AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Scientific Papers found: Click to Expand⟱
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
250- AL,    Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells
- in-vitro, Liver, HepG2
P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1/ATG6↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, Akt↓, ERK↓, IGF-1R↓, Furin↓, Ki-67↓, AMPK↑, mTOR↓,
276- ALA,    Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B
P53↑, EMT↓, AMPK↑, cycD1/CCND1↓, TumCMig↓,
1124- ALA,    Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, HTH-83 - in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, FTC-133 - in-vivo, NA, NA
TumCP↓, AMPK↑, mTOR↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, Vim↓, Snail↓, Twist↓, TGF-β↓, p‑SMAD2↓, TumCG↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2/PTGS2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
2583- Api,  Rad,    The influence of apigenin on cellular responses to radiation: From protection to sensitization
- Review, Var, NA
radioP↑, RadioS↑, *COX2/PTGS2↓, *ROS↓, VEGF↓, MMP2↓, STAT3↓, AMPK↑, Apoptosis↑, MMP9↓, glucose↓,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2/PTGS2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
1076- ART/DHA,    The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer
- Review, NA, NA
Ferroptosis↑, ROS↑, ER Stress↑, i-Iron↓, TumAuto↑, AMPK↑, mTOR↑, P70S6K↑, Fenton↑, lipid-P↑, ROS↑, ChemoSen↑, NRF2↑, NRF2↓,
5135- ART/DHA,    Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells
- vitro+vivo, Var, NA
mTORC1↓, AMPK↑, TumCG↓,
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, eff↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,
1524- Ba,    AMPK_in_Human_Lung_Carcinoma_A549_Cells">Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
1395- BBR,    Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation
- in-vitro, GC, NA
Apoptosis↑, ROS↑, MMP↓, ATP↓, AMPK↑, TP53↑, p‑MAPK↓, p‑ERK↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
2714- BBR,    Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
AMPK↑, ITGB1↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
5509- bemA,    Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
- Review, Nor, NA
LDL↓, AMPK↑, ACLY↓,
5513- bemA,    ACLY inhibition promotes tumour immunity and suppresses liver cancer
- in-vitro, Liver, NA
ACLY↓, AMPK↑, eff↑, other↝, eff↝,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP/DDIT3↑, *toxicity↓,
2730- BetA,    Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2/PTGS2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
1650- CA,    Adjuvant Properties of Caffeic Acid in Cancer Treatment
- Review, Var, NA
ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2/PTGS2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5841- CAP,    The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ
- in-vitro, HCC, HepG2
AMPK↑, CaMKII ↑, tumCV↓, Akt↓, mTOR↓, ROS↑,
5844- CAP,    Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers
- in-vitro, Lung, DMS114
eff↑, AMPK↑, toxicity↝, BioAv↑, TRPV1↑, TumCI↓,
5848- CAP,  SRF,    Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
ChemoSen↑, Apoptosis↑, Casp9↑, PARP↑, Akt↓, AMPK↑, p‑ACC↑,
5843- CAP,    The Effects of Capsaicin on Gastrointestinal Cancers
- Review, GC, NA
*BioAv↑, ROS↑, Apoptosis↑, Glycolysis↓, HK2↓, MMP9↓, AMPK↑, TumCP↓, Casp3↑, Bcl-2↓, P53↑, BAX↑,
1263- CAP,    Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression
- in-vitro, ESCC, Eca109
TumCMig↓, TumCI↓, MMP9↓, p‑AMPK↑, SIRT1↑, NF-kB↓, p‑IκB↑,
2012- CAP,    Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways
- NA, OS, MG63
AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,
2017- CAP,    Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease
- Review, Var, NA
RenoP↑, AntiTum↑, AMPK↑, mTOR↑, PD-1↓, PD-L1↓,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
2801- CHr,    AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells
- in-vitro, Lung, A549
AMPK↑, Akt↓, ChemoSen↑, ROS↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,

Showing Research Papers: 1 to 50 of 140
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 140

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APOE4↑, 1,   ASAP2↓, 1,   BMP7/OP1↓, 1,   CDK7↓, 1,   LRIG1↑, 1,   miR-122-5p↑, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-326-5p↑, 1,   MYCN↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   Fenton↑, 1,   Ferroptosis↑, 8,   GPx4↓, 3,   GSH↓, 5,   GSH↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 4,   HO-1↑, 4,   Iron↑, 4,   i-Iron↓, 1,   lipid-P↑, 7,   MAD↓, 1,   MDA↑, 5,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 8,   OXPHOS↓, 2,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PARK2↑, 1,   Prx↓, 1,   RNS↑, 1,   ROS↓, 5,   ROS↑, 64,   ROS⇅, 3,   mt-ROS↑, 5,   SIRT3↑, 3,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   TKT↝, 1,   TrxR1↓, 1,   VDAC1↓, 2,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 15,   mt-ATP↓, 1,   BOK↑, 1,   CDC2↓, 1,   CDC25↓, 3,   EGF↓, 1,   ETC↓, 1,   ETC↑, 1,   Insulin↓, 1,   MEK↓, 1,   mitResp↓, 2,   MMP↓, 33,   MPT↑, 1,   mtDam↑, 5,   OCR↓, 4,   OCR↑, 1,   PINK1↑, 1,   Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 5,   ACC↑, 5,   p‑ACC↑, 2,   p‑ACC-α↑, 1,   ACLY↓, 5,   adiP↑, 1,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 124,   p‑AMPK↑, 18,   ATG7↑, 4,   cMyc↓, 8,   CRM↑, 1,   ECAR↓, 3,   FAO↑, 1,   FASN↓, 9,   FDG↓, 1,   G6PD↓, 3,   GLS↓, 3,   glucose↓, 2,   GlucoseCon↓, 6,   GlucoseCon↑, 1,   glut↓, 1,   GLUT2↓, 1,   GlutaM↓, 1,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 20,   Glycolysis↑, 1,   HK2↓, 14,   HK2↑, 1,   lactateProd↓, 7,   lactateProd↑, 3,   LDH↓, 5,   p‑LDH↓, 1,   LDHA↓, 6,   LDHA↑, 1,   LDL↓, 1,   lipidLev↓, 2,   lipoGen↓, 2,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   NPC1L1↓, 1,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PFK1↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 11,   PKM2↑, 1,   PPARγ↑, 1,   PPP↓, 2,   R5P↝, 1,   p‑S6K↓, 4,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 5,   SREBP2↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TCA↓, 2,   TCA↑, 2,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

Akt↓, 35,   Akt↑, 4,   p‑Akt↓, 9,   p‑Akt↑, 1,   APAF1↑, 2,   Apoptosis↑, 45,   BAD↓, 1,   BAD↑, 3,   Bak↑, 4,   BAX↓, 2,   BAX↑, 20,   Bax:Bcl2↑, 6,   Bcl-2↓, 28,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 4,   BIM↑, 3,   Casp↑, 8,   Casp3↓, 1,   Casp3↑, 30,   cl‑Casp3↑, 9,   Casp7↑, 3,   Casp8↑, 8,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 18,   cl‑Casp9↑, 1,   cFLIP↓, 4,   Cyt‑c↑, 20,   Cyt‑c↝, 1,   Diablo↑, 4,   DR4↑, 2,   DR4∅, 1,   DR5↑, 8,   FADD↑, 5,   Fas↓, 1,   Fas↑, 8,   FasL↑, 6,   Ferroptosis↑, 8,   IAP1↓, 1,   iNOS↓, 4,   JNK↓, 1,   JNK↑, 10,   MAPK↓, 8,   MAPK↑, 4,   p‑MAPK↓, 1,   Mcl-1↓, 6,   Mcl-1↑, 1,   MCT1↓, 1,   MDM2↓, 2,   Myc↓, 3,   NAIP↓, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 6,   p38↓, 1,   p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 9,   Telomerase↓, 1,   TRAIL↑, 2,   TRPV1↑, 2,   TumCD↑, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↑, 1,   EF-1α↓, 1,   p70S6↓, 1,   Sp1/3/4↓, 3,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 3,   cJun↑, 1,   H3↑, 1,   p‑H3↑, 1,   H4↑, 1,   HATs↑, 1,   miR-21↓, 2,   miR-21↑, 1,   other↓, 3,   other↑, 1,   other↝, 3,   tumCV↓, 18,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 3,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↑, 14,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP90↓, 5,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 9,   lysosome↓, 1,   p62↓, 6,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 25,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   CYP1B1↑, 1,   DNAdam↑, 18,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 2,   NBR2↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 25,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↑, 4,   cl‑PARP↑, 18,   cl‑PARP1↑, 1,   PCNA↓, 4,   TP53↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 2,   CDK2↓, 6,   CDK2↑, 2,   CDK4↓, 9,   CDK4↑, 2,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 6,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 15,   cycE/CCNE↓, 3,   cycE1↓, 1,   E2Fs↓, 2,   P21?, 1,   P21↓, 2,   P21↑, 13,   RB1↑, 2,   p‑RB1↓, 1,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 1,   TumCCA↑, 37,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↑, 1,   p‑4E-BP1↓, 1,   ALDH↓, 2,   BMI1↓, 2,   CD133↓, 3,   CD24↓, 2,   CD44↓, 5,   cFos↓, 4,   CIP2A↓, 1,   cMET↓, 2,   CSCs↓, 11,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↓, 1,   Diff↑, 2,   EMT↓, 23,   EMT↑, 1,   ERK↓, 9,   ERK↑, 3,   p‑ERK↓, 2,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 1,   Gli1↓, 4,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   HDAC↓, 4,   HDAC∅, 1,   HDAC1↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 3,   HH↓, 3,   IGF-1↓, 4,   IGF-1R↓, 1,   IGFBP1↑, 2,   Let-7↑, 2,   miR-34a↑, 2,   mTOR↓, 51,   mTOR↑, 10,   mTOR∅, 1,   p‑mTOR↓, 4,   mTORC1↓, 7,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 1,   Nanog↓, 3,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH1↓, 2,   NOTCH3↓, 3,   OCT4↓, 2,   P70S6K↓, 4,   P70S6K↑, 1,   P90RSK↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 21,   PI3K↑, 4,   p‑PI3K↓, 1,   PTCH1↓, 3,   PTEN↑, 4,   RAS↓, 2,   Shh↓, 3,   Smo↓, 1,   SOX2↓, 2,   Src↓, 1,   STAT↓, 2,   STAT3↓, 17,   STAT3↑, 1,   p‑STAT3↓, 5,   Sufu↓, 1,   TCF↓, 2,   TCF-4↓, 1,   TOP1↓, 2,   TOP2↓, 3,   TumCG↓, 25,   TumCG↑, 1,   Wnt↓, 14,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↑, 1,   AP-1↓, 4,   Ca+2↑, 6,   CAFs/TAFs↝, 1,   CD31/PECAM-1↓, 1,   DLC1↑, 1,   E-cadherin↑, 14,   F-actin↑, 1,   FAK↓, 3,   Fibronectin↓, 1,   Furin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   Ki-67↓, 4,   KRAS↓, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-206↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-29b↓, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 19,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 21,   MMPs↓, 6,   N-cadherin↓, 7,   PKCδ↓, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 3,   p‑SMAD2↓, 1,   Snail↓, 5,   SOX4↓, 2,   talin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP2↓, 1,   TSP-1↑, 1,   TumCI?, 1,   TumCI↓, 25,   TumCMig↓, 21,   TumCP↓, 39,   TumCP↑, 1,   TumCP⇅, 1,   TumMeta↓, 13,   Twist↓, 5,   TXNIP↓, 1,   uPA↓, 6,   Vim↓, 13,   Zeb1↓, 3,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 17,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16,   angioG↑, 1,   ATF4↓, 1,   ATF4↑, 4,   EGFR↓, 10,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 18,   Hif1a↑, 2,   Hypoxia↓, 1,   LOX1↓, 1,   miR-126↑, 1,   miR-34b-5p↑, 1,   NO↑, 4,   PHDs↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 20,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 7,   GLUT1↑, 1,   GLUT3↓, 1,   P-gp/ABCB1↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 26,   CXCL1↓, 1,   CXCR4↓, 4,   IKKα↓, 2,   IL1↓, 3,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 8,   IL8↓, 1,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 7,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 3,   pol-M1↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   NF-kB↓, 34,   NF-kB↑, 2,   p‑NF-kB↓, 2,   NK cell↑, 1,   p50↓, 1,   p65↓, 4,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 5,   PGE2↓, 8,   PSA↓, 2,   TNF-α↓, 7,   TNF-α↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 4,   CDK6↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 10,   BioAv↑, 4,   BioAv↝, 3,   ChemoSen↑, 36,   ChemoSen⇅, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 3,   Dose↝, 12,   Dose∅, 4,   eff↓, 20,   eff↑, 47,   eff↝, 5,   Half-Life↓, 3,   Half-Life↝, 4,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 18,   selectivity↑, 16,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BMD↑, 1,   EGFR↓, 10,   Ferritin↓, 1,   FOXM1↓, 2,   GutMicro↑, 2,   IL6↓, 8,   Ki-67↓, 4,   KRAS↓, 1,   LDH↓, 5,   p‑LDH↓, 1,   Myc↓, 3,   PD-L1↓, 5,   PSA↓, 2,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiCan⇅, 1,   antiNeop↑, 1,   AntiTum↑, 6,   cardioP↑, 3,   chemoP↑, 1,   chemoPv↑, 6,   ChemoSideEff↓, 3,   hepatoP↑, 1,   NDRG1↑, 1,   neuroP↑, 6,   OS?, 1,   OS↑, 5,   QoL↑, 2,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 5,   toxicity↓, 1,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 4,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 573

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   CYP2D6↓, 1,   Stress↓, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 12,   mt-antiOx↑, 1,   Catalase↑, 3,   Ferroptosis↓, 1,   GPx↑, 2,   GPx4↑, 1,   GSH↑, 6,   GSTs↑, 1,   HO-1↑, 3,   i-Iron↓, 1,   lipid-P↓, 3,   MDA↓, 3,   NRF2↑, 7,   ROS↓, 13,   SOD↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   p‑cMyc↑, 1,   p‑CREB↑, 1,   ECAR↓, 1,   glucose↓, 2,   GlucoseCon↑, 2,   Glycolysis↓, 1,   H2S↑, 1,   LDL↓, 1,   p‑PPARγ↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   BAX↓, 1,   Casp3↓, 2,   Casp9↓, 1,   Ferroptosis↓, 1,   JNK↓, 1,   MAPK↓, 2,   p38↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 1,   other↓, 1,   other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 2,   mTOR↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   RAS↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   PDGFR-BB↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 2,   CRP↓, 1,   IL18↓, 1,   IL1β↓, 3,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 9,   NF-kB↓, 2,   TLR2↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 2,   ChAT↑, 1,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 3,   BioAv↝, 4,   Dose↑, 1,   Dose↝, 4,   eff↝, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiCan↑, 1,   antiCG↑, 1,   cardioP↑, 3,   chemoP↑, 1,   chemoPv↑, 3,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 5,   neuroP↑, 6,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 1,   toxicity↓, 9,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Diar↓, 1,  
Total Targets: 108

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
9 Metformin
8 Capsaicin
8 Fisetin
7 Berberine
5 Alpha-Lipoic-Acid
5 EGCG (Epigallocatechin Gallate)
4 Caffeic acid
4 Curcumin
4 Resveratrol
4 Sulforaphane (mainly Broccoli)
3 Artemisinin
3 Baicalein
3 Betulinic acid
3 Chrysin
3 diet FMD Fasting Mimicking Diet
3 diet Short Term Fasting
3 Honokiol
3 itraconazole
3 lambertianic acid
3 Ursolic acid
2 2-DeoxyGlucose
2 Allicin (mainly Garlic)
2 Aspirin
2 Ashwagandha(Withaferin A)
2 bempedoic acid
2 Gambogic Acid
2 isoquercitrin
2 Juglone
2 Methylene blue
2 Thymoquinone
2 Vitamin K2
1 Astragalus
1 Andrographis
1 Apigenin (mainly Parsley)
1 Radiotherapy/Radiation
1 Baicalin
1 Chemotherapy
1 Boswellia (frankincense)
1 Butyrate
1 Propolis -bee glue
1 Sorafenib (brand name Nexavar)
1 Celastrol
1 Chlorogenic acid
1 Cinnamon
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Dandelion Root
1 Ellagic acid
1 Ginkgolic acids
1 HydroxyCitric Acid
1 Hibiscus sabdariffa
1 Hyperoside
1 Inositol
1 Isoliquiritigenin
1 isoorientin
1 Kaempferol
1 Licorice
1 Magnolol
1 Methyl salicylate / Sweet Birch oil
1 Magnetic Field Rotating
1 nicotinamide adenine dinucleotide
1 Niclosamide (Niclocide)
1 Pterostilbene
1 Quercetin
1 Rosmarinic acid
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Shikonin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:9  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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