Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5345- ,    Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation
- in-vitro, Nor, NA
*AntiAg↑,
4113- ,    Post-exposure Effects of PEMF on ROS levels in H2O2-treated Glioblastoma Cell Line
- in-vitro, Nor, U87MG
*ROS↓, *SOD2↑,
4051- ,    Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women
- Study, AD, NA
*cognitive↑, *neuroP↑, *other↝, *other⇅,
4039- ,    Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI
- Study, AD, NA
*cognitive↑, *memory↑, *Mood↑,
4572- ,    Mitochondrial electron transport chain, ROS generation and uncoupling
- Review, NA, NA
*UCPs↝, *ETC↝, *ROS↝,
4384- ,    Silver nanoparticles: synthesis, properties, and therapeutic applications
- Review, Var, NA
AntiCan↑, RadioS↑, CellMemb↑, ROS↑, DNAdam↑, PhotoS↑, eff↑,
4442- ,    Anticancer and Hepatoprotective Role of Selenium Nanoparticles against
- in-vivo, Liver, HepG2 - NA, Nor, NA
*hepatoP↑, AntiCan↑,
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE↓, *cardioP↑, MFN2↑,
6478- 1,8-Cin,    The Combination of Amoxicillin and 1,8-Cineole Improves the Bioavailability and the Therapeutic Effect of Amoxicillin in a Rabbit Model
- in-vivo, Nor, NA
*BioEnh↑,
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
6476- 1,8-Cin,    Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line
- in-vitro, AML, NA
TumCG↓, selectivity↑, Apoptosis↑,
6475- 1,8-Cin,    1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expression
- in-vitro, HNSCC, NA
*P-sel↓, Inflam↓, AntiTum↑, AntiAg↑,
6474- 1,8-Cin,    Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation
- in-vitro, Nor, HT29 - in-vivo, Nor, NA - in-vivo, IBD, NA
*Inflam↓, *NRF2↑, *antiOx↑, *PPARγ↑, eff↑,
6473- 1,8-Cin,    The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage
- in-vivo, Colon, NA
tumCV∅, TumCCA∅, ROS↑, DNAdam↑,
6472- 1,8-Cin,    Protective Effects of 1,8-Cineole Microcapsules Against Inflammation and Gut Microbiota Imbalance Associated Weight Loss Induced by Heat Stress in Broiler Chicken
- in-vivo, Nor, NA
*Inflam↓, *GutMicro↑,
6471- 1,8-Cin,    The Effect of 1,8-Cineole Inhalation on Preoperative Anxiety: A Randomized Clinical Trial
- Trial, Nor, NA
*ANXi↓,
6469- 1,8-Cin,    Pharmacokinetic Studies of the Fragrance Compound 1,8-Cineol in Humans during Inhalation
- Human, Nor, NA
*BioAv↑, *Half-Life↝,
6468- 1,8-Cin,    Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *eff↑,
6467- 1,8-Cin,    Evaluation of in vitro anticancer activity of 1,8-Cineole-containing n-hexane extract of Callistemon citrinus (Curtis) Skeels plant and its apoptotic potential
- in-vitro, Melanoma, A431 - in-vitro, OS, MG63 - in-vitro, Nor, HaCaT
TumCP↓, selectivity↑, AntiCan↑, TumCD↑, Apoptosis↑, Dose↝, ROS↑,
6466- 1,8-Cin,    Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y
- in-vitro, neuroblastoma, SH-SY5Y
AntiTum↑, TumCCA↑, PDGFRB↓, Myc↓, LEF1↓, BAD↑, APC↑, TBX3↑,
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
6463- 1,8-Cin,    Antitumor effect of 1, 8-cineole against colon cancer
- vitro+vivo, Colon, HCT116
TumCP↓, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3↑, TumVol↓,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, eff↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
6470- 1,8-Cin,    Determination of orally administered 1,8-Cineol in nasal polyp tissues from chronic rhinosinusitis patients using gas chromatography: mass spectrometry
- Human, Nor, NA
*BioAv↑,
2435- 2DG,    Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds
- in-vitro, SCC, CAL27
MMP↓, HK2↓,
2325- 2DG,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, eff↑,
2326- 2DG,    Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway
- in-vivo, Nor, NA
PKM2↓, Inflam↓, TNF-α↓, IL6↓, OS↑,
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
2432- 2DG,    Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- in-vitro, Lung, H23 - in-vitro, Lung, KP2 - in-vivo, NA, NA
HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,
2424- 2DG,  SRF,    The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells
- in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
ChemoSen↓, Glycolysis↓, HK1↓, HK2↓, ATP↓,
2433- 2DG,    Hexokinase inhibitor 2-deoxyglucose coordinates citrullination of vimentin and apoptosis of fibroblast-like synoviocytes by inhibiting HK2 /mTORC1-induced autophagy
- in-vitro, Arthritis, NA - in-vivo, NA, NA
Vim↓, HK2↓,
2423- 2DG,  SRF,    2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells
- in-vitro, HCC, NA
ChemoSen↑, TumCP↓, cycD1/CCND1↓, MMP9↓,
2434- 2DG,    Inhibition of Key Glycolytic Enzyme Hexokinase 2 Ameliorates Psoriasiform Inflammation in vitro and in vivo
- in-vitro, PSA, NA - in-vivo, PSA, NA
HK2↓, NF-kB↓, NLRP3↓,
1336- 2DG,    2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells
- in-vitro, GBM, SK-N-SH
ROS↑, GlucoseCon↓, other↓,
1337- 2DG,  Rad,    2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer
- in-vivo, NA, NA
ChemoSen↑, GlucoseCon↓, ROS↑,
1339- 2DG,  Cisplatin,    2-Deoxy-d-Glucose Combined with Cisplatin Enhances Cytotoxicity via Metabolic Oxidative Stress in Human Head and Neck Cancer Cells
- in-vitro, HNSCC, FaDu
ChemoSen↑, ROS↑, GSH↓, other↓,
1340- 3BP,    Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
- Review, NA, NA
Glycolysis↓, HK2↓, LDH↓, OXPHOS↓, angioG↓, H2O2↑, eff↑,
1341- 3BP,    The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- Review, NA, NA
Glycolysis↓, OXPHOS↓, *toxicity↓, ROS↑, GSH↓, eff↑,
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5281- 3BP,    A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
- Case Report, Var, NA
Glycolysis↓, mt-OXPHOS↓, ATP↓, selectivity↑, toxicity↝, OS↑, QoL↑,
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,
5280- 3BP,    Anticancer Efficacy of the Metabolic Blocker 3-Bromopyruvate: Specific Molecular Targeting
- in-vitro, PC, NA
mtDam↑, HK2↓, TGF-β↓, Casp3↑, selectivity↑,
5279- 3BP,  Rad,    Abstract 5243: 3-Bromopyruvate in combination with radiation inhibits pancreatic cancer growth by dismantling mitochondria and ATP generation in a preclinical mouse model
- in-vivo, PC, NA
ATP↓, HK2↓, RadioS↑,
5278- 3BP,    The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression
- in-vitro, CRC, HCT116 - in-vitro, CRC, Caco-2 - in-vitro, CRC, SW48
ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
5277- 3BP,    3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model
- in-vivo, PC, Panc02
HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,
5276- 3BP,    A Translational Study 'Case Report' on the Small Molecule 'Energy Blocker' 3-Bromopyruvate (3BP) as a Potent Anticancer Agent: From Bench Side to Bedside(2012)
- Case Report, HCC, NA
Dose↓, Remission↑,
5275- 3BP,    3-Bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: Introduction to a special issue
- Review, Var, NA
AntiCan↑, HK2↓, OCR↓,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5273- 3BP,    The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view
- Review, Var, NA
AntiCan↑, ROS↑, angioG↓, CSCs↓, Warburg↓, GSH↓, Thiols↓,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,

Showing Research Papers: 1 to 50 of 6585
Page 1 of 132 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6585

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

MFN2↑, 1,   TBX3↑, 1,  

Redox & Oxidative Stress ⓘ

GPx↓, 1,   GSH↓, 7,   H2O2↑, 1,   HK1↓, 1,   OXPHOS↓, 3,   mt-OXPHOS↓, 2,   ROS↑, 13,   mt-ROS↑, 1,   Thiols↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 8,   MMP↓, 1,   mtDam↑, 3,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 1,   ECAR↓, 1,   GAPDH↓, 2,   GlucoseCon↓, 2,   Glycolysis↓, 11,   HK2?, 1,   HK2↓, 14,   lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 1,   NADPH↓, 2,   PKM2↓, 2,   PPP↓, 1,   PPP↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↑, 1,   Apoptosis↑, 6,   BAD↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   cl‑Casp3⇅, 1,   Casp9↑, 1,   Cyt‑c↑, 4,   JNK↓, 1,   MAPK↝, 1,   Mcl-1↓, 1,   Myc↓, 1,   p38↑, 2,   survivin↓, 2,   TumCD↑, 3,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↝, 1,   PhotoS↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,  

Autophagy & Lysosomes ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   P53↑, 1,   PARP↓, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 2,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   mTOR↓, 1,   mTOR↝, 1,   PDGFRB↓, 1,   PI3K↓, 1,   TumCG↓, 4,   Wnt↓, 1,  

Migration ⓘ

AntiAg↑, 1,   APC↑, 1,   E-cadherin↓, 1,   fascin↓, 1,   LEF1↓, 1,   MMP2↓, 1,   MMP9↓, 3,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 2,   TumCA↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 2,   Twist↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 5,   Dose↓, 1,   Dose↝, 4,   eff↓, 3,   eff↑, 11,   Half-Life↓, 1,   RadioS↑, 4,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

IL6↓, 1,   LDH↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 5,   AntiTum↑, 2,   OS↑, 3,   QoL↑, 1,   Remission↑, 1,   toxicity↓, 2,   toxicity↝, 2,   TumVol↓, 1,  
Total Targets: 124

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 1,   ANXi↓, 1,   MUC19↓, 1,   MUC2↓, 1,   P-sel↓, 1,   TRPA1↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 2,   GSH↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 3,   ROS↝, 1,   SOD↑, 1,   SOD2↑, 1,   TAC↑, 1,   UCPs↝, 1,  

Mitochondria & Bioenergetics ⓘ

ETC↝, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   NADPH↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Transcription & Epigenetics ⓘ

other⇅, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   GSK‐3β↓, 2,  

Migration ⓘ

AntiAg↑, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   IL1β↓, 3,   IL4↓, 1,   IL6↓, 2,   Inflam↓, 5,   MyD88↓, 1,   NF-kB↓, 3,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 1,   BACE↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 5,   BioEnh↑, 1,   eff↑, 2,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 2,   hepatoP↑, 2,   memory↑, 1,   Mood↑, 1,   neuroP↑, 3,   toxicity↓, 2,  

Infection & Microbiome ⓘ

AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 1,  
Total Targets: 67

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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