eff Cancer Research Results

eff, efficacy: Click to Expand ⟱

Source:

Type:

Power to enhance an anti cancer effect

CRC, Colorectal Cancer: Click to Expand ⟱

Colorectal cancer is a broader term that encompasses both colon and rectal cancer.

Scientific Papers found: Click to Expand⟱

5278-

3BP,

effect-of-3-bromopyruvate-on-human-colorectal">The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

Caco-2

in-vitro,

CRC,

SW48

ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,

5263-

3BP,

CET,

3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis

in-vitro,

CRC,

DLD1

NA,

HCT116

eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,

4774-

5-FU,

TQ,

CoQ10,

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation

in-vitro,

CRC,

AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,

5469-

AF,

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation

in-vitro,

CRC,

HCT116

eff↑, Half-Life↑,

4403-

AgNPs,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

GL26

in-vitro,

Cerv,

HeLa

in-vitro,

CRC,

RKO

AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

4412-

AgNPs,

Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties

in-vitro,

CRC,

HCT116

in-vitro,

Melanoma,

A2780S

Bacteria↓, antiOx↑, AntiCan↑, eff↑,

4362-

AgNPs,

Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers

in-vitro,

CRC,

HCT116

18–45 nm.

in-vitro,

CRC,

HT29

in-vivo,

NA,

Male Swiss nu/nu mice aged 5–8 weeks

eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,

4379-

AgNPs,

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

in-vitro,

CRC,

LoVo

eff↑, TumCD↑, ROS↑, Bacteria↓,

4561-

AgNPs,

VitC,

Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

HEK293

NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,

5142-

AgNPs,

Biosynthesized Protein-Capped Silver Nanoparticles Induce ROS-Dependent Proapoptotic Signals and Prosurvival Autophagy in Cancer Cells

in-vitro,

CRC,

HUH7

220 and 249 nm

ROS↑, Apoptosis↑, eff↑, ChemoSen↑, EPR↑, Casp↑, MAPK↑,

1351-

And,

MEL,

Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids

in-vitro,

CRC,

T84

in-vitro,

CRC,

COLO205

in-vitro,

CRC,

HT-29

in-vitro,

CRC,

DLD1

eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP↑, eff↑,

2573-

ART/DHA,

effects_of_halofuginone_and_artemisinin_in_colorectal_cancer_cells">Cell death mechanisms induced by synergistic effects of halofuginone and artemisinin in colorectal cancer cells

in-vitro,

CRC,

HCT116

eff↑,

2582-

ART/DHA,

5-ALA,

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

in-vivo,

CRC,

HCT116

mouse xenograft CRC model

in-vitro,

CRC,

HCT116

eff↑, ROS↑, selectivity↑, TumCG↓, toxicity↓,

5381-

ART/DHA,

Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

NCM460

in-vitro,

CRC,

HT29

in-vitro,

CRC,

HCT8

Ferroptosis↑, CYP24A1↓, Ca+2↑, SCD1↓, FAO↑, lipid-P↑, eff↑, selectivity↑, other?,

5376-

ART/DHA,

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

HT29

in-vitro,

CRC,

SW48

in-vitro,

BC,

MDA-MB-453

Ferroptosis↑, Ferritin↓, Iron↑, eff↑, TumAuto↑, LC3II↑, ROS↑,

1360-

Ash,

immuno,

Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer

in-vitro,

Lung,

H1650

in-vitro,

Lung,

A549

in-vitro,

CRC,

HCT116

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

mice

PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP↑, p‑eIF2α↑, ICD↑, eff↑,

1451-

Bos,

Phytochemical Analysis and Anti-cancer Investigation of Boswellia serrata Bioactive Constituents In Vitro

in-vitro,

CRC,

HepG2

1.58 and 5.82 μg/mL at 48 h

HepG2 cell line, extracts 1 and 2

in-vitro,

CRC,

HCT116

eff↑,

5866-

CA,

Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells

in-vitro,

CRC,

HCT116

in-vitro,

Colon,

SW480

in-vitro,

Colon,

HT29

tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, eff↑,

1518-

CAP,

Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo

in-vitro,

CRC,

HCT116

ENOX2↑, TumCP↑, TumCMig↑, Dose?, eff↑,

5823-

capec,

Capecitabine: a review

Review,

CRC,

eff↑, BioAv↑, eff↑,

5968-

CET,

Cetuximab as a Key Partner in Personalized Targeted Therapy for Metastatic Colorectal Cancer

in-vitro,

CRC,

eff↑, Half-Life↑, Half-Life↑, EGFR↓, OS↑, QoL↑, eff↑, KRAS↓,

5967-

CET,

FDA grants accelerated approval to adagrasib with cetuximab for KRAS G12C-mutated colorectal cancer

Study,

CRC,

eff↑, Dose↝,

5981-

Chit,

Chitosan-Based Drug Delivery Systems for Targeted Chemotherapy in Colorectal Cancer: A Scoping Review

Review,

CRC,

DDS↑, eff↑, BioAv↑, BioEnh↑, eff↑,

3578-

CUR,

SIL,

Curcumin, but not its degradation products, in combination with silibinin is primarily responsible for the inhibition of colon cancer cell proliferation

in-vitro,

CRC,

DLD1

eff↑, BioAv↓, TumCG↓,

1878-

DCA,

5-FU,

Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer

in-vitro,

CRC,

LS174T

57mM

in-vitro,

CRC,

LoVo

29mM

in-vitro,

CRC,

SW-620

38mM

in-vitro,

CRC,

HT-29

47mM

tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,

1884-

DCA,

Sal,

Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines

in-vitro,

CRC,

DLD1

in-vitro,

CRC,

HCT116

eff↑, pH↓, PDKs↓, Warburg↓,

1885-

DCA,

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate

in-vitro,

CRC,

HCT116

These three cell lines do not express SLC5A8

in-vitro,

CRC,

SW-620

in-vitro,

CRC,

HT-29

SMCT1∅, eff↓, eff↑, eff↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,

1850-

dietFMD,

Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression

in-vivo,

CRC,

mice

TumCP↑, angioG↓, CD8+↑, GutMicro↑, eff↑,

1896-

dietMet,

Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies

in-vivo,

CRC,

mice

TumCG↓, *GSH↓, RadioS↑, eff↑,

6607-

Ech,

Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines

in-vitro,

PC,

MIA PaCa-2

in-vitro,

CRC,

Colo320

tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2↓, 5LO↓,

684-

EGCG,

effect_of_EGCG_in_colorectal_cancer_cells_by_blocking_EGCG-induced_YAP_activation">Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation

in-vitro,

CRC,

eff↑, Akt↓, VEGFR2↓, STAT3↓, P53↓, Hippo↓, YAP/TEAD↑,

3241-

EGCG,

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

in-vitro,

CRC,

HCT116

0.5 ± 0.05 mm

in-vitro,

CRC,

HT29

0.8 ± 0.06 mm

in-vitro,

Liver,

HepG2

 > 1 mm

in-vitro,

Liver,

HUH7

 > 1 mm

tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, eff↑,

6391-

Eug,

BCP,

5-FU,

Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology

in-vitro,

CRC,

HCT116

eff↑, ChemoSen↑, HSP90↓, Dose↝, TumAuto↑, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, JNK↓, p38↓, EMT↓,

4523-

HNK,

MAG,

BA,

Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

LoVo

in-vivo,

CRC,

HCT116

mice

AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,

2390-

KaempF,

Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis

in-vitro,

CRC,

HCT8

eff↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, glucose↑,

595-

MFrot,

VitC,

MF,

The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

in-vitro,

PC,

MIA PaCa-2

4mT, 1000rpm

51% reduction

reduces IC50 value of cells treated with Vit C and magnetic field

in-vitro,

CRC,

SW-620

23% reduction

in-vitro,

NA,

HT1080

37% reduction

in-vitro,

Pca,

PC3

40% reduction

in-vitro,

OS,

U2OS

46% reduction

in-vitro,

BC,

MCF-7

33% reduction

in-vitro,

Nor,

CCD-18Co

-7% reduction

health normal colon cells *****

TumCD↑, eff↑, *TumCG∅,

2070-

PB,

Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells

in-vitro,

CRC,

HT-29

TumCG↓, Apoptosis↑, MMP↓, Casp3↑, PARP↓, NF-kB↓, eff↑,

1678-

PBG,

5-FU,

sericin,

In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

in-vitro,

CRC,

Caco-2

in-vivo,

NA,

105 in bred- albino mice

PI3K↓, Akt↓, mTOR↓, TumCP↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, ROS↓, FOXO1↑, *toxicity∅, eff↑,

4926-

PEITC,

PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT

in-vitro,

CRC,

SW48

TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, eff↑, E-cadherin↑, N-cadherin↓, Vim↓,

1952-

PL,

5-FU,

Piperlongumine induces ROS accumulation to reverse resistance of 5-FU in human colorectal cancer via targeting TrxR

in-vivo,

CRC,

HCT8

10uM

mice

ROS↑, TrxR↓, eff↑, p‑Akt↓,

2943-

PL,

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

in-vitro,

CRC,

HCT116

in-vitro,

Lung,

A549

in-vitro,

BC,

MCF-7

TrxR1?, TumCD↑, ROS↑, GSH↓, eff↑,

1996-

PTL,

Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells

in-vitro,

CRC,

COLO205

Apoptosis↑, GSH↓, ROS↑, Ca+2↑, GRP78/BiP↑, ER Stress↑, eff↓, eff↑, Thiols↓,

5041-

SAS,

Cisplatin,

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

in-vitro,

CRC,

xCT↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,

4470-

SeNPs,

Chit,

Synthesis and cytotoxic activities of selenium nanoparticles incorporated nano-chitosan

in-vitro,

CRC,

HCT116

in-vitro,

Liver,

HepG2

in-vitro,

BC,

MCF-7

Dose↝, AntiCan↑, eff↑,

1501-

SFN,

The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation

in-vitro,

CRC,

T24/HTB-9

2.5 µM vs >10uM

Dose↝, NRF2↑, GSH↓, eff↑,

1496-

SFN,

VitD3,

Association between histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human colorectal cancer cells

in-vitro,

CRC,

Caco-2

24 h to vitamin D (100 nmol L-1 ) either alone or in combination with SFN and trichostatin A (20 and 1 μmol L-1 , respectively)

eff↑, VDR↑, CYP11A1↓, HDAC↓,

5101-

SK,

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

vitro+vivo,

CRC,

SW-620

vitro+vivo,

CRC,

HCT116

Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,

6433-

T4O,

CET,

Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers

in-vitro,

Colon,

HT29

in-vitro,

CRC,

HCT116

in-vitro,

PC,

COLO357

Human,

Colon,

Male athymic nude mice, 6–8 weeks old

TumCG↓, eff↑, ChemoSen↑, Apoptosis↑, TumVol↓, TumW↓, *Inflam↓, *antiOx↓, BioAv↝,

5339-

TFdiG,

Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line

in-vitro,

CRC,

HCT116

eff↑, TumCCA↑, Inflam↓, COX2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,

3138-

VitC,

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

in-vitro,

RCC,

RCC4

in-vitro,

CRC,

HCT116

in-vitro,

BC,

MDA-MB-435

in-vitro,

Ovarian,

SKOV3

in-vitro,

Colon,

SW48

in-vitro,

GBM,

U251

eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,

Showing Research Papers: 1 to 50 of 51
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 51

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 2, CD8+↑, 1,
Total Targets: 169

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↓, 1, GSH↓, 1,

Cell Death ⓘ

JNK↑, 1,

Protein Folding & ER Stress ⓘ

CHOP↑, 1, cl‑eIF2α↑, 1, GRP78/BiP↑, 1, p‑PERK↑, 1,

Proliferation, Differentiation & Cell State ⓘ

TumCG∅, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,

Functional Outcomes ⓘ

toxicity↓, 1, toxicity↝, 1, toxicity∅, 1,

Infection & Microbiome ⓘ

AntiViral↑, 1,
Total Targets: 13

Scientific Paper Hit Count for: eff, efficacy

6 Silver-NanoParticles
5 5-fluorouracil
4 cetuximab
4 Vitamin C (Ascorbic Acid)
4 Artemisinin
3 Dichloroacetate
2 3-bromopyruvate
2 chitosan
2 EGCG (Epigallocatechin Gallate)
2 Piperlongumine
2 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Coenzyme Q10
1 Auranofin
1 Andrographis
1 Melatonin
1 5-Aminolevulinic acid
1 Ashwagandha(Withaferin A)
1 immunotherapy
1 Boswellia (frankincense)
1 Carnosic acid
1 Capsaicin
1 capecitabine
1 Curcumin
1 Silymarin (Milk Thistle) silibinin
1 salinomycin
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Echinacea
1 Eugenol
1 Beta-Caryophyllene
1 Honokiol
1 Magnolol
1 Baicalin
1 Kaempferol
1 Magnetic Field Rotating
1 Magnetic Fields
1 Phenylbutyrate
1 Propolis -bee glue
1 sericin
1 Phenethyl isothiocyanate
1 Parthenolide
1 Sulfasalazine
1 Cisplatin
1 Selenium NanoParticles
1 Vitamin D3
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:961  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

eff Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Cell Death ⓘ

Protein Folding & ER Stress ⓘ

Proliferation, Differentiation & Cell State ⓘ

Immune & Inflammatory Signaling ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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