Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5345- ,    Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation
- in-vitro, Nor, NA
*AntiAg↑,
4113- ,    Post-exposure Effects of PEMF on ROS levels in H2O2-treated Glioblastoma Cell Line
- in-vitro, Nor, U87MG
*ROS↓, *SOD2↑,
4051- ,    Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women
- Study, AD, NA
*cognitive↑, *neuroP↑, *other↝, *other⇅,
4039- ,    Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI
- Study, AD, NA
*cognitive↑, *memory↑, *Mood↑,
4572- ,    Mitochondrial electron transport chain, ROS generation and uncoupling
- Review, NA, NA
*UCPs↝, *ETC↝, *ROS↝,
4384- ,    Silver nanoparticles: synthesis, properties, and therapeutic applications
- Review, Var, NA
AntiCan↑, RadioS↑, CellMemb↑, ROS↑, DNAdam↑, PhotoS↑, eff↑,
4442- ,    Anticancer and Hepatoprotective Role of Selenium Nanoparticles against
- in-vivo, Liver, HepG2 - NA, Nor, NA
*hepatoP↑, AntiCan↑,
2435- 2DG,    Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds
- in-vitro, SCC, CAL27
MMP↓, HK2↓,
2325- 2DG,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, eff↑,
2326- 2DG,    Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway
- in-vivo, Nor, NA
PKM2↓, Inflam↓, TNF-α↓, IL6↓, OS↑,
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
2432- 2DG,    Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- in-vitro, Lung, H23 - in-vitro, Lung, KP2 - in-vivo, NA, NA
HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,
2424- 2DG,  SRF,    The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells
- in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
ChemoSen↓, Glycolysis↓, HK1↓, HK2↓, ATP↓,
2433- 2DG,    Hexokinase inhibitor 2-deoxyglucose coordinates citrullination of vimentin and apoptosis of fibroblast-like synoviocytes by inhibiting HK2 /mTORC1-induced autophagy
- in-vitro, Arthritis, NA - in-vivo, NA, NA
Vim↓, HK2↓,
2423- 2DG,  SRF,    2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells
- in-vitro, HCC, NA
ChemoSen↑, TumCP↓, cycD1/CCND1↓, MMP9↓,
2434- 2DG,    Inhibition of Key Glycolytic Enzyme Hexokinase 2 Ameliorates Psoriasiform Inflammation in vitro and in vivo
- in-vitro, PSA, NA - in-vivo, PSA, NA
HK2↓, NF-kB↓, NLRP3↓,
1336- 2DG,    2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells
- in-vitro, GBM, SK-N-SH
ROS↑, GlucoseCon↓, other↓,
1337- 2DG,  Rad,    2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer
- in-vivo, NA, NA
ChemoSen↑, GlucoseCon↓, ROS↑,
1339- 2DG,  Cisplatin,    2-Deoxy-d-Glucose Combined with Cisplatin Enhances Cytotoxicity via Metabolic Oxidative Stress in Human Head and Neck Cancer Cells
- in-vitro, HNSCC, FaDu
ChemoSen↑, ROS↑, GSH↓, other↓,
1340- 3BP,    Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
- Review, NA, NA
Glycolysis↓, HK2↓, LDH↓, OXPHOS↓, angioG↓, H2O2↑, eff↑,
1341- 3BP,    The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- Review, NA, NA
Glycolysis↓, OXPHOS↓, *toxicity↓, ROS↑, GSH↓, eff↑,
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5281- 3BP,    A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
- Case Report, Var, NA
Glycolysis↓, mt-OXPHOS↓, ATP↓, selectivity↑, toxicity↝, OS↑, QoL↑,
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,
5280- 3BP,    Anticancer Efficacy of the Metabolic Blocker 3-Bromopyruvate: Specific Molecular Targeting
- in-vitro, PC, NA
mtDam↑, HK2↓, TGF-β↓, Casp3↑, selectivity↑,
5279- 3BP,  Rad,    Abstract 5243: 3-Bromopyruvate in combination with radiation inhibits pancreatic cancer growth by dismantling mitochondria and ATP generation in a preclinical mouse model
- in-vivo, PC, NA
ATP↓, HK2↓, RadioS↑,
5278- 3BP,    The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression
- in-vitro, CRC, HCT116 - in-vitro, CRC, Caco-2 - in-vitro, CRC, SW48
ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
5277- 3BP,    3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model
- in-vivo, PC, Panc02
HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,
5276- 3BP,    A Translational Study 'Case Report' on the Small Molecule 'Energy Blocker' 3-Bromopyruvate (3BP) as a Potent Anticancer Agent: From Bench Side to Bedside(2012)
- Case Report, HCC, NA
Dose↓, Remission↑,
5275- 3BP,    3-Bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: Introduction to a special issue
- Review, Var, NA
AntiCan↑, HK2↓, OCR↓,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5273- 3BP,    The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view
- Review, Var, NA
AntiCan↑, ROS↑, angioG↓, CSCs↓, Warburg↓, GSH↓, Thiols↓,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,
5257- 3BP,    Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- Review, Var, NA
Glycolysis↓, mt-OXPHOS↓, HK2↓, Cyt‑c↑, Casp3↓, Bcl-2↓, Mcl-1↓, GAPDH↓, LDH↓, PDH↓, TCA↓, GlutaM↓, GSH↓, ATP↓, mitResp↓, ROS↑, ChemoSen↑, toxicity↝,
5258- 3BP,    3-bromopyruvate: Targets and outcomes
- Review, Var, NA
Glycolysis↓, TumCG↓,
5259- 3BP,    Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
- in-vivo, HCC, NA
ATP↓, TumCD↑, toxicity↓, eff↑, tumCV↓, Dose↝,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5261- 3BP,    The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH
- in-vitro, BC, NA
eff↑, eff↓,
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
5264- 3BP,    Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- Review, Var, NA
toxicity↑, Glycolysis↓, eff↑, OS↑, QoL↑, toxicity↝,
5265- 3BP,    KAT/3BP: A Metabolism-Targeting Agent with Single and Combination Activity in Aggressive B-Cell Lymphomas
- Review, lymphoma, NA
Glycolysis↓, HK2↓, AIF↓, Apoptosis↑, NK cell↑,
5266- 3BP,    3-bromopyruvate-based agent KAT-101
- Review, Var, NA
eff↑, Glycolysis↓, OXPHOS↓, ATP↓, TumCP↓, Apoptosis↑, HK2↓, MPT↑, LDH↓, PDH↓,
5267- 3BP,    Targeting Energy Metabolism in Cancer Treatment
- Review, Var, NA
HK2↓,
5270- 5-ALA,  PDT,    5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
- Review, Var, NA
other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,
3453- 5-ALA,    The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis
- in-vitro, Lung, A549
OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
3537- 5-HTP,    5-Hydroxytryptophan: a clinically-effective serotonin precursor
- Review, NA, NA
*5HT↑, *BioAv↑, *BBB↑,
3538- 5-HTP,    Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression
- in-vivo, Nor, NA
*GutMicro↑, *BBB↑, *5HT↑, *Weight↓,

Showing Research Papers: 1 to 50 of 5729
Page 1 of 115 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5729

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   Catalase↑, 1,   Ferroptosis↓, 1,   GPx↓, 1,   GSH↓, 9,   H2O2↑, 1,   HK1↓, 1,   HO-1↑, 1,   MDA↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 1,   mt-OXPHOS↓, 3,   ROS↑, 15,   mt-ROS↑, 1,   SOD2↑, 1,   Thiols↓, 1,   xCT↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   AIF↑, 1,   ATP↓, 13,   mitResp↓, 1,   MMP↓, 1,   MPT↑, 1,   mtDam↑, 4,   OCR↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 1,   ECAR↓, 2,   GAPDH↓, 4,   GlucoseCon↓, 2,   GlutaM↓, 1,   Glycolysis↓, 18,   HK2?, 1,   HK2↓, 20,   lactateProd↓, 1,   LDH↓, 4,   LDHA↓, 2,   NADPH↓, 2,   PDH↓, 2,   PDH↑, 1,   PKM2↓, 2,   PPP↓, 1,   PPP↑, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↑, 1,   Apoptosis↑, 9,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 5,   Cyt‑c↑, 5,   Ferroptosis↓, 1,   Mcl-1↓, 2,   p27↑, 1,   survivin↓, 1,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 2,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↝, 4,   PhotoS↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 3,  

Autophagy & Lysosomes ⓘ

p‑Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   PARP↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,   TumCG↓, 5,  

Migration ⓘ

Ca+2↑, 1,   MMP9↓, 2,   TGF-β↓, 1,   TumCA↑, 1,   TumCI↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 1,   NK cell↑, 2,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 6,   Dose↓, 1,   Dose↝, 7,   eff↓, 5,   eff↑, 16,   eff↝, 2,   Half-Life↓, 1,   RadioS↑, 4,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

IL6↓, 1,   LDH↓, 4,  

Functional Outcomes ⓘ

AntiCan↑, 6,   AntiTum↑, 1,   OS↑, 4,   QoL↑, 2,   Remission↑, 1,   toxicity↓, 6,   toxicity↑, 4,   toxicity↝, 4,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 125

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,   ROS↝, 1,   SOD2↑, 1,   UCPs↝, 1,  

Mitochondria & Bioenergetics ⓘ

ETC↝, 1,  

Transcription & Epigenetics ⓘ

other⇅, 1,   other↝, 1,  

Migration ⓘ

AntiAg↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Synaptic & Neurotransmission ⓘ

5HT↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   Mood↑, 1,   neuroP↑, 1,   toxicity↓, 1,   Weight↓, 1,  
Total Targets: 19

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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