selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
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The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
6467- 1,8-Cin,    Evaluation of in vitro anticancer activity of 1,8-Cineole-containing n-hexane extract of Callistemon citrinus (Curtis) Skeels plant and its apoptotic potential
- in-vitro, Melanoma, A431 - in-vitro, OS, MG63 - in-vitro, Nor, HaCaT
TumCP↓, selectivity↑, AntiCan↑, TumCD↑, Apoptosis↑, Dose↝, ROS↑,
5461- AF,    Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,
5236- AgNPs,    Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury
- in-vitro, Liver, HepG2 - in-vitro, Nor, L02
tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
4411- AgNPs,    Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities
- in-vitro, Lung, A549 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,
4431- AgNPs,  doxoR,    Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1 - in-vitro, Nor, 3T3
AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,
4433- AgNPs,    Advancements in metal and metal oxide nanoparticles for targeted cancer therapy and imaging: Mechanisms, applications, and safety concerns
- in-vitro, Liver, HepG2 - in-vitro, Nor, L02
selectivity↑, selectivity↓, mt-ROS↑,
4376- AgNPs,    Interaction of multi-functional silver nanoparticles with living cells
- in-vitro, Nor, L929 - in-vitro, Lung, A549
eff↑, selectivity↑,
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
4541- AgNPs,  RosA,    Eco-friendly synthesis of silver nanoparticles: multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities
- in-vitro, Nor, WI38 - in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1
*antiOx↑, TumCD↓, selectivity↑,
4540- AgNPs,  VitC,    Silver nanoparticles from ascorbic acid: Biosynthesis, characterization, in vitro safety profile, antimicrobial activity and phytotoxicity
- in-vitro, Nor, NA
*Bacteria↓, *selectivity↑,
2000- AL,    Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, NA
selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,
3442- ALA,    α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, C4-2B - in-vitro, Nor, 3T3
tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,
1999- Api,  doxoR,    Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation
- in-vitro, Nor, NRK52E - in-vitro, Nor, MPC5 - in-vitro, BC, 4T1 - in-vivo, NA, NA
neuroP↑, ChemoSen∅, RenoP↑, selectivity↑, chemoP↑, ROS↑, *ROS∅, *antiOx↑, *toxicity↓,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
2570- ART/DHA,    Discovery, mechanisms of action and combination therapy of artemisinin
- Review, Nor, NA
*BioAv↓, *Half-Life↓, *toxicity↓, *ROS↑, GSH↓, selectivity↑,
5381- ART/DHA,    Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, Nor, NCM460 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT8
Ferroptosis↑, CYP24A1↓, Ca+2↑, SCD1↓, FAO↑, lipid-P↑, eff↑, selectivity↑, other?,
2003- Ash,    Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Nor, TIG-1 - in-vitro, PC, LNCaP
TumCD↑, selectivity↑, cFos↑, ROS↑, *ROS∅, HSP70/HSPA5↑, Apoptosis↑, ER Stress↑, TumCCA↑,
3172- Ash,    Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis
- in-vitro, HCC, HepG2 - in-vitro, Nor, HL7702
Keap1↑, NRF2↓, EMT↓, TumCP↓, TumCI↓, selectivity↑, *toxicity↓, ROS↑, MDA↑, GSH↓, Ferroptosis↑,
1142- Ash,    Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer
- Review, BC, MCF-7 - NA, BC, MDA-MB-231 - NA, Nor, HMEC
Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,
4818- ASTX,  MEL,    Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
1533- Ba,    Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation
- in-vitro, BrCC, MCF-7 - in-vitro, Nor, MCF10
tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,
1523- Ba,    Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,
2023- BBR,    Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
- in-vitro, Colon, NA - in-vitro, Nor, YAMC
TumCD↑, *toxicity↓, selectivity↑, ROS↑, *ROS∅, MMP↓, *MMP∅, PARP↑, BioAv↝,
2022- BBR,  GoldNP,  Rad,    Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
- in-vitro, Liver, SMMC-7721 cell - in-vitro, Nor, HL7702
*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,
2700- BBR,    Cell-specific pattern of berberine pleiotropic effects on different human cell lines
- in-vitro, GBM, U343 - in-vitro, GBM, MIA PaCa-2 - in-vitro, Nor, HDFa
selectivity↑, TumCCA↑, Casp3↑, TumCI↓, TumCMig↓, N-cadherin?, DNMT1↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
2732- BetA,  Chemo,    Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
ChemoSen↑, selectivity↑, GRP78/BiP↑, ER Stress↑, PERK↑, Ca+2↑, Cyt‑c↑, BAX↑, Bcl-2↓,
738- Bor,    Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways
- in-vitro, GBM, U251 - in-vitro, GBM, A172 - in-vitro, Nor, SVGp12
TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,
3513- Bor,    Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status
- in-vitro, Pca, DU145 - in-vitro, Nor, MEF
NRF2↑, selectivity↑, NQO1↑, GCLC↑, HO-1↑, TumCP↓,
2024- Bos,    Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
MMP↓, Cyt‑c↑, ROS↑, Casp8↑, Casp9↑, AntiTum↑, selectivity↑, TumCCA↑,
6547- BSB,    Antitumor effects of a-bisabolol against pancreatic cancer
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, KLM1 - in-vitro, PC, KP4 - in-vitro, Nor, ACBRI515
TumCP↓, selectivity↑, Apoptosis↑, Akt↓, EGR1↑, TumCG↓, Dose↝, PI3K↓, PDK1↓, mTORC2↑,
1646- CA,    Caffeic acid: a brief overview of its presence, metabolism, and bioactivity
- Review, Nor, NA
*BioAv↓, ROS⇅, selectivity↑, other∅, VEGF↓, MMP2↓, MMP9↓,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
1642- Cu,  HCAs,    Copper-assisted anticancer activity of hydroxycinnamic acid terpyridine conjugates on triple-negative breast cancer
- in-vitro, BC, 4T1 - in-vitro, Nor, L929
tumCV↓, selectivity↑,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
4455- DFE,    Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest
- in-vitro, BC, MCF-7 - in-vitro, Nor, 3T3
TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2↑, OXPHOS↓, ETC↓,
6327- DRE,    Effect of Methanolic Extract of Dandelion Roots on Cancer Cell Lines and AMP-Activated Protein Kinase Pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, CRC, HCT116 - in-vitro, Nor, Hs27
TumCG↓, selectivity↑, p‑AMPK↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
6617- Ech,    Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
Dose↝, selectivity↑, TumCCA↑, Apoptosis↑, toxicity↓, ChemoSen↑, other↝, *antiOx↑,

Showing Research Papers: 1 to 50 of 116
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 116

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   Catalase↓, 1,   compI↓, 1,   Fenton↑, 1,   Ferroptosis↑, 3,   GCLC↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 6,   GSH/GSSG↓, 1,   HO-1↑, 1,   Keap1↑, 1,   lipid-P↑, 2,   MDA↑, 2,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 2,   OXPHOS↓, 2,   ROS↑, 22,   ROS⇅, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 1,   TrxR↓, 1,   mt-TrxR1↓, 1,   mt-TrxR2↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   compIII↓, 1,   ETC↓, 2,   MEK↓, 2,   MMP↓, 12,   mtDam↑, 1,   OCR↑, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑AMPK↑, 1,   FABP4↓, 1,   FAO↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 2,   LDH?, 1,   LDH↑, 2,   p‑PDH↑, 1,   PDK1↓, 3,   PDKs↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   p‑S6K↓, 1,   SCD1↓, 2,  

Cell Death ⓘ

Akt↓, 5,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 19,   BAD↑, 1,   BAX↑, 7,   BAX⇅, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 14,   Bcl-xL↓, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 4,   Casp1↑, 1,   Casp3↑, 10,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 3,   Casp9↑, 6,   cl‑Casp9↑, 1,   Cyt‑c↑, 7,   DR5↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 3,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p27↑, 1,   p‑p38↓, 1,   Paraptosis↑, 2,   survivin↓, 1,   Telomerase↓, 1,   TumCD↓, 1,   TumCD↑, 7,   TUNEL↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,   other↝, 3,   other∅, 1,   tumCV↓, 9,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3?, 1,   LC3B↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNA-PK↑, 1,   DNAdam↑, 10,   DNMT1↑, 1,   P53↑, 4,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 1,   p‑PARP↑, 1,   cl‑PARP↑, 3,   SIRT6↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   cFos↑, 1,   CSCs↓, 1,   Diff↓, 1,   EMT↓, 2,   ERK↓, 1,   mTOR↓, 1,   mTOR⇅, 1,   p‑mTORC1↓, 1,   mTORC2↑, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   PI3K↓, 4,   PTEN↑, 2,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT6↓, 1,   TRPM7↓, 1,   TumCG?, 1,   TumCG↓, 4,   TumCG↑, 1,  

Migration ⓘ

Ca+2↑, 3,   p‑Cofilin↑, 1,   F-actin↓, 1,   Ki-67↓, 1,   MMP2↓, 4,   MMP9↓, 3,   N-cadherin?, 1,   PAK1↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   TSC1↑, 1,   TumCI↓, 4,   TumCMig↓, 5,   TumCP↓, 10,   uPA↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   EGR1↑, 1,   EPR↑, 1,   Hif1a↓, 3,   Hif1a↑, 1,   VEGF↓, 2,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

CCR7↓, 1,   COX2↓, 1,   COX2↑, 1,   CXCR4↓, 1,   IKKα↓, 1,   IL1β↑, 1,   IL6↓, 1,   Inflam↓, 2,   JAK1↓, 1,   JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,   PGE2↓, 2,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP24A1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 7,   ChemoSen∅, 1,   Dose?, 1,   Dose↓, 3,   Dose↑, 1,   Dose↝, 9,   Dose∅, 3,   eff↓, 8,   eff↑, 18,   eff↝, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 2,   selectivity↓, 2,   selectivity↑, 54,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH?, 1,   LDH↑, 2,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 1,   AntiTum↑, 3,   cardioP↑, 2,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 2,   OS↑, 1,   radioP↑, 2,   RenoP↑, 1,   toxicity↓, 3,   toxicity↝, 2,   TumVol↓, 1,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 229

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   ROS↓, 2,   ROS↑, 2,   ROS∅, 7,  

Mitochondria & Bioenergetics ⓘ

MMP∅, 1,  

Cell Death ⓘ

Casp1↓, 1,   JNK↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   p‑PERK↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 1,   BioEnh↑, 1,   Half-Life↓, 1,   Half-Life∅, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   toxicity↓, 7,   toxicity↝, 2,   toxicity∅, 4,  

Infection & Microbiome ⓘ

AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 31

Scientific Paper Hit Count for: selectivity, selectivity
11 Magnetic Fields
10 Silver-NanoParticles
5 Shikonin
5 Thymoquinone
4 Radiotherapy/Radiation
4 Berberine
4 EGCG (Epigallocatechin Gallate)
3 doxorubicin
3 Ashwagandha(Withaferin A)
3 Baicalein
3 Chemotherapy
3 Dandelion Root
3 Propolis -bee glue
3 Piperlongumine
3 Selenium NanoParticles
2 1,8-Cineole
2 Vitamin C (Ascorbic Acid)
2 Rosmarinic acid
2 Apigenin (mainly Parsley)
2 Metformin
2 Artemisinin
2 Astaxanthin
2 Boron
2 Carvacrol
2 Hydroxycinnamic-acid
2 D-limonene
2 Fisetin
2 Graviola
2 Lycopene
2 Quercetin
2 Selenium
2 chitosan
2 Sulforaphane (mainly Broccoli)
1 Auranofin
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Melatonin
1 Baicalin
1 Gold NanoParticles
1 Betulinic acid
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Capsaicin
1 Copper and Cu NanoParticles
1 Curcumin
1 Dichloroacetate
1 Date Fruit Extract
1 Docetaxel
1 Ellagic acid
1 Echinacea
1 PXD, phenoxodiol
1 Emodin
1 Eugenol
1 Shilajit/Fulvic Acid
1 Gambogic Acid
1 Honokiol
1 HydroxyTyrosol
1 Linalool
1 Luteolin
1 Magnetic Field Rotating
1 Phenylbutyrate
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Phenethyl isothiocyanate
1 Cisplatin
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 Resveratrol
1 α-Santalol/Sandalwood oil
1 polyethylene glycol
1 Vitamin K2
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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