Beclin-1/ATG6 Cancer Research Results

Beclin-1/ATG6, Beclin-1 (BECN1 gene): Click to Expand ⟱

Source:

Type: Protein Coding gene

Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown.
A key biomarker of autophagy is Beclin-1. Beclin-1 stimulates LC3-I’s lipidation to produce LC3-II, which localizes to the autophagosome membrane to activate the development of autophagosomes.
-BECN1 = the official gene symbol (human gene name)
-Beclin-1 = the protein name encoded by the BECN1 gene

BECN1 - Beclin 1

Abbreviation: BECN1, Beclin 1

Alternative Names: ATG6, VPS30

Type: Autophagy regulator / class III PI3K complex component

Function: Beclin 1 is a core component of the VPS34/class III PI3K complex and promotes phosphatidylinositol-3-phosphate production required for autophagosome nucleation and membrane trafficking.

Cancer: ↕ Context-dependent. Reduced BECN1 expression can contribute to tumor initiation and genomic instability, supporting a tumor-suppressive role in some tissues. However, established cancers can also exploit Beclin 1-dependent autophagy for survival under metabolic and therapeutic stress.

Scientific Papers found: Click to Expand⟱

5263-

3BP,

CET,

3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis

in-vitro,

CRC,

DLD1

NA,

HCT116

eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1/ATG6↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT/SLC7A11↑, GSH↓, eff↓, MDA↑,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

Review,

Var,

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

400-

AgNPs,

MF,

Polyvinyl Alcohol Capped Silver Nanostructures for Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field

in-vitro,

Laryn,

HEp2

50mT/30mins

3.29 0.4 mol/mL

6x improvement when LEMF added (50mT/15mins)

TumCP↓, Casp3↑, P53↑, Beclin-1/ATG6↑, TumAuto↑, GSR↑, ROS↑, MDA↑, ROS↑, SIRT1↑, Ca+2↑, Endon↑, DNAdam↑, Apoptosis↑, NF-kB↓,

387-

AgNPs,

Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells

in-vitro,

Colon,

HT-29

33.45 μg/mL

Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1/ATG6↑, CHOP/DDIT3↑, LC3s↑, XBP-1↑,

250-

AL,

Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells

in-vitro,

Liver,

HepG2

 35uM

P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1/ATG6↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,

7393-

Amla,

Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors

vitro+vivo,

Ovarian,

OVCAR-3

mouse xenograft tumors.

in-vitro,

Ovarian,

SW626

TumCP↓, Beclin-1/ATG6↑, LC3B-II↑, Hif1a↓, Dose↝, TumAuto↑, angioG↓, COL4A3↓, CXCL6/GCP-2↓, TYMP/ECGF1↓, IL1β↓, PDGFRB↓, ChemoSen↑, Dose↝,

584-

Api,

Cisplatin,

Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

in-vivo,

Var,

Eighty Swiss albino male mice

Beclin-1/ATG6↑, Casp3↑, Casp9↑, JNK↑, Mcl-1↓, Ki-67↓,

313-

Api,

Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

in-vitro,

Thyroid,

BCPAP

 25 uM

LC3s↝, p62↓, ROS↑, TumCCA↑, CDC25↓, TumAuto↑, Beclin-1/ATG6↑, AVOs↑, DNAdam↑,

3383-

ART/DHA,

Dihydroartemisinin: A Potential Natural Anticancer Drug

Review,

Var,

TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,

1528-

Ba,

Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma

in-vitro,

OS,

CAL27

1-100uM

Apoptosis↑, ROS↑, eff↓, TumAuto↑, cl‑PARP↑, Bax:Bcl2↑, Beclin-1/ATG6↑, p62↓,

5547-

BBM,

Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway

in-vitro,

CRC,

HT29

tumCV↓, selectivity↑, Casp3↑, Casp9↑, Bax:Bcl2↑, ATG5↑, Beclin-1/ATG6↑, TumCP↓, MEK↓, ERK↓,

5680-

BML,

Anticancer properties of bromelain: State-of-the-art and recent trends

Review,

Var,

*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,

5678-

BML,

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

in-vivo,

CRC,

investigated using different CRC cell lines, a zebrafish model, and a xenograft mouse model.

AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1/ATG6↑, p62↑, PARP↑,

5662-

BNL,

Rad,

Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma

vitro+vivo,

GBM,

RadioS↑, Beclin-1/ATG6↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,

739-

Bor,

Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells

in-vitro,

GBM,

U87MG

in-vitro,

Nor,

HMC3

this report calls HMC3 "normal cells"

TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1/ATG6↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,

1580-

Citrate,

Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway

in-vitro,

Pca,

PC3

 (0-3 mM)

in-vivo,

PC,

50 mg/kg/day, i.p.)

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

WPMY-1

 (0-3 mM)

Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑, TumAuto↑, CaMKII ↓,

4772-

CoQ10,

The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells

in-vitro,

BC,

MDA-MB-468

 IC50 values of 4.8, 7.6, and 20.6 µM

in-vitro,

BC,

MDA-MB-231

TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1/ATG6↑, TumAuto↑, ROS↑,

4776-

CoQ10,

Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy

vitro+vivo,

Ovarian,

SKOV3

(SKOV-3) cells and xenografted nude mice

ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1/ATG6↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,

1571-

Cu,

Copper in cancer: From pathogenesis to therapy

Review,

NA,

*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1/ATG6↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,

471-

CUR,

Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells

in-vitro,

Ovarian,

SKOV3

5, 10, 20, 40 and 80 μM, 24, 48 and 72 h

in-vitro,

Ovarian,

A2780S

Apoptosis↑, TumAuto↑, p62↓, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Casp9↑, PARP↑, ATG3↑, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↑,

463-

CUR,

Curcumin induces autophagic cell death in human thyroid cancer cells

in-vitro,

Thyroid,

10, 12.5, 20, 25, 30, 40 and 50 µM, 24 and 72 h

in-vitro,

Thyroid,

FTC-133

in-vitro,

Thyroid,

BCPAP

in-vitro,

Thyroid,

8505C

TumAuto↑, LC3II↑, Beclin-1/ATG6↑, p‑p38↑, p‑JNK↑, p‑ERK↑, p62↓, p‑PDK1 / PDPK1↓, p‑Akt↓, p‑p70S6↓, p‑PIK3R1↓, p‑S6↓, p‑4E-BP1↓,

404-

CUR,

Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy

vitro+vivo,

Lung,

A549

mice

vitro+vivo,

Lung,

H1299

TumAuto↑, TumCG↓, TumCP↓, Iron↑, GSH↓, lipid-P↑, GPx↓, mtDam↑, autolysosome↑, Beclin-1/ATG6↑, LC3s↑, p62↓, Ferroptosis↑,

435-

CUR,

Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway

in-vitro,

Lung,

A549

5, 10, 20 and 40 μM, 24, 48, 72 and 96 h

Apoptosis↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, p‑mTOR↓,

457-

CUR,

Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

in-vitro,

GC,

SGC-7901

10, 20 and 40 μM, 24 h

in-vitro,

GC,

BGC-823

TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1/ATG6↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,

448-

CUR,

Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation

in-vitro,

CRC,

HT-29

15, 20 and 25 μM, 48 h

Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1/ATG6↑, p62↑, GPx1↓, GPx4↓,

1863-

dietFMD,

Chemo,

Effect of fasting on cancer: A narrative review of scientific evidence

Review,

Var,

eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,

6328-

DRE,

Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells

in-vitro,

BC,

4T1

330.21, 262.38 and 145.90 µg mL-1 for 24, 48 and 72 hr, respectively.

TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1/ATG6↑, ATG7↑, Bcl-2↓, NO↓,

3205-

EGCG,

The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas

Review,

Var,

Review,

AD,

Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,

1656-

FA,

Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

Review,

Var,

tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,

2827-

FIS,

The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment

Review,

Var,

*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,

6984-

Form,

Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling

in-vitro,

Colon,

HCT116

Review,

IBD,

RAW264.7

*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,

1962-

GamB,

HCQ,

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

in-vitro,

PC,

LC3II↑, Beclin-1/ATG6↑, p62↓, MMP↓, ROS↑, TumAuto⇅, eff↑,

1970-

GamB,

Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway

NA,

Lung,

NCI-H441

TumCG↓, TumAuto↑, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↑, ROS↑, eff↓,

7102-

GEN,

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

Review,

Var,

*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, eff↑, ChemoSen↑,

7365-

HibSad,

Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L

Review,

Var,

chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,

7353-

HibSad,

Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy

in-vitro,

Melanoma,

A375

cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,

2865-

HNK,

Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma

in-vitro,

MB,

DAOY

vitro+vivo,

NA,

BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, eff↑, ChemoSen↑, *toxicity↓,

7855-

isoO,

Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells

in-vitro,

Liver,

HepG2

in-vitro,

Nor,

HL7702

TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,

7794-

ISQ,

Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway

in-vitro,

Liver,

HepG2

in-vitro,

Liver,

HUH7

tumCV↓, Apoptosis↑, TumAuto↑, AMPK↑, TumCG↓, ATG5↑, Beclin-1/ATG6↑, p‑mTOR↓, Casp3↑, cl‑PARP↑, Bax:Bcl2↑, LC3II↑, p62↓,

8039-

IVM,

Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

NA,

neuroblastoma,

SH-SY5Y

*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,

8040-

IVM,

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

Review,

Var,

Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,

7893-

IVT,

Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress

vitro+vivo,

Liver,

TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,

1917-

JG,

Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion

in-vitro,

AML,

HL-60

0-80uM

selectivity↑, LC3I↑, LC3II↑, Beclin-1/ATG6↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,

5118-

JG,

Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells

in-vitro,

HCC,

HepG2

m-ROS↑, DNAdam↑, Apoptosis↑, TumAuto↑, p38↑, MAPK↑, JNK↑, MMP↓, LC3II↑, Beclin-1/ATG6↑,

8098-

KAE,

Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway

in-vitro,

HCC,

HepG2

in-vitro,

HCC,

HUH7

TumAuto↑, ER Stress↑, CHOP/DDIT3↓, chemoPv↑, RadioS↑, Akt↓, PI3K↓, ERK↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑,

8107-

KAE,

Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B

in-vitro,

Ovarian,

A2780S

Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,

8235-

LCA,

Anticancer effects of licochalcones: A review of the mechanisms

Review,

Var,

mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,

8236-

LE,

Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects

Review,

Var,

Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,

8384-

LT,

Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors

Review,

GC,

Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, eff↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,

8369-

LT,

Luteolin inhibits proliferation of lung cancer A549 cells by increasing ROS production and inhibiting the AKT/mTOR signaling pathway and HO-1 expression

in-vitro,

Lung,

A549

tumCV↓, TumCP↓, ROS↑, BAX↑, cl‑Casp9↑, Beclin-1/ATG6↑, LC3B-II↑, Bcl-2↓, p62↓, TumAuto↑, p‑Akt↓, p‑mTOR↓, HO-1↓,

Showing Research Papers: 1 to 50 of 64
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 64

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1, Sepsis↓, 1,
Total Targets: 475

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1, colonLen↑, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8, Catalase↑, 2, GPx↑, 1, GSH↑, 2, GSR↑, 1, GSTs↑, 1, HO-1↑, 3, lipid-P↓, 2, MDA↓, 2, MPO↓, 1, NQO1↑, 1, NRF2↑, 4, ROS↓, 8, ROS↑, 1, SOD↑, 4,

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1, MMP↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1, AMPK↑, 1, glucose↓, 1, LDHA↑, 1, LDL↓, 1, PPARα↑, 1, SIRT1↑, 1, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

BAX↓, 1, Casp1↓, 1, Casp3↓, 1, Casp9↓, 1, Cyt‑c↓, 1, iNOS↓, 2, JNK↓, 1, MAPK↓, 2, p38↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, ER Stress↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,

Migration(tgid=13) ⓘ

Ca+2?, 1, TXNIP↓, 1, ZO-1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1, NO↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1, COX2/PTGS2↓, 2, IFN-γ↓, 1, IL10↓, 1, IL18↓, 1, IL1β↓, 1, IL2↓, 1, IL6↓, 2, Inflam↓, 10, IκB?, 1, NF-kB↓, 3, PGE2↓, 1, TLR4↓, 1, TNF-α↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2, NLRP3↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7, BioAv↝, 1, Dose↝, 2,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AST↓, 1, GutMicro↑, 1, IL6↓, 2,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiDiabetic↑, 2, AntiP↑, 1, cardioP↑, 1, chemoP↑, 1, chemoPv↑, 1, cognitive↑, 1, hepatoP↑, 2, memory↑, 1, neuroP↑, 4, Pain↓, 1, radioP↑, 1, toxicity↓, 3, toxicity↑, 1, toxicity↝, 1, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2, Bacteria↓, 2, Diar↓, 1,
Total Targets: 89

Scientific Paper Hit Count for: Beclin-1/ATG6, Beclin-1 (BECN1 gene)

6 Curcumin
5 Luteolin
2 Silver-NanoParticles
2 Magnetic Fields
2 Apigenin (mainly Parsley)
2 Bromelain
2 Coenzyme Q10
2 Gambogic Acid
2 Hibiscus sabdariffa
2 Ivermectin
2 Juglone
2 Kaempferol
2 Thymoquinone
1 3-bromopyruvate
1 cetuximab
1 Astragalus
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Cisplatin
1 Artemisinin
1 Baicalein
1 Berbamine
1 borneol
1 Radiotherapy/Radiation
1 Boron
1 Citric Acid
1 Copper and Cu NanoParticles
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Dandelion Root
1 EGCG (Epigallocatechin Gallate)
1 Ferulic acid
1 Fisetin
1 Formononetin
1 hydroxychloroquine
1 Genistein (soy isoflavone)
1 Honokiol
1 isoorientin
1 isoquercitrin
1 Isovitexin
1 Licochalcone A
1 Licorice
1 Magnetic Field Rotating
1 Phenylbutyrate
1 Parthenolide
1 Quercetin
1 Rutin
1 buckwheat sprouts
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spermidine
1 Selenite (Sodium)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:30  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Beclin-1/ATG6 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

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