Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
2570- ART/DHA,    Discovery, mechanisms of action and combination therapy of artemisinin
- Review, Nor, NA
*BioAv↓, *Half-Life↓, *toxicity↓, *ROS↑, GSH↓, selectivity↑,
2569- ART/DHA,    A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction
- Human, Nor, NA
*Half-Life↝, BioAv↝, *Half-Life↓, BioAv↑, *Dose↝,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, Nor, NA
*COX1↓, *COX2/PTGS2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
5400- ASA,    Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention
- Review, Nor, NA
Risk↓, *Inflam↓, *COX1↓, *AntiAg↑, *Half-Life↓, *BioAv↑,
5402- ASA,    Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
- Review, Var, NA
COX1↓, TumMeta↓, *Half-Life↓, *COX2/PTGS2↓, *TXA2↓,
5393- Ash,    Studies on oral bioavailability and first-pass metabolism of withaferin A in rats using LC-MS/MS and Q-TRAP
- in-vivo, Nor, NA
*BioAv↝, *other↝, *Half-Life↓,
2672- BBR,    The anti-aging mechanism of Berberine associated with metabolic control
- Review, Var, NA
*BioAv↝, *BioAv↝, *BioAv↝, *Half-Life↓,
2673- BBR,    Therapeutic potential and recent delivery systems of berberine: A wonder molecule
- Review, Var, NA
*BioAv↓, *Half-Life↓, *neuroP↑, BBB↑, toxicity↓,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5928- Catechins,    Bioavailability of Tea Catechins and Its Improvement
- Review, Nor, NA
*CompStab↝, *BioAv↓, *ROS⇅, *NRF2↑, *BioAv↑, *Half-Life↓, *BioAv↑, *BioAv↑, BioAv↑,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
6206- CUR,    Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study
- Review, Nor, NA
*BioAv↓, *Half-Life↓, *BioAv↑,
6222- CUR,    Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials
- Review, Var, NA
RadioS↑, ChemoSen↑, MMPs↓, TumMeta↓, TumCI↓, Inflam↓, NF-kB↓, BioAv↓, BioAv↑, MAPK↓, PI3K↓, Akt↓, *ROS↓, *MDA↓, *lipid-P↓, *Half-Life↓, mTOR↓,
6770- CUR,    A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin
- Review, Nor, NA
*AntiBio↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *Half-Life↓,
6681- DCA,    Dichloroacetate (DCA) in Cancer Care
- Review, Var, NA
PDK1 / PDPK1↓, Apoptosis↑, ROS↑, lactateProd↓, Dose↝, eff↝, toxicity↓, NP/CIPN↑, Dose↝, *BioAv↑, *Half-Life↓, GSTZ1↝, Glycolysis↓, OXPHOS↑, MPT↑, Cyt‑c↑, AIF↑, Casp↑, CSCs↓, Remission↑, ChemoSen↑, RadioS↑, toxicity↑,
6575- EU,    Eurycomanone from Eurycoma longifolia Jack upregulates neurotrophin-3 gene expression in retinal Müller cells in vitro
- in-vivo, Nor, NA
*Hypoxia↓, *NTF3/NT-3↑, *other↑, *Half-Life↓,
6581- EU,    Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract
- in-vitro, Colon, Caco-2 - in-vivo, Nor, NA
*Half-Life↓, *BioAv↝,
6895- FIS,    Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study
- in-vivo, Nor, NA
*neuroP↑, *cardioP↑, *chemoPv↑, *AntiDiabetic↑, *Inflam↓, *ROS↓, *BioAv↓, *BioAv↑, *eff↑, *Half-Life↓,
7027- GA,    Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans
- Human, Nor, NA
AntiCan↑, *Inflam↓, *BioAv↑, *Half-Life↓, *eff↝,
7135- GI,    Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans
- Trial, Nor, NA
*Dose↝, *Half-Life↝, *antiOx↑, *Inflam↓, *AntiTum↑, *Half-Life↓,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
7349- HibSad,    Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract
- Trial, Nor, NA
*Dose↝, *Half-Life↓, *Half-Life↝, *BioAv↓, *antiOx↑, *BioAv↓,
4645- HT,    Hydroxytyrosol: Bioavailability, toxicity, and clinical applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, AntiTum↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↓,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
8551- Matr,    Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
- Review, Nor, NA
*BioAv↓, *toxicity↑, *AntiTum↑, *AntiViral↑, *Inflam↓, *hepatoP↑, *Analgesic↑, *Half-Life↓, *toxicity↓,
8889- MOR,    Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review
- Review, BC, NA - Review, Ovarian, NA
*BioAv↝, *BioAv↝, *Half-Life↓, VCAM-1↓, MMP9↓, N-cadherin↓, p‑Akt↓, Akt↓, TumCMig↓, ChemoSen↑, Gal-3↓,
3248- PBG,    Propolis as a promising functional ingredient: A comprehensive review on extraction, bioactive properties, bioavailability, and industrial applications
- Review, Nor, NA
*BioAv↓, *Half-Life↓,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, Var, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
- Review, Var, NA
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,

Showing Research Papers: 1 to 37 of 37

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 37

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   NADH↓, 1,   ROS↓, 1,   ROS↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OXPHOS↑, 1,   PDH↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 3,   FDG↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   PDK1 / PDPK1↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↑, 5,   Bcl-2↓, 1,   Casp↑, 3,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 4,   DR5↑, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   p‑Akt↓, 1,   EGFR↓, 3,   ERK↓, 1,   MAPK↓, 2,   mTOR↓, 3,   PI3K↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   TOP1↓, 2,   TOP2↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Ki-67↓, 1,   TumCG↓, 3,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   TRIB3↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumMeta↓, 3,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGR4↓, 1,   Hif1a↓, 1,   VCAM-1↓, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↓, 3,   MPT↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   Gal-3↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   ChemoSen↑, 4,   Dose↑, 1,   Dose↝, 2,   eff↑, 1,   eff↝, 2,   GSTZ1↝, 1,   Half-Life↓, 1,   RadioS↑, 2,   selectivity↑, 3,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 3,   NP/CIPN↑, 1,   Obesity↓, 1,   radioP↑, 2,   Remission↑, 1,   Risk↓, 3,   toxicity↓, 2,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 87

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 13,   Catalase↑, 1,   GPx↑, 4,   GSH↑, 5,   HO-1↑, 5,   lipid-P↓, 4,   MDA↓, 3,   MPO↓, 1,   NQO1↝, 1,   NRF2↑, 6,   ROS↓, 12,   ROS↑, 1,   ROS⇅, 1,   SOD↑, 6,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,   ATP↑, 1,   cAMP↑, 1,   G6PD↑, 1,   GlucoseCon↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↑, 3,   other↝, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↑, 1,   MMP3↓, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hypoxia↓, 1,   NO↓, 1,   TXA2↓, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 5,   MMP↑, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 4,   IFN-γ↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL4↓, 1,   IL6↓, 4,   Imm↑, 1,   INF-γ↓, 1,   Inflam↓, 16,   NF-kB↓, 2,   NF-kB↑, 1,   PGE2↓, 3,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 3,   AChE↓, 1,   BDNF↑, 1,   ChAT↑, 3,   NTF3/NT-3↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 19,   BioAv↝, 14,   CompStab↝, 1,   Dose↝, 5,   eff↑, 2,   eff↝, 1,   Half-Life↓, 38,   Half-Life↝, 3,   P-gp/ABCB1↓, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 4,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 2,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 6,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 8,   hepatoP↑, 5,   memory↑, 4,   motorD↑, 1,   neuroP↑, 12,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 2,   Bacteria↓, 1,   GutMicro↑, 2,  
Total Targets: 115

Scientific Paper Hit Count for: Half-Life, Half-Life
4 Alpha-Lipoic-Acid
3 Aspirin
3 Curcumin
2 Artemisinin
2 Berberine
2 Eurycomanone
2 Resveratrol
1 Ashwagandha(Withaferin A)
1 Boswellia (frankincense)
1 Capsaicin
1 Catechins
1 Chlorogenic acid
1 Dichloroacetate
1 Fisetin
1 Gallic acid
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 HydroxyTyrosol
1 Isoliquiritigenin
1 Matrine
1 Morin
1 Propolis -bee glue
1 Silymarin (Milk Thistle) silibinin
1 Selenite (Sodium)
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1109  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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