Dose Cancer Research Results

Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,
5410- ASA,    Low-Dose Aspirin and the Prevention of Colorectal Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study
- Study, CRC, NA
Risk↓, Dose↝, Risk↓,
5404- ASA,    Low-Dose Aspirin and Prevention of Colorectal Cancer: Evidence From a Nationwide Registry-Based Cohort in Norway
- Study, CRC, NA
Risk↓, other↝, Dose↝, Risk↓, other↓, other↝, KRAS↓, other↓, other↓,
5406- ASA,    Adjuvant aspirin therapy and colorectal cancer survival
- Trial, CRC, NA
Dose↝, OS∅,
5407- ASA,    Low-dose aspirin reduces the risk of colorectal cancer recurrence in patients with resected PI3K-altered localised disease, according to the ALASCCA trial.
- Trial, CRC, NA
Dose↝, Risk↓,
6518- BCP,    beta-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116
angioG↓, VEGF↓, TumVol↓, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, TumCP↓, TumCMig↓, TumCG↓, Dose↝,
2734- BetA,    Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,
5917- Cats,    Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
- Trial, CRC, NA
Dose↝, *DNArepair↑, toxicity↝, BioAv↝, eff∅,
6615- Cen,    Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
Dose↝, TumCP↓, selectivity↑, MMP↓, Apoptosis↑, TumCCA↑, NF-kB↓, CDK4↓, cycD1/CCND1↓, Casp9↑, Casp3↑, Bax:Bcl2↑, TumCG↓, ChemoSen↑, TNF-α↓, IL1β↓, P53↑, P21↑,
5970- CET,    Cetuximab
- Review, CRC, NA - Review, HNSCC, NA
EGFR↓, OS↑, QoL↑, Dose↝,
5967- CET,    FDA grants accelerated approval to adagrasib with cetuximab for KRAS G12C-mutated colorectal cancer
- Study, CRC, NA
eff↑, Dose↝,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
7445- CYN,    Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
- vitro+vivo, CRC, RKO - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1
tumCV↓, STAT↓, LIFR/CD118↓, STAT3↓, STAT4↑, TumCG?, cl‑PARP1↑, Bcl-2↓, BAX↑, STAT3↓, Dose↝, TumVol↓, TumW↓, toxicity↓,
6745- DHA,    Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, eff↑, eff↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2↑, OXPHOS↓, ETC↓,
6391- Eug,  BCP,  5-FU,    Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
- in-vitro, CRC, HCT116
eff↑, ChemoSen↑, HSP90↓, Dose↝, TumAuto↑, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, JNK↓, p38↓, EMT↓,
6846- EVO,    Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116
TumCP↓, TumCI↓, TumCCA↑, PI3K↓, AKT1↓, P53↑, Bcl-2↓, BAX↑, Apoptosis↑, p‑Casp9↑, E-cadherin↑, N-cadherin↓, MMP9↓, CSCs↓, EGFR↓, PDGFRA↓, Dose↝, TumCG↓,
7014- Fuc,  5-FU,    Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
tumCV↓, ChemoSen↑, TumCCA↑, cl‑PARP↑, KRAS↓, p‑ERK↓, PI3K↓, p‑Akt↓, TumCMig↓, MMP2↓, Dose↝,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
7245- Gink,    Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116 - in-vitro, Nor, MCF10
STAT3↓, cycD1/CCND1↓, survivin↓, Bcl-2↓, Bcl-xL↓, TumCG↓, Dose↝, TumCCA↑, Apoptosis↑, TumVol↓, TumW↓,
7258- Gink,    Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116
STAT3↓, survivin↓, TumCCA↑, TumCG↓, Dose↝,
2505- H2,    Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
- Trial, CRC, NA
PGC-1α↑, Dose↝, CD8+↑, OS↑,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7461- HNK,    Honokiol: a potent chemotherapy candidate for human colorectal carcinoma
- vitro+vivo, CRC, RKO
Apoptosis↑, Casp↑, Dose↝, OS↑, *Inflam↓, *AntiThr↑, *antiOx↑, *Half-Life↝, TumCG↓,
7539- HT,    Polyphenols Extracts from Oil Production Waste Products (OPWPs) Reduce Cell Viability and Exert Anti-Inflammatory Activity via PPARγ Induction in Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo
tumCV↓, Apoptosis↑, TumCCA↑, p‑NF-kB↑, TNF-α↑, IL8↓, PPARγ↑, Inflam↓, Dose↝,
7540- HT,    Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT116
TrxR1↑, ROS↑, TumCP↓, Apoptosis↑, TumCCA↑, Dose↝, eff↓,
5599- NaHCO3,    Acidity generated by the tumor microenvironment drives local invasion
- in-vivo, BC, MDA-MB-231 - in-vitro, CRC, HCT116
e-pH↑, TumCG↓, TumCI↓, Dose↝,
1695- Se,    Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study
- Trial, CRC, NA
Risk↓, selm↑, Dose↓, antiOx↑, Dose↑, Dose↝,
4495- Se,    Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
- Study, CRC, NA
Risk↓, Dose↝,
4734- SeNPs,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,
4470- SeNPs,  Chit,    Synthesis and cytotoxic activities of selenium nanoparticles incorporated nano-chitosan
- in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7
Dose↝, AntiCan↑, eff↑,
1501- SFN,    The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
- in-vitro, CRC, T24/HTB-9
Dose↝, NRF2↑, GSH↓, eff↑,
2361- SK,    Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer
- in-vivo, CRC, NA
GutMicro↑, Dose↝, IL1β↓, IL6↓, TNF-α↓, PKM2↓,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,

Showing Research Papers: 1 to 34 of 34

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 34

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSP60/HSPD1↓, 1,   HTRA↓, 1,   LIFR/CD118↓, 1,   SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   GSH↓, 2,   lipid-P↑, 1,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↑, 5,   mt-ROS↑, 2,   Trx↓, 1,   TrxR1↑, 1,   xCT↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

selm↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ETC↓, 1,   MMP↓, 5,   mtDam↑, 2,   PGC-1α↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 1,   HK2↓, 1,   PKM2↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 12,   mt-Apoptosis↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   BID↑, 1,   Casp↑, 2,   Casp1↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 2,   Casp8↑, 2,   Casp9↑, 3,   p‑Casp9↑, 1,   Cyt‑c↑, 2,   Fas↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   JNK↓, 1,   p38↓, 1,   survivin↓, 3,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 3,   other↑, 1,   other↝, 2,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5⇅, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p‑Beclin-1↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 3,   PARP↓, 1,   cl‑PARP↑, 1,   cl‑PARP1↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   P21↑, 2,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   p‑ERK↓, 1,   FOXO3↑, 1,   mTOR↓, 1,   PDGFRA↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   STAT↓, 1,   STAT3↓, 4,   STAT4↑, 1,   TumCG?, 1,   TumCG↓, 13,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   KRAS↓, 2,   MMP2↓, 2,   MMP9↓, 2,   N-cadherin↓, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 2,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↑, 1,   IL1β↓, 2,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,   p‑NF-kB↑, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 5,   Dose↓, 1,   Dose↑, 2,   Dose↝, 34,   eff↓, 3,   eff↑, 7,   eff∅, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   GutMicro↑, 1,   IL6↓, 1,   KRAS↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   OS↑, 3,   OS∅, 1,   QoL↑, 1,   Risk↓, 7,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 134

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Cell Death(tgid=5) ⓘ

Casp1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 3,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   toxicity↓, 2,  
Total Targets: 12

Scientific Paper Hit Count for: Dose, Dosage
4 Aspirin
3 cetuximab
2 Beta-Caryophyllene
2 5-fluorouracil
2 Ginkgetin
2 HydroxyTyrosol
2 Selenium
2 Selenium NanoParticles
2 Shikonin
1 3-bromopyruvate
1 Betulinic acid
1 Cat’s Claw
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Cynaropicrin
1 Docosahexaenoic Acid
1 Dandelion Root
1 Eugenol
1 Evodiamine
1 Fucoidan
1 Geraniol
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Honokiol
1 Bicarbonate(Sodium)
1 irinotecan
1 chitosan
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:1114  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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