Cancer Database Query Results

Ovarian, Ovarian Cancer: Click to Expand ⟱
Ovarian Cancer
Scientific Papers found: Click to Expand⟱
5459- AF,    Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells
- in-vitro, Ovarian, NA
ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,
5977- AgNPs,  CDT,    Silver Nitroprusside as an Efficient Chemodynamic Therapeutic Agent and a Peroxynitrite nanogenerator for Targeted Cancer Therapy
- in-vivo, Ovarian, A2780S - NA, Ovarian, SKOV3
Fenton↑, ROS↑, eff↑, angioG↓, p‑Akt↓, EPR↑, selectivity↑, selectivity↑, eff↑, Cyt‑c↑, HO-1↑,
4389- AgNPs,    Graphene Oxide-Silver Nanocomposite Enhances Cytotoxic and Apoptotic Potential of Salinomycin in Human Ovarian Cancer Stem Cells (OvCSCs): A Novel Approach for Cancer Therapy
- in-vitro, Ovarian, NA
tumCV↓, ROS↑, LDH↓, MMP↑, CSCs↓, AntiCan↑,
4563- AgNPs,  Rad,    Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study
- in-vitro, BC, MCF7 - in-vitro, Ovarian, SKOV3 - in-vitro, GBM, U87MG - in-vitro, Melanoma, A431
RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,
4539- AgNPs,  VitC,  Citrate,    Investigating the Anti-cancer Potential of Silver Nanoparticles Synthesized by Chemical Reduction of AgNO3 Using Trisodium Citrate and Ascorbic Acid
- in-vitro, Nor, L929 - in-vitro, Ovarian, SKOV3
AntiCan↑,
322- AgNPs,  Cisplatin,    Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, OVCAR-3
ROS↑, DNAdam↑, GSH/GSSG↓,
358- AgNPs,    Preparation of triangular silver nanoparticles and their biological effects in the treatment of ovarian cancer
- vitro+vivo, Ovarian, SKOV3
TumCCA↑, ROS↑, Casp3↑, TumCG↓, cycD1/CCND1↓,
397- AgNPs,  GEM,    Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment
- in-vitro, Ovarian, A2780S
P53↑, P21↑, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, MMP↓,
299- ALA,  Cisplatin,  PacT,    Anti-cancer effects of alpha lipoic acid, cisplatin and paclitaxel combination in the OVCAR-3 ovarian adenocarcinoma cell line
- in-vitro, Ovarian, OVCAR-3
MMP9↓, MMP11↓, MAPK↓,
266- ALA,    Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death
- in-vitro, Ovarian, IGROV1
Mcl-1↓, Bcl-xL↓, BIM↑, ROS↑,
7394- Amla,    Emblica officinalis extract downregulates pro-angiogenic molecules via upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
- vitro+vivo, Ovarian, NA
antiNeop↑, TumCP↓, TumCMig↓, TumCI↓, TumCG↓, miR-375↑, IGFR↓, Snail↓, E-cadherin↑,
7393- Amla,    Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
- vitro+vivo, Ovarian, OVCAR-3 - in-vitro, Ovarian, SW626
TumCP↓, Beclin-1/ATG6↑, LC3B-II↑, Hif1a↓, Dose↝, TumAuto↑, angioG↓, COL4A3↓, CXCL6/GCP-2↓, TYMP/ECGF1↓, IL1β↓, PDGFRB↓, ChemoSen↑, Dose↝,
577- Api,  PacT,    Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
p‑Akt↓, Bcl-xL↓, Bcl-2↓, AXL↓, Tyro3↓,
275- Api,    Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells
- in-vitro, Ovarian, SKOV3
HH↓, CK2↓, Gli1↓,
273- Api,    Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase
- in-vivo, Ovarian, A2780S
FAK↓,
1147- ART/DHA,    Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1
- vitro+vivo, Ovarian, HO-8910 - vitro+vivo, Nor, HUVECs
angioG↓, TumCG↓, VEGF↓, VEGFR2/KDR/Flk1↓, *toxicity↓,
1028- ASA,    Aspirin Suppressed PD-L1 Expression through Suppressing KAT5 and Subsequently Inhibited PD-1 and PD-L1 Signaling to Attenuate OC Development
- vitro+vivo, Ovarian, NA
TumCP↓, TumW↓, PD-L1↓, Ki-67↓, H3K27ac∅, eff↑,
3157- Ash,    Withaferin A and Ovarian Cancer Antagonistically Regulate Skeletal Muscle Mass
- in-vivo, Ovarian, A2780S
*cachexia↑, *UPR↑, Strength↑,
1363- Ash,  doxoR,    Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, CaOV3 - in-vivo, NA, NA
ChemoSen↑, ROS↑, DNAdam↑, TumCCA↑, LC3B↑, TumCG↓, cl‑Casp3↑,
4660- Ash,    Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells
- in-vitro, Ovarian, NA
CSCs↓, TumCG↓, TumMeta↓, CD44↓, CD34↓, OCT4↓, NOTCH1↓, HEY1↓,
4677- Ash,    Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
- vitro+vivo, Ovarian, NA
CSCs↓, Securin↓, ALDH1A1↓,
4982- ATV,    Inhibiting the mevalonate pathway with atorvastatin alters gut microbiota and has potential as an anti-cancer treatment for ovarian cancer
- in-vivo, Ovarian, NA
HMG-CoA↓, GutMicro↑,
1520- Ba,    Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, TOV-21G
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, Chk2↑, Dose∅, p‑γH2AX↑, CDC25↓, CHK1↓, cycD1/CCND1↓, eff↓, 12LOX↓,
1381- BBR,  Rad,    Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3)
- in-vitro, Ovarian, SKOV3
RadioS↑, ROS↑, GSH↓, Apoptosis↑,
2710- BBR,    Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
Warburg↓, miR-145↑, HK2↓, TET3↑, Glycolysis↓, PKM2↓, GLUT1↓, LDH↓, PFK2↓, PDK1 / PDPK1↓,
6500- BCP,    Beta-Caryophyllene Suppresses Ovarian Cancer Proliferation by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, Ovarian, NA
TumCP↓, TumCCA↑, Apoptosis↑, Casp3↑, cl‑PARP↑,
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, ROS↑, miR-21↓, miR-130a↓, Casp8∅, Casp10∅, cycD1/CCND1∅, CDK6∅, CDK4∅, FADD∅, DR4∅, DR5∅,
7967- BUL,    Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin
- in-vivo, Ovarian, A2780S - in-vivo, AML, L1210
compI↓, ETC↓,
7975- BUL,    Bullatacin--in vivo and in vitro experience in an ovarian cancer model
- in-vitro, Ovarian, OVCAR-3
toxicity↝, TumCD↑,
1297- CA,    Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes
- in-vitro, Ovarian, OV7
lysosome↓, Apoptosis↑, Bax:Bcl2↑,
5941- Cela,    Celastrol inhibits migration and invasion through blocking the NF-κB pathway in ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, OVCAR-3
TumCMig↓, TumCI↓, NF-kB↓, p65↓, MMP9↓, eff↑, AntiTum↑, Inflam↓, AntiDiabetic↑,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
952- Cin,    Cinnamon Extract Reduces VEGF Expression Via Suppressing HIF-1α Gene Expression and Inhibits Tumor Growth in Mice
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U251 - in-vivo, Ovarian, SKOV3
VEGF↓, Hif1a↓, p‑STAT3↓, p‑Akt↓, angioG↓, TumCG↓, TumW↓, ascitic↓,
1592- Citrate,    Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, IGROV1
eff↑, tumCV↓, Mcl-1↓, eff↑,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1/ATG6↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,
6292- Cro,    Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms
- in-vitro, Cerv, HeLa - in-vitro, Lung, A549 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, P21↑, Apoptosis↑, eff↑,
472- CUR,    Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis
- vitro+vivo, Ovarian, SKOV3 - vitro+vivo, Ovarian, A2780S
TumCP↓, Apoptosis↑, PCNA↓, miR-320a↓, BAX↑, cl‑Casp3↑, circ‑PLEKHM3↑, SMG1↑,
471- CUR,    Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
Apoptosis↑, TumAuto↑, p62↓, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Casp9↑, PARP↑, ATG3↑, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↑,
470- CUR,    Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line
- in-vitro, Ovarian, SKOV3
Wnt/(β-catenin)↓, EMT↓, DNMT3A↓, cycD1/CCND1↓, cMyc↓, Fibronectin↓, Vim↓, E-cadherin↑, SFRP5↑,
469- CUR,    The inhibitory effect of curcumin via fascin suppression through JAK/STAT3 pathway on metastasis and recurrence of ovary cancer cells
- in-vitro, Ovarian, SKOV3
fascin↓, STAT3↓, JAK↓,
1874- DCA,    Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, MDAH-2774
Apoptosis↑, MPO↓, iNOS↓, Hif1a↓, SOD↑, Casp3↑,
2169- dietF,    Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy
- Case Report, Ovarian, NA
OS↑, CA125↓, eff↑,
6734- Dipy,  Cisplatin,    Adenosine enhances cisplatin sensitivity in human ovarian cancer cells
- in-vitro, Ovarian, NA
eff↑, eff↓, ADO↓,
6788- EGCG,    A systematic review and meta-analysis of the effects of green tea extracts and polyphenols in female hormone-dependent cancers for benefit-risk evaluation
- Review, BC, NA - Review, Ovarian, NA
TumVol↓, TumW↓, *toxicity↝,
4681- EGCG,    Epigallocatechin-3-Gallate Prevents the Acquisition of a Cancer Stem Cell Phenotype in Ovarian Cancer Tumorspheres through the Inhibition of Src/JAK/STAT3 Signaling
- in-vitro, Ovarian, ES-2
TumCP↓, Apoptosis↑, Nanog↓, SOX2↓, Fibronectin↓, CD133↓,
1247- EMD,    Emodin exerts antitumor effects in ovarian cancer cell lines by preventing the development of cancer stem cells via epithelial mesenchymal transition
- vitro+vivo, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
TumCP↓, TumCMig↓, TumCI↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, TumCG↓, CD133↓, OCT4↓, CSCs↓,
5047- erastin,    The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
- in-vitro, Ovarian, NA
xCT/SLC7A11↓, GSH↓, Ferroptosis↑, ChemoSen↑, eff↑,
6855- FBZ,    Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study
- vitro+vivo, Ovarian, A2780S - vitro+vivo, Ovarian, SKOV3
TumCP↓, Apoptosis↑, TumCG↓, cl‑Casp3↑, Bax:Bcl2↑, CDK1↓,

Showing Research Papers: 1 to 50 of 130
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 130

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ADO↓, 1,   COL4A3↓, 1,   CXCL6/GCP-2↓, 1,   DCR↑, 1,   EDEM↑, 1,   miR-375↑, 1,   OGF↑, 3,   OGFr↑, 3,   OTUB2↓, 1,   PAF↓, 1,   PFS↑, 2,   PXR, NR1I2↓, 1,   SUV39H↓, 1,   TumNum?, 1,   TYMP/ECGF1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   compI↓, 1,   Fenton↑, 1,   Ferroptosis↑, 4,   GPx↓, 3,   GPx4↓, 1,   GSH↓, 10,   GSH/GSSG↓, 1,   GSTA1↓, 1,   H2O2↑, 3,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 2,   MDA↑, 3,   MPO↓, 1,   NADPH/NADP+↓, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 37,   i-ROS↑, 1,   SOD↓, 1,   SOD↑, 1,   Trx↓, 1,   TrxR↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 3,   CDC25↓, 1,   ETC↓, 1,   MEK↓, 2,   mitResp↓, 1,   MMP↓, 11,   MMP↑, 1,   mtDam↑, 4,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   AKT1↓, 1,   AMPK↓, 1,   p‑AMPK↑, 1,   cMyc↓, 4,   CYP3A4↓, 1,   FASN↓, 2,   GlucoseCon↓, 1,   GlutaM↓, 1,   Glycolysis↓, 7,   HK2↓, 3,   HMG-CoA↓, 1,   IR↓, 1,   lactateProd↓, 2,   LDH↓, 3,   PDK1 / PDPK1↓, 1,   PFK2↓, 1,   PFKP↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 2,   Pyruv↓, 1,   p‑S6K↓, 1,   SREBP1/SREBF1↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   Akt↑, 1,   p‑Akt↓, 9,   p‑Akt↑, 1,   Apoptosis↑, 33,   BAD↑, 1,   Bak↑, 1,   BAX↑, 16,   Bax:Bcl2↑, 5,   Bcl-2↓, 14,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 2,   cl‑Casp↑, 1,   Casp10∅, 1,   Casp3↑, 15,   cl‑Casp3↑, 8,   Casp7↑, 2,   Casp8↑, 1,   Casp8∅, 1,   Casp9↑, 8,   cFLIP↓, 1,   Chk2↑, 1,   CK2↓, 1,   Cyt‑c↑, 7,   DR4∅, 1,   DR5∅, 1,   FADD∅, 1,   Ferroptosis↑, 4,   GSDME-N↑, 1,   HEY1↓, 1,   iNOS↓, 1,   JNK↑, 3,   MAPK↓, 4,   MAPK↑, 2,   Mcl-1↓, 4,   MDM2↓, 1,   Myc↓, 1,   necrosis↑, 1,   p38↓, 1,   p38↑, 3,   Pyro↑, 1,   survivin↓, 2,   TumCD↑, 6,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   HER2/EBBR2↓, 2,   p‑p70S6↑, 1,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-145↑, 1,   miR-21↓, 1,   other↓, 1,   other↝, 3,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 9,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 3,   eIF2α↑, 1,   ER Stress↑, 6,   ERStress↑, 1,   GRP78/BiP↑, 3,   HSP90↑, 1,   IRE1↑, 1,   PERK↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 1,   LC3s↑, 1,   lysosome↓, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   DNAdam↑, 8,   DNMT3A↓, 1,   GADD45A↑, 1,   P53↑, 5,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 2,   p‑PARP↑, 1,   cl‑PARP↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 2,   RAD51↓, 1,   SMG1↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 1,   CDK4∅, 1,   cycD1/CCND1↓, 10,   cycD1/CCND1∅, 1,   P21↑, 3,   Securin↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 2,   CD133↓, 3,   CD34↓, 1,   CD44↓, 2,   CSCs↓, 7,   CSCsMark↓, 1,   EMT↓, 5,   EMT↑, 1,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 2,   p‑ERK↑, 1,   Gli1↓, 1,   H3K27ac∅, 1,   HH↓, 4,   IGFR↓, 1,   LRP6↓, 1,   mTOR↓, 6,   p‑mTOR↓, 3,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 1,   OCT4↓, 2,   p‑P70S6K↓, 1,   PDGFRB↓, 1,   PI3K↓, 5,   PI3K↑, 1,   p‑PI3K↓, 1,   circ‑PLEKHM3↑, 1,   PTEN↑, 1,   PTPN6↑, 1,   SFRP5↑, 1,   SOX2↓, 2,   STAT↓, 1,   STAT3↓, 5,   p‑STAT3↓, 5,   TOP2↓, 1,   TumCG↓, 25,   TumCG∅, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 2,   CD31/PECAM-1↓, 1,   E-cadherin↑, 5,   FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 2,   ITGA5↓, 1,   ITGB1↓, 1,   Ki-67↓, 3,   miR-130a↓, 1,   miR-320a↓, 1,   MMP11↓, 1,   MMP2↓, 1,   MMP9↓, 5,   N-cadherin↓, 3,   p‑p44↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TumCI↓, 11,   TumCI↑, 1,   TumCMig↓, 13,   TumCMig↑, 1,   TumCP↓, 28,   TumCP↑, 1,   TumMeta↓, 2,   Tyro3↓, 1,   Vim↓, 4,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 11,   ATF4↑, 1,   EGFR↓, 1,   EPR↑, 3,   Hif1a↓, 7,   NO↑, 1,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 2,   VEGFR2/KDR/Flk1↑, 1,   VM↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↓, 1,   CTR1↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 2,   SVCT-2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 1,   CRP↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   JAK↓, 2,   NF-kB↓, 3,   p65↓, 1,   PD-L1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6∅, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↑, 3,   BioAv↝, 2,   ChemoSen↑, 16,   ChemoSen∅, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 13,   Dose∅, 3,   eff↓, 14,   eff↑, 25,   eff∅, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   RadioS↑, 2,   selectivity↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ascitic↓, 1,   CA125↓, 3,   CA125∅, 1,   CRP↓, 1,   EGFR↓, 1,   GutMicro↑, 2,   HER2/EBBR2↓, 2,   IL6↓, 1,   Ki-67↓, 3,   LDH↓, 3,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↑, 1,   chemoP↑, 2,   OS↓, 1,   OS↑, 5,   Pain↑, 1,   QoL↑, 1,   Risk↓, 5,   Strength↑, 1,   toxicity↓, 5,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 7,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 327

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ARE↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH↑, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

UPR↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   SVCT-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,  

Functional Outcomes(tgid=23) ⓘ

cachexia↑, 1,   chemoP↑, 1,   toxicity↓, 5,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 26

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:20  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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