eff Cancer Research Results
eff, efficacy: Click to Expand ⟱
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Power to enhance an anti cancer effect
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CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
Caco-2 |
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in-vitro, |
CRC, |
SW48 |
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ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
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in-vitro, |
CRC, |
DLD1 |
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NA, |
NA, |
HCT116 |
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eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
eff↑, Half-Life↑,
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in-vitro, |
GBM, |
U251 |
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in-vitro, |
GBM, |
U87MG |
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in-vitro, |
GBM, |
GL26 |
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in-vitro, |
Cerv, |
HeLa |
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in-vitro, |
CRC, |
RKO |
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AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Melanoma, |
A2780S |
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Bacteria↓, antiOx↑, AntiCan↑, eff↑,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
HT29 |
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in-vivo, |
NA, |
NA |
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eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
eff↑, TumCD↑, ROS↑, Bacteria↓,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Nor, |
HEK293 |
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NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
ROS↑, Apoptosis↑, eff↑, ChemoSen↑, EPR↑, Casp↑, MAPK↑,
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in-vitro, |
CRC, |
T84 |
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in-vitro, |
CRC, |
COLO205 |
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in-vitro, |
CRC, |
HT-29 |
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in-vitro, |
CRC, |
DLD1 |
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eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP↑, eff↑,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Nor, |
NCM460 |
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in-vitro, |
CRC, |
HT29 |
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in-vitro, |
CRC, |
HCT8 |
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Ferroptosis↑, CYP24A1↓, Ca+2↑, SCD1↓, FAO↑, lipid-P↑, eff↑, selectivity↑, other?,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
HT29 |
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in-vitro, |
CRC, |
SW48 |
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in-vitro, |
BC, |
MDA-MB-453 |
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Ferroptosis↑, Ferritin↓, Iron↑, eff↑, TumAuto↑, LC3II↑, ROS↑,
eff↑,
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in-vivo, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
HCT116 |
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eff↑, ROS↑, selectivity↑, TumCG↓, toxicity↓,
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in-vitro, |
Lung, |
H1650 |
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in-vitro, |
Lung, |
A549 |
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
BC, |
MDA-MB-231 |
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in-vivo, |
NA, |
NA |
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PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP↑, p‑eIF2α↑, ICD↑, eff↑,
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in-vitro, |
CRC, |
HepG2 |
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in-vitro, |
CRC, |
HCT116 |
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eff↑,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Colon, |
SW480 |
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in-vitro, |
Colon, |
HT29 |
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tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, eff↑,
ENOX2↑, TumCP↑, TumCMig↑, Dose?, eff↑,
eff↑, BioAv↑, eff↑,
eff↑, Half-Life↑, Half-Life↑, EGFR↓, OS↑, QoL↑, eff↑, KRAS↓,
eff↑, Dose↝,
DDS↑, eff↑, BioAv↑, BioEnh↑, eff↑,
eff↑, BioAv↓, TumCG↓,
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in-vitro, |
CRC, |
LS174T |
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in-vitro, |
CRC, |
LoVo |
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in-vitro, |
CRC, |
SW-620 |
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in-vitro, |
CRC, |
HT-29 |
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tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,
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in-vitro, |
CRC, |
DLD1 |
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in-vitro, |
CRC, |
HCT116 |
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eff↑, pH↓, PDKs↓, Warburg↓,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
SW-620 |
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in-vitro, |
CRC, |
HT-29 |
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SMCT1∅, eff↓, eff↑, eff↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,
TumCP↑, angioG↓, CD8+↑, GutMicro↑, eff↑,
TumCG↓, *GSH↓, RadioS↑, eff↑,
eff↑, Akt↓, VEGFR2↓, STAT3↓, P53↓, Hippo↓, YAP/TEAD↑,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
HT29 |
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in-vitro, |
Liver, |
HepG2 |
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in-vitro, |
Liver, |
HUH7 |
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tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, eff↑,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
LoVo |
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in-vivo, |
CRC, |
HCT116 |
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AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,
eff↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, glucose↑,
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in-vitro, |
PC, |
MIA PaCa-2 |
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in-vitro, |
CRC, |
SW-620 |
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in-vitro, |
NA, |
HT1080 |
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in-vitro, |
Pca, |
PC3 |
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in-vitro, |
OS, |
U2OS |
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in-vitro, |
BC, |
MCF-7 |
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in-vitro, |
Nor, |
CCD-18Co |
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TumCD↑, eff↑, *TumCG∅,
TumCG↓, Apoptosis↑, MMP↓, Casp3↑, PARP↓, NF-kB↓, eff↑,
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in-vitro, |
CRC, |
Caco-2 |
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in-vivo, |
NA, |
NA |
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PI3K↓, Akt↓, mTOR↓, TumCP↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, ROS↓, FOXO1↑, *toxicity∅, eff↑,
TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, eff↑, E-cadherin↑, N-cadherin↓, Vim↓,
ROS↑, TrxR↓, eff↑, p‑Akt↓,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Lung, |
A549 |
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in-vitro, |
BC, |
MCF-7 |
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TrxR1?, TumCD↑, ROS↑, GSH↓, eff↑,
Apoptosis↑, GSH↓, ROS↑, Ca+2↑, GRP78/BiP↑, ER Stress↑, eff↓, eff↑, Thiols↓,
xCT↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Liver, |
HepG2 |
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in-vitro, |
BC, |
MCF-7 |
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Dose↝, AntiCan↑, eff↑,
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in-vitro, |
CRC, |
T24/HTB-9 |
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Dose↝, NRF2↑, GSH↓, eff↑,
eff↑, VDR↑, CYP11A1↓, HDAC↓,
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vitro+vivo, |
CRC, |
SW-620 |
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vitro+vivo, |
CRC, |
HCT116 |
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Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,
eff↑, TumCCA↑, Inflam↓, COX2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,
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in-vitro, |
RCC, |
RCC4 |
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
BC, |
MDA-MB-435 |
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in-vitro, |
Ovarian, |
SKOV3 |
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in-vitro, |
Colon, |
SW48 |
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in-vitro, |
GBM, |
U251 |
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eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
Glycolysis↓, eff↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,
Showing Research Papers: 1 to 48 of 48
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 48
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
antiOx↓, 1, antiOx↑, 1, ENOX2↑, 1, Ferroptosis↓, 1, Ferroptosis↑, 2, GSH↓, 5, ICD↑, 1, Iron↑, 1, lipid-P↑, 2, MDA↑, 1, NRF2↑, 2, ROS↓, 1, ROS↑, 19, Thiols↓, 1, TrxR↓, 1, TrxR1?, 1, xCT↓, 1, xCT↑, 1,
Metal & Cofactor Biology ⓘ
Ferritin↓, 1,
Mitochondria & Bioenergetics ⓘ
ATP↓, 4, ETC↓, 1, mitResp↑, 2, MMP↓, 3, mtDam↑, 1, XIAP↓, 1,
Core Metabolism/Glycolysis ⓘ
AMPK↑, 1, FAO↑, 1, glucose↑, 1, GlucoseCon↓, 1, Glycolysis↓, 4, HK2?, 1, HK2↓, 2, lactateProd↓, 2, LDHA↓, 2, lipoGen↓, 1, PDH↑, 1, PDKs↓, 3, PKM2↓, 2, SCD1↓, 1, Warburg↓, 3,
Cell Death ⓘ
Akt↓, 3, p‑Akt↓, 1, p‑Akt↑, 1, Apoptosis↓, 1, Apoptosis↑, 12, BAD↑, 1, Bak↑, 1, BAX↑, 6, Bcl-2↓, 6, Bcl-xL↓, 1, Casp↑, 2, Casp3↑, 6, cl‑Casp3↑, 1, Casp9↑, 3, Cyt‑c↑, 3, Ferroptosis↓, 1, Ferroptosis↑, 2, cl‑GSDME↑, 1, Hippo↓, 1, iNOS↓, 1, MAPK↑, 1, MDM2↓, 1, necrosis↑, 1, p27↑, 1, Pyro↑, 1, survivin↓, 3, TumCD↑, 4, YAP/TEAD↑, 1,
Kinase & Signal Transduction ⓘ
AMPKα↑, 2,
Transcription & Epigenetics ⓘ
other?, 1, other↝, 1, tumCV↓, 5,
Protein Folding & ER Stress ⓘ
CHOP↑, 2, p‑eIF2α↑, 1, ER Stress↑, 3, GRP78/BiP↑, 1, UPR↑, 1, XBP-1↑, 1,
Autophagy & Lysosomes ⓘ
p‑Beclin-1↑, 1, LC3II↑, 1, TumAuto↑, 3,
DNA Damage & Repair ⓘ
DNAdam↑, 4, P53↓, 1, P53↑, 2, PARP↓, 1, PARP↑, 1, cl‑PARP↑, 2,
Cell Cycle & Senescence ⓘ
cycD1/CCND1↓, 2, CycD3↓, 1, P21↑, 2, TumCCA↓, 1, TumCCA↑, 4,
Proliferation, Differentiation & Cell State ⓘ
EMT↓, 1, FOXO1↑, 1, FOXO3↑, 1, HDAC↓, 1, mTOR↓, 2, PI3K↓, 2, PTEN↑, 1, STAT3↓, 2, TumCG↓, 7, VDR↑, 1,
Migration ⓘ
Ca+2↑, 2, E-cadherin↑, 1, Ki-67↓, 1, KRAS↓, 1, N-cadherin↓, 1, Slug↓, 1, Smad1↓, 1, Snail↓, 1, TGF-β1↓, 1, TumCI↓, 1, TumCMig↓, 1, TumCMig↑, 1, TumCP↓, 3, TumCP↑, 2, Vim↓, 1, Zeb1↓, 1, ZEB2↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, EGFR↓, 1, EPR↑, 2, Hif1a↓, 2, VEGFR2↓, 1,
Barriers & Transport ⓘ
GLUT1↓, 1, SMCT1∅, 1,
Immune & Inflammatory Signaling ⓘ
CD4+↑, 1, COX2↓, 1, Gal1↑, 1, Inflam↓, 2, NF-kB↓, 2, PD-L1↓, 1, PD-L1↑, 1,
Cellular Microenvironment ⓘ
pH↓, 1,
Hormonal & Nuclear Receptors ⓘ
CYP11A1↓, 1, CYP24A1↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1, BioAv↑, 3, BioEnh↑, 1, ChemoSen↑, 1, DDS↑, 1, Dose?, 1, Dose↝, 4, eff↓, 6, eff↑, 57, eff↝, 1, Half-Life↑, 3, RadioS↑, 2, selectivity↑, 6,
Clinical Biomarkers ⓘ
EGFR↓, 1, Ferritin↓, 1, GutMicro↑, 1, Ki-67↓, 1, KRAS↓, 1, PD-L1↓, 1, PD-L1↑, 1,
Functional Outcomes ⓘ
AntiCan↑, 8, OS↑, 3, QoL↑, 1, toxicity↓, 2, TumVol↓, 1, TumW↓, 1,
Infection & Microbiome ⓘ
Bacteria↓, 2, CD8+↑, 2,
Total Targets: 164
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
GSH↓, 1,
Cell Death ⓘ
JNK↑, 1,
Protein Folding & ER Stress ⓘ
CHOP↑, 1, cl‑eIF2α↑, 1, GRP78/BiP↑, 1, p‑PERK↑, 1,
Proliferation, Differentiation & Cell State ⓘ
TumCG∅, 1,
Functional Outcomes ⓘ
toxicity↓, 1, toxicity↝, 1, toxicity∅, 1,
Infection & Microbiome ⓘ
AntiViral↑, 1,
Total Targets: 11
Scientific Paper Hit Count for: eff, efficacy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:6 Cells:% prod#:% Target#:961 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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