Pain Cancer Research Results

Pain, Pain: Click to Expand ⟱
Source:
Type:
Pain
Scientific Papers found: Click to Expand⟱
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
6508- BCP,    The CB2 Agonist β-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain
- in-vivo, Nor, NA
*Pain↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
5661- BNL,    A clinical and mechanistic study of topical borneol‐induced analgesia
- Trial, Nor, NA
*Pain↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5860- CAP,    Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *memory↑, *Pain↓, *TRPV1↑, *Aβ↓, *tau↓, *cognitive↑, *Risk↓, *motorD↓, *ROS↓, *TNF-α↓, *IL1β↓, *Stroke↓, *Risk↓,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, Asthma, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2/PTGS2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *Synergy↑, *BChE↓, *CRP↓, *antiAll↑,
5964- CEL,    Celecoxib pathways: pharmacokinetics and pharmacodynamics
- Review, Var, NA
COX2/PTGS2↓, *Pain↓, *Inflam↓, Apoptosis↑, TumCCA↑, angioG↓, ER Stress↑, VEGF↓, MMP9↓, PDK1 / PDPK1↓, Akt↓, CA↓, CardioT↑,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6687- DFC,    Diclofenac-containing medicines - referral
- Review, Nor, NA
*Pain↓, *Inflam↓, *AntiArt↑, *cardioP↓,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
6411- EGCG,    Pharmacological and Genetic Approaches to Downregulate FIS1 Mitigate Neuropathic Pain
- in-vivo, Nor, NA
*FIS1↓, *Pain↓, *ROS↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *CompStab↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *Synergy↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑, *antiAll↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
8604- FSO,  VitD3,    An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management
- Trial, Diabetic, NA
*TAC↑, *Weight↓, *glucose↓, *Insulin↓, *TG/TAG↓, *TC↓, *QoL↑, *Pain↓, *toxicity↓, *Dose↝,
7080- GABA,    The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
- Review, AD, NA
*BBB↝, *cognitive↑, *Dose↝, *toxicity↓, *Stress↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL1β↓, *TNF-α↓, *Sleep↑, *Pain↓, *neuroP↑, *eff↑, *Ach↑, *AST↓, *ALAT↓, *BP↓, *other↝,
7082- GABA,    Contributions of Gamma-Aminobutyric Acid (GABA) Produced by Lactic Acid Bacteria on Food Quality and Human Health: Current Applications and Future Prospects
- Review, AD, NA
*neuroP↑, *Sleep↑, *Pain↓, *Inflam↓, *BP↓, *cognitive↑, *memory↑, *eff↑, *AChE↓, *Wound Healing↑,
2871- HNK,    Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *VEGF↓, *NRF2↑, *SOD2↑, *HO-1↑, *Inflam↓, *Pain↓, *NO↓, toxicity↓,
7840- ISQ,    Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β-catenin signaling pathway inhibition
- in-vivo, Diabetic, NA
*Pain↓, *Wnt↓, *β-catenin/ZEB1↓, *neuroP↑,
1272- LA,    Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults
- Trial, Nor, NA
*Pain↓, *other↑,
8273- LE,    A Systematic Review of the Effect of Licorice on Head and Neck Chemotherapy- and Radiotherapy-Induced Mucositis
- Review, HNSCC, NA
radioP↑, chemoP↑, *Pain↓, *Inflam↓, IL1β↓, PGE2↑, COX2/PTGS2↓, *toxicity↝, *Mucositis↓,
6541- MeSal,    Toxicology Answer: Oil of Wintergreen
- Review, Nor, NA
*Inflam↓, *Pain↓, *BioAv↝, *BloodF↑, *toxicity↑,
9294- MF,    Pulsed electromagnetic fields in muscle and tendon injuries: a narrative review of preclinical and clinical evidence
- Review, Nor, NA
*VEGF↑, *COL1↑, *IL6↑, *IL10↑, *Fibronectin↑, *Pain↓, *other↑, *Inflam↓,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
3566- MF,    Positive and Negative Effects of Administering a Magnetic Field to Patients with Rheumatoid Arthritis (RA)
- Study, Arthritis, NA
*Inflam↓, *QoL↑, *Pain↓, *motorD↑, *toxicity↓, *Cartilage↑, *Inflam↓,
3568- MF,    The Efficacy of Pulsed Electromagnetic Fields on Pain, Stiffness, and Physical Function in Osteoarthritis: A Systematic Review and Meta-Analysis
- Review, Arthritis, NA
*eff↑, *Pain↓, *motorD↑,
3569- MF,    Current Evidence Using Pulsed Electromagnetic Fields in Osteoarthritis: A Systematic Review
- Review, Arthritis, NA
*Pain↓, *QoL↑, *motorD↑,
6939- MF,    A prospective, randomized, placebo controlled, double-blind study of pelvic electromagnetic therapy for the treatment of chronic pelvic pain syndrome with 1 year of followup
- Trial, Nor, NA
*Pain↓,
6941- MF,  Ex,    The effects of pulsed electromagnetic field therapy on muscle strength and pain in patients with end-stage knee osteoarthritis: a randomized controlled trial
- Trial, Arthritis, NA
*Strength↑, *Pain↓, *eff↑, *Dose↝,
6940- MF,    Meta-analysis of the effectiveness and safety of magnetic stimulation for chronic pelvic pain
- Review, BPH, NA
*UFR↑, *other?, *Pain↓, *BloodF↑, *other↑, *Inflam↓, *QoL↑,
4349- MF,    Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial
- Trial, ostP, NA
*BMD↑, *Pain↓, *QoL↑, *toxicity↓, *Dose↝, *Inflam↓,
8769- MSM,    Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
- Trial, Arthritis, NA
*Pain↓,
3851- MSM,    Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
- Trial, Arthritis, NA
*Pain↓, *QoL↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
7534- OLE,    An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and post hoc analysis
- Trial, Arthritis, NA
*Pain↓, *Dose↝,
5937- P,    Peppermint and the gut
- Review, IBD, NA
other↝, *Bacteria↓, *Pain↓, *BowelM↑,
5936- P,    The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data
- Review, IBD, NA
*Pain↓, *other↝, *Bacteria↓, *Inflam↓, *Imm↑, *eff↑, *toxicity↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
9025- Phyco,    Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation
- Trial, Nor, NA
*Dose↝, *AST↓, *ALAT↓, *Pain↓, *hepatoP↑,
9112- Pomi-T,    The effect of boosting polyphenol intake for women’s cancer survivors on arthralgia, mood and hot flushes - a pilot real World evaluation
- Trial, Var, NA - Trial, Arthritis, NA
*Pain↓, *Mood↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3606- QC,    The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial
- Trial, Arthritis, NA
*motorD↑, *Pain↓, *TNF-α↓, *IL8↓, *IL6↓, *IL1β↓, *NF-kB↓, *p38↓,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
6453- TUR,    Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,

Showing Research Papers: 1 to 48 of 48

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 48

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 1,   HO-1↓, 1,   lipid-P↓, 1,   MDA↓, 1,   RNS↑, 1,   ROS↓, 1,   ROS↑, 8,   SOD↑, 1,   SOD2↓, 1,   Thiols↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   ALAT↓, 1,   AMPK↑, 1,   lactateProd↓, 1,   PDK1 / PDPK1↓, 2,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 10,   BAD↓, 1,   Bak↓, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 3,   Bcl-2↓, 3,   BID↑, 1,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 2,   Fas↑, 1,   iNOS↓, 1,   MDM2↓, 1,   necrosis↑, 1,   survivin↓, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   EGFR↑, 1,   ERK↓, 3,   HER2/EBBR2↓, 2,   JNK↓, 1,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 4,   PKCδ↓, 1,   RAS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   FOXO3↝, 1,   Myc↓, 1,   OCT4↓, 1,   other↓, 1,   other↝, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3I↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   P53↑, 3,   p73↑, 1,   PARP↑, 2,   cl‑PARP↑, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   E2Fs↓, 1,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CSCs↓, 1,   FGF↓, 1,   IGF-1?, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   TumCG↓, 2,   TumCP↑, 1,  

Migration(tgid=13) ⓘ

CA↓, 1,   EpCAM↓, 1,   KRAS↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MMPs↓, 1,   RECK↑, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 3,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX2/PTGS2↓, 5,   IFN-γ↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 1,   Imm↑, 1,   NF-kB↓, 4,   NF-kB↑, 1,   PGE2↓, 2,   PGE2↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   Dose↑, 1,   Dose↝, 2,   eff↑, 1,   Half-Life↓, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 2,   selectivity↑, 3,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   CEA↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 2,   IL6↓, 1,   KRAS↓, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   antiNeop↑, 1,   CardioT↑, 1,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 1,   OS↑, 1,   radioP↑, 2,   Risk↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 146

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 11,   ARE↑, 1,   Catalase↑, 7,   GPx↑, 4,   GPx3↑, 1,   GSH↑, 6,   GSR↓, 1,   GSR↑, 3,   GSTs↑, 1,   HO-1↑, 3,   Keap1↑, 1,   lipid-P↓, 3,   MDA↓, 4,   Nrf1↑, 1,   NRF2↑, 6,   RNS↓, 1,   ROS↓, 11,   ROS↑, 1,   SOD↑, 8,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 1,   uricA↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 1,   PINK1↑, 1,   SIRT3↑, 1,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 2,   AMPK↑, 1,   ATP↑, 2,   FABP4↓, 1,   glucose↓, 2,   GSK‐3β↓, 1,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Cyt‑c↓, 1,   iNOS↓, 8,   necrosis↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   AMPKα↑, 1,   JNK↓, 1,   MAPK↓, 1,   PKCδ↓, 1,   STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   HDAC↑, 1,   other?, 1,   other↓, 1,   other↑, 4,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3B↑, 1,   p62↓, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

Telomerase↓, 1,   TOP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 7,   Ca+2↑, 2,   Cartilage↑, 3,   COL1↑, 1,   Fibronectin↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 2,   TGF-β↑, 1,   TGF-β1↓, 1,   uPA↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 3,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 2,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 1,   TRPM7↓, 1,   TRPV1↑, 3,   TRPV3↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 11,   IL1↓, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 1,   IL1β↓, 9,   IL4↑, 1,   IL6↓, 10,   IL6↑, 2,   IL8↓, 1,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 29,   MCP1/CCL2↓, 3,   NF-kB↓, 5,   NLRP3↓, 2,   PGE2↑, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 6,   BChE↓, 3,   BDNF↑, 2,   MAOA↓, 2,   MAOB↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 8,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 1,   Dose↝, 10,   eff↑, 8,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 2,   P450↓, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 3,   BloodF↑, 3,   BMD↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 1,   IL6↓, 10,   IL6↑, 2,   LDH↓, 1,   TC↓, 1,   TG/TAG↓, 1,   TMAO↓, 1,   UFR↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 2,   AntiArt↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 2,   BowelM↑, 1,   cardioP↓, 1,   cardioP↑, 9,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 5,   hepatoP↑, 6,   memory↑, 2,   Mood↑, 1,   motorD↓, 1,   motorD↑, 7,   Mucositis↓, 1,   neuroP↑, 16,   NP/CIPN↓, 1,   Obesity↓, 3,   OS↑, 1,   Pain↓, 48,   QoL↑, 7,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 2,   Sleep↑, 2,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 2,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Weight↓, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 3,   AntiViral↑, 1,   Bacteria↓, 8,   Diar↓, 3,   GutMicro↑, 2,  
Total Targets: 199

Scientific Paper Hit Count for: Pain, Pain
9 Magnetic Fields
3 Capsaicin
3 Carvacrol
3 Methylsulfonylmethane
2 Beta-Caryophyllene
2 Diclofenac
2 Eugenol
2 Gamma-aminobutyric acid
2 Peppermint
2 Quercetin
1 Cannabidiol
1 Bromelain
1 borneol
1 α-Bisabolol / Chamomile oil
1 Celecoxib
1 Diindolylmethane
1 Indole-3-carbinol
1 EGCG (Epigallocatechin Gallate)
1 Flaxseed Oil
1 Vitamin D3
1 Honokiol
1 isoquercitrin
1 Lactobacillus
1 Licorice
1 Methyl salicylate / Sweet Birch oil
1 Exercise
1 Oleuropein
1 Propolis -bee glue
1 Phycocyanin
1 Pomi-T
1 Selenite (Sodium)
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:576  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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