TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.
Scientific Papers found: Click to Expand⟱
2432- 2DG,    Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- in-vitro, Lung, H23 - in-vitro, Lung, KP2 - in-vivo, NA, NA
HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1/ATG6↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT/SLC7A11↑, GSH↓, eff↓, MDA↑,
5270- 5-ALA,  PDT,    5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
- Review, Var, NA
other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
5432- AG,    Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies
- Review, Cerv, NA
ChemoSen↑, eff↑, RadioS↑, CEA↓, Wnt↓, β-catenin/ZEB1↓, γH2AX↑, ER Stress↑, mt-TumAuto↑, QoL↑, Imm↑,
4559- AgNPs,    Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation
- in-vitro, BC, SkBr3 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
MMP2↓, MMP9↓, ROS↑, TumAuto↑, Apoptosis↑, ER Stress↑,
5146- AgNPs,    Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent
- in-vitro, Liver, HepG2
TumAuto↑, EPR↑, LC3B↑, CHOP/DDIT3↑, ER Stress↑, NLRP3↑, Casp1↓,
328- AgNPs,  Rad,    Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
- vitro+vivo, GBM, U251
Apoptosis↑, TumAuto↑,
343- AgNPs,    Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma
- in-vitro, PC, PANC1
BAX↑, Bcl-2↓, P53↑, TumAuto↑,
330- AgNPs,  Rad,    Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
- in-vitro, GBM, U251
TumAuto↑, ROS↑,
329- AgNPs,  Rad,    Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells
- in-vitro, GBM, U251
Apoptosis↑, TumAuto↑,
327- AgNPs,  MS-275,    Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells
- in-vitro, Lung, A549
Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,
318- AgNPs,    Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells
- in-vitro, Pca, PC3
lysoM↓, lysosome↓, AMPKα↑, TumAuto↑, mTOR↑,
317- AgNPs,    Autophagic effects and mechanisms of silver nanoparticles in renal cells under low dose exposure
- in-vitro, Kidney, HEK293
TumAuto↑, p62↑,
312- AgNPs,  wortm,    Inhibition of autophagy enhances the anticancer activity of silver nanoparticles
- vitro+vivo, Cerv, HeLa
APA↑, p62↓, PIK3CA↑, TumVol↓, TumAuto↑, eff↑,
400- AgNPs,  MF,    Polyvinyl Alcohol Capped Silver Nanostructures for Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field
- in-vitro, Laryn, HEp2
TumCP↓, Casp3↑, P53↑, Beclin-1/ATG6↑, TumAuto↑, GSR↑, ROS↑, MDA↑, ROS↑, SIRT1↑, Ca+2↑, Endon↑, DNAdam↑, Apoptosis↑, NF-kB↓,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
250- AL,    Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells
- in-vitro, Liver, HepG2
P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1/ATG6↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,
2648- AL,    Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway
- in-vitro, OS, SaOS2 - in-vivo, OS, NA
ROS↑, TumCG↓, TumAuto↑, Wnt↓, β-catenin/ZEB1↓, MALAT1↓,
2666- AL,    Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
- Review, Var, NA
Inflam↓, AntiCan↑, ROS↑, MAPK↑, JNK↑, TumAuto↑, other↑, Dose↝, MALAT1↓, Wnt↓, β-catenin/ZEB1↓,
7393- Amla,    Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
- vitro+vivo, Ovarian, OVCAR-3 - in-vitro, Ovarian, SW626
TumCP↓, Beclin-1/ATG6↑, LC3B-II↑, Hif1a↓, Dose↝, TumAuto↑, angioG↓, COL4A3↓, CXCL6/GCP-2↓, TYMP/ECGF1↓, IL1β↓, PDGFRB↓, ChemoSen↑, Dose↝,
1354- And,    Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,
6406- ANE,    Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways
- in-vitro, Oral, Ca9-22
TumCP↓, Apoptosis↑, TumAuto↑, ROS↓, GSH↑, cycD1/CCND1↓, P21↑, P53↑, EMT↓, Casp3↑, PARP1↑, TumMeta↓, MMPs↓, TIMP1↑,
1008- Api,    Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
Wnt/(β-catenin)↓, β-catenin/ZEB1↓, TumAuto↑, Akt↓, mTOR↓, tumCV↓, TumCCA↑, TumAuto↑, p‑Akt↓, p‑p70S6↓, p‑4E-BP1↓,
313- Api,    Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
- in-vitro, Thyroid, BCPAP
LC3s↝, p62↓, ROS↑, TumCCA↑, CDC25↓, TumAuto↑, Beclin-1/ATG6↑, AVOs↑, DNAdam↑,
2631- Api,    Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
- in-vivo, GC, NA - in-vitro, GC, AGS
ER Stress↑, Hif1a↓, EZH2↓, HDAC↓, TumAuto↑, p‑mTOR↓, AMPKα↑, GRP78/BiP↑, ROS↑, MMP↓, Ca+2↑, ATF4↑, CHOP/DDIT3↑,
2635- Api,  CUR,    Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
- in-vitro, Cerv, HeLa
TumCD↑, eff↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,
2638- Api,    Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
- in-vitro, lymphoma, PEL
TumCD↑, TumAuto↑, ROS↓, P53↑, Catalase↑, STAT3↓,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2/PTGS2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
5380- ART/DHA,    Artemisinin and Its Derivatives as Potential Anticancer Agents
- Review, Var, NA
TumCG↓, angioG↓, Ferroptosis↑, TumCP↑, TumAuto↑, CSCs↑, eff↑, YAP/TEAD↓, TumCCA↑, ROS↑, ChemoSen↑, N-cadherin↓, Vim↓, MMP9↓, eff↑, STAT3↓, CD133↓, CD44↓, Nanog↓, cMyc↓, OCT4↓, Akt↓, mTOR↓,
5376- ART/DHA,    Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, SW48 - in-vitro, BC, MDA-MB-453
Ferroptosis↑, Ferritin↓, Iron↑, eff↑, TumAuto↑, LC3II↑, ROS↑,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, VEGFR2/KDR/Flk1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27/CDKN1B↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,
1076- ART/DHA,    The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer
- Review, NA, NA
Ferroptosis↑, ROS↑, ER Stress↑, i-Iron↓, TumAuto↑, AMPK↑, mTOR↑, P70S6K↑, Fenton↑, lipid-P↑, ROS↑, ChemoSen↑, NRF2↑, NRF2↓,
5137- ART/DHA,    Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin
- vitro+vivo, ESCC, Eca109
tumCV↓, TumCCA↑, ROS↑, TumAuto↑, eff↓, TRF2↓, TumCP↓,
5134- ART/DHA,    Dihydroartemisinin induces autophagy by suppressing NF-κB activation
- in-vitro, Var, NA
TumAuto↑, NF-kB↓, ChemoSen↑,
5133- ART/DHA,    Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP/DDIT3↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, eff↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,
5451- ATV,    In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U87MG - in-vitro, GBM, A172
TumAuto↑, CSCs↓, HMG-CoA↓, TumCP↓, tumCV↓, TumCCA↑, TumCG↓, HMGCR↓,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
5505- Ba,    Baicalein inhibits the progression of thyroid cancer by suppressing the TPL2/MEK2/ERK2 pathway
- in-vitro, Thyroid, NA
ERK↓, PI3K↓, Akt↓, Apoptosis↑, TumAuto↑, NF-kB↑, MEK↓,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
1528- Ba,    Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma
- in-vitro, OS, CAL27
Apoptosis↑, ROS↑, eff↓, TumAuto↑, cl‑PARP↑, Bax:Bcl2↑, Beclin-1/ATG6↑, p62↓,

Showing Research Papers: 1 to 50 of 274
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 274

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,   ACE/ACE1↓, 1,   ASAP2↓, 1,   ATG13↑, 2,   ATG16L1↑, 1,   ATGL/PNPLA2↓, 1,   BMP7/OP1↓, 1,   CBR1↓, 1,   CDK7↓, 1,   COL4A3↓, 1,   compV↓, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   CXCL6/GCP-2↓, 1,   ERCC3↑, 1,   FFA/NEFA↓, 1,   HLA-I/II↑, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   Ingr↝, 1,   LRIG1↑, 1,   miR-107↑, 1,   miR-224↓, 1,   miR-375↑, 1,   miR-422a↑, 1,   MMP16↓, 1,   MTA1↓, 1,   NOD1↓, 1,   PDE3B↓, 1,   PLA2↓, 1,   PTN↓, 1,   Rictor↓, 1,   RUBCN↓, 1,   SCP2↓, 1,   SFXN2↓, 1,   SUV39H↓, 1,   TFE3↑, 2,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TYMP/ECGF1↓, 1,   ULK1/ATG1↑, 1,   WEE1↑, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↓, 1,   Catalase↓, 4,   Catalase↑, 3,   compI↓, 3,   CYP1A1↑, 2,   CYP2E1↑, 1,   DJ-1↓, 1,   Fenton↑, 3,   Ferroptosis↓, 1,   Ferroptosis↑, 19,   GPx↓, 1,   GPx4↓, 9,   GPx4↑, 1,   GSH↓, 14,   GSH↑, 1,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↑, 1,   GSTZ1↓, 1,   H2O2↑, 7,   HK1↓, 1,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 3,   ICD↑, 2,   Iron↑, 8,   i-Iron↓, 1,   i-Iron↑, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 1,   lipid-P↑, 6,   MAD↓, 1,   MDA↑, 5,   NAF1↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 8,   NRF2↑, 3,   NRF2↝, 1,   OXPHOS↓, 4,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PARK2↑, 3,   Prx↓, 2,   PrxI↓, 1,   PrxII↓, 1,   ROS↓, 7,   ROS↑, 154,   ROS⇅, 1,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 4,   SIRT3↑, 2,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   mt-SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TKT↓, 1,   TrxR↓, 2,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 6,   FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 4,   ATP↓, 26,   ATP↝, 1,   BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 6,   compIII↓, 1,   EGF↓, 1,   ETC↓, 3,   MEK↓, 3,   MEK↑, 1,   mitResp↓, 2,   mitResp↑, 1,   MKK4↓, 1,   MMP↓, 66,   MMP↑, 1,   Mortalin↓, 1,   MPT↑, 5,   mtDam↑, 25,   OCR↓, 6,   OCR↑, 1,   PINK1↑, 4,   Raf↓, 1,   XIAP↓, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 3,   ACSL4↑, 1,   AKT1↓, 2,   ALAT↓, 1,   ALDOA↓, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↑, 23,   p‑AMPK↑, 2,   ATG7↑, 7,   BCAP↓, 1,   Cav1↓, 1,   cMyc↓, 9,   p‑cMyc↑, 1,   CRM↑, 2,   CYP3A4↓, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 1,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 4,   GlucoseCon↑, 1,   Glycolysis↓, 22,   Glycolysis↑, 1,   Histones↝, 1,   HK2↓, 13,   HK2↑, 1,   HMG-CoA↓, 3,   lactateProd↓, 12,   lactateProd↑, 1,   LDH↓, 8,   LDH↑, 2,   p‑LDH↓, 1,   LDHA↓, 4,   LDHA↑, 1,   LDL↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDH↓, 1,   PDH↝, 1,   PDK1 / PDPK1↓, 3,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFKP↓, 1,   PI3k/Akt/mTOR↓, 2,   PIK3CA↑, 1,   p‑PIK3R1↓, 1,   PKM2↓, 10,   PKM2↑, 1,   PPARγ↑, 1,   p‑S6↓, 1,   SIRT1↓, 5,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 71,   Akt↑, 4,   p‑Akt↓, 17,   p‑Akt↑, 1,   APAF1↑, 3,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 158,   mt-Apoptosis↑, 1,   ATF2↓, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 1,   BAX↓, 1,   BAX↑, 43,   Bax:Bcl2↑, 12,   Bcl-2↓, 50,   Bcl-2↑, 1,   Bcl-xL↓, 12,   BID↑, 2,   cl‑BID↑, 1,   BIM↑, 1,   BMP2↓, 1,   Casp↑, 11,   cl‑Casp↑, 1,   Casp1↓, 2,   proCasp1↓, 1,   Casp12↑, 2,   Casp3↓, 2,   Casp3↑, 55,   cl‑Casp3↑, 27,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 13,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 29,   cl‑Casp9↑, 7,   proCasp9↑, 1,   cFLIP↓, 2,   p‑Chk2↑, 1,   Cyt‑c↑, 36,   DR4↑, 4,   DR5↑, 8,   Endon↑, 1,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 12,   FasL↑, 7,   Ferroptosis↓, 1,   Ferroptosis↑, 19,   GRP58↓, 1,   Hippo↓, 1,   hTERT/TERT↓, 4,   IAP1↓, 4,   iNOS↓, 5,   iNOS↑, 1,   JNK↓, 3,   JNK↑, 15,   p‑JNK↑, 2,   MAPK↓, 13,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   Mcl-1↓, 3,   MCT1↓, 1,   MDM2↓, 5,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↑, 4,   Myc↓, 2,   Necroptosis↑, 3,   necrosis↑, 6,   NICD↓, 1,   NOXA↑, 1,   oncosis↑, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 8,   P2X7↓, 1,   p38↓, 4,   p38↑, 9,   p‑p38↑, 3,   Paraptosis↑, 2,   Proteasome↓, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP1↓, 2,   survivin↓, 17,   Telomerase↓, 3,   TRAIL↑, 1,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 15,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 3,   CaMKII ↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   miR-25-5p↓, 1,   p‑p70S6↓, 2,   Sp1/3/4↓, 7,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cJun↑, 2,   COMP↓, 1,   EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   miR-21↓, 2,   other↓, 3,   other↑, 4,   other↝, 14,   tumCV?, 1,   tumCV↓, 35,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 16,   CHOP/DDIT3↝, 1,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 47,   ERStress↑, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 8,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 10,   HSP90↑, 1,   HSPs↑, 1,   IRE1↓, 1,   IRE1↑, 2,   PERK↑, 6,   UPR↑, 6,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

APA↑, 1,   ATG3↑, 5,   ATG5↑, 16,   ATG5↝, 1,   autoF↓, 1,   autolysosome↑, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 41,   Beclin-1/ATG6↝, 1,   p‑Beclin-1/ATG6↑, 1,   BNIP3?, 1,   BNIP3↝, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 14,   LC3B↑, 5,   LC3B-II↓, 1,   LC3B-II↑, 9,   LC3I↓, 1,   LC3I↑, 2,   LC3II↑, 37,   LC3s↓, 1,   LC3s↑, 3,   LC3s↝, 1,   lysoM↓, 1,   lysosome↓, 2,   MitoP↑, 3,   p62↓, 24,   p62↑, 11,   TFEB↑, 1,   TumAuto↓, 1,   TumAuto↑, 274,   mt-TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   p‑CHK1↑, 2,   DFF45↑, 1,   DNAdam↑, 26,   DNArepair↓, 1,   DNArepair↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 1,   m-FAM72A↓, 1,   HR↓, 1,   p16↑, 2,   P53↓, 2,   P53↑, 38,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 8,   p‑PARP↑, 1,   cl‑PARP↑, 32,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 4,   RAD51↓, 1,   TP53↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 2,   CDK4↓, 4,   CDK4↑, 1,   CycB/CCNB1↓, 8,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 14,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 2,   cycE1↓, 1,   E2Fs↓, 2,   mitA↓, 1,   mitA↑, 1,   P21↓, 2,   P21↑, 16,   RB1↑, 1,   TFAP2A↓, 1,   TumCCA↓, 3,   TumCCA↑, 78,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   4E-BP1↑, 1,   p‑4E-BP1↓, 3,   ALDH↓, 2,   BMI1↓, 2,   CD133↓, 2,   CD24↓, 1,   CD44↓, 5,   cFos↓, 1,   CIP2A↓, 2,   cMET↓, 1,   p‑cMET↑, 1,   cMYB↓, 1,   CREBBP↓, 1,   CSCs↓, 22,   CSCs↑, 1,   CSCsMark↓, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↑, 2,   EIF4E↓, 1,   EMT↓, 25,   EMT↑, 1,   EpCAM↓, 1,   ERK↓, 13,   ERK↑, 3,   ERK↝, 2,   p‑ERK↓, 5,   p‑ERK↑, 2,   FOXO↓, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   Gli1↓, 2,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 7,   HDAC∅, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   HH↓, 4,   HMGCR↓, 2,   IGF-1↓, 2,   IGFR↓, 1,   p‑Jun↑, 1,   LGR5↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↑, 1,   mTOR↓, 57,   mTOR↑, 7,   mTOR∅, 1,   p‑mTOR↓, 12,   mTORC1↓, 6,   mTORC2↓, 2,   Nanog↓, 3,   NOTCH↓, 5,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH3↓, 1,   OCT4↓, 3,   P70S6K↓, 6,   P70S6K↑, 1,   p‑P70S6K↓, 1,   PDGFRB↓, 1,   PI3K↓, 50,   PI3K↑, 1,   p‑PI3K↓, 1,   PTCH1↓, 1,   PTEN↑, 3,   RAS↓, 4,   Shh↓, 2,   SHP1↑, 1,   Smo↓, 1,   SOX2↓, 1,   Src↓, 1,   STAT↓, 1,   STAT1↓, 1,   STAT3↓, 15,   STAT3↑, 3,   STAT3↝, 2,   p‑STAT3↓, 1,   TAZ↓, 1,   TCF↓, 1,   TCF↝, 1,   TRF2↓, 1,   TumCG↓, 51,   TumCG↑, 1,   TumCG⇅, 1,   Wnt↓, 19,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AP-1↓, 1,   AP-1↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 19,   CAFs/TAFs↓, 1,   CC(CDKs/cyclins)↓, 1,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 2,   CDK4/6↓, 1,   CEA↓, 1,   Chl↑, 1,   CLDN1↓, 1,   COL2A1↓, 1,   COL9A3↓, 1,   E-cadherin↑, 8,   ER-α36↓, 1,   F-actin↓, 1,   FAK↓, 5,   FAK↑, 1,   GLI2↓, 1,   GP1BB↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   ITGB6↓, 2,   Ki-67↓, 8,   LAMA5↓, 1,   LAMP1?, 1,   LRP1↓, 1,   LysoPr↑, 1,   MALAT1↓, 2,   MET↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 1,   miR-340↓, 1,   miR-384↑, 1,   miR-486↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP15↓, 1,   MMP2↓, 22,   MMP3↓, 4,   MMP9↓, 27,   MMP9:TIMP1↓, 1,   MMPs↓, 6,   N-cadherin↓, 5,   NCAM↑, 1,   PAK1↓, 3,   PAK1↑, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 3,   RAGE↓, 2,   RECK↑, 1,   Rho↓, 1,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 2,   ROCK1↓, 2,   Slug↓, 1,   Smad1↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 5,   SOX4↓, 1,   STAC2↓, 1,   TET1↑, 2,   TGF-β↓, 6,   TGF-β↑, 2,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↓, 2,   TIMP2↑, 4,   TSC1↑, 1,   TumCA↓, 2,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 39,   TumCMig↓, 33,   TumCP?, 1,   TumCP↓, 88,   TumCP↑, 2,   TumMeta↓, 32,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 4,   VEGFR1↓, 1,   Vim↓, 9,   Zeb1↓, 1,   ZEB2↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 15,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 41,   angioG↑, 2,   ATF4↑, 7,   ECM/TCF↓, 1,   EGFR↓, 11,   eNOS↓, 1,   eNOS↑, 1,   EPR↑, 2,   HIF-1↓, 2,   Hif1a↓, 19,   Hif1a↑, 2,   NO↓, 2,   NO↑, 3,   PDGFR-BB↑, 1,   PDI↑, 2,   VEGF↓, 26,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 1,   GLUT1↓, 7,   GLUT1↑, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 12,   P-gp/ABCB1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   COX2/PTGS2↓, 21,   COX2/PTGS2↑, 1,   CXCR4↓, 3,   FOXP3↑, 1,   Gal1↑, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IL1↓, 4,   IL10↓, 3,   IL17↓, 1,   IL1β↓, 5,   IL1β↑, 1,   IL4↓, 2,   IL6↓, 11,   IL8↓, 3,   Imm↑, 10,   Imm↝, 3,   Inflam↓, 19,   Inflam↝, 1,   IκB↑, 1,   JAK↓, 1,   JAK1↓, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 47,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 6,   T-Cell↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 9,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 2,   i-pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   NLRP3↑, 2,   PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   CDK6↓, 3,   CDK6↑, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 15,   BioAv↑, 13,   BioAv↝, 3,   BioEnh↑, 2,   ChemoSen↓, 4,   ChemoSen↑, 64,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 25,   Dose∅, 5,   eff↓, 42,   eff↑, 99,   eff↝, 4,   Half-Life↓, 4,   Half-Life↝, 3,   MDR1↓, 6,   P450↓, 1,   RadioS↑, 20,   selectivity↓, 1,   selectivity↑, 32,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   AR↓, 4,   AST↓, 1,   BRCA1↓, 1,   BRCA1↝, 1,   CEA↓, 1,   EGFR↓, 11,   EZH2↓, 1,   Ferritin↓, 6,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 4,   IL6↓, 11,   Ki-67↓, 8,   LDH↓, 8,   LDH↑, 2,   p‑LDH↓, 1,   Myc↓, 2,   PD-L1↓, 3,   RAGE↓, 2,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 29,   antiNeop↑, 2,   AntiP↑, 1,   AntiTum↑, 13,   cardioP↑, 3,   CardioT↑, 1,   chemoP↑, 5,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 1,   hepatoP∅, 1,   neuroP↑, 2,   OS↑, 8,   PRAS40↑, 1,   QoL↑, 3,   RenoP↑, 2,   Risk↓, 6,   toxicity↓, 9,   toxicity↑, 3,   toxicity↝, 8,   toxicity∅, 3,   TumVol↓, 13,   TumW↓, 10,   Weight∅, 1,  
Total Targets: 791

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 5,   colonLen↑, 1,   cough?, 1,   CYP2D6↓, 1,   Ingr↝, 1,   SoreThr?, 1,   Stroke↓, 4,   Stroke↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 25,   ARE↑, 1,   Catalase↑, 7,   Ferroptosis↓, 1,   GPx↑, 5,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 4,   i-Iron↓, 1,   lipid-P↓, 5,   MDA↓, 4,   MPO↓, 1,   NRF2↑, 9,   ROS↓, 21,   ROS↑, 1,   SOD↑, 6,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   MMP↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   BUN↓, 1,   glucose↓, 1,   glucose↝, 1,   H2S↑, 1,   LDH↓, 1,   LDL↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 3,   BAX↓, 1,   Casp3↓, 3,   Casp9↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   MAPK↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other↑, 2,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   neuroG↑, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,   PDGFR-BB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   CRP↓, 1,   CXCR4↓, 1,   IL10↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 6,   IL8↓, 2,   Imm↝, 1,   Inflam↓, 25,   NF-kB?, 1,   NF-kB↓, 9,   NF-kB↑, 1,   PGE2↓, 2,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 3,   GABA↑, 1,   NGF↑, 1,   p‑tau↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   NLRP3↓, 3,   NLRP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 10,   BioAv↝, 2,   Dose⇅, 2,   Dose↝, 6,   eff↑, 4,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BloodF↑, 1,   BP↓, 1,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 6,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 1,   AntiArt↑, 4,   AntiCan↓, 1,   AntiCan↑, 8,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 7,   AntiP↑, 6,   AntiTum↑, 2,   cardioP↑, 14,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 8,   memory↑, 3,   neuroP?, 1,   neuroP↑, 18,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   QoL↑, 1,   RenoP↑, 3,   toxicity?, 1,   toxicity↓, 9,   toxicity↑, 2,   toxicity↝, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 2,   AntiViral↑, 5,   Bacteria↓, 8,   CD8+↑, 1,   Diar↓, 1,   Sepsis↓, 2,  
Total Targets: 152

Scientific Paper Hit Count for: TumAuto, Tumor autophagy
15 Curcumin
13 Silver-NanoParticles
11 Artemisinin
8 salinomycin
7 EGCG (Epigallocatechin Gallate)
7 Ivermectin
6 Magnetic Fields
6 Apigenin (mainly Parsley)
6 Baicalein
6 Gambogic Acid
6 Kaempferol
5 Celastrol
5 Eugenol
5 Spermidine
5 itraconazole
5 Licochalcone A
5 Luteolin
5 Shikonin
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Capsaicin
4 Dandelion Root
4 Ginkgetin
4 Hyperoside
4 Juglone
4 Phenethyl isothiocyanate
4 Selenite (Sodium)
4 Vitamin K2
3 Atorvastatin
3 Betulinic acid
3 Cynaropicrin
3 Dichloroacetate
3 Hibiscus sabdariffa
3 Isoliquiritigenin
3 Isovitexin
3 Licorice
3 Quercetin
3 Urolithin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Astragalus
2 Ashwagandha(Withaferin A)
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Chrysin
2 Resveratrol
2 diet Methionine-Restricted Diet
2 diet Short Term Fasting
2 Emodin
2 Fisetin
2 Cisplatin
2 Gossypol/AT-101
2 Graviola
2 HydroxyCitric Acid
2 Honokiol
2 isoquercitrin
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Propolis -bee glue
2 Psoralidin
2 Sulforaphane (mainly Broccoli)
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Metformin
1 Bufalin/Huachansu
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Celecoxib
1 chaetocin
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 CUSP9
1 D-limonene
1 Ellagic acid
1 Chemotherapy
1 Bortezomib
1 Beta-Caryophyllene
1 5-fluorouracil
1 Evodiamine
1 Formononetin
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 isoorientin
1 Vitexin
1 Magnolol
1 immunotherapy
1 Magnetic Field Rotating
1 Mushroom Chaga
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Phenylbutyrate
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 α-Santalol/Sandalwood oil
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:321  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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