Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
2432- 2DG,    Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- in-vitro, Lung, H23 - in-vitro, Lung, KP2 - in-vivo, NA, NA
HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,
1334- AG,    Astragalus membranaceus: A Review of Its Antitumor Effects on Non-Small Cell Lung Cancer
- Review, NA, NA
TumCP↓, Apoptosis↑, NF-kB↓, p50↓, cycD1/CCND1↓, Bcl-xL↓, ChemoSen↑, angioG↓, ChemoSen↑,
4432- AgNPs,    Emerging nanostructure-based strategies for breast cancer therapy: innovations, challenges, and future directions
- Review, NA, NA
ROS↑, TumCP↓, Apoptosis↑,
4377- AgNPs,    Interaction between silver nanoparticles of 20 nm (AgNP20 ) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates
- in-vitro, NA, NA
eff↑, Apoptosis↑,
4542- AgNPs,    Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity─A 2024 Update
- Review, NA, NA
AntiCan↑, DNAdam↑, ATP↓, Apoptosis↑, ROS↓, TumCCA↑, *Bacteria↓, *BMD↑,
342- AgNPs,    Silver nanoparticles; a new hope in cancer therapy?
- Review, NA, NA
ROS↑, DNAdam↑, Apoptosis↑, mtDam↑,
306- AgNPs,    Cancer Therapy by Silver Nanoparticles: Fiction or Reality?
- Analysis, NA, NA
EPR↝, ROS↑, IL1↑, IL8↑, ER Stress↑, MMP9↑, MMP↓, Cyt‑c↑, Apoptosis↑, Hif1a↑, BBB↑, GutMicro↝, eff↑, eff↑, RadioS↑,
374- AgNPs,    Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
ER Stress↑, DNAdam↑, ROS↑, Apoptosis↑, GSH/GSSG↓, NADPH/NADP+↓, TumCG↓, UPR↑,
347- AgNPs,    The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?
- Review, NA, NA
ROS↑, Apoptosis↑, ER Stress↑,
355- AgNPs,    Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines
- in-vitro, Lung, A549 - in-vitro, NA, BEAS-2B
ROS↑, DNAdam↑, Apoptosis↑,
251- AL,    Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706 - in-vivo, NA, NA
Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,
1151- Api,    Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study
- in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
TumCCA↑, Apoptosis↑, HDAC↓, P21↑, BAX↑, TumCG↓, Bcl-2↓, Bax:Bcl2↑, HDAC1↓, HDAC3↓,
1546- Api,    Apigenin in Cancer Prevention and Therapy: A Systematic Review and Meta-Analysis of Animal Models
- Review, NA, NA
TumVol↓, TumW↓, AntiCan↑, Apoptosis↑, TumCCA↑,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1560- Api,    Apigenin as an anticancer agent
- Review, NA, NA
Apoptosis↑, Casp3∅, Casp8∅, TNF-α∅, Cyt‑c↑, MMP2↓, MMP9↓, Snail↓, Slug↓, NF-kB↓, p50↓, PI3K↓, Akt↓, p‑Akt↓,
1564- Api,    Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
- in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
MDM2↓, NF-kB↓, p65↓, P21↑, ROS↑, GSH↓, MMP↓, Cyt‑c↑, Apoptosis↑, P53↑, eff↓, Bcl-xL↓, Bcl-2↓, BAX↑, Casp↑, TumCG↓, TumVol↓, TumW↓,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,
2576- ART/DHA,  AL,    The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo
- in-vitro, OS, MG63 - in-vivo, NA, NA
eff↑, tumCV↓, Casp3↑, Casp9↑, Apoptosis↑, TumCG↓,
1304- ASA,    Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T Cells
- in-vitro, CRC, NA - in-vivo, NA, NA
TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, IL10↓, TNF-β↓,
1360- Ash,  immuno,    Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer
- in-vitro, Lung, H1650 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP↑, p‑eIF2α↑, ICD↑, eff↑,
1176- Ash,    Metabolic Alterations in Mammary Cancer Prevention by Withaferin A in a Clinically Relevant Mouse Model
- in-vivo, NA, NA
TumVol↓, Apoptosis↑, Glycolysis↓, PKM2↓, PGK1↓, ALDOAiso2↓,
4808- ASTX,    Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer
- in-vitro, Pca, DU145 - in-vivo, NA, NA
TumCP↓, STAT3↓, Apoptosis↑, TumCMig↓, TumCI↓,
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, NA, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
2599- Ba,    Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, Apoptosis↑, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IKKα↓, IKKα↑, PI3K↓, MMP↓, TumAuto↑, TumVol↓, TumW↓,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, NA, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, NA, NA
*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,
2692- BBR,    Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, SaOS2 - in-vivo, NA, NA
Casp1↓, IL1β↓, TumCG↓, Dose↝, Apoptosis↑, Inflam↓,
2711- BBR,    Berberine inhibits the progression of breast cancer by regulating METTL3-mediated m6A modification of FGF7 mRNA
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, FGF↓, IGFBP3↑,
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,
2733- BetA,    Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling
- in-vitro, Oral, KB - in-vivo, NA, NA
TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,
2745- BetA,    Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors
- in-vitro, CRC, RKO - in-vitro, CRC, SW480 - in-vivo, NA, NA
Apoptosis↑, TumCG↓, Sp1/3/4↓, survivin↓, VEGF↓, p65↓, EGFR↓, cycD1/CCND1↓, ROS↑, MMP↓,
697- Bor,    Boron-containing compounds as preventive and chemotherapeutic agents for cancer
- Review, NA, NA
serineP↓, NADHdeh↓, Apoptosis↑,
718- Bor,    Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells
- in-vitro, NA, NA
OSI↑, TNF-α↓, IL1↓, Casp3↑, Apoptosis↑, TOS↑,
5910- CAR,    Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage
- in-vitro, Melanoma, B16-F10 - NA, NA, A375
ROS↑, TumCP↓, Apoptosis↑, Necroptosis↑, mtDam↑, DNAdam↑, selectivity↑, Dose↝, MPT↓,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
4487- Chit,  PreB,    Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review
- Review, NA, NA
*GutMicro↑, Apoptosis↑, BAX↑, Bcl-2↓, *Inflam↓, AntiTum↑,
1143- CHr,    Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2
- in-vitro, HCC, HepG2 - in-vivo, NA, NA - in-vitro, HCC, HepG3 - in-vitro, HCC, HUH7
HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, Apoptosis↑,
1583- Citrate,    Extracellular citrate and metabolic adaptations of cancer cells
- Review, NA, NA
Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, eff↑, Apoptosis↑, TumCG↓, PFK1↓,
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,
5810- CPT,  CPT-11,    Camptothein-Based Anti-Cancer Therapies and Strategies to Improve Their Therapeutic Index
- Review, NA, NA
AntiCan↑, BioAv↓, toxicity⇅, TOP1↓, Apoptosis↑, TumCP↓, other↝, BioAv↑, other↝, eff↑,
1571- Cu,    Copper in cancer: From pathogenesis to therapy
- Review, NA, NA
*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
483- CUR,  PDT,    Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin
- in-vivo, NA, A431
TumVol↓, TumCP↓, Apoptosis↑,
1505- CUR,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
TumCCA↑, Apoptosis↑, DNMTs↓, HDAC↓, HATs↓, TumCP↓, p300↓, HDAC1↓, HDAC3↓, HDAC8↓, NF-kB↓,
1868- DCA,  MET,    Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
- Case Report, NA, NA
eff↑, toxicity∅, MMP↓, Apoptosis↑, selectivity↑, pH↝, Dose↝, Dose↝, eff↑,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,

Showing Research Papers: 1 to 50 of 123
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 123

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   GSH↓, 2,   GSH/GSSG↓, 1,   HNE↑, 1,   HO-1↑, 1,   ICD↑, 1,   lipid-P↓, 1,   MDA↑, 1,   NADHdeh↓, 1,   NADPH/NADP+↓, 1,   NQO1↑, 1,   NRF2↓, 1,   OSI↑, 1,   OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 24,   ROS⇅, 1,   mt-ROS↑, 1,   TOS↑, 1,   xCT↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 4,   MMP↓, 10,   MPT↓, 1,   mtDam↑, 4,   OCR↓, 1,   OCR↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ALDOAiso2↓, 1,   AminoA↓, 1,   AMP↓, 1,   ATG7↑, 1,   ATP:AMP↓, 1,   cMyc↓, 2,   p‑CREB↓, 1,   GlucoseCon↓, 2,   GLUT2↓, 1,   Glycolysis↓, 3,   HK2↓, 4,   lactateProd↓, 2,   LDH↓, 1,   PFK1↓, 2,   PGK1↓, 1,   PKM2↓, 1,   p‑S6↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 6,   p‑Akt↓, 4,   Apoptosis↑, 49,   mt-Apoptosis↑, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 13,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-2↑, 1,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 1,   Casp1↓, 2,   proCasp1↓, 1,   Casp3↑, 9,   Casp3∅, 1,   Casp8↑, 1,   Casp8∅, 1,   Casp9↑, 5,   p‑Chk2↓, 1,   p‑Chk2↑, 1,   Cupro↑, 1,   Cyt‑c↑, 7,   DR5↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   JNK↑, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   Myc↓, 1,   Necroptosis↑, 2,   oncosis↑, 2,   p27↑, 2,   P2X7↓, 1,   p38↑, 1,   p‑p38↓, 1,   Paraptosis↑, 1,   Pyro↑, 1,   p‑RSK↓, 1,   survivin↓, 3,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   other↝, 2,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 6,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   p‑Beclin-1↑, 1,   BNIP3↑, 1,   LC3B↑, 1,   p62↑, 1,   TumAuto↑, 8,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   DNAdam↑, 9,   DNMT1↓, 1,   DNMTs↓, 1,   HR↓, 1,   p16↑, 2,   P53↑, 5,   p‑P53↑, 1,   p‑PARP↑, 1,   cl‑PARP↑, 1,   RAD51↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 3,   cycD1/CCND1↑, 1,   cycE1↓, 1,   P21↑, 4,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↑, 1,   cMET↓, 1,   CREBBP↓, 1,   EMT↓, 1,   ERK↓, 4,   p‑ERK↓, 2,   FGF↓, 1,   FOXO3↑, 1,   HDAC↓, 2,   HDAC1↓, 2,   HDAC10↑, 1,   HDAC3↓, 2,   HDAC8↓, 1,   IGFBP3↑, 1,   mTOR↓, 4,   p‑mTOR↓, 2,   p300↓, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 7,   PTEN↑, 1,   STAT3↓, 4,   p‑STAT5↓, 1,   TOP1↓, 1,   TumCG↓, 8,   TumCG↑, 1,   Wnt?, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 3,   Wnt/(β-catenin)↑, 1,  

Migration ⓘ

AP-1↓, 1,   AP-1↑, 1,   Ca+2↑, 1,   CDK4/6↓, 1,   E-cadherin↑, 2,   GLI2↓, 1,   ITGB1↑, 1,   LysoPr↑, 1,   MMP2↓, 3,   MMP9↓, 2,   MMP9↑, 1,   MMPs↓, 1,   N-cadherin↓, 1,   NCAM↑, 1,   PKA↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   serineP↓, 1,   Slug↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TIMP2↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 14,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 3,   EPR↝, 1,   Hif1a↓, 4,   Hif1a↑, 1,   KDR/FLK-1↓, 1,   NO↓, 1,   VEGF↓, 6,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   COX2↑, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL6↓, 3,   IL8↑, 1,   Inflam↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   MIP2↓, 1,   NF-kB↓, 9,   p50↓, 2,   p65↓, 2,   PD-L1↑, 1,   PGE2↓, 1,   SOCS1↑, 1,   TNF-α↓, 4,   TNF-α∅, 1,   TNF-β↓, 1,  

Cellular Microenvironment ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 5,   Dose↝, 5,   Dose∅, 2,   eff↓, 5,   eff↑, 18,   RadioS↑, 3,   selectivity↓, 1,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AR↓, 2,   BG↓, 1,   EGFR↓, 3,   GutMicro↝, 1,   IL6↓, 3,   LDH↓, 1,   Myc↓, 1,   PD-L1↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 1,   toxicity↓, 1,   toxicity⇅, 1,   toxicity∅, 1,   TumVol↓, 8,   TumW↓, 6,  
Total Targets: 252

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx?, 1,   MDA↓, 1,   ROS↓, 1,  

Migration ⓘ

TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   GutMicro↑, 1,  

Functional Outcomes ⓘ

toxicity↝, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: Apoptosis, Apoptosis
9 EGCG (Epigallocatechin Gallate)
8 Silver-NanoParticles
8 Magnetic Fields
6 Apigenin (mainly Parsley)
5 Berberine
4 Artemisinin
4 Thymoquinone
3 Metformin
3 Curcumin
3 Sulforaphane (mainly Broccoli)
3 Resveratrol
3 Honokiol
3 HydroxyTyrosol
3 Piperlongumine
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
2 Allicin (mainly Garlic)
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Betulinic acid
2 Boron
2 Citric Acid
2 irinotecan
2 Copper and Cu NanoParticles
2 Chemotherapy
2 Genistein (soy isoflavone)
2 Fucoidan
2 Graviola
2 Luteolin
2 Phenylbutyrate
2 Selenium NanoParticles
2 Cisplatin
2 Vitamin C (Ascorbic Acid)
1 2-DeoxyGlucose
1 3-bromopyruvate
1 cetuximab
1 Astragalus
1 Aspirin -acetylsalicylic acid
1 immunotherapy
1 Astaxanthin
1 Radiotherapy/Radiation
1 Carvacrol
1 Cannabidiol
1 chitosan
1 Prebiotic
1 Chrysin
1 Coenzyme Q10
1 Vitamin E
1 Camptothecin
1 Photodynamic Therapy
1 Dichloroacetate
1 diet FMD Fasting Mimicking Diet
1 Gold NanoParticles
1 Aflavin-3,3′-digallate
1 Emodin
1 Galloflavin
1 Gambogic Acid
1 Garcinol
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Hyperthermia
1 Ivermectin
1 Juglone
1 Naringin
1 Nimbolide
1 Oleuropein
1 Oxygen, Hyperbaric
1 Piperine
1 Quercetin
1 Rosmarinic acid
1 Rutin
1 Orlistat
1 Gemcitabine (Gemzar)
1 Urolithin
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:14  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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