HDAC Cancer Research Results

HDAC, Histone deacetylases: Click to Expand ⟱
Source:
Type:
Enzymes involved in regulating gene expression by removing acetyl groups from histones, the proteins around which DNA is wrapped.
-Many cancers exhibit altered expression levels of HDACs, which can contribute to the dysregulation of genes involved in cell growth, survival, and differentiation.
-HDACs can repress the expression of tumor suppressor genes, leading to uncontrolled cell proliferation and survival. This repression can be a key factor in the development and progression of cancer.
-HDAC inhibitors (HDACi) have been developed and are being investigated for their ability to reactivate silenced genes, induce cell cycle arrest, and promote apoptosis in cancer cells.
-HDAC1, HDAC2): Often overexpressed in various cancers, including breast, prostate, and colorectal cancers. Their overexpression is associated with poor prognosis.
-HDAC4, HDAC5): These may have both oncogenic and tumor-suppressive roles depending on the context and cancer type.
-While HDACs are not classified as traditional oncogenes, their overexpression and activity can contribute to oncogenic processes.
-HDAC inhibitor works by preventing the removal of acetyl groups from histones, thereby modulating gene expression, influencing cell behavior, and potentially reversing aberrant gene silencing seen in various diseases.
-HDAC inhibitors can help reactivate these genes, thereby inhibiting growth and inducing apoptosis in cancer cells.
Scientific Papers found: Click to Expand⟱
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
2663- AL,    Therapeutic Effect of Allicin on Glioblastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
BioAv↝, TumCCA↑, P53↑, HDAC↓, CSCs↓, ROS↑, ChemoSen↑, MGMT↓,
5326- ALC,    L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro
- vitro+vivo, Liver, HepG2
TumCG↓, P21↑, ac‑H3↑, HDAC↓, *ATP↑, selectivity↑, ac‑H4↑,
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
1156- And,    Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach
- Analysis, NA, NA
HDAC↓,
177- Api,    Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression
- in-vitro, BC, MDA-MB-231
Cyc↓, CycB/CCNB1↓, CDK1↓, P21↑, PCNA↝, HDAC↓, TumCP↓, TumCCA↑, ac‑H3↑, TumW↓, TumVol↓,
2631- Api,    Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
- in-vivo, GC, NA - in-vitro, GC, AGS
ER Stress↑, Hif1a↓, EZH2↓, HDAC↓, TumAuto↑, p‑mTOR↓, AMPKα↑, GRP78/BiP↑, ROS↑, MMP↓, Ca+2↑, ATF4↑, CHOP/DDIT3↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2664- Api,    Progress in discovery and development of natural inhibitors of histone deacetylases (HDACs) as anti-cancer agents
- Review, Var, NA
HDAC↓,
1151- Api,    Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study
- in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
TumCCA↑, Apoptosis↑, HDAC↓, P21↑, BAX↑, TumCG↓, Bcl-2↓, Bax:Bcl2↑, HDAC1↓, HDAC3↓,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
3175- Ash,  SFN,    Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNMTs↓, HDAC↓, eff↑,
1433- Ash,  SFN,    A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↑, Bcl-2↓, BAX↑, tumCV↓, DNMT1↓, DNMT3A↓, HDAC↓,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
2699- BBR,    Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line
- in-vitro, Lung, A549
HDAC↓, TumCCA↑, TNF-α↓, COX2/PTGS2↓, MMP2↓, MMP9↓, P21↑, P53↑, Casp↑, ac‑H3↑, ac‑H4↑, ROS↑, MMP↓,
2697- BBR,    Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes
- Analysis, Var, NA
HDAC↓,
2764- BetA,    In silico profiling of histone deacetylase inhibitory activity of compounds isolated from Cajanus cajan
- Analysis, Var, NA
HDAC↓,
3523- Bor,    Design, Synthesis, and Biological Activity of Boronic Acid-Based Histone Deacetylase Inhibitors
- in-vitro, Var, NA
HDAC↓,
3522- Bor,    The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry
- Review, Var, NA
Hif1a↓, HDAC↓, *CXCR2↑, ROS↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
5745- Buty,    Microbial Oncotarget: Bacterial-Produced Butyrate, Chemoprevention and Warburg Effect
- Review, Var, NA
selectivity↑, HDAC↓, TumCP↓, Apoptosis↑, Warburg↓, chemoPv↑,
5743- Buty,    Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status
- Review, Var, NA
*GutMicro↑, *other↑, *Inflam↓, *ROS↓, AntiCan↑, HCAR2↑, HDAC↓,
5742- Buty,    Butyrate: A Double-Edged Sword for Health?
- Review, Var, NA
HCAR2↑, Inflam↓, HDAC↓, *IFN-γ↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↑, *LTA/TNF-β↑, *NF-kB↓, *ROS↓, PPARγ↓, Weight↓,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2/PTGS2↓, eff↝, eff↑, other↝,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2/PTGS2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,
5732- Buty,    GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
- Study, CRC, NA
HCAR2↑, other↓, Apoptosis↑, HDAC↓, Bcl-2↓, Bcl-xL↓, cycD1/CCND1↓, DR5↑, NF-kB↓, GutMicro↑, SLC12A5↝,
5731- Buty,    The Warburg Effect Dictates the Mechanism of Butyrate Mediated Histone Acetylation and Cell Proliferation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
HDAC↓, Warburg↓, TumCP⇅, HATs↑, BioAv↓, other↝, Risk↓,
5737- Buty,    Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming
- in-vitro, CRC, HCT116
HDAC↓, TumCP↓, PKM2↑, Warburg↓,
1080- Buty,    Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition
- in-vitro, CRC, HT-29
HDAC↓, TNF-α↓, COX2/PTGS2↓,
2050- Buty,    The Role of Sodium Phenylbutyrate in Modifying the Methylome of Breast Cancer Cells
- in-vitro, BC, MCF7
eff↑, HDAC↓, TumCG↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
7160- CHA,    Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
- in-vitro, Lung, A549
selectivity↑, eff↑, ROS↑, Apoptosis↓, HDAC↓, MMP↓, cl‑PARP↑, eff↑, eff↓, i-GSH∅,
2798- CHr,    Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
HDAC↓, HDAC8↓, TumCG↓, Diff↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
1505- CUR,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
TumCCA↑, Apoptosis↑, DNMTs↓, HDAC↓, HATs↓, TumCP↓, p300↓, HDAC1↓, HDAC3↓, HDAC8↓, NF-kB↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1 / PDPK1↓, Beclin-1/ATG6↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
163- CUR,    Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells
- in-vitro, Pca, LNCaP
MeCP2↓, Neurog1↑, HDAC↓,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
3230- EGCG,    Green Tea Polyphenol Epigallocatechin 3-Gallate, Contributes to the Degradation of DNMT3A and HDAC3 in HCT 116 Human Colon Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
HDAC↓, DNMTs↓,
3229- EGCG,    Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells
- in-vitro, Nor, HMEC - in-vitro, Nor, HUVECs
HDAC↓,
3235- EGCG,    (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells
- in-vivo, Cerv, HeLa
DNMTs↓, HDAC↓,
3236- EGCG,  Buty,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
672- EGCG,    Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and Cancer
- Review, NA, NA
DNMT1↓, HDAC↓, G9a↓, PRC2↓, DNMT3A↓, 67LR↓, Apoptosis↑, TumCCA↑,

Showing Research Papers: 1 to 50 of 139
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 139

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Buty↑, 1,   PA↑, 1,   SCFAs↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   CYP1A1↓, 3,   Ferroptosis↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 8,   GSH↑, 1,   i-GSH∅, 1,   GSR↓, 1,   GSS↑, 1,   GSTA1↑, 1,   GSTs↓, 1,   HO-1↓, 4,   HO-1↑, 5,   Iron↑, 1,   lipid-P↓, 3,   lipid-P↑, 2,   MDA↑, 1,   Mets↑, 1,   NADH↓, 1,   NAF1↓, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 4,   NRF2↑, 15,   NRF2∅, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   mt-OXPHOS↓, 2,   PARK2↑, 1,   ROS?, 1,   ROS↓, 5,   ROS↑, 44,   ROS⇅, 4,   i-ROS?, 1,   mt-ROS↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↓, 3,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 4,   ATP↑, 1,   CDC25↓, 1,   ETC↓, 1,   Insulin↓, 1,   MEK↓, 1,   MMP?, 1,   MMP↓, 20,   MMP↑, 1,   mtDam↑, 3,   PINK1↑, 1,   Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 9,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   ALAT↓, 2,   AMPK↑, 5,   ATG7↑, 1,   cAMP↓, 1,   Cav1↓, 1,   cMyc↓, 8,   CYP3A4↓, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 7,   Histones↝, 1,   HK2↓, 6,   HMG-CoA↓, 2,   lactateProd↓, 1,   lactateProd↑, 1,   LDH↓, 1,   LDHA↓, 1,   LDL↓, 2,   NADPH↑, 1,   NH3↓, 1,   PDH↑, 1,   p‑PDH↓, 1,   PDK1 / PDPK1↓, 3,   PKM2↓, 3,   PKM2↑, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 1,   RARβ↑, 1,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

Akt↓, 18,   p‑Akt↓, 6,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 38,   ASK1↑, 1,   BAD↑, 1,   Bak↑, 3,   BAX↑, 21,   BAX⇅, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 25,   Bcl-xL↓, 16,   BID↑, 2,   BIM↓, 1,   BIM↑, 2,   Casp↑, 10,   Casp1↓, 1,   Casp12?, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 28,   Casp3↝, 1,   cl‑Casp3↑, 3,   Casp7↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 4,   Casp8∅, 1,   Casp9↑, 14,   cl‑Casp9↑, 1,   cFLIP↓, 2,   p‑Chk2↑, 1,   CK2↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 20,   Cyt‑c↝, 1,   Diablo↑, 3,   DR5↑, 5,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 2,   HGF/c-Met↓, 2,   hTERT/TERT↓, 9,   IAP1↓, 4,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↑, 1,   iNOS↓, 4,   JNK↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 2,   Mcl-1↓, 4,   Mcl-1↑, 1,   MCT1↓, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   NOXA↑, 1,   p27/CDKN1B↑, 6,   p38↓, 1,   p38↑, 3,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 16,   Telomerase↓, 7,   TRAIL↑, 2,   TumCD↑, 2,   TUNEL↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   HCAR2↑, 4,   HER2/EBBR2↓, 4,   p70S6↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 2,   EZH2↓, 6,   H3↓, 2,   H3↑, 3,   ac‑H3↓, 2,   ac‑H3↑, 13,   ac‑H3↝, 1,   H4↓, 1,   H4↑, 3,   ac‑H4↓, 2,   ac‑H4↑, 9,   HATs↓, 6,   HATs↑, 7,   MeCP2↓, 1,   miR-30a-5p↑, 1,   other?, 1,   other↓, 1,   other↝, 3,   pRB↑, 1,   PRC2↓, 1,   Prot↓, 1,   TET3↑, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ChemChap↑, 1,   CHOP/DDIT3↑, 4,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 9,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   ac‑HSP90↑, 1,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 4,   p62↓, 2,   p62↑, 1,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   BRCA1↑, 2,   CYP1B1↑, 1,   DNAdam↑, 7,   DNArepair↓, 3,   DNMT1↓, 12,   DNMT3A↓, 10,   DNMTs↓, 24,   G9a↓, 3,   GADD45A↑, 2,   MGMT↓, 1,   p16↑, 2,   P53↑, 16,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 12,   PARP1↑, 1,   PCNA↓, 7,   PCNA↝, 1,   SIRT6↓, 1,   UHRF1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 2,   CDK2↓, 8,   CDK2↑, 1,   CDK4↓, 9,   Cyc↓, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 15,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   p19↑, 2,   P21?, 1,   P21↑, 26,   p‑RB1↓, 2,   TumCCA?, 2,   TumCCA↓, 1,   TumCCA↑, 44,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMI1↓, 2,   CD133↓, 3,   CD34↓, 2,   CD44↓, 5,   cFos↑, 1,   p‑cMET↑, 1,   cMYB↓, 1,   CSCs↓, 6,   Diff↑, 3,   EMT?, 1,   EMT↓, 14,   ERK↓, 7,   ERK↑, 2,   p‑ERK↓, 3,   p‑ERK↑, 1,   FGF↓, 1,   FOXO↑, 2,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 2,   Gli↓, 1,   Gli1↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HDAC↓, 140,   HDAC∅, 1,   HDAC1↓, 14,   HDAC11↓, 1,   HDAC2↓, 7,   HDAC3↓, 9,   HDAC4↓, 2,   HDAC6↓, 1,   HDAC8↓, 6,   HMGCR↓, 1,   HMTs↓, 3,   HMTs↑, 1,   IGF-1↓, 3,   IGF-2↑, 1,   IGFBP3↑, 2,   Jun↓, 1,   KLF4↓, 1,   Let-7↑, 1,   mTOR↓, 10,   mTOR↑, 1,   mTOR∅, 1,   p‑mTOR↓, 3,   mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   Neurog1↑, 1,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH1↑, 1,   NOTCH3↓, 1,   OCT4↓, 3,   p300↓, 2,   PI3K↓, 12,   p‑PI3K↓, 2,   PTEN↓, 1,   PTEN↑, 9,   p‑PTEN↓, 1,   RAS↓, 1,   RAS↑, 1,   Shh↓, 2,   Smo↓, 1,   SOX2↓, 1,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 13,   STAT3↑, 1,   p‑STAT3↓, 3,   p‑STAT3↑, 2,   STAT5↓, 2,   p‑STAT6↓, 1,   SUZ12↓, 1,   TOP1↓, 1,   TOPflash↑, 1,   TumCG↓, 22,   VDR↑, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

67LR↓, 1,   AntiAg↓, 1,   AP-1↓, 5,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 5,   CD31/PECAM-1↓, 1,   Cdc42↓, 1,   CDH1↑, 1,   CDKN1C/p57↑, 1,   CEA↓, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CXCL12↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 10,   ER-α36↓, 1,   FAK↓, 9,   p‑FAK↑, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   Ki-67↓, 5,   MET↓, 1,   p‑MET↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-22↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 16,   proMMP2↓, 1,   MMP7↓, 1,   MMP9↓, 19,   MMPs↓, 13,   MUC4↓, 3,   N-cadherin↓, 4,   PDGF↓, 2,   PKA↓, 1,   PKCδ↓, 1,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 1,   Smad1↑, 1,   Snail↓, 5,   SOX4↓, 1,   TET1↑, 3,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP1↑, 2,   TIMP2↑, 2,   TIMP3↑, 1,   Treg lymp↓, 1,   TSP-1↑, 1,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 10,   TumCMig↓, 11,   TumCP↓, 22,   TumCP⇅, 1,   TumMeta↓, 14,   TumMeta↑, 1,   Twist↓, 7,   TXNIP↑, 2,   Tyro3↓, 1,   uPA↓, 6,   Vim↓, 5,   Vim↑, 1,   Zeb1↓, 6,   ZO-1↑, 1,   α-tubulin↑, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   ATF4↑, 1,   EGFR↓, 7,   EGFR↑, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 21,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 26,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 3,   NHE1↓, 1,   P-gp/ABCB1↓, 1,   SLC12A5↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   B2M↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCR4↓, 3,   CXCR4↑, 1,   HCAR2↑, 4,   ICAM-1↓, 1,   IFN-γ↑, 2,   Igs↑, 1,   IKKα↓, 2,   IL1↓, 1,   IL10↓, 3,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 6,   IL2↓, 1,   IL2↑, 4,   IL6↓, 8,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 5,   JAK2↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   NF-kB↓, 29,   NF-kB↑, 1,   NK cell↑, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE1↓, 1,   PGE2↓, 4,   PSA↓, 2,   SOCS1↑, 1,   TLR4↓, 1,   TNF-α↓, 9,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   CDK6↓, 3,   CYP11A1↓, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 5,   BioEnh↑, 1,   ChemoSen↑, 27,   Dose?, 2,   Dose↑, 1,   Dose↝, 19,   Dose∅, 2,   eff↓, 9,   eff↑, 55,   eff↝, 4,   eff∅, 1,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P450↓, 1,   RadioS↑, 8,   selectivity?, 1,   selectivity↑, 26,   TET2↓, 1,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 2,   AR↓, 4,   AST↓, 1,   B2M↓, 1,   BG↓, 1,   BMPs↑, 1,   BRCA1↓, 1,   BRCA1↑, 2,   CEA↓, 1,   EGFR↓, 7,   EGFR↑, 1,   EZH2↓, 6,   GutMicro↑, 6,   GutMicro↝, 1,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 9,   IL6↓, 8,   Ki-67↓, 5,   LDH↓, 1,   Maspin↑, 2,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 2,   RBM3↑, 1,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   AntiTum↑, 4,   cachexia↓, 1,   cardioP↑, 4,   CardioT↓, 2,   chemoP↑, 8,   chemoPv↑, 6,   ChemoSideEff↓, 3,   hepatoP↑, 6,   K17↓, 1,   neuroP↑, 7,   OS↑, 7,   Remission↑, 2,   RenoP↑, 3,   Risk↓, 7,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 6,   TumW↓, 6,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 566

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 10,   Catalase↑, 6,   GPx↑, 3,   GSH↑, 6,   GSR↑, 1,   GSTA1↑, 1,   GSTs↑, 4,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   MPO↑, 1,   NQO1↑, 1,   NRF2↑, 6,   RNS↓, 1,   ROS↓, 17,   ROS↝, 1,   ROS∅, 1,   SAM-e↑, 1,   SOD↑, 6,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   ATP↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   cytoP450↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Casp3↓, 2,   Cyt‑c↓, 1,   IAP1↓, 1,   iNOS↓, 2,   MAPK↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   HDAC3↓, 2,   IGF-1R↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↝, 1,   CLDN1↑, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP2↓, 1,   p‑Rac1↓, 1,   serineP↓, 1,   TIMP1↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,   PDGFR-BB↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   CRP↓, 1,   CXCR2↑, 1,   HCAR2↑, 1,   IFN-γ↓, 1,   IKKα↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 3,   IL17↓, 2,   IL1β↓, 5,   IL22↓, 1,   IL6↓, 7,   IL8↓, 3,   Inflam↓, 13,   Inflam↑, 1,   JAK↓, 1,   LTA/TNF-β↑, 1,   NF-kB↓, 6,   PGE2↓, 2,   TNF-α↓, 10,   VitD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 7,   BioAv↑, 9,   BioAv↝, 3,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 4,   Half-Life↝, 3,   Half-Life∅, 1,   P450↓, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 2,   BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   CRP↓, 1,   GutMicro↑, 1,   hs-CRP↓, 1,   IL6↓, 7,   Ki-67↓, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↑, 2,   antiPs↑, 1,   cardioP↑, 4,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 2,   hepatoP↓, 1,   hepatoP↑, 1,   memory↑, 2,   neuroP↑, 5,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 2,  
Total Targets: 126

Scientific Paper Hit Count for: HDAC, Histone deacetylases
30 Sulforaphane (mainly Broccoli)
17 Phenylbutyrate
14 Thymoquinone
12 Butyrate
7 EGCG (Epigallocatechin Gallate)
6 Apigenin (mainly Parsley)
5 Curcumin
4 Chemotherapy
4 Luteolin
4 Quercetin
3 Berberine
3 Boron
3 Chrysin
3 Honokiol
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Ashwagandha(Withaferin A)
2 Atorvastatin
2 Inulin Prebiotic
2 Cisplatin
2 Propolis -bee glue
2 Phenethyl isothiocyanate
1 3-bromopyruvate
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 Andrographis
1 Betulinic acid
1 chaetocin
1 diet FMD Fasting Mimicking Diet
1 Emodin
1 Formononetin
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Kaempferol
1 Magnolol
1 Radiotherapy/Radiation
1 Piperlongumine
1 Vorinostat
1 diet Plant based
1 Gemcitabine (Gemzar)
1 Vitamin D3
1 doxorubicin
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:140  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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