eff Cancer Research Results

eff, efficacy: Click to Expand ⟱

Source:

Type:

Power to enhance an anti cancer effect

Scientific Papers found: Click to Expand⟱

2327-

2DG,

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

-

Review,

Var,

NA

Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,

7857-

3BP,

A Mechanism of Isoorientin-Induced Apoptosis and Migration Inhibition in Gastric Cancer AGS Cells

-

in-vitro,

NA,

AGS

tumCV↓, selectivity↑, *toxicity↓, Apoptosis↑, ROS↑, eff↓, TumCCA↑, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, TumCMig↓, Twist↓, N-cadherin↑, β-catenin/ZEB1↓, E-cadherin↑,

5272-

3BP,

The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

Nor,

HEK293

Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,

5263-

3BP,

CET,

3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis

-

in-vitro,

CRC,

DLD1

-

NA,

NA,

HCT116

eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1/ATG6↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT/SLC7A11↑, GSH↓, eff↓, MDA↑,

5261-

3BP,

The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH

-

in-vitro,

BC,

NA

eff↑, eff↓,

5459-

AF,

Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells

-

in-vitro,

Ovarian,

NA

ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,

5460-

AF,

Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

-

vitro+vivo,

Var,

4T1

RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,

5472-

AF,

Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion

-

in-vitro,

Cerv,

HeLa

TrxR↓, AntiCan↑, TumCG↓, Apoptosis↑, necrosis↑, cl‑PARP↑, MMP↓, ROS↑, GSH↓, eff↓,

5468-

AF,

The gold complex auranofin: new perspectives for cancer therapy

-

Review,

Var,

NA

TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,

5236-

AgNPs,

Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury

-

in-vitro,

Liver,

HepG2

-

in-vitro,

Nor,

L02

tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,

5237-

AgNPs,

Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes

-

in-vitro,

Liver,

HepG2

Ferroptosis↑, p62↑, NRF2↝, eff↓,

1907-

AgNPs,

GoldNP,

Cu,

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands

-

in-vitro,

Lung,

A549

-

in-vitro,

BC,

MCF7

-

in-vitro,

Melanoma,

A375

-

in-vitro,

Colon,

HCT15

-

in-vitro,

Cerv,

HeLa

TrxR↓, eff↓, eff↓, other∅,

1906-

AgNPs,

GoldNP,

Cu,

Current Progresses in Metal-based Anticancer Complexes as Mammalian TrxR Inhibitors

-

Review,

Var,

NA

TrxR↓, eff↓, eff↓,

4400-

AgNPs,

Rad,

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

-

in-vitro,

BC,

MCF7

-

in-vitro,

Nor,

MCF10

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

BT549

-

in-vivo,

BC,

MDA-MB-231

right hind flanks of the mice

ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,

4381-

AgNPs,

Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells

-

in-vitro,

Liver,

HepG2

 human hepatoma cells.

eff↓, ROS↑, other↑,

4380-

AgNPs,

Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways

-

in-vitro,

Lung,

A549

ROS↑, tumCV↓, MMP↓, TumCCA↑, PCNA↓, eff↓,

4375-

AgNPs,

The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells

-

in-vitro,

AML,

K562

eff↑, ROS↑, Apoptosis↑, eff↓,

4564-

AgNPs,

GoldNP,

Cu,

Chemo,

PDT

Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review

-

Review,

Var,

NA

ROS↑, DNAdam↑, TumCCA↑, eff↑, Apoptosis↑, eff↓, ChemoSen↑,

346-

AgNPs,

RSQ,

Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment

-

in-vivo,

Melanoma,

SK-MEL-28

 AgNP (2 mg/kg) and RSQ (25 mg/kg) administration routes used were peri- and intratumora

 mice

-

in-vivo,

Melanoma,

WM35

ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,

357-

AgNPs,

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

L132

mtDam↑, ROS↑, Hif1a↑, LC3s↑, p62↑, eff↓,

235-

AL,

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

-

in-vitro,

GBM,

U87MG

 90 μM

Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

-

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

2646-

AL,

Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress

-

in-vitro,

Pca,

DU145

-

in-vitro,

Melanoma,

RPMI-8226

AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,

3454-

ALA,

Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness

-

in-vitro,

BC,

MCF7

(0.5 mM, 1 mM, 2.5 mM, and 5 mM)

-

in-vitro,

BC,

MDA-MB-231

TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,

281-

ALA,

Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation

-

in-vitro,

Lung,

H460

0-100uM

mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,

5360-

almon,

BEV,

Case report: Almonertinib in combination with bevacizumab for leptomeningeal metastases from epidermal growth factor receptor-mutation non-small cell lung cancer: Case series

-

Case Report,

NSCLC,

NA

BBB↑, Dose↝, eff↓, OS↑,

1440-

AMQ,

Lysosomotropism depends on glucose: a chloroquine resistance mechanism

-

in-vitro,

BC,

4T1

eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,

6601-

Anamu,

Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model

-

in-vitro,

AML,

NA

AntiTum↑, GlucoseCon↓, ROS↑, TumCP↓, eff↓, Glycolysis↓,

1354-

And,

Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer

-

in-vitro,

PC,

NA

0, 10, 20, 40 µM

-

in-vivo,

PC,

NA

Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,

6401-

ANE,

Anethole and Its Role in Chronic Diseases

-

Review,

Var,

NA

-

Review,

PSA,

NA

*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,

4765-

antiOx,

Chemo,

Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity – Exploring the armoury of obscurity

-

Review,

Var,

NA

chemoP↑, ChemoSen↑, OS↑, Dose↑, Risk↓, eff↓,

4746-

antiOx,

Chemo,

VitA,RetA,

VitC,

Se

Using Supplements During Chemo: Yes or No?

-

Review,

Var,

NA

eff↓, ChemoSen↓, RadioS↓, other↝,

206-

Api,

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

-

in-vitro,

Lung,

H1299

 20 uM

-

in-vitro,

Lung,

H460

-

in-vitro,

Lung,

A549

 40 uM

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Melanoma,

A375

-

in-vitro,

Lung,

H2030

-

in-vitro,

CRC,

SW480

Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,

1536-

Api,

Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells

-

in-vitro,

MM,

MSTO-211H

0, 10, 30, and 50 µM) of apigenin for 48 h and 72 h

-

in-vitro,

MM,

H2452

tumCV↓, ROS↑, MMP↓, ATP↓, Apoptosis↑, Necroptosis↑, DNAdam↑, TumCCA↑, Casp3↑, cl‑PARP↑, MLKL↑, p‑RIP3↑, Bax:Bcl2↑, eff↓, eff↓,

1564-

Api,

Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation

-

in-vitro,

Pca,

22Rv1

10–80 μM

-

in-vivo,

NA,

NA

MDM2↓, NF-kB↓, p65↓, P21↑, ROS↑, GSH↓, MMP↓, Cyt‑c↑, Apoptosis↑, P53↑, eff↓, Bcl-xL↓, Bcl-2↓, BAX↑, Casp↑, TumCG↓, TumVol↓, TumW↓,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

-

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

-

in-vitro,

PC,

AsPC-1

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

LNCaP

-

in-vivo,

NA,

NA

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

3391-

ART/DHA,

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

-

Review,

Var,

NA

TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,

5378-

ART/DHA,

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

-

Review,

Var,

NA

Ferroptosis↑, Iron↑, lipid-P↑, MOMP↑, AntiCan↑, NCOA4↑, GSH↓, GPx4↓, ROS↑, ChemoSen↑, ER Stress↑, DNAdam↑, angioG↓, TumCCA↑, eff↓,

5137-

ART/DHA,

Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin

-

vitro+vivo,

ESCC,

Eca109

tumCV↓, TumCCA↑, ROS↑, TumAuto↑, eff↓, TRF2↓, TumCP↓,

5130-

ART/DHA,

Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway

-

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, eff↓, Apoptosis↑, Casp3↑, ROS↑, Cyt‑c↑, MMP↓, Bcl-2↓, BAX↑, MOMP↑, TumCG↓,

2580-

ART/DHA,

VitC,

Effects of Antioxidants and Pro-oxidants on Cytotoxicity of Dihydroartemisinin to Molt-4 Human Leukemia Cells

-

in-vitro,

AML,

NA

Molt-4 cell culture

eff↓, other↝, ROS↑, eff↓, eff↓,

1142-

Ash,

Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer

-

Review,

BC,

MCF7

typ 2-5uM

Ashwagandha was well tolerated at a dose of 300 mg per day in an eight-week study [147]. For insomnia, a dose of 600 milligrams per day has been found to be safe and <span class="wphighlight">eff</span>ective

-

NA,

BC,

MDA-MB-231

-

NA,

Nor,

HMEC

Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,

1369-

Ash,

Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis

-

in-vitro,

Melanoma,

U266

9 μM

tumCV↓, Apoptosis↑, BAX↑, Cyt‑c↑, Bcl-2↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, ROS↑, eff↓,

1370-

Ash,

Withaferin A induces mitochondrial-dependent apoptosis in non-small cell lung cancer cells via generation of reactive oxygen species

-

in-vitro,

Lung,

A549

ROS↑, eff↓,

1371-

Ash,

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine

-

in-vitro,

AML,

HL-60

ROS↑, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, eff↓,

1373-

Ash,

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

-

in-vitro,

Kidney,

Caki-1

ER Stress↑, p‑eIF2α↑, XBP-1↑, GRP78/BiP↑, CHOP/DDIT3↑, eff↓,

1357-

Ash,

Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

-

in-vitro,

GBM,

U87MG

 1.07±0.071µM

-

in-vitro,

GBM,

U251

0.69±0.041µM

-

in-vitro,

GBM,

GL26

0.23±0.015µM

mouse line

TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,

1360-

Ash,

immuno,

Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer

-

in-vitro,

Lung,

H1650

-

in-vitro,

Lung,

A549

-

in-vitro,

CRC,

HCT116

-

in-vitro,

BC,

MDA-MB-231

-

in-vivo,

NA,

NA

mice

PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP/DDIT3↑, p‑eIF2α↑, ICD↑, eff↑,

1361-

Ash,

SRF,

Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells

-

in-vitro,

Liver,

HUH7

-

in-vivo,

Liver,

HUH7

TrxR↓, ROS↑, DNA-PK↑, ER Stress↑, Apoptosis↑, eff↓,

1364-

Ash,

Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress

-

in-vitro,

Bladder,

J82

cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, MMP↓, DNAdam↑, eff↓,

Showing Research Papers: 1 to 50 of 399
Page 1 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 399

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

ADO↓, 1, Buty↑, 1, compII↓, 1, DIDO1/DIO-1↑, 1, EDEM↑, 1, KCNH2/hERG↓, 1, miR-199↓, 1, miR-375↑, 1, NA↑, 2, SCFAs↑, 1, SRC3↓, 1, SUV39H↓, 2, TFE3↑, 2,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 6, Catalase↓, 4, Catalase↑, 2, Catalase∅, 1, compI↓, 3, cystine↓, 1, DJ-1↓, 1, Fenton↑, 5, Ferroptosis↓, 2, Ferroptosis↑, 12, GCLM↓, 1, GPx↓, 5, GPx4↓, 8, GSH↓, 42, GSH↑, 1, GSH∅, 1, i-GSH∅, 1, GSH/GSSG↓, 9, GSR↓, 1, GSSG↓, 1, GSTA1↓, 2, GSTs↓, 1, GSTs∅, 1, GSTZ1↓, 1, GSTZ1∅, 1, H2O2?, 1, H2O2↑, 13, i-H2O2↑, 1, mt-H2O2↑, 1, HK1↓, 1, HO-1↓, 2, HO-1↑, 4, HO-2↑, 1, ICD↑, 3, Iron↑, 7, i-Iron↑, 1, Keap1↓, 1, Keap1↑, 1, lipid-P↓, 2, lipid-P↑, 19, MDA↓, 1, MDA↑, 8, NADPH/NADP+↓, 1, NQO1↓, 1, Nrf1↑, 1, NRF2↓, 7, NRF2↑, 10, NRF2↝, 1, p‑NRF2↑, 1, OXPHOS↓, 3, OXPHOS↑, 2, OXPHOS⇅, 1, PARK2↑, 3, Prx6↑, 1, ROS?, 4, ROS↓, 7, ROS↑, 305, ROS⇅, 2, ROS↝, 2, i-ROS↑, 4, mt-ROS↑, 13, RPM↑, 1, SIRT3↑, 1, SOD↓, 7, SOD↑, 1, mt-SOD↑, 1, SOD1↓, 1, SOD1↑, 1, SOD2↓, 3, SOD2↑, 3, Thiols↓, 3, i-Thiols↓, 1, Trx↓, 4, Trx↑, 1, Trx1↓, 1, ox-Trx1↑, 1, TrxR↓, 14, TrxR1↓, 8, TrxR1↑, 1, TrxR2↓, 1, xCT/SLC7A11↓, 3, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, FTH1↓, 3, NCOA4↑, 2,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1, AIF↑, 11, ATP↓, 18, i-ATP↑, 1, CDC2↓, 2, CDC25↓, 7, CDC25↑, 1, ETC↓, 5, MEK↓, 1, p‑MEK↑, 1, mitResp↓, 7, mitResp↑, 1, MMP?, 1, MMP↓, 110, MPT↑, 4, mtDam↑, 26, OCR↓, 9, OCR↑, 2, mt-OCR↓, 1, PGC-1α↑, 1, PINK1↑, 3, Raf↓, 1, SDH↓, 3, XIAP↓, 5,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, ACC↓, 2, ACC↑, 1, p‑ACC↑, 1, ACLY↓, 1, AKT1↓, 1, ALAT∅, 1, ALDOA↓, 1, AMPK↑, 11, p‑AMPK↑, 3, ATG7↑, 1, citrate↓, 1, cMyc↓, 7, cMyc↑, 1, CPT1A↓, 1, CRM↝, 1, ECAR↓, 3, ENO1↓, 1, FASN↓, 1, FASN↑, 1, glucose↓, 2, GlucoseCon↓, 6, GlucoseCon↑, 1, GlucoseCon∅, 1, Glycolysis↓, 17, Glycolysis↑, 1, Histones↑, 1, HK2↓, 11, HK2↑, 1, HMG-CoA↓, 1, lactateProd↓, 9, lactateProd↑, 3, lactateProd∅, 1, LDH?, 1, LDH↑, 2, LDH↝, 1, LDHA↓, 4, LDHA↑, 1, lipidLev↓, 1, lipoGen↓, 1, NAD↓, 2, NADPH↓, 3, PDH↓, 2, PDK1 / PDPK1↓, 3, PDKs↓, 2, PFK↓, 2, PFK2?, 1, PFKP↓, 1, PGK1↓, 1, PI3K/Akt↓, 1, PKM2↓, 7, PPARγ↑, 1, PPP↓, 2, Pyruv↓, 1, SIRT1↓, 4, SIRT1↑, 4, p‑STK11/LKB1↑, 1, TCA?, 1, TCA↓, 2, TS↓, 1, Warburg↓, 2, β-oxidation↓, 1,

Cell Death(tgid=5) ⓘ

Akt↓, 36, Akt↑, 2, p‑Akt↓, 18, p‑Akt↑, 1, APAF1↑, 1, Apoptosis↓, 7, Apoptosis↑, 171, mt-Apoptosis↑, 3, p‑ASK1↑, 1, BAD↓, 1, BAD↑, 5, Bak↑, 5, BAX↓, 2, BAX↑, 71, Bax:Bcl2↑, 20, Bcl-2↓, 80, Bcl-2↑, 3, Bcl-2∅, 1, Bcl-xL↓, 24, BID↓, 1, BID↑, 4, BIM↑, 3, Casp↓, 1, Casp↑, 29, Casp12?, 1, Casp12↑, 1, Casp2↑, 1, Casp3↓, 2, Casp3↑, 87, cl‑Casp3↑, 34, proCasp3↓, 3, proCasp3↑, 2, Casp6↑, 1, Casp7↑, 9, cl‑Casp7↑, 1, Casp8↑, 17, Casp8∅, 2, cl‑Casp8↑, 2, Casp9↑, 54, cl‑Casp9↓, 1, cl‑Casp9↑, 16, proCasp9↓, 1, proCasp9↑, 1, cFLIP↓, 4, Chk2↑, 2, Cupro↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 53, Diablo↑, 1, DR4↑, 4, DR4∅, 1, DR5↑, 10, Endon↑, 1, FADD↑, 3, Fap1↓, 1, Fas↑, 3, FasL↑, 6, Ferroptosis↓, 2, Ferroptosis↑, 12, GSDMD↑, 1, GSDME↑, 1, GSDME-N↑, 1, Hippo↓, 1, hTERT/TERT↓, 4, IAP1↓, 4, IAP2/BIRC3↓, 2, iNOS↓, 2, JNK↓, 3, JNK↑, 20, p‑JNK↑, 8, MAPK↓, 5, MAPK↑, 9, p‑MAPK↓, 1, p‑MAPK↑, 4, Mcl-1↓, 9, MDM2↓, 6, MKP1↓, 1, MKP2↓, 1, MLKL↑, 3, p‑MLKL↓, 1, MOMP↑, 2, Myc↓, 1, Necroptosis↑, 7, necrosis↑, 3, NOXA↑, 2, p27/CDKN1B↑, 7, p38↑, 13, p‑p38↑, 7, Paraptosis↑, 3, PUMA↑, 1, Pyro↑, 4, RIP1↓, 2, RIP1↑, 2, survivin↓, 23, Telomerase↓, 3, TRAIL↑, 3, TRPV1↑, 2, TumCD↓, 2, TumCD↑, 32, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 3, CaMKII ↓, 1, cSrc↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 2, p70S6↓, 2, Sp1/3/4↓, 3, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 2, H3↓, 1, p‑H3↑, 1, miR-30a-5p↑, 1, other↓, 1, other↑, 5, other↝, 14, other∅, 1, SETBP1↓, 1, tumCV?, 1, tumCV↓, 66, tumCV↑, 2,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, CHOP/DDIT3↓, 2, CHOP/DDIT3↑, 13, eIF2α↑, 4, p‑eIF2α↓, 1, p‑eIF2α↑, 6, ER Stress↓, 1, ER Stress↑, 41, ERStress↑, 1, GRP78/BiP↓, 1, GRP78/BiP↑, 11, HSF1↓, 1, HSP27↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 1, HSP90↓, 2, HSP90↑, 1, HSPs↑, 1, HSPs∅, 1, IRE1↑, 1, PERK↑, 3, p‑PERK↑, 1, UPR↑, 7, XBP-1↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 5, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 10, p‑Beclin-1/ATG6↑, 1, BNIP3?, 2, LC3‑Ⅱ/LC3‑Ⅰ↑, 2, LC3B↑, 3, LC3B-II↑, 5, LC3II↑, 11, LC3s↑, 2, MitoP↑, 2, p62↓, 5, p62↑, 6, p‑p62↑, 1, TFEB↑, 1, TumAuto↓, 3, TumAuto↑, 37, TumAuto↝, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3, ATR↑, 1, CHK1↓, 1, DNA-PK↑, 2, DNAdam↓, 3, DNAdam↑, 40, DNArepair↓, 1, DNMT1↑, 1, DNMTs↓, 2, GADD45A↑, 1, p16↑, 1, P53↓, 2, P53↑, 30, P53∅, 1, p‑P53↑, 3, PARP↓, 2, PARP↑, 8, p‑PARP↑, 1, cl‑PARP↑, 66, proPARP↓, 1, cl‑PARP1↑, 3, PCNA↓, 4, TP53↓, 1, γH2AX↑, 5, p‑γH2AX↑, 5,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3, p‑CDK1↑, 1, CDK2↓, 8, CDK4↓, 7, CDK4↑, 1, Cyc↓, 1, cycA1/CCNA1↓, 5, cycA1/CCNA1↑, 2, CycB/CCNB1↓, 14, CycB/CCNB1↑, 3, cycD1/CCND1↓, 25, cycD1/CCND1↑, 1, CycD3↓, 1, cycE/CCNE↓, 5, E2Fs↓, 1, mitA↓, 1, p19↑, 1, P21↓, 1, P21↑, 23, RB1↑, 1, p‑RB1↓, 1, TumCCA?, 1, TumCCA↓, 3, TumCCA↑, 95,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1, BMI1↓, 3, CD24↓, 2, CD44↓, 5, cDC2↓, 3, cMET↓, 1, cMYB↓, 1, CSCs↓, 13, CTNNB1↓, 1, Diff↑, 1, EMT↓, 11, ERK↓, 9, ERK↑, 9, p‑ERK↓, 3, p‑ERK↑, 4, e-ERK↑, 1, FGF↓, 1, FOXO1↑, 1, FOXO3↑, 3, FOXO4↑, 1, GSK‐3β↓, 2, GSK‐3β↑, 2, p‑GSK‐3β↓, 2, HDAC↓, 9, HDAC1↓, 1, HDAC10↓, 1, IGF-1↓, 2, IGF-1R↓, 1, mTOR↓, 19, mTOR↑, 1, p‑mTOR↓, 7, mTORC1↓, 3, mTORC2↑, 1, Nanog↓, 2, OCT4↓, 1, p85S6K↓, 1, PI3K↓, 26, PI3K↑, 2, p‑PI3K↓, 2, PTEN↑, 5, Shh↓, 2, SOX2↓, 2, STAT↓, 2, STAT3↓, 15, STAT3↑, 2, STAT3↝, 1, p‑STAT3↓, 9, p‑STAT3↑, 1, TCF↓, 1, TCF↝, 1, TCF-4↓, 1, TOP1↑, 1, TOP2↓, 1, TOP2↑, 1, TRF2↓, 1, TumCG↓, 73, TumCG↑, 4, Wnt↓, 7,

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 1, AP-1↓, 3, ATPase↑, 1, BACH1↑, 1, Ca+2↓, 4, Ca+2↑, 17, Ca+2↝, 1, i-Ca+2?, 1, i-Ca+2↑, 2, Cdc42↑, 1, Chl↑, 1, Chl∅, 1, E-cadherin↑, 8, FAK↓, 2, FOSB↑, 1, Ki-67↓, 8, LAMP1?, 1, LEF1↓, 1, miR-139-5p↑, 1, miR-22↑, 1, MMP1↓, 1, MMP2↓, 14, proMMP2↓, 1, MMP3↓, 1, MMP7↓, 1, MMP9↓, 17, MMPs↓, 4, N-cadherin↓, 2, N-cadherin↑, 1, PAK1↓, 2, PAK1↑, 1, PKCδ↓, 1, Rho↓, 1, RIP3↑, 3, p‑RIP3↑, 2, ROCK1↓, 1, Slug↓, 2, Snail↓, 3, SPARC↑, 1, TIMP1↑, 2, TIMP2↑, 2, TSP-1↑, 1, TumCI?, 1, TumCI↓, 16, TumCMig↓, 23, TumCP↓, 90, TumCP↑, 3, TumMeta↓, 13, Twist↓, 3, TXNIP↑, 1, uPA↓, 1, Vim↓, 4, Zeb1↓, 1, β-catenin/ZEB1↓, 11,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23, angioG↑, 3, ATF4↑, 7, EGFR↓, 6, EGR1↑, 1, EPR↑, 2, Hif1a↓, 14, Hif1a↑, 2, LOX1↓, 1, NO↓, 1, NO↑, 6, VEGF↓, 14,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, BBB∅, 1, CellMemb↓, 1, GLUT1↓, 6, GLUT1↑, 1, GLUT3↓, 1, P-gp/ABCB1↓, 6, SLC12A5↓, 1, SMCT1∅, 1, sonoP↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2, cellSen↑, 1, COX2/PTGS2↓, 11, COX2/PTGS2↑, 3, CXCR4↓, 1, IFN-γ↑, 1, Igs↑, 1, IKKα↓, 2, IKKα↑, 2, p‑IKKα↓, 1, IL10↑, 1, IL1β↓, 5, IL2↓, 1, IL2↑, 1, IL6↓, 5, IL8↓, 1, Imm↑, 3, Inflam↓, 5, Inflam↑, 1, IRAK4↓, 1, JAK↓, 1, JAK1?, 1, p‑JAK1↓, 1, JAK2↓, 3, p‑JAK2↓, 3, pol-M1↑, 1, M2 MC↓, 1, pol-M2 MC↓, 1, NF-kB↓, 37, NF-kB↑, 2, NK cell↑, 2, p65↓, 4, PD-L1↓, 2, PD-L1↑, 2, PGE2↓, 2, T-Cell↝, 1, TLR1↑, 1, TLR4↓, 1, TNF-α↓, 3, TRAF1↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1, pH↑, 1, e-pH↑, 1, i-pH↓, 1, Temp↓, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3, CDK6↓, 2, CDK6↑, 1, ER(estro)↓, 1, SXR↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12, BioAv↑, 14, BioAv↝, 1, BioAv∅, 1, BioEnh↑, 2, ChemoSen?, 1, ChemoSen↓, 3, ChemoSen↑, 64, DDS↑, 1, Dose?, 3, Dose↓, 4, Dose↑, 6, Dose↝, 31, Dose∅, 9, eff↓, 427, eff↑, 146, eff↝, 6, eff∅, 2, Half-Life↓, 5, Half-Life↑, 1, Half-Life↝, 1, Half-Life∅, 2, MDR1↓, 2, RadioS↓, 1, RadioS↑, 22, selectivity↓, 1, selectivity↑, 83, selectivity∅, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT∅, 1, AR↓, 3, AST∅, 1, BMD↑, 1, EGFR↓, 6, Ferritin↓, 1, GutMicro↑, 2, GutMicro↝, 1, HER2/EBBR2↓, 2, hTERT/TERT↓, 4, IL6↓, 5, Ki-67↓, 8, LDH?, 1, LDH↑, 2, LDH↝, 1, Myc↓, 1, PD-L1↓, 2, PD-L1↑, 2, TP53↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2, AntiCan↓, 2, AntiCan↑, 21, antiNeop↑, 1, AntiP↑, 2, AntiTum↓, 1, AntiTum↑, 9, AntiTum⇅, 1, cardioP↑, 2, CardioT↓, 1, chemoP↑, 7, chemoPv↑, 6, ChemoSideEff↓, 2, fatigue↓, 1, hepatoP↑, 1, MusCon↓, 1, NDRG1↑, 1, neuroP↑, 3, NKG2D↑, 1, OS↑, 11, radioP↑, 1, Risk↓, 4, Risk↑, 1, Risk∅, 1, toxicity↓, 7, toxicity↝, 8, toxicity∅, 2, TumVol↓, 21, TumW↓, 17, Weight↑, 1, Weight∅, 3,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, CD8+↑, 3,
Total Targets: 661

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1, Stress↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 8, Catalase↓, 1, Catalase↑, 4, GPx↑, 2, GPx1↑, 1, GPx4↑, 1, GSH↓, 2, GSH↑, 2, GSTA1↓, 1, GSTs↑, 2, H2O2↓, 1, HO-1↑, 2, Keap1↓, 1, lipid-P↓, 2, MDA↓, 1, NQO1↑, 1, NRF2↑, 2, RNS↓, 1, ROS↓, 14, ROS↑, 6, ROS⇅, 1, ROS∅, 4, SOD↓, 2, SOD↑, 4, SOD1↑, 1, TAC↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2, Insulin↓, 1, mitResp↑, 1, MMP∅, 1, PGC-1α↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1, AMPK↑, 1, glucose↓, 1, LDH↓, 1,

Cell Death(tgid=5) ⓘ

Apoptosis∅, 1, Casp3∅, 1, Cyt‑c∅, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, other↓, 1, other↝, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1, DNAdam↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1, Wnt↑, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 1, Ca+2↑, 1, FAK↑, 1, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1, VEGF↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1, IL6↓, 2, Imm↑, 2, Inflam↓, 9, NF-kB↓, 2, TNF-α↓, 2,

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1, BioAv↓, 4, BioAv↑, 6, BioAv↝, 2, Dose∅, 1, eff↑, 5, Half-Life↝, 1, Half-Life∅, 1, selectivity↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1, IL6↓, 2, LDH↓, 1,

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1, AntiCan↑, 1, AntiDiabetic↓, 1, AntiDiabetic↑, 2, AntiP↓, 1, AntiP↑, 2, AntiTum↑, 1, cardioP↑, 2, chemoP↑, 2, cognitive↑, 2, hepatoP↑, 1, neuroP↑, 5, Obesity↓, 1, toxicity?, 1, toxicity↓, 15, toxicity↑, 3, toxicity↝, 1, toxicity∅, 8, Weight∅, 1, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3, Bacteria↓, 3,
Total Targets: 97

Scientific Paper Hit Count for: eff, efficacy

22 Sulforaphane (mainly Broccoli)
14 Curcumin
13 Magnetic Fields
13 Shikonin
12 Copper and Cu NanoParticles
11 Silver-NanoParticles
11 Baicalein
11 Thymoquinone
10 Ashwagandha(Withaferin A)
10 Phenethyl isothiocyanate
10 Piperlongumine
9 Gambogic Acid
9 Ivermectin
9 Selenite (Sodium)
8 Plumbagin
7 chaetocin
6 Betulinic acid
6 Propolis -bee glue
5 Auranofin
5 Vitamin C (Ascorbic Acid)
5 Apigenin (mainly Parsley)
5 Artemisinin
5 Berberine
5 Cisplatin
5 Carnosic acid
5 Capsaicin
5 Cynaropicrin
5 Magnetic Field Rotating
5 Parthenolide
5 Vitamin K2
4 3-bromopyruvate
4 Dichloroacetate
4 Quercetin
4 Lemongrass Extract/Citral
4 Disulfiram
4 EGCG (Epigallocatechin Gallate)
4 Formononetin
4 Isobavachalcone
4 Juglone
4 Licochalcone A
4 Luteolin
3 Gold NanoParticles
3 Radiotherapy/Radiation
3 Chemotherapy
3 Photodynamic Therapy
3 Allicin (mainly Garlic)
3 Selenium
3 Cannabidiol
3 Citric Acid
3 Fisetin
3 Honokiol
3 Hyperthermia
3 isoorientin
3 isoquercitrin
3 salinomycin
3 Sulfasalazine
2 Alpha-Lipoic-Acid
2 almonertinib
2 Anti-oxidants
2 Metformin
2 immunotherapy
2 α-Bisabolol / Chamomile oil
2 chitosan
2 Coenzyme Q10
2 Resveratrol
2 Melatonin
2 Silymarin (Milk Thistle) silibinin
2 diet Methionine-Restricted Diet
2 Docetaxel
2 eicosapentaenoic acid
2 erastin
2 Eugenol
2 γ-linolenic acid (Borage Oil)
2 Gossypol/AT-101
2 HydroxyTyrosol
2 lambertianic acid
2 Lycopene
2 doxorubicin
2 Nimbolide
2 Phenylbutyrate
2 SonoDynamic Therapy UltraSound
2 VitK3,menadione
2 Spermidine
2 Terpinen-4-ol / Tea Tree Oil
2 Urolithin
1 2-DeoxyGlucose
1 cetuximab
1 Resiquimod
1 Bevacizumab (brand Avastin)
1 Amodiaquine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Anethole/trans-Anethole
1 Vitamin A, Retinoic Acid
1 Sorafenib (brand name Nexavar)
1 5-fluorouracil
1 Bufalin/Huachansu
1 Bifidobacterium
1 borneol
1 Boron
1 Bullatacin
1 Butyrate
1 Caffeic acid
1 Caffeine
1 urea
1 Carvacrol
1 Celastrol
1 Chlorogenic acid
1 Carica papaya leaf extract
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Cucurbitacin
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 diet FMD Fasting Mimicking Diet
1 diet Short Term Fasting
1 Dipyridamole
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Bortezomib
1 Emodin
1 Electrical Pulses
1 Exercise
1 Folic Acid, Vit B9
1 Fenbendazole
1 Paclitaxel/Taxol
1 Fucoidan
1 Gallic acid
1 Germanium inorganic
1 Germanium-Spirogermanium
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Hydrogen Gas
1 HydroxyCitric Acid
1 tamoxifen
1 hydroxychloroquine
1 Helleborus niger extracts – Christmas Rose
1 iodine
1 Inulin Prebiotic
1 Isoliquiritigenin
1 Geldanamycin
1 Linalool
1 1,8-Cineole
1 Methylene blue
1 Matrine
1 Methyl Jasmonate
1 Myricetin
1 Marjoram (Origanum majorana)
1 Propyl gallate
1 Piperine
1 EMF
1 Rhein
1 Rosmarinic acid
1 Oxaliplatin
1 Scoulerine
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Wogonin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:961  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

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