPWR-1E,NorRAW264.7,NorRCC4 ,RCCREN,RCCRKO,CRCRM-1,PcaRPE-1,NorRPMI-7951,MelanRPMI-8226,MelanRT112,BladderRT4,BladderRWPE-1,NorS180,sarcomaSALTO,BCSaOS2,OSSCC-154,SCCSCC15 ,SCCSCC25,SCCSCC25,TongSCC4,SCCSCC9,TongSCM1,GCSGC-7901,GCSH-SY5Y,neuroblSiHa,CervSK-HEP-1,adrenaSK-LU-1,LungSK-MEL-28,MelanSK-N-BE,PCSK-N-SH,neuroblSkBr3,BCSKM-1,AMLSkMC,NorSKOV3,OvarianSMMC-7721 cell,SNB19,GBMSNU-407,CRCSNU1041,GISNU1076,GISNU5,GCSNU620,GCSUM159,BCSUNE-1,NPCSV-HUC-1,NorSVGp12,NorSW-620,CRCSW1353,ChonSW48,ColonSW480,ColonSW780 ,BladderT24,CRCT47D,BCT84,ColonT98G,GBMTca8113,TongTCAM-2,TestiTCCSUP,BladderTCO1 ,ALLTCO2,ALLTE1,ESCCTF1,AMLTHESCs ,NorTHP1,AMLTIG-1,NorTK6,lymphomaTM4,NorTMK-1,GCTOV-21G,OvarianTPC-1,ThyroidTRAMP-C1,PcaTSCCa,TongTSGH8301,BladdeTUBO,BCU118MG,GBMU1285,SCCU251,GBMU266,MelanomaU2OS,OSU373MG,GBMU87MG,GBMU937,lymphomaUM-SCC-1,HNSCCUMUC3,BladderUTSCC15 ,HNSCCUW-BCC1,NMSCWalker256,BCWI38,NAWM35,MelanomaWM983B,MelanomaWPMY-1,NorWRL68,NorYAMC,NorYPEN-1,PcaZR-75-1,BCNA

ApplyTo	Target	State	Effect	Note
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	Plumbagin induced persistent activation of JNK
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	plumbagin induced cytochrome c release, FasL expression and Bax levels via activation of JNK pathway
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	plumbagin has been reported to induce ROS in normal as well as in tumor cells
DiseaseNormalNormal	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	induce ROS in normal as well as in tumor cells
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	plumbagin induced oxidative stress may suppress MKP activity in lymphoma cells leading to sustained JNK activation resulting in apoptosis.
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	Plumbagin induced cell death in EL4(normal) cells and Jurkat cells
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	cell viability dramatically decreased with increasing concentrations of plumbagin (0.05-2.5uM) when incubated for 24 or 48 h
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	Bax dependent cytochrome c release and apoptosome complex formation is followed by the cleavage of pro-caspase-3
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	progressive decrease in GSH/GSSG ratio in tumor cells following plumbagin treatment
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	simultaneous increase in the levels of intracellular ROS was observed in both these cell lines which remained high up to 4 h indicating an increase in oxidative stress in tumor cells
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	While we observed low basal mtROS levels in untreated cells, plumbagin treatment resulted in a significant increase in mtROS levels
DiseaseNormalNormal	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	both cell lines, meaning normal EL4 cells too
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅	NAC, GSH and PEG-catalase were able to abrogate plumbagin induced ROS and cell death.
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓NA	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓NA	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓NA	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅
DiseaseNormalDisease	0-reuse,0-reuse?12LOX,12â€�lipoxygenase↑14-3-3 proteins,14-3-3 proteins↑4-HNE,4‑Hydroxynonenal↑4E-BP1,eukaryotic translation in↓5HT,5-hydroxytryptamine↑5LO,5-lipoxygenase (5-LO)↑67LR,67-kDa laminin receptor↑6PGD,6-phosphogluconate dehydrog↑ABC,ABC transporter↑ABCG2,ATP-binding cassette sub-f↑ABL1,Tyrosine-protein kinase ABL↑Ac-histone H3,Acetylated Histone↓ACAA1,Acetyl-CoA Acyltransferase⇅ACC,Acetyl-CoA Carboxylase↑ACC-α,Acetyl-CoA Carboxylase al↑ACC1,acetylâ€�CoA carboxylase 1↑ACLY,ATP citrate lyase↑ACOX1,Acyl-CoA Oxidase 1↑ACSL4,Acyl-CoA Synthetase Long-C↑ACSL5,(Acyl-CoA Synthetase Long ↑ACSS2,Acyl-CoA Synthetase Short ↑ACTA2,Actin Alpha Cardiac Muscle↑ACVR1B,activin A receptor, type ⇅ADAM17,A Disintegrin and Metallo↑adiP,adiponectin↓ADP:ATP,ADP/ATP ratio↑AEG1,Astrocyte Elevated Gene-1↑AFP,α-fetal protein↑AGRN,agrin↑AhR,aryl hydrocarbon receptor↑AIF,Apoptosis-Inducing Factor↑AIM2,Absent In Melanoma 2↓AKR1C2,Aldo-keto reductase famil↑Akt,Protein kinase B↑AKT1,v-akt murine thymoma viral ↑Akt2,RAC-beta serine/threonine-p↑ALAT,ALT, alanine aminotransfera↑Albumin,Albumin↓ALC,absolute lymphocyte count↑ALDH,Aldehyde Dehydrogenase↑ALDH1A1,Aldehyde Dehydrogenase 1↑ALDOA,Aldolase A↑ALDOAiso2,fructose-bisphosphate ↑Alix/AIP‑1,Alix (ALG‑2–int↑ALK,anaplastic lymphoma receptor↑ALP,Alkaline Phosphatase↑AMACR,alpha-methylacyl-CoA racem↑AminoA,Amino Acids↑AMP,Adenosine Monophosphate↑AMPK,adenosine monophosphate-act↓AMPKα,AMP-activated protein kin↓angioG,angiogenesis↑angioS,angiostatin↓annexin II,ANXA2↑AntiAg,Antiplatelet aggregation?AntiAge,Anti-aging↓AntiCan,Anticancer Effect?antiOx,anti-oxidant activities↑AntiTum,AntiTumor?ANXA7,annexin A7↓AP-1,Activator protein 1↑APA,autophagosome accumulation↑APAF1,Apoptotic Protease Activat↓APC,adenomatous polyposis coli↓Apoptosis,Apoptosis↓APP,amyloid-beta precursor prote↑Appetite,Appetite?AR,androgen receptor↑AR-FL,full-length androgen recep↑AR-V7,androgen receptor splice v↑ARG,Arginases ARG1/2↑ARID1A,AT rich interactive domaiâ†�ARID1B,AT rich interactive domai⇅ARID2,AT rich interactive domain↓ARNT,aryl hydrocarbon receptor n↑ASC,Apoptosis-associated Speck-l⇅ascitic,ascitic fluid↑ASCT2,ASCT2 glutamine transporte↑ASK1,Apoptosis Signal-regulating↑aSmase,Acid Sphingomyelinase↓AST,Aspartate Aminotransferase↑ASXL1,additional sex combs like ↓ATF2,Activating Transcription Fa↑ATF3,Activating Transcription Fa↑ATF4,Activating Transcription Fa↑ATF6,Activating Transcription Fa↑ATFs,activating transcription fa↑ATG3,Autophagy-related 3↑ATG5,Autophagy-related 5↑ATG7,ATG7⇅ATM,similar to Serine-protein ki↓ATP,Adenosine triphosphate⇅ATP:AMP,ATP:AMP ratioâ†�ATPase,ATPase (Vâ€�ATPase)?ATR,Ataxia-Telangiectasia and Ra↑ATRX,alpha thalassemia/mental re↓autolysosome,autolysosome?autoS,autoschizis?AVOs,Acidic vesicular organelles↓AXIN1,Axis inhibition protein 1↓Axin2,↑AXL,Anexelekto↑B2M,beta-2-microglobulin?BACH1,BTB and CNC homology 1↑Bacteria,Effect on Bacteria?BAD,BCL2 associated agonist of c↑Bak,BAK or BAK1↓BAP1,BRCA1 associated protein-1 ↓BAX,Apoptosis regulator BAX↓Bax:Bcl2,Bax:Bcl2 ratio↓BBB,Blood-Brain Barrier∅BCAP,B cell adaptor for phosphat↑Bcl-2,B-cell CLL/lymphoma 2↑Bcl-xL,↑BCOR,BCL6 co-repressor↓BCR,Breakpoint Cluster Region?BCR-ABL,↑Beclin-1,Beclin-1↓Bfl-1,Bfl-1 (A1)↑BG,Blood Glucose?BID,BH3 interacting-domain death↓BIM,BIM protein (BCL-2 Interacti↓BioAv,bioavailability?BioEnh,bioenhancer?BMAL1,ARNTL⇅BMD,bone mineral density↓BMI1,B cell-specific Moloney mur↑BMP2,Bone Morphogenetic Protein ↑BMP3,Bone Morphogenetic Protein ↓BMPs,Bone morphogenetic protein⇅BNIP3,BCL2/adenovirus E1B intera↑BNP,Brain Natriuretic Peptide↑BOK,Bcl-2-related ovarian killer↓BowelM,Regular Bowel Movement?BP,Blood Pressure?BRAF,v-raf murine sarcoma viral ↑BRCA1,BReast CAncer gene 1↓BRCA2,BReast CAncer gene 2↓breath,breathing ability?BRG1,Brahma-related gene 1↓Brk/PTK6,Breast Tumor Kinase/Pro↑BTG3,B-cell translocation gene 3↓CA,Carbonic anhydrases↑Ca+2,Calcium Ion Ca+2↑CA125,CA125↑cachexia,cachexia↑CAFs/TAFs,cancer/tumor-associate↑CAIX,Carbonic Anhydrase IX↑cal2,calpain-2↓Calcium,Calcium mineralization↑CaMKII ,Calcium/Calmodulin-depe↑cAMP,cyclic adenosine monophosph⇅carcinogenesis,carcinogenesis↑CARD11,caspase recruitment domai↑cardioP,cardioProtective∅CardioT,Cardiotoxicity↑CarnA,Carnitine Acyltransferase↑Cartilage,Cartilage↓Casp,caspase?Casp1,Caspase-1↑Casp10,cysteine-aspartic proteas↓Casp12,Caspase-12?Casp2,caspase-2↓Casp3,CPP32, Cysteinyl aspartate↓Casp6,Caspase-6↑Casp7,Caspase-7?Casp8,CASP8, caspase 8, apoptosi?Casp9,Caspase-9↓Catalase,Catalase?Cav1,Caveolin-1?CBL,Casitas B-lineage Lymphoma?CBP,CREB-binding protein↑CC(CDKs/cyclins),Cell cycle (CDK↑CC/Apoptosis,Cell Cycle / Apopto?CCDC150,CCDC150, Coiled-coil dom↑CCL20,Chemokine [C-C motif] liga↑CD11b,CD11b↑CD133,prominin-1↑CD14,CD14↑CD24-,CD24-?CD25+,IL-2Rα interleukin-2 rec↑CD31,platelet endothelial cell a↑CD34,CD34 transmembrane phosphog↑CD38,CD38 protein↑CD4+,CD4+ T Cells?CD44,CD44↑CD69,CD69?CD8+,CD8+ T cell?CDC16,Cell Division Cycle 16?cDC2,type 2 conventional dendrit?CDC25,Cell Division Cycle 25↑Cdc42,Cdc42cdc2↑CDC7,Cell Division Cycle 7↑CDC73,cell division cycle 73, Pa?CDH1,cadherin 1, type 1, E-cadhe↓CDK1,Cyclin-dependent kinase 1↑CDK1/2/5/9,Cyclin-dependent kina↑CDK2,Cyclin-dependent kinase 2↑CDK4,Cyclin-dependent kinase 4↑CDK4/6,CDK4/6↑CDK6,Cyclin-dependent kinase 6↑CDK8,cyclinâ€�dependent kinase 8↑CDKN1C,cyclin-dependent kinase (↓CDKN2A,cyclin-dependent kinase i↓CDX2,Caudal-type homeobox 2↑CEA,Carcinoembryonic antigen↑CEBPA,CCAAT/enhancer binding pro↓CEBPB,CCAAT/enhancerâ€�binding p↑cellD,cell Death?CellMemb,Cellular Membrane alter?cellSen,cellular senescence⇅CentClus,Centrosome clustering↑Ceru,ceruloplasmin↑cFLIP,cellular FLICE-like inhibi↑cFos,cellular Fos↑ChemChap,chemical chaperones?chemoP,ChemoProtective∅chemoR,chemoresistance↑ChemoSen,chemo-sensitization↓ChemoSideEff,Side Effects of Che↑CHK1,Checkpoint Kinase 1↑Chk2,Checkpoint Kinase 2↓Chl,chloride↑cholinesterase,cholinesterase↓CholMet,Cholesterol metabolites↑CholSyn,Cholesterol synthesis↑CHOP,GADD153↑ChrMod,Chromatin modification?CIC,capicua homolog (Drosophila)↓CIP2A,Cancerous Inhibitor of Pro↑circ-PRKCA,circular RNA PRKCA↑citrate,citrate levels↓cJun,cellular Transcription fact↑CK2,Casein Kinase 2↑CLDN1,claudin-1↑CLDN2,claudin-2↑CLDN3,claudin‑3↑CLP,bone marrow common lymphoid ↓cMET,cellular hepatocyte growth ↑cMYB,c-MYB↑cMyc,cellular-MYC oncogene↑Cofilin,Cofilin⇅cognitive,cognitive?COL1,Collagen I↑COL1A1,Collagen Type I Alpha 1 C↑COL2A1,COL2A1↑COL3A1,collagen3a↑COL4,Collagen IV alpha chain↑COL9A3,COL9A3↓COMP,Cartilage Oligomeric Matrix↑compI,mitochondrial complex-I⇅compIII,Mitochondrial complex II↑COMT,catechol-O-methyl transfera?Copper,↑CoQ10,coenzyme Q10↓cortisol,cortisol↑COX1,COX-1↑COX2,cycloocygenase-2 (Cox-2) mR↑cPLA2,cytosolic phospholipase A2↑CPT1A,Carnitine Palmitoyltransfe↑CR3,Complement Receptor Type 3⇅creat,creatinine↑CREB,cAMP Response Element Bindi↑CREB2,cAMP response elementâ€�bi⇅CREBBP,CREB binding protein⇅CRLF2,cytokine receptor-like fac↑CRM,Calorie restriction mimetics∅CRM1,Nuclear exporter CRM1↑CRP,C-reactive protein↑CRT,calreticulin↑CSCs,Cancer Stem Cells↑CSCsMark,Cancer Stem Cell Marker↑CSF1R,colony stimulating factor ↑CSR1,Cellular stress response 1?cSrc,cellular Proto-oncogene tyr↑CT-I,Chymotrypsin-like (CT-l) ac↑CTC,Circulating-Tumour-Cells↑CTGF,Connective Tissue Growth Fa↑CTLA-4,Cytotoxic T-Lymphocyte An↑CTNNB1,catenin (cadherin-associa↑CTR1,Copper Transporter 1↑CUL4B,Cullin 4B↑Cupro,Cuproptosis∅CXCc,CXC chemokine family↑CXCL1,CXCL1↑CXCL12,SDF–1↑CXCL9,CXCL9↑CXCR2,CXCR2↑CXCR4,Chemokine Receptor Type 4↑Cyc,Cyclin?cycA1,cyclin A1↑CycB,Cyclin B↑cycD1,cyclin D1 pathway↑CycD3,Cyclin D3↑cycE,Cyclin E↑cycE1,cyclin E1↑cycF,CCNF cyclin F↑CYFRA21-1,cytokeratin 19 fragmen↑CYLD,cylindromatosis (turban tum↓CYP11A1,CYP11A1↑CYP17A1,cytochrome P450 CYP17A1↑CYP19,CYP19, also known as aroma↑CYP1A1,Cytochrome P450 1A1↑CYP1A2,CYP1A2?CYP27B1,CYP27B1↓CYP2C6,CYP2C6?CYP2C9,CYP2C9?CYP2D1,CYP2D1?CYP2E1,cytochrome P450 2E1 (CYP2↑CYP3A2,CYP3A2?CYP3A4,CYP3A4↑Cyt‑c,cyt-c Release into Cytos↓cytoP,cytoprotection?cytoP450,cytochrome P450 (CYP)↑DAXX,death-domain associated pro↓DCells,dendritic Cells↓Dcr,Disturbed circadian rhythms↑decorin,decorin↓DFF45,DNA Fragmentation Factor 4?DGAT1,Diacylglycerol O-acyltrans↑DHCR24,24-Dehydrocholesterol Red⇅DHT,dihydrotestosterone level↑Diablo,Diablo↓Diff,differentiation↓DJ-1,DJ-1↑DLC1,deleted in liver cancer 1↓DLEU1,Deleted in Lymphocytic Leu↑DNA-PK,DNA-dependent protein kin↑DNAdam,DNA damage↑DNAdamC,DNA damage control?DNArepair,DNA repair?DNMT1,DNA (cytosine-5-)-methyltr↑DNMT3A,DNA (cytosine-5-)-methylt↑DNMTs,DNA methyltransferase↑Dose,Dosage∅DPPH,2,2-diphenyl-1-picrylhydraz?DR4,Death Receptor 4↓DR5,Death receptor 5↑E-cadherin,↓E-sel,E-selectin↑E2Fs,E2F family of transcription↑E6,E6↑E7,E7↑ECAR,Extracellular Acidification↑ECM/TCF,Endothelial cell migrati↑EF-1α,elongation factor 1 alpha↑EFEMP,EGF-containing fibulin-lik⇅eff,efficacy∅EGF,Epidermal Growth Factor expr?EGFR,Epidermal Growth Factor Rec↑EGR1,Early Growth Response 1⇅EGR4,Early Growth Response 4⇅eIF2α,Eukaryotic translation in?EIF4E,eukaryotic translation ini↑Eifp,Elevated interstitial fluid↑Elvol3,ELOVL fatty acid elongase?EM,epithelial markers↓EMMPRIN,Extracellular Matrix Met↑EMT,Epithelial-Mesenchymal Trans↑Endoglin,CD105↑Endon,endonuclease⇅ENO1,α-Enolase↑ENO2,Enolase 2↑eNOS,endothelial Nitric Oxide Sy⇅ENOX,enolase↑ENOX2,NADH oxidases↑EP2,Prostaglandin E2 receptor 2↑EP300,E1A binding protein p300↑EP4,Prostaglandin E2 receptor 4↑EpCAM,epithelial Cell Adhesion M↑EphB4,tyrosine kinase EphB4↑EPR,enhanced permeability and re↑EpRE/ARE,electrophile response e?ER Stress,endoplasmic reticulum ?ER-α36,estrogen receptor alpha ↑ER(estro),Estrogen receptor↑ERCC1,Excision Repair Cross Comp↑ERK,ERK signaling↑ERK5,extracellular signal-regula↑ERS,Endoplasmic reticulum stress↑ERα,Estrogen Receptor alpha⇅ERβ,Estrogen receptor beta also↓Estro,Estrogen↑EstroRS,Estrogen receptor signal↑EZH2,enhancer of zeste homolog 2↑F-actin,fibrous actin↑FABP4,Fatty acid-binding protein↑FADD,↑FAK,FAK signaling↑FAM123B,family with sequence sim↑FAM72A,FAM72A↑FAO,Fatty Acid Oxidation↑Fap1,PTPN13↑Fas,Fas Death receptor↑fascin,fascin↑FasL,Fas ligand⇅FASN,Fatty acid synthase↑FBI-1,FBI‑1 (Pokemon/ZBTB7A)↑FBP1,fructose-1,6-bisphosphatase↓FBPase,Fructose-1,6-Bisphosphata↓FBXW7,F-box and WD repeat domain↓Fenton,Fenton Reaction↑Ferritin,SF serum Ferritin↑Ferroptosis,?FGF,Fibroblast growth factors↑FGF21,FGF21⇅FGFR1,Fibroblast Growth Factor R↑FGFR2,fibroblast growth factor r↑FGFR3,fibroblast growth factor r↑Fibronectin,Fibronectin↑Fibrosis,↑FKBP5,FK506 binding protein 51↑FLRT2,FLRT2 gene?FLT3,fms-related tyrosine kinase↑FLT4,Fms-related tyrosine kinase↑FOSB,FOSB↓FOSL1,FOSL1 (FRA-1)↑FOXD3,FOXD3↓FOXL2,forkhead box L2↑Foxm1,FOXM1 transcription factor↑FOXO,Forkhead box O↓FOXO1,Forkhead box O1↓FOXO3,Forkhead Box O3↓FOXO4,Forkhead box O 4↓FOXP3,forkhead box P3↑FoxP3+,Forkhead box P3+↑frataxin,frataxin↓FTH1,ferritin heavy chain↑FTL,ferritin light chain↑FUBP1,far upstream element (FUSE↑Furin,Furin↑G6PD,Glucose-6-phosphate dehydro↑G9a,G9a↑GABA,γ-aminobutyric acid↑GADD34,Growth Arrest and DNA Dam↑GADD45A,Growth Arrest and DNA Da↓Galectin-9,⇅GAPDH,Glyceraldehyde-3-phosphate↑GATA1,GATA binding protein 1 (gl⇅GATA2,GATA binding protein 2↑GATA3,GATA binding protein 3?GCLC,Glutamate-Cysteine Ligase, ⇅GCLM,Glutamate-Cysteine Ligase M↑GDF15,Growth differentiation fac↑GDH,Glutamate dehydrogenase↑GFR,glomerular filtration rate↓GIT1,GIT-1 gene?Gli,GLI↑Gli1,glioma-associated oncogene ↑GLI2,GLI2?GLI3,GLI3?GLO-I,glyoxalase I↑GLO1,Glyoxalase 1 enzymne↑GLS,glutaminase↑glucoNG,gluconeogenesis↑glucose,glucose↑GlucoseCon,Glucose Consumption↑glut,glutamine↑GLUT1,Glucose Transporter 1↑GLUT2,Glucose Transporter 2â†�GLUT3,GLUT3↑GLUT4,Glucose Transporter 4↑GlutaM,Glutaminolysis↑GlutMet,Glutamine metabolism↑glyC,glycogen↑Glycolysis,Glycolysis↑GM-CSF,Granulocyte-macrophage co↑GNA11/Gαq,guanine nucleotide bi↑GNAQ,guanine nucleotide binding ↑GNAS,GNAS complex locus↑GNLY,Granulysin⇅GnT-V,N-acetylglucosaminyltransf↑GP1BB,glycoprotein Ib beta subun↑GPI,Glucose-6-Phosphate Isomeras↑GPx,Glutathione peroxidases↑GPX1,Glutathione Peroxidase↑GPX3,Glutathione Peroxidase 3↓GPX4,Glutathione Peroxidase 4↑GPX8,Glutathione Peroxidase 8↑GR,glucocorticoid receptors⇅GranA,granzyme A⇅GranB,Granzyme B⇅GREM1,Gremlin1↑GRP58,GRP58/ERp57↑GRP78/BiP,P-glycoprotein↑GRP94,Glucose-Regulated Protein ↑GS3Kβ,Glycogen Synthase Kinase ⇅GSDMC,Gasdermin C↑GSDMD,gasdermin D↓GSDME,gasdermin E↓GSDME-N,Nâ€�terminal domain of G↓GSH,Glutathione↑GSH/GSSG,GSH/GSSG ratio↑GSKâ€�3β,Glycogen synthase kina⇅GSR,Glutathione Reductase↑GSS,Glutathione Synthetase↑GSSG,oxidized glutathione↓GSTA1,Glutathione S-Transferase ↑GSTP1/GSTÏ€,Glutathione S-transf↑GSTs,Glutathione S-transferases↑GSTZ1,Glutathione S-transferase ⇅GTPBP4,GTP-binding protein 4↑GutMicro,Gut Microbiotaâ†�H19,H19 long non-coding RNA (lnc↑H2O2,Hydrogen peroxide (H2O2)↑H2S,hydrogen sulfide⇅H3,Histone 3↑H3F3A,H3F3A↑H3K18,Histone 3 Lysine 18↑H3K27ac,histone H3 lysine 27 ace↑H4,Histone 4↑Half-Life,Half-Life∅HATs,histone acetyltransferases↑HbA1c,hemoglobin A1c↑HCAR1,Hydroxycarboxylic acid rec↑HDAC,Histone deacetylases↑HDAC1,Histone Deacetylase 1↑HDAC10,HDAC10↑HDAC11,Histone Deacetylase 11⇅HDAC2,Histone Deacetylase 2↑HDAC3,Histone Deacetylase 3↑HDAC4,Histone deacetylases↑HDAC8,Histone deacetylase 8↑HDL,HDL cholesterol↓HEC1,highly expressed in cancer ↑HemoG,Hemoglobin↓heparanase,heparan sulfate degra↑hepatoP,hepatoprotective↓HER2/EBBR2,Human epidermal growt↑HEY1,Hairy/enhancer-of-split rel↑HGF/c-Met,met proto-oncogene (he↑HH,Hedgehog signaling↑HIF-1,HIF-1 signaling↑Hif1a,HIF1α/HIF1a↑HIF2a,Hypoxia-Inducible Factor 2↑Hippo,Hippo signaling pathway↓HIST1H3B,histone cluster 1, H3j,⇅Histones,Histones?HK1,Hexokinase 1↑HK2,Hexokinase 2↑HLA,Human Leukocyte Antigen (HLA↓HMG-CoA,3â€�hydroxy-3â€�methylgl↑HMGB1,High Mobility Group Box 1↑HMGCR,3-hydroxy-3-methylglutaryl↑HMTs,Histone methyltransferases ↑HNE,4-hydroxynonenal (HNE)↑HNF1A,HNF1 homeobox A↓hnRNPA1,Heterogeneous nuclear ri↑HO-1,HMOX1↑HO-2,HO-2↑homoC,homocysteine↑HR,Homologous recombination⇅HRAS,v-Ha-ras Harvey rat sarcoma↑HRI,Heme-regulated eIF2α kinase⇅hs-CRP,High-sensitivity C-reacti↑Hsc70,Heat Shock Cognate Protein↑HSD17B4,hydroxysteroid 17-beta d↑HSD3B,HSD3B↑HSF1,Heat Shock Factor 1↑HSP27,Heat shock protein 27↑HSP70/HSPA5,heat shock proteins ↑HSP72,Heat Shock Protein 72↑HSP90,HSP90↑HSPs,Heat shock proteins↑hTERT,human telomerase reverse t↑hyperG,hyperglycemia↑Hypoxia,Hypoxia↑IAP1,cIAP1, cellular Inhibitor o↑IAP2,cIAP2, cellular Inhibitor o↑ICAD,inhibitor of caspase-activa⇅ICAM-1,Intercellular Adhesion Mo↑ICD,immunogenic cell death (ICD)↓Id1,Inhibitor of DNA binding 1(I↑IDH1,isocitrate dehydrogenase 1 ↑IDH2,isocitrate dehydrogenase 2 ↑IDO,indoleamine 2,3-dioxygenase↑IDO1,indoleamine 2, 3-dioxygenas↑IFN-γ,Interferon-γ?IGF-1,insulin-like growth factor↑IGF-1R,insulin-like growth facto↑IGF-2,Insulin-like growth factor↑IGFBP1,Insulin-like Growth Facto↓IGFBP3,Insulin-Like Growth Facto↓IGFBP7,Insulin-like Growth Facto↓IGFR,Insulin-like Growth Factor ↑Igs,immunoglobulins (IgG and IgM⇅Ikaros,Ikaros↓IKKα,IκB kinase alpha)↑IL-1,Interleukin-1↑IL-10,Interleukin-10↑IL-12,Interleukin-12↓IL-17,Interleukin-17↑IL-18,Interleukin 18↑IL-1α,interleukin-1 alpha↑IL-1β,interleukin-1 beta↑IL-2,Interleukin-2⇅IL-22,Interleukin-22↑IL-23,Interleukin 23↑IL-28,Interleukin-28↑IL-33,Interleukin-33↑IL-4,interleukin 4↑IL-5,Interleukin-5⇅IL-6,Interleukin-6↑IL-8,Interleukin-8↑IL-9,Interleukin-9⇅IM,interstitial markers↑IMPDH1,inosine monophosphate deh↑IMPDH2,inosine monophosphate deh↑importin α/β,importin α/β (k↑Inf,Infection↑INF-γ,interferon gamma↓Inflam,inflammation↑iNOS,Inducible nitric oxide synt↑Insulin,Insulin↑IP-10/CXCL-10,Interferon-γ(IFN)⇅IR,Insulin Receptor pathway↑IRAK4,interleukin-1 receptor-ass↑IRE1,Inositol-Requiring Enzyme 1↑IRF3,Interferon Regulatory Facto↓Iron,Iron↑IronCh,Iron Chelator?IRP1,Iron regulatory protein 1↑ITGA1,Integrin Subunit Alpha 1↑ITGA11,Integrin α11↑ITGA5,Integrin alpha 5↑ITGB1,Integrin beta-1↑ITGB4,Integrin Subunit Beta 4↑ITGB6,Integrin Subunit Beta 6↑IκB,IκB kinase(α)↓JAK,Janus kinases↑JAK1,Janus kinase 1↑JAK2,Janus kinase 2↑JAK3,Janus kinase 3↑JAML,Junctional Adhesion Molecul⇅JNK,c-Jun N-terminal kinase (JNK↑Jun,Jun↑JWA,JWA protein or JWA gene↓K17,Keratin 17↑KCNQ1OT1,KCNQ1OT1↑KDM5C,lysine (K)-specific demeth↓KDM6A,lysine (K)-specific demeth↓KDR/FLK-1,Kinase insert Domain-C↑Keap1,Kelch-like ECH-associated ↓KeyT,Keytones∅Ki-67,Ki-67 protein↑KIF2C,Kinesin Family Member 2C↑KISS1,KISS1↓KIT,↑KLF2,Krüppel-like factor 2↓KLF4,Kruppel-like factor 4↓KLF5,Krüppel-like factor 5↑KRAS,v-Ki-ras2 Kirsten rat sarco↑L-sel,L‑selectin/CD62L↓lact/pyru,lactate/pyruvate ratio↑lactateProd,lactate production↑LAMA5,laminin alpha 5↑LAMB3,Laminin subunit beta-3↑LAMP1,Lysosome-Associated Membra↑LAMP2,Lysosome-Associated Membra↑LAR,lactate receptor↑LAT,L-Type Amino Acid Transporte↑LATgene,linker for activation of↓LC3‑Ⅱ/LC3‑Ⅰ,ratio of LC3↑LC3A,Microtubule-associated prot↑LC3B,microtubule-associated prot↑LC3B-II,LC3B-II↑LC3I,Lysosomal-associated membra↓LC3II,Microtubule-associated pro↑LC3s,Autophagosome Proteins↑LDH,Lactate Dehydrogenase↑LDHA,Lactate dehydrogenase A↑LDHB,Lactate dehydrogenase B↑LDL,LDL-cholesterol↑LEF1,Lymphoid enhancer-binding f↑Let-7,Let-7↓LGR5,Leucine-rich repeat-contain↑LIF,leukemia inhibitory factor↑lipid-P,lipid peroxidation↑lipidDe,Lipid Deposition↑lipidLev,Lipid Levels↑lipoGen,lipogenesis↑LOX1,Lectin-like oxidized low-de↑LPS,↑LRP6,Low-density lipoprotein rec↑LymphAG,Lymphangiogenesis↑lysoM,Lysosome Membrane Integritâ†�lysoMP,lysosomal membrane permea↑LysoPr,lysosomal proteolysis↑lysosome,lysosome/lysosomal↑M1,M1 macrophages↓M2 MC,M2 macrophage conversion↑Macrophages,Macrophages⇅MAD,MAD proteins↓Mag,Magnesium↓MALAT1,Metastasis Associated Lun↑MAOA,Monoamine Oxidase A↑MAP2K1/MEK1,mitogen-activated pr↑MAP3K1,mitogen-activated protein↓MAPK,mitogen-activated protein k↑MARK4,Microtubule Affinity-Regul↑Matr,matriptase↑MATs,Methionine Adenosyltransfer↑MBD2,Methyl-CpG binding domain p↑Mcl-1,myeloid cell leukemia 1↑MCP1,monocyte chemotactic protei↑MCT1,Multiple Copies in T-cell m↑MCT4,Monocarboxylate Transporter↑MCU,mitochondrial calcium unipor↑MDA,Serum malondialdehyde↑MDM2,Double Minute 2 homolog↑MDMX,MDM4↑MDR1,Multidrug Resistance 1↑MDSCs,Myeloid-derived suppressor↑MeCP2,Methyl-CpG-Binding Protein↑MED12,mediator complex subunit 1↑MEG3,Maternally Expressed Gene 3↓MEK,Mitogen-Activated Protein Ki↑memory,memory?MEN1,multiple endocrine neoplasi↑MET,mesenchymal-epithelial-trans↑Mets,Metallothioneins↓MGMT,O^6^-methylguanine-DNA meth↓MGO,Methylglyoxal↑Mich,Michael addition reaction.∅MIF,Macrophage Migration Inhibit↑MIP-1β,Macrophage Inflammatory ↑MIP‑1α,CCL3?MIP2,Macrophage Inflammatory Pro⇅miR-125b,miR-125b↑miR-126,miR-126↓miR-127-5p,miR-127-5p↓MiR-1275,MiR-1275↑miR-129-5p,miR-129-5p↓miR-130a,miR-130a microRNA↑miR-133a-3p,miR-133a-3p↓miR-139-5p,↓miR-141,miR-141⇅miR-142-3p,miR-142-3p microRNA?miR-143,miR-143↓miR-145,miR-145↓miR-148a,Micro RNA 148a↓miR-155,miR-155↑miR-192-5p,↓miR-19b,MicroRNA-19↑miR-200b,miR-200b↓miR-200c,miR-200c↓miR-203,miR-203?miR-205,microRNA 205⇅miR-21,miR-21↑miR-210,miR-210↑miR-215-5p,miR-215-5p↓miR-218,miR-218?miR-22,miR-22↓miR-25-5p,miR-25-5p↑miR-27a-3p,↑miR-29b,miR-29b↓miR-301a-3p,miR-301a-3p↑miR-30a-5p,miR-30a-5p↓miR-320a,miR-320a↓miR-330-5p,miR-330-5p↓miR-340,miR-340↓miR-34a,mir-34 precursor family↓miR-34b-5p,miR-34b-5p↓miR-384,miR-384↓miR-409-3p,↓miR-486,miR-486↓miR-497,↓miR-548ah-5p,⇅miR-7641,miR-7641⇅mitResp,mitochondrial respiratio↓MKI67,MKI67 (coding for the prot↑MKK4,Mitogen-Activated Protein K⇅MKP1,MAP kinase phosphatase 1↑MKP2,MAP kinase phosphatase 2↑MKP5,MKP5↓MLH1,mutL homolog 1, colon cance↓MLKL,Mixed Lineage Kinase Domain↓MLL2,myeloid/lymphoid or mixed-l↓MLL3,myeloid/lymphoid or mixed-l↓MLPH,Melanophilin↓MMP,ΔΨm, mitochondrial membran↓MMP-10,Matrix Metalloproteinase-↑MMP1,Matrix metalloproteinases↑MMP1:TIMP1,MMP1:TIMP1 ratio↑MMP11,matrix metalloproteinase 1↑MMP13,↑MMP14,↑MMP17,Metalloproteinase 17↑MMP2,metalloproteinase-2↑MMP3,Matrix metalloproteinase-3↑MMP7,metalloproteinase-7↑MMP9,↑MMP9:TIMP1,MMP-9/TIMP-1 ratio↑MMPs,Matrix metalloproteinases↑MOB1,MOB Kinase Activator 1↑Mortalin,mtHsp70↑motorD,motor function?mPGES-1,Microsomal prostaglandin↑MPL,myeloproliferative leukemia ↑MPO,myeloperoxidase (MPO)↑MPT,mitochondrial permeability t⇅MRGPRF,Mas-related G-protein cou↑MRP,Multidrug Resistance-Associa↑MRP1,Multidrug Resistance Protei↑MSCmark,MSC markers?MSCs,mesenchymal stem cells?MSH2,mutS homolog 2, colon cance↓MSH6,mutS homolog 6 (E. coli)↓Mst1,Mammalian Ste20-like kinase↓mtDam,mitochondrial damage?mTOR,mammalian target of rapamyc↑mTORC1,mammalian target of rapam↑mTORC2,mammalian target of rapam↑MUC1,Mucin 1↑MUC1-C,↑MUC4,mucin, a high-molecular-wei↑Myc,v-myc avian myelocytomatosis↑MyD88,Myeloid differentiation fa↑N-cadherin,N-cadherin↑n-MYC,n-MYC Oncogene↑NA,NA?NAD,Nicotinamide adenine dinucle↓NADH,Nicotinamide Adenine Dinucl↑NADH:NAD,NADH:NAD+ ratio↑NADHdeh,NADH dehydrogenases⇅NADPH,Nicotinamide adenine dinuc↑NADPH/NADP+,NADPH/NADP+ ratio↑NAF1,Neutrophil-activating facto↑NAIP,Neuronal Apoptosis Inhibito⇅Nanog,human hNanog protein coded↑NBR2,long noncoding RNA neighbor↑NCAM,Neural Cell Adhesion Molecu↑NCOA4,Nuclear Receptor Coactivat?NCOR1,nuclear receptor co-repres?NDRG1,N-myc Downstream Regulated↓Necroptosis,Necroptosis⇅necrosis,necrosis?NEDD9,Neural precursor cell expr↑Nestin,Nestin↑Netrins,Netrins↑neuroG,neurogenesis?Neurog1,Neurogenin 1↑neuroP,neuroprotective↓NeuroT,neurotensin↑Neut,neutrophils↑NF-kB,Nuclear factor kappa B↑NF1,neurofibromin 1↓NF2,neurofibromin 2 (merlin)↓NFAM1,Neural Factor Activating M↑NFAT,nuclear factor of activated↑NFE2L2,nuclear factor (erythroid↑NH3,ammonia↑NHE1,Na+/H+ exchanger isoform 1↑NHE3,Sodium/Hydrogen Exchanger 3⇅NK cell,NK cell activity?NKD2,Naked cuticle homolog 2↓NKG2D,natural killer group 2, me⇅NKX3.1,Homeobox protein Nkx-3.1↓NLRP3,NOD-like receptor pyrin do↑NM23,NM23↓NNMT,Nicotinamide N-methyltransf↑NO,Nitric Oxide↑NOS2,nitric oxide synthase 2↑NOTCH,↑NOTCH1,Notch homolog 1, transloc⇅NOTCH2,Notch homolog 2 (Drosophi⇅NOTCH3,Notch homolog 3↑NOX,NADPH oxidase↑NOX4,NADPH oxidase 4↑NOXA,Phorbol-12-myristate-13-ace↓NPC1L1,Niemann–Pick C1-Like 1⇅NPM1,nucleophosmin 1 (nucleolar ↑NPY,Neuropeptide Y⇅NQO1,NAD(P)H quinone dehydrogena↑NQO2,N-ribosyldihydronicotinamid?NRAS,neuroblastoma RAS viral (v-↑Nrf1,Nuclear factor erythroid 2-⇅NRF2,nuclear factor erythroid 2-↑NSE,Neuron-specific enolase↑nucleolin,nucleolin↑OAA,oxaloacetate∅OATPs,Organic Anion Transporting⇅OATs,Organic Anion Transporters?Obesity,Obesity↑OCN,Osteocalcin↑OCR,Oxygen consumption rate↓OCT4,Octamer-binding transcripti↑oncosis,oncosis?OPG,OPG?OPN,Osteopontin↑OS,overall survival?OSI,oxidative stress index?OSM,oncostatin⇅other,other?OV6,OV6↑OXPHOS,Oxidative phosphorylation↑P-gp,permeability-glycoprotein↑p16,protein 16↓p19,p19/CDKN2D↓P21,↓p27,p27kip1↓P2X7,purinoceptor 7↑p300,p300↑p38,p38↑p42,p42 MAPK↑p44,p44/ERK1↑P450,cytochrome P450 (CYP) famil↑p50,p50↑P53,P53-Guardian of the Genome↑p53 Wildtype,↓p62,p62/sequestosome 1 (SQSTM1)↑p65,RelA↑p66Shc,p66Shc⇅p70S6,phospho-S6↑P70S6K,p70 S6 kinase↑p73,p73↓p85S6K,isoform of S6 kinase↑P90RSK,90 kDa Ribosomal S6 Kinas↑Pain,Pain?PAK,p21-activated kinases↑PAK1,↑PAO,PAO gene↑PAR-2,Protease-activated recepto↑Paraptosis,Paraptosis↓PARK2,PARKIN↓PARP,poly ADP-ribose polymerase ↑PARP1,Poly [ADP-ribose] polymera↑pax,paxillin↑PAX5,paired box 5↓PBRM1,polybromo 1↓PCAF,p300/CBP-associated factor↑PCBP1,Poly(rC) Binding Protein 1↑PCK1,phosphoenolpyruvate carboxy⇅PCLAF,Proliferating Cell Nuclear↑PCNA,Proliferating Cell Nuclear ↑PD-1,Programmed Death-1↑PD-L1,Programmed Death-Ligand 1↑PD-L2,Programmed Death-Ligand 2↑PDCD4,↓PDGF,Platelet-derived growth fac↑PDGFR-BB,Platelet-Derived Growth↑PDGFRA,platelet-derived growth f↑PDH,mitochondrial pyruvate dehyd↓PDHA1,Pyruvate Dehydrogenase E1 ↓PDHB,pyruvate dehydrogenase E1 b↓PDI,Protein Disulfide Isomerase↑PDK1,Pyruvate dehydrogenase kina↑PDK3,Pyruvate Dehydrogenase Kina↑PDKs,pyruvate dehydrogenase kina↑PDT+,PDT+cells↑Perforin,Perforin⇅PERK,protein kinase-like ER kina↑PFK,Phosphofructokinase↑PFK1,Phosphofructokinase-1↑PFK2,PFK2↑PFKFB2,6-Phosphofructo-2-Kinase/↑PFKL,Phosphofructokinase, Liver↑PFKM,Phosphofructokinase, Muscle↑PFKP,Phosphofructokinase, Platel↑PGAM1,Phosphoglycerate mutase 1↑PGC-1α,Peroxisome proliferator-↑PGC1A,PPARγ Coactivator 1-alpha↑PGD2,prostaglandin D2⇅PGE1,Prostaglandin E1?PGE2,Prostaglandin E2↑PGK1,Phosphoglycerate kinase 1↑PGM1,Phosphoglucomutase 1↑pH,↓PHDs,Prolyl Hydroxylases↓PHF6,PHD finger protein 6↓PI3K,Phosphatidylinositide-3-Kin↑PI3K/Akt,PI3K/Akt signaling↑PI3k/Akt/mTOR,Phosphoinositide 3↑PI3K/mTOR/ETS2,PI3K/mTOR/ETS2 pa↑PIAS-3,Protein Inhibitor of Acti↓Piezo1,Piezo1↑PIK3CA,phosphoinositide-3-kinase↑PIK3R1,PIK3R1/p85S6 Phosphatidyl↑Pin1,Peptidyl-prolyl cis-trans i↑PINK1,PTEN-induced kinase 1↓PIP3,Phosphatidylinositol (3,4,5↑PIR,Phosphoinositide-interacting↑Pirin,Pirin↑PKA,protein kinase A↑PKCδ,Protein Kinase C delta⇅PKL,liver isoform of pyruvate ki?PKM1,pyruvate kinase muscle isof?PKM2,Pyruvate Kinase, Muscle 2↑PKM2:PKM1,PKM2/PKM1 ratio↑PLC,perlecan?PleEff,pleural effusion↑PLEKHM3,↑PLIN1,Perilipin 1?polyA,polyamine↑PONs,paraoxonase↑Poor perfusion,?PPARα,Peroxisome Proliferator-A⇅PPARγ,Peroxisome proliferator-a↑PPP,pentose phosphate pathway↑PPP2R1A,protein phosphatase 2 (f↓PR,Progesterone receptor↓PRAS40,proline-rich Akt substrat↑pRB,retinoblastoma protein↓PRC2,Polycomb repressive complex↑PRDM1,PR domain containing 1, wi↓PRDX,Peroxiredoxin↑PRDX4,Peroxiredoxin 4↑PRDX6,Peroxiredoxin 6⇅PRKCG,Protein Kinase C Gamma↑proApCas,proapoptotic cascade↓PRODH,proline dehydrogenase↓proline,proline↑Prot,Protein Levels?Proteasome,Proteasome↑PrxI,Peroxiredoxin I↑PrxII,Peroxiredoxin II↑pS2/TFF1,pS2/TFF1↓PSA,prostate-specific antigen↑PSMB5,proteasome subunit beta ty↑PTCH1,12-transmembrane cell surf↓PTCH2,PTCH2↓PTEN,phosphatase and tensin homo↓PTP1B,protein tyrosine phosphata↑PTPN11,protein tyrosine phosphat↑PTPN6,SHP1/Protein Tyrosine Phos↓PUMA,p53 upregulated modulator o↓PYCR1,Pyrroline-5-Carboxylate Re↑Pyro,Pyroptosis?Pyruv,Pyruvate↑QoL,Quality of Life↓R5P,ribose-5-phosphate↑Rac1,Ras-related C3 botulinum to↑RAD51,RAD51?radioP,RadioProtective↓RadioS,RadioSensitizer↓Raf,RAF kinases↑RAGE,Receptor for advanced glyca?RANKL,Receptor Activator of Nucl↑RANTES,CCL5↑RARα,RARα (NR1B1)↑RARβ,RARβ (NR1B2)↓RARγ,RARγ (NR1B3)↑RAS,RAS↑RB1,retinoblastoma 1 gene↓RBM3,RNA-binding motif protein 3↓RECK,Reversion Inducing Cysteine↓REL,V-rel avian reticuloendothel↑Remission,Remission?RenoP,Renoprotection↓RET,Rearranged during Transfecti?RHBDD1,Rhomboid Domain Containin↑Rho,Rho GTPases?RIP1,Receptor-Interacting Protei↑RIP3,Receptorâ€�Interacting Prot↓Risk,Risk?RNF43,ring finger protein 43?RNR,Ribonucleotide Reductase↑RNS,reactive nitrogen species?ROCK1,Rho-associated coiled-coil↑ROMO1,Reactive Oxygen Species Mo?ROS,Reactive Oxygen Species?RPM,radical pair mechanism?RPS6KA1,ribosomal protein S6 kin↑RPSA,Ribosomal Protein SA↑RSK,Ribosomal S6 Kinase↑RTK-RAS,↑RUNX1,runt-related transcription?RUNX2,Runt-related transcription↑S6,ribosomal protein S6↑S6K,S6 kinase↑SA,Sialic acid↑SA of VW,Structural abnormalitie?SAM-e,S-adenosylmethionine⇅SAPK,stress-activated protein ki?SAT1,Spermidine/Spermine N1-Acet↑SCD1,Stearoyl-CoA Desaturase 1↑SCF,Stem Cell Factor?SD,Stable Disease?SDC1,Syndecan-1 (SDC-1)↓SDH,Succinate dehydrogenase/Comp?SE-cad,Selenocysteine-containing?selectivity,selectivity∅selenoP,selenoproteins⇅selm,selenium↓Sema3A/PlexinA1,Sema3A/PlexinA1⇅Sepsis,Sepsis↑serineP,serine protease↑SESN2,Sestrin 2↓Set9,SETD7 (SET domain containin⇅SETBP1,SET binding protein 1?SETD2,SET domain containing 2?SF3B1,splicing factor 3b, subuni?sFasL,soluble Fas Ligand↑SFRP5,Secreted Frizzled-Related ↓SGLTs,Sodium-Glucose Cotransport↑SHARP,SHARP1/BHLHE41⇅Sharpin,SHANK-associated RH doma↑SHBG,Sex Hormone-Binding Globuli↑Shc,Shc signaling proteins?Shh,sonic hedgehog↑SIRT1,Sirtuin 1 protein?SIRT2,Sirtuin 2↓SIRT3,Sirtuin 3↓SIRT6,Sirtuin 6↓SK,Sphingosine kinases↑SLC12A5,SLC12A5↑SLC25A1,CIC↑Sleep,Sleep Quality?Slug,transcription factor Slug↑Smad1,⇅SMAD2,SMAD family member 2?SMAD3,SMAD3↑SMAD4,SMAD family member 4↓SMAD5,⇅Smad7,?SMARCA4,SWI/SNF related, matrix ↓SMARCB1,SWI/SNF related, matrix ↓SMCT1,SLC5A8↓SMG1,Suppressor of Morphogenetic↓Smo,G-protein-coupled receptor-l↑Snail,Snail↑SNCG,SNCG gene↑SOCS-3,Suppressor of Cytokine Si↓SOCS1,suppressor of cytokine sig↓SOD,superoxide dismutase↑SOD1,superoxide dismutase 1⇅SOD2,MnSOD⇅sonoP,sonoporation↓sonoS,sonosensitizer∅SOX2,SOX2↑SOX4,SRYâ€�box transcription fac↑SOX9,SRY (sex determining region↑Sp1/3/4,Specificity Protein?SPARC,secreted protein acidic an⇅SPOP,speckle-type POZ protein?SPP1,Secreted phosphoprotein 1?Src,Src kinase↑SRD5A1,SRD5A1↑SREBF2,Sterol Regulatory Element↑SREBP1,sterol regulatory element↑SREBP2,Sterol Regulatory Element↑SRSF2,SRSF2 serine/arginine-rich?SSAT,Spermidine/Spermine N1-Acet?SSBP1,single-stranded DNA bindin⇅STAC2,SH3 and cysteine-rich doma↑STAG2,stromal antigen 2↓StAR,Steroidogenic Acute Regulat↑STAT,Signal transducer and activ↑STAT1,Signal transducer and acti↓STAT2,Signal Transducer and Acti↓STAT3,Signal transducer and acti↑STAT4,Signal transducer and acti↓STAT5,Signal transducer and acti↑STAT6,Signal Transducer and Acti↑STEAP3,Six Transmembrane Epithel↑STK11,serine/threonine kinase 11↓Strength,physical strength?Sufu,Sufu gene↓survivin,↑SUZ12,Suppressor of zeste 12↑SVCT-2,Sodium-dependent Vitamin ↑SXR,PXR-Steroid and Xenobiotic R↑Symptoms,Symptoms?T-cadherin,T-cadherin/CDH13↑T-Cell,T lymphocytes↓T-SOD,tissue superoxide dismutas⇅TAC,total antioxidant capacity↓talin,talin↑TAMS,tumor-associated macrophage↑TANs,tumor-associated neutrophil↑TAp63α,TAp63α↓TarDef DNArep,Target deficient D?TAS,Tumor Angiogenesis Score↑TASc,Tumor Angiogenesis Score↑tau,tau?TAZ,Transcriptional Coactivator ↑TBARS,Thiobarbituric Acid Reacti↑TBX15,T-box transcription factor?TCA,Tricarboxylic Acid Cycle⇅TCF,T-cell factor (Tcf) family↑TCF-4,Transcription Factor 4⇅Telomerase,Telomerase↑testos,testosterone↑TET1,Ten-Eleven Translocation 1↓TET2,tet oncogene family member ↓Tf,Transferrin↑TFAP2A,Transcription Factor AP-2⇅TFEB,Transcription Factor EB↑TfR1/CD71,Transferrin receptor p↑TGF-β,transforming growth facto↑TGF-β1,Transforming Growth Fact↑TGFβR1,transforming growth fact↑Th1 response,T helper response↓Th17,T helper 17 (Th17) cells⇅Th2,Type 2 helper cell↑THBS2,thrombospondin 2 gene↑Thiols,Thiols↑TILs,tumor-infiltrating lymphocy↓TIM-3,T-cell immunoglobulin and ↑TIMP-1,Tissue Inhibitor of Metal↑TIMP-2,Tissue Inhibitor of Metal⇅TIMP3,tissue inhibitor of metall?TJ,Tight junctions⇅TKT,transketolase↑TLR1,Toll-Like Receptor 1⇅TLR2,Toll-Like Receptor 2⇅TLR4,Toll-like receptor 4?TLS,Tumor lysis syndrome?TNC,tenascin-C↑TNF-α,TNF-α↑TNF-β,Tumor Necrosis Factor-bet↑TNFAIP3,tumor necrosis factor, a↓TNFR 1,Tumor necrosis factor rec⇅TOP1,Topoisomerase I↑TOP2,Topoisomerase II↑TOPflash,TOPflash∅TOS,total oxidant status↑toxicity,toxicity?TP53,tumor protein p53↓TPI,Triosephosphate Isomerase↑TPM4,Tropomyosin 4↑TRAF7,TNF receptor-associated fa⇅TRAIL,tumor necrosis factor-relaâ†�TRAILR,tumor necrosis factor-relâ†�Trans Reg,Transcriptional regulaâ†�Treg lymp,Treg lymphocytes↑TregCell,Treg cells↑TREM-1,triggering receptor expre↑TRIB3,tribbles homolog 3↑TRIF,Toll/IL-1 receptor domain-c⇅TrkB,Tropomyosin receptor kinase↑Trop2,Trop2↑TRPM7,transient receptor potenti↑TRPV1,transient receptor potenti⇅TRX,Thioredoxin↑TRX1,Thioredoxin 1↑TRX2,thioredoxin 2↑TrxR,Thioredoxin Reductase↑TrxR1,thioredoxin reductase 1↑TrxR2,thioredoxin reductase-mito↑trypsin,trypsin↑TS,thymidylate synthase↑TSC1,tuberous sclerosis 1↓TSC2,tuberous sclerosis complex ↓TSHR,thyroid stimulating hormone↓TSP-1,Thrombospondin-1↓TumAuto,Tumor autophagy↓TumCA,Tumor Cell adhesion↑TumCCA,Tumor cell cycle arrest↓TumCD,Tumor Cell Death↓TumCG,Tumor cell growth↑TumCI,Tumor Cell invasion↑TumCM/A,Tumor cell metabolism/ac↑TumCMig,Tumor cell migration↑TumCP,Tumor Cell proliferation↑tumCV,Cell Viability↑TumMeta,Cancer Metastasis↑TumN,Tumor necrosis↓TumPF,Tumor-promoting fibroblast↑TumPInf,Tumor-promoting inflamma↑TumVol,Tumor Volume↑TumW,Tumor Weight↑TUNEL,Terminal deoxynucleotidyl ⇅Twist,Twist↑TXA2,thromboxane A2↑TXNIP,TBP-2↓Tyro3,Tyro3↑tyrosinase,tyrosinase↑U2AF1,U2 small nuclear RNA auxil↑UBE2C,Ubiquitin-conjugating enzy↑UCP1,mitochondrial uncoupling pr↑UHRF1,Ubiquitin-like with PHD an↑uPA,Urokinase plasminogen activa↑uPAR,Urokinase-type plasminogen ↑UPR,Unfolded Protein Response↑uricA,uric acid↑UrinaryC,urinary continence↓UroPA,Urokinase plasminogen acti↑USF1,Upstream transcription fact↑VCAM-1,Vascular cell adhesion pr↑VDR,Vitamin D receptor↓VEGF,Vascular endothelial growth↑VEGFR2,Vascular Endothelial Grow↑VGCC,Voltage-gated calcium chann↑VHL,von Hippel-Lindau tumor supp↓Vim,Vimentin↑vinculin,vinculin⇅VitC,Vitamin C levels?VitD,Vitamin D↓VitE,Vitamin E levels?VM,vasculogenic mimicry↑Warburg,Warburg Effect↑Weight,Weight↓Wmax,Wmax↓Wnt,Wingless-related integration↑Wnt/(β-catenin),Wnt/(β-catenin↑WT1,Wilms tumor 1↑XBP-1,X-box binding protein 1↑xCT,SLC7A11↑XIAP,X-linked inhibitor of apopt↑XIST,X-inactive specific transcr↑YAP/TEAD,YAP/TEAD activity↑YMcells,YOUNG’S MODULUS cancer↓ZBTB10,ZBTB transcription Factor↓Zeb1,Zinc finger E-box-binding h↑ZEB2,Zinc Finger E-Box Binding H↑ZFX,Zinc Finger X-linked↑ZO-1,Zonula occludens-1↓α-SMA,α-smooth muscle actin↑α-tubulin,α-tubulin↑β-Amyloid,β-Amyloid Fibrils↑β-catenin/ZEB1,β-catenin/ZEB1↑β-Endo,β-Endorphin↓β-oxidation,Beta Oxidation?β-TRCP,beta-transducin repeat-c↑β1-integrin,β1-integrin↑γH2AX,gamma-H2AX↑γδ T-cell activity,γδ T-cell↓NA	,NAp‑,cl‑pro,pe-,excircâproâ€ac‑i-,inm-,momt-,mpol-,ox-,ord-,rc-,ce	?↓↑⇅â†�?∅

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