Edit Target: 77
Natural Product : FA, Ferulic acid
Ferulic acid is an antioxidant found in some skin creams and serums.
Foods: popcorn, bamboo, whole-grain rye bread, whole-grain oat flakes, sweet corn (cooked)
-Ferulic acid found in dietary strand fractions, especially its free form, has important functions for protecting the human health.
-AChE inhibitor (AD)
-Cooking results in an increase in free ferulic acid quantity and in a reduction in bound ferulic acid quantity.
Bamboo shoots 243.6 mg/100g
Sugar-beet pulp 800 mg/100g
Popcorn 313 mg/100g
Wheat bran 500–1500mg/100g
Whole wheat flour 100–300mg/100g
| Type of corn | p-coumaric acid | ferulic acid |
|---|
| | mg/kg, DW | mg/kg, DW |
| Yellow dent | 18.9 | 265 |
| American blue | N.D. | 927 |
| Mexican blue | 1.3 | 202 |
| white | 6.6 | 2484 |
Pathway / Target Modulation by FA / Direction
Aβ aggregation ↓ Inhibits fibril formation and destabilizes existing Aβ fibrils
BACE‑1 & APP ↓ Reduces BACE-1 and APP expression; ↑ MMP‑2/‑9 expression promoting Aβ clearance
Tau hyperphosphorylation Implicitly ↓ through modulation of Ca²⁺/CDK5/GSK3β pathways
Ca²⁺ ↓ FA lowers STEP levels via chelation of Ca²⁺, suppressing PP2B → restores synaptic plasticity
(AChE / BChE) ↓ Inhibition of AChE (FA IC₅₀~15 µM, derivatives IC₅₀ down to 0.006 µM); also BChE
(MAO‑A/B) ↓ Inhibits MAO‑B (derivatives IC₅₀ ~0.3–0.7 µM), reducing ROS
ROS ↓ Scavenges ROS, enhances antioxidant enzymes (e.g., catalase), ↓ MDA
(COX‑2, 5‑LOX, NLRP3) ↓ Derivatives inhibit COX‑2/5‑LOX; derivative 13a ↓ NLRP3 inflammasome
Iron/Cu²⁺ chelation ↓ Metal-induced Aβ aggregation via chelation by FA and derivatives
Autophagy & Aβ clearance ↗ Suggested promotion of autophagy mechanisms targeting Aβ
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