VEGF Cancer Research Results

VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
4426- AgNPs,    Antiangiogenic properties of silver nanoparticles
- Study, NA, NA
angioG↑, TumCG↓, TumCI↓, TumMeta↓, VEGF↓, PI3K↓, Akt↓,
4383- AgNPs,    Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies
- in-vitro, Lung, A549 - in-vivo, Lung, A549
Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, eff↑, CTR1↑,
366- AgNPs,    Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis
- in-vitro, BC, MCF-7
HIF-1↓, Hif1a↓, VEGF↓, GLUT1↓,
392- AgNPs,    VEGF_mediated_angiogenesis_in_prostate_cancer_cells">Biogenic silver nanoparticles synthesized from Piper longum fruit extract inhibit HIF-1α/VEGF mediated angiogenesis in prostate cancer cells
VEGF↓, HIF-1↓,
391- AgNPs,    Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells
- in-vitro, Nor, NA
*VEGF↓, *IL1↓, toxicity↝, other↝,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3455- ALA,    Alpha-lipoic acid inhibits proliferation and migration of human vascular endothelial cells through downregulating HSPA12B/VEGF signaling axis
- in-vitro, Nor, HUVECs
*cMyc↓, *VEGF↓, *eNOS↓, angioG↓,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1537- Api,    Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer
- Review, PC, NA
TumCP↓, TumCCA↑, Apoptosis↑, MMPs↓, Akt↓, *BioAv↑, *BioAv↓, Half-Life∅, Hif1a↓, GLUT1↓, VEGF↓, ChemoSen↑, ROS↑, Bcl-2↓, Bcl-xL↓, BAX↑, BIM↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2583- Api,  Rad,    The influence of apigenin on cellular responses to radiation: From protection to sensitization
- Review, Var, NA
radioP↑, RadioS↑, *COX2↓, *ROS↓, VEGF↓, MMP2↓, STAT3↓, AMPK↑, Apoptosis↑, MMP9↓, glucose↓,
2299- Api,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCP↓, angioG↓, Hif1a↓, VEGF↓, GLUT1↓, PKM2↓, Glycolysis↓,
958- Api,    Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1α expression in non-small cell lung carcinoma
- in-vitro, Lung, NCIH1299
Hif1a↓, VEGF↓, VEGFR2↓, PDGF↓, angioG↓,
176- Api,    Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells
- in-vitro, BC, BT474
cl‑Casp8↑, cl‑Casp3↑, p‑JAK1↓, p‑JAK2↓, p‑STAT3↓, P53↑, VEGF↓, Hif1a↓, MMP9↓, TumCG↓, TumCCA↑, cl‑PARP↑,
179- Api,    Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells
- in-vitro, BC, SkBr3
cl‑Casp8↑, cl‑Casp3↑, VEGF↓, TumCG↓, TumCCA↑, cl‑PARP↑, p‑STAT3↓, p‑JAK2↓,
180- Api,    Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells
- in-vitro, BC, MDA-MB-231
cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, BAX∅, Bcl-2∅, Bcl-xL∅, p‑STAT3↓, P53↑, P21↑, p‑JAK2↓, VEGF↓,
211- Api,    Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
- in-vivo, Pca, NA
IKKα↓, NF-kB↓, cycD1/CCND1↓, COX2↓, Bcl-2↓, Bcl-xL↓, VEGF↓, PCNA↓, BAX↑,
244- Api,    Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma
- in-vivo, Melanoma, B16-F10 - in-vivo, Melanoma, A375 - in-vivo, Melanoma, G361
STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, E-cadherin↑, N-cadherin↓, EMT↓,
238- Api,    Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
VEGF↓, TGF-β↓, Src↓, FAK↓, Akt↓, SMAD2↓, SMAD3↓,
419- Api,    Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line
- in-vitro, SCC, HN30 - in-vitro, SCC, HN8
CD44↓, Nanog↓, Endoglin↓, VEGF↓, CSCs↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
1147- ART/DHA,    Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1
- vitro+vivo, Ovarian, HO-8910 - vitro+vivo, Nor, HUVECs
angioG↓, TumCG↓, VEGF↓, KDR/FLK-1↓, *toxicity↓,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
564- ART/DHA,  Cisplatin,    Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling
- in-vitro, NA, HN30
JAK2↓, STAT3↓, MMP2↓, MMP9↓, Mcl-1↓, Bcl-xL↓, cycD1/CCND1↓, VEGF↓, TumCCA↑, ChemoSen↑,
2323- ART/DHA,    Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706
PKM2↓, lactateProd↓, GlucoseCon↓, cycD1/CCND1↓, Bcl-2↓, MMP2↓, VEGF↓, Casp3↑, cl‑PARP↑, BAX↑, DNAdam↑, ROS↑,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
1178- Ash,    Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription factor
- in-vitro, Nor, HUVECs - in-vivo, NA, NA
*VEGF↓, *angioG↓, *ascitic↓, *Sp1/3/4↓,
1146- AsP,    Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms
- in-vivo, Nor, NA
TumCCA↑, Apoptosis↑, IL6↓, STAT3↓, angioG↓, TumMeta↓, VEGF↓, MMP9↓, SOD↑, Catalase↑, GSH↓, MDA↓, NO↓, *BioAv↑,
4816- ASTX,    Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells
- in-vitro, Pca, NA
*antiOx↑, *Inflam↓, ChemoSen↑, E-cadherin↑, N-cadherin↓, VEGF↓, cMyc↓, PSA↓, cl‑Casp3↑, PARP1↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
5499- Ba,    Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, A549
TumCP↓, Apoptosis↑, F-actin↓, TumVol↓, OS↑, 12LOX↓, VEGF↓, angioG↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp↓, BioAv↑, selectivity↑,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
2298- Ba,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCG↓, TumCP↓, Hif1a↓, VEGF↓, ChemoSen↑, Glycolysis↓, HK2↓, PDK1↓, LDHA↓, p‑Akt↓, PTEN↑,

Showing Research Papers: 1 to 50 of 299
Page 1 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 299

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   Catalase↑, 1,   Copper↑, 1,   Ferroptosis↑, 3,   GPx4↓, 3,   GSH↓, 4,   GSR↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↑, 2,   MDA↓, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 2,   p‑NRF2↓, 1,   ROS↑, 18,   ROS⇅, 2,   i-ROS↑, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 1,   TrxR↓, 2,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   AIF↑, 1,   ATP↓, 2,   BCR-ABL↓, 1,   CDC2↓, 1,   CDC25↓, 1,   mitResp↓, 1,   MMP↓, 8,   Mortalin↓, 1,   MPT↑, 1,   Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 2,   AMPK↑, 2,   p‑AMPK↑, 1,   cMyc↓, 9,   FASN↓, 2,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 6,   HK2↓, 2,   lactateProd↓, 2,   LDHA↓, 3,   NADPH↓, 1,   NADPH↑, 2,   PDK1↓, 2,   PKM2↓, 4,   PPARγ↓, 1,   PPARγ↑, 3,   p‑S6↓, 1,   SIRT1↓, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 14,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 13,   ASK1↑, 1,   BAX↑, 11,   BAX∅, 1,   Bax:Bcl2↑, 4,   Bcl-2↓, 14,   Bcl-2∅, 1,   Bcl-xL↓, 6,   Bcl-xL∅, 1,   BIM↑, 1,   Casp↑, 2,   Casp12↑, 2,   Casp3↓, 1,   Casp3↑, 12,   cl‑Casp3↑, 7,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 3,   cl‑Casp8↑, 4,   Casp9↑, 9,   cl‑Casp9↑, 2,   Chk2↓, 1,   p‑Chk2↑, 1,   CK2↓, 3,   Cyt‑c↑, 11,   DR5↑, 3,   FADD↑, 1,   Fas↑, 3,   Ferroptosis↑, 3,   HEY1↓, 1,   cl‑IAP2↑, 1,   iNOS↓, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↑, 1,   Mcl-1↓, 3,   MDM2↓, 1,   oncosis↑, 1,   p27↑, 4,   p38↓, 1,   p38↑, 4,   survivin↓, 4,   Telomerase↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

H3↑, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   ER Stress↓, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   BNIP3↑, 1,   LC3A↑, 1,   LC3II↑, 1,   p62↓, 2,   TumAuto↑, 6,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   DNAdam↑, 6,   m-FAM72A↓, 1,   HR↓, 1,   p16↑, 2,   P53↓, 2,   P53↑, 10,   PARP↑, 2,   cl‑PARP↑, 10,   PARP1↑, 1,   PCNA↓, 3,   RAD51↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 4,   CDK2↓, 4,   CDK4↓, 9,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 9,   CycD3↓, 1,   cycE/CCNE↓, 3,   cycE/CCNE↑, 2,   cycE1↓, 1,   E2Fs↓, 1,   P21↑, 8,   p‑RB1↓, 1,   TumCCA↑, 22,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 2,   cMET↓, 1,   cMYB↓, 1,   CSCs↓, 8,   EMT↓, 7,   ERK↓, 4,   p‑ERK↓, 2,   FOXO3↑, 2,   Gli↓, 1,   Gli1↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC3↓, 1,   HH↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   mTOR↓, 6,   p‑mTOR↓, 3,   Nanog↓, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 8,   PTEN↑, 4,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 1,   Src↓, 1,   STAT3↓, 12,   p‑STAT3↓, 4,   TOP2↓, 2,   TumCG↓, 8,   Wnt↓, 3,   Wnt/(β-catenin)↓, 3,  

Migration ⓘ

annexin II↓, 1,   AntiAg↑, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 6,   CAFs/TAFs↓, 2,   cal2↑, 1,   Cdc42↑, 1,   CDK4/6↓, 1,   E-cadherin↑, 9,   ER-α36↓, 1,   F-actin↓, 1,   FAK↓, 3,   p‑FAK↓, 1,   ITGB1↑, 1,   ITGB4↓, 1,   Ki-67↓, 1,   miR-133a-3p↑, 1,   MMP2↓, 16,   MMP7↓, 1,   MMP9↓, 17,   MMPs↓, 5,   N-cadherin↓, 5,   NCAM↑, 1,   PDGF↓, 2,   PKCδ↓, 1,   ROCK1↓, 2,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 3,   TGF-β↓, 3,   TIMP1↓, 1,   TIMP2↓, 1,   TIMP2↑, 2,   TumCI↓, 9,   TumCMig↓, 6,   TumCP↓, 12,   TumMeta↓, 7,   Twist↓, 5,   uPA↓, 7,   Vim↓, 7,   Zeb1↓, 1,   ZEB2↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature ⓘ

angioG↓, 16,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 4,   Endoglin↓, 1,   HIF-1↓, 3,   Hif1a↓, 21,   KDR/FLK-1↓, 2,   NO↓, 3,   PDGFR-BB↓, 1,   VEGF↓, 46,   VEGFR2↓, 4,  

Barriers & Transport ⓘ

CTR1↑, 1,   GLUT1↓, 6,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 8,   CRP↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 2,   IL1↓, 2,   IL1α↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 8,   IL8↓, 5,   Imm↑, 2,   Inflam↓, 2,   p‑JAK1↓, 1,   JAK2↓, 2,   p‑JAK2↓, 3,   M2 MC↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 15,   NK cell↑, 1,   PD-L1↓, 2,   PGE2↓, 2,   PSA↓, 2,   TNF-α↓, 5,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 1,   BioEnh↑, 3,   ChemoSen↑, 13,   Dose∅, 1,   eff↓, 2,   eff↑, 24,   eff↝, 3,   Half-Life↓, 2,   Half-Life∅, 1,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

AR↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 4,   Ferritin↓, 1,   HER2/EBBR2↓, 2,   IL6↓, 8,   Ki-67↓, 1,   PD-L1↓, 2,   PSA↓, 2,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 3,   AntiTum↑, 3,   chemoP↑, 2,   chemoPv↑, 2,   OS↑, 2,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 2,  
Total Targets: 323

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 7,   Catalase↑, 2,   Ferroptosis↓, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   Keap1↓, 1,   lipid-P↓, 3,   MDA↓, 2,   MPO↓, 2,   NRF2↑, 3,   Prx↑, 1,   ROS↓, 6,   SOD↑, 2,   SOD2↑, 1,   TBARS↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 3,   p‑AMPK↑, 1,   cMyc↓, 1,   H2S↑, 1,   LDH↓, 2,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↓, 1,   BAX↓, 1,   Casp3?, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 3,   MAPK↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 2,  

Migration ⓘ

5LO↓, 1,   PKCδ↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   NO↓, 3,   VEGF↓, 5,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   IL1↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 7,   NF-kB↓, 3,   PGE2↓, 2,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   ascitic↓, 1,   AST↓, 3,   BP↓, 1,   creat↓, 1,   GutMicro↑, 2,   IL6↓, 2,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 2,   hepatoP↑, 4,   memory↑, 1,   neuroP↑, 4,   RenoP↑, 1,   toxicity↓, 3,   Wound Healing↑, 1,  
Total Targets: 79

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
15 Apigenin (mainly Parsley)
14 Thymoquinone
12 EGCG (Epigallocatechin Gallate)
11 Betulinic acid
11 Sulforaphane (mainly Broccoli)
10 Quercetin
9 Resveratrol
8 Baicalein
8 Propolis -bee glue
8 Curcumin
7 Artemisinin
7 Berberine
7 Boswellia (frankincense)
7 Chrysin
7 Fisetin
7 Silymarin (Milk Thistle) silibinin
6 Silver-NanoParticles
5 Radiotherapy/Radiation
5 Chlorogenic acid
5 Ellagic acid
5 Garcinol
5 Honokiol
4 Ashwagandha(Withaferin A)
4 Caffeic acid
4 Deguelin
4 Luteolin
4 Phenethyl isothiocyanate
3 Cisplatin
3 Bevacizumab (brand Avastin)
3 Capsaicin
3 Carvacrol
3 Cinnamon
3 Emodin
3 Juglone
3 Lycopene
3 Magnolol
3 Melatonin
3 Magnetic Fields
3 Piperine
3 Selenite (Sodium)
2 Biochanin A
2 Chemotherapy
2 Boron
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 Fucoidan
2 Ferulic acid
2 Gambogic Acid
2 Ginger/6-Shogaol/Gingerol
2 Proanthocyanidins
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Methylsulfonylmethane
2 Naringin
2 Phenylbutyrate
2 Piperlongumine
2 Rosmarinic acid
2 Shikonin
2 Vitamin C (Ascorbic Acid)
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Andrographis
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Berbamine
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 chitosan
1 Coenzyme Q10
1 Vitamin E
1 Docetaxel
1 Gallic acid
1 Paclitaxel
1 Genistein (soy isoflavone)
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 itraconazole
1 mebendazole
1 metronomic chemo
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Niclosamide (Niclocide)
1 Oleuropein
1 Plumbagin
1 VitK3,menadione
1 Psoralidin
1 Pterostilbene
1 Kaempferol
1 salinomycin
1 Sanguinarine
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Theobromine
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Urolithin
1 Vitamin D3
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:334  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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