Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱

Source:

Type: type of cell death

Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.

Scientific Papers found: Click to Expand⟱

2327-

2DG,

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

-

Review,

Var,

NA

Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,

2432-

2DG,

Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth

-

in-vitro,

Lung,

H23

-

in-vitro,

Lung,

KP2

-

in-vivo,

NA,

NA

HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,

5263-

3BP,

CET,

3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis

-

in-vitro,

CRC,

DLD1

-

NA,

NA,

HCT116

eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,

5269-

3BP,

The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.

-

in-vitro,

HCC,

NA

toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,

5265-

3BP,

KAT/3BP: A Metabolism-Targeting Agent with Single and Combination Activity in Aggressive B-Cell Lymphomas

-

Review,

lymphoma,

NA

Glycolysis↓, HK2↓, AIF↓, Apoptosis↑, NK cell↑,

5266-

3BP,

3-bromopyruvate-based agent KAT-101

-

Review,

Var,

NA

eff↑, Glycolysis↓, OXPHOS↓, ATP↓, TumCP↓, Apoptosis↑, HK2↓, MPT↑, LDH↓, PDH↓,

5270-

5-ALA,

PDT,

5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy

-

Review,

Var,

NA

other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,

3453-

5-ALA,

The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis

-

in-vitro,

Lung,

A549

OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,

4774-

5-FU,

TQ,

CoQ10,

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation

-

in-vitro,

CRC,

NA

AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,

5459-

AF,

Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells

-

in-vitro,

Ovarian,

NA

ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,

5463-

AF,

Will Auranofin Become a Golden New Treatment Against COVID-19?

-

Review,

Covid,

NA

IL6↓, NF-kB↓, ATF2↓, TrxR↓, ROS↑, Apoptosis↑, IL6↓, Dose↑,

5462-

AF,

Repurposing Auranofin for Oncology and Beyond: A Brief Overview of Clinical Trials as Mono- and Combination Therapy

-

Review,

Var,

NA

AntiTum↑, Bacteria↓, TrxR↓, ChemoSen↑, Dose↝, ROS↑, Apoptosis↑, mTOR↓,

5460-

AF,

Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

-

vitro+vivo,

Var,

4T1

RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,

5472-

AF,

Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion

-

in-vitro,

Cerv,

HeLa

TrxR↓, AntiCan↑, TumCG↓, Apoptosis↑, necrosis↑, cl‑PARP↑, MMP↓, ROS↑, GSH↓, eff↓,

5468-

AF,

The gold complex auranofin: new perspectives for cancer therapy

-

Review,

Var,

NA

TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,

1334-

AG,

Astragalus membranaceus: A Review of Its Antitumor Effects on Non-Small Cell Lung Cancer

-

Review,

NA,

NA

TumCP↓, Apoptosis↑, NF-kB↓, p50↓, cycD1/CCND1↓, Bcl-xL↓, ChemoSen↑, angioG↓, ChemoSen↑,

1338-

AG,

The Modulatory Properties of Astragalus membranaceus Treatment on Triple-Negative Breast Cancer: An Integrated Pharmacological Method

-

in-vitro,

BC,

NA

TumCI↓, Apoptosis↑, Symptoms↓, PIK3CA↓, Akt↓, Bcl-2↓,

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

1000-

AG,

5-FU,

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

-

vitro+vivo,

BC,

4T1

TumCG↓, TumCCA↑, Apoptosis↑, *IL2↑, *TNF-α↑, *IFN-γ↑,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5434-

AG,

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview

-

Review,

Liver,

NA

AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,

5239-

AgNPs,

NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells

-

in-vitro,

Nor,

HUVECs

*ROS↑, *Apoptosis↑, *NRF2↝,

4403-

AgNPs,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

-

in-vitro,

GBM,

U251

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

GL26

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

CRC,

RKO

AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

4398-

AgNPs,

Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier

-

in-vitro,

Colon,

HT29

0.33 μg mL(-1)

Apoptosis↑, MMP↓, Casp3↑, ROS↑, eff↑,

4394-

AgNPs,

Silver nanoparticles provoke apoptosis of Dalton's ascites lymphoma in vivo by mitochondria dependent and independent pathways

-

in-vivo,

lymphoma,

NA

OS↑, TumVol↓, Weight↑, AntiTum↑, Apoptosis↑, mtDam↑,

4391-

AgNPs,

Silver Nanoparticles Induce Apoptosis in HepG2 Cells through Particle-Specific Effects on Mitochondria

-

NA,

Liver,

HepG2

Apoptosis↑,

4388-

AgNPs,

Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells

-

in-vitro,

Cerv,

NA

47.5 nm

tumCV↓, CSCs↓, selectivity↑, Apoptosis↑, ROS↑, LDH↓, Casp3↑, BAX↑, Bak↑, cMyc↑, MMP↓,

4414-

AgNPs,

Silver nanoparticles: Forging a new frontline in lung cancer therapy

-

Review,

Lung,

NA

tumCV↑, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, angioG↓,

4417-

AgNPs,

Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways

-

in-vitro,

BC,

MDA-MB-231

ROS↑, MDA↑, COX2↑, IL1β↑, TNF-α↑, GSH↓, Cyt‑c↑, Casp3↑, BAX↑, Bcl-2↓, LDH↓, cycD1/CCND1↓, CDK2↓, TumCCA↑, mt-Apoptosis↑,

4416-

AgNPs,

Efficacy of curcumin-synthesized silver nanoparticles on MCF-7 breast cancer cells

-

in-vitro,

BC,

MCF-7

TumCMig↓, Apoptosis↑, BAX↑, P53↑, Bcl-2↓,

4411-

AgNPs,

Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities

-

in-vitro,

Lung,

A549

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

PC3

-

in-vitro,

Nor,

HEK293

AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,

4406-

AgNPs,

Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway

-

in-vitro,

BC,

MCF-7

63.1 ± 8.3 nm

tissues from 64 patients

-

in-vitro,

BC,

T47D

-

in-vitro,

BC,

MDA-MB-231

TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,

4405-

AgNPs,

Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis

-

in-vitro,

OS,

NA

Apoptosis↑, other↑, ROS↑, eff↑, P53↝, Apoptosis↑, cl‑Casp3↑, survivin↓, MMP↓, Cyt‑c↑,

4428-

AgNPs,

p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells

-

in-vitro,

AML,

Jurkat

toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,

4432-

AgNPs,

Emerging nanostructure-based strategies for breast cancer therapy: innovations, challenges, and future directions

-

Review,

NA,

NA

ROS↑, TumCP↓, Apoptosis↑,

4435-

AgNPs,

Gluc,

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

-

in-vitro,

Pca,

PC3

average size of 61nm

911ug/mL

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

DU145

1579ug/mL

selectivity↑, ROS↑, mtDam↑, TumCCA↑, TumCP↓, Apoptosis↑, MMP↓,

4436-

AgNPs,

Silver Nanoparticles (AgNPs) as Enhancers of Everolimus and Radiotherapy Sensitivity on Clear Cell Renal Cell Carcinoma

-

in-vitro,

Kidney,

786-O

61 ± 10 nm

AgNP doses ranging from 500 to 3000 µg/mL for 24 h

ROS↑, MMP↑, TumCCA↑, TumCP↓, Apoptosis↑, RadioS↑,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

-

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

4439-

AgNPs,

Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA)

-

in-vitro,

Cerv,

HeLa

33 nm

ROS↑, lipid-P↑, MMP↓, GSH↓, TumCCA↑, Apoptosis↑, Necroptosis↑, TumCD↑, Dose↝,

4377-

AgNPs,

Interaction between silver nanoparticles of 20 nm (AgNP20 ) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates

-

in-vitro,

NA,

NA

human neutrophils (white blood cell) ie transportation

eff↑, Apoptosis↑,

4375-

AgNPs,

The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells

-

in-vitro,

AML,

K562

eff↑, ROS↑, Apoptosis↑, eff↓,

4371-

AgNPs,

Effects of Green Silver Nanoparticles on Apoptosis and Oxidative Stress in Normal and Cancerous Human Hepatic Cells in vitro

-

in-vitro,

Liver,

HUH7

20−50 nm

eco-friendly approach silver nanoparticles (AgNPs) using root extracts of Beta vulgaris L.

ROS↑, selectivity↑, DNAdam↑, Apoptosis↑, GSH↓, lipid-P↑, MMP↓, DNAdam↑,

4370-

AgNPs,

Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line

-

in-vitro,

Liver,

HepG2

 30.71 nm

75 μg/mL

tumCV↓, ROS↑, Apoptosis↑,

4383-

AgNPs,

Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies

-

in-vitro,

Lung,

A549

AgNPs was 23.45 nm, with zeta potentials lying on −20.33 mV.

-

in-vivo,

Lung,

A549

A549 and A549/DDP-bearing mice

Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, eff↑, CTR1↑,

4552-

AgNPs,

ART/DHA,

Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS)

-

in-vitro,

GC,

AGS

AntiCan↑, Apoptosis↑, eff↑,

4564-

AgNPs,

GoldNP,

Cu,

Chemo,

PDT

Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review

-

Review,

Var,

NA

ROS↑, DNAdam↑, TumCCA↑, eff↑, Apoptosis↑, eff↓, ChemoSen↑,

4563-

AgNPs,

Rad,

Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study

-

in-vitro,

BC,

MCF-7

-

in-vitro,

Ovarian,

SKOV3

-

in-vitro,

GBM,

U87MG

-

in-vitro,

Melanoma,

A431

RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,

4561-

AgNPs,

VitC,

Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Nor,

HEK293

NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,

4559-

AgNPs,

Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation

-

in-vitro,

BC,

SkBr3

IC50 value of 5 μg/ml

-

in-vitro,

CRC,

HT-29

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Colon,

Caco-2

MMP2↓, MMP9↓, ROS↑, TumAuto↑, Apoptosis↑, ER Stress↑,

4555-

AgNPs,

Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Liver,

HepG2

*Bacteria↓, tumCV↓, selectivity↑, ROS↑, Apoptosis↑, TumCMig↓, AntiCan↑,

Showing Research Papers: 1 to 50 of 1104
Page 1 of 23 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1104

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

antiOx↓, 1, Catalase↑, 1, Ferroptosis↓, 1, Ferroptosis↑, 1, GPx4↓, 2, GSH↓, 8, HO-1↑, 1, c-Iron↑, 1, lipid-P↑, 4, MDA↑, 2, NRF2↓, 1, NRF2↑, 1, OXPHOS↓, 1, OXPHOS↑, 1, ROS↑, 31, mt-ROS↑, 1, SOD2↑, 1, TrxR↓, 6, xCT↓, 1, xCT↑, 1,

Mitochondria & Bioenergetics ⓘ

AIF↓, 1, AIF↑, 2, ATP↓, 4, ETC↓, 1, MMP↓, 13, MMP↑, 1, MPT↑, 1, mtDam↑, 3, OCR↑, 1, mt-OCR↓, 1,

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1, AMPK↑, 2, cMyc↑, 1, Glycolysis↓, 5, HK2↓, 6, LDH↓, 3, LDHA↓, 1, NADPH↓, 1, PDH↓, 1, PDH↑, 1, PIK3CA↓, 1, PPP↓, 1, SIRT1↓, 1, SREBP1↓, 1, Warburg↓, 1,

Cell Death ⓘ

Akt↓, 5, Apoptosis↑, 50, mt-Apoptosis↑, 1, ATF2↓, 1, Bak↑, 1, BAX↑, 8, Bax:Bcl2↑, 2, Bcl-2↓, 7, Bcl-2↑, 1, Bcl-xL↓, 1, Casp↑, 2, Casp3↑, 10, cl‑Casp3↑, 1, Casp7↑, 1, Casp9↑, 3, Cyt‑c↑, 4, Fas↑, 1, Ferroptosis↓, 1, Ferroptosis↑, 1, JNK↓, 1, Necroptosis↑, 1, necrosis↑, 1, p27↑, 1, p38↑, 1, survivin↓, 2, TumCD↑, 2,

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

other↓, 1, other↑, 1, other↝, 5, tumCV↓, 7, tumCV↑, 1,

Protein Folding & ER Stress ⓘ

ER Stress↑, 3, UPR↑, 1,

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1, p‑Beclin-1↑, 1, TumAuto↑, 5,

DNA Damage & Repair ⓘ

DNAdam↑, 11, P53↓, 1, P53↑, 3, P53↝, 1, cl‑PARP↑, 2, γH2AX↑, 1,

Cell Cycle & Senescence ⓘ

CDK2↓, 1, cycD1/CCND1↓, 3, P21↑, 2, TumCCA↑, 17,

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1, CD44↓, 1, CSCs↓, 3, EMT↓, 2, FOXO3↑, 1, GSK‐3β↓, 1, mTOR↓, 5, NOTCH1↓, 2, NOTCH3↓, 1, PI3K↓, 4, PTEN↑, 1, TumCG↓, 7, Wnt↓, 2,

Migration ⓘ

Ca+2↑, 1, miR-133a-3p↑, 1, MMP2↓, 1, MMP9↓, 2, SOX4↓, 1, TumCI↓, 2, TumCMig↓, 2, TumCP↓, 8, TumMeta↓, 1, Vim↓, 2, β-catenin/ZEB1↓, 2,

Angiogenesis & Vasculature ⓘ

angioG↓, 3, EGFR↓, 1, EPR↑, 2, Hif1a↓, 3, VEGF↓, 3,

Barriers & Transport ⓘ

CTR1↑, 1, P-gp↓, 2,

Immune & Inflammatory Signaling ⓘ

COX2↑, 1, CXCR4↓, 1, IL12↑, 1, IL1β↑, 1, IL2↑, 1, IL6↓, 2, Imm↑, 3, NF-kB↓, 4, NF-kB↝, 1, NK cell↑, 2, p50↓, 1, PD-L1↓, 1, TNF-α↑, 2,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, ChemoSen↑, 10, Dose↑, 1, Dose↝, 5, eff↓, 9, eff↑, 25, eff↝, 2, Half-Life↓, 1, MDR1↓, 1, RadioS↑, 4, selectivity↑, 8,

Clinical Biomarkers ⓘ

EGFR↓, 1, IL6↓, 2, LDH↓, 3, PD-L1↓, 1,

Functional Outcomes ⓘ

AntiCan↑, 9, AntiTum↑, 6, chemoP↑, 1, OS↑, 1, QoL↑, 2, Symptoms↓, 1, toxicity↓, 2, toxicity↑, 2, toxicity↝, 1, TumVol↓, 2, TumW↓, 1, Weight↑, 1,

Infection & Microbiome ⓘ

Bacteria↓, 2,
Total Targets: 164

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

NRF2↝, 1, ROS↑, 1,

Cell Death ⓘ

Apoptosis↑, 1, JNK↑, 1,

Protein Folding & ER Stress ⓘ

CHOP↑, 1, cl‑eIF2α↑, 1, GRP78/BiP↑, 1, p‑PERK↑, 1,

Immune & Inflammatory Signaling ⓘ

IFN-γ↑, 1, IL2↑, 1, TNF-α↑, 1,

Functional Outcomes ⓘ

toxicity↓, 1, toxicity↝, 1,

Infection & Microbiome ⓘ

AntiViral↑, 1, Bacteria↓, 1,
Total Targets: 15

Scientific Paper Hit Count for: Apoptosis, Apoptosis

66 Silver-NanoParticles
59 Curcumin
37 Magnetic Fields
35 Quercetin
31 Berberine
31 Sulforaphane (mainly Broccoli)
30 Thymoquinone
27 Baicalein
26 EGCG (Epigallocatechin Gallate)
24 Capsaicin
22 Phenethyl isothiocyanate
22 Shikonin
21 Ashwagandha(Withaferin A)
20 Betulinic acid
19 Resveratrol
19 Selenite (Sodium)
18 Artemisinin
18 Radiotherapy/Radiation
18 Apigenin (mainly Parsley)
17 Boron
17 Garcinol
16 Honokiol
14 Chemotherapy
14 chitosan
13 Magnolol
13 Lycopene
12 Astaxanthin
12 salinomycin
12 Graviola
12 Luteolin
12 Urolithin
11 Cisplatin
11 Carvacrol
11 Chrysin
11 Gambogic Acid
10 Allicin (mainly Garlic)
10 Piperlongumine
10 Selenium NanoParticles
9 Vitamin C (Ascorbic Acid)
9 Metformin
9 Propolis -bee glue
9 Chlorogenic acid
9 Silymarin (Milk Thistle) silibinin
9 Juglone
8 Photodynamic Therapy
8 Alpha-Lipoic-Acid
8 Bufalin/Huachansu
8 Selenium
8 Dichloroacetate
8 Fisetin
8 Magnetic Field Rotating
8 Nimbolide
8 Phenylbutyrate
8 Rosmarinic acid
7 5-fluorouracil
7 Auranofin
7 Copper and Cu NanoParticles
7 Gemcitabine (Gemzar)
7 Paclitaxel
7 Atorvastatin
7 Biochanin A
7 Boswellia (frankincense)
7 Electrical Pulses
7 Emodin
7 HydroxyTyrosol
7 Ursolic acid
6 Coenzyme Q10
6 Astragalus
6 Andrographis
6 borneol
6 Caffeic acid
6 Carnosic acid
6 Citric Acid
6 Ellagic acid
6 Piperine
5 immunotherapy
5 doxorubicin
5 Thymol-Thymus vulgaris
5 Celecoxib
5 Celastrol
5 Aflavin-3,3′-digallate
5 Genistein (soy isoflavone)
5 Plumbagin
5 Pterostilbene
5 Vitamin K2
4 3-bromopyruvate
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Melatonin
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Chlorophyllin
4 Disulfiram
4 Ferulic acid
4 Parthenolide
4 Spermidine
3 2-DeoxyGlucose
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Cat’s Claw
3 Cannabidiol
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Ginkgo biloba
3 γ-linolenic acid (Borage Oil)
3 Hyperthermia
3 Magnesium
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 VitK3,menadione
3 Zerumbone
2 5-Aminolevulinic acid
2 Fenbendazole
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 Sorafenib (brand name Nexavar)
2 Dipyridamole
2 Aloe anthraquinones
2 beta-glucans
2 tamoxifen
2 Docetaxel
2 Bortezomib
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Chocolate
2 irinotecan
2 Deguelin
2 Folic Acid, Vit B9
2 Fucoidan
2 Shilajit/Fulvic Acid
2 Galloflavin
2 Methylglyoxal
2 Naringin
2 Oleuropein
2 Oleocanthal
2 Orlistat
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Rutin
2 polyethylene glycol
2 Vitamin D3
1 cetuximab
1 Glucose
1 entinostat
1 Trichostatin A
1 temozolomide
1 Aspirin -acetylsalicylic acid
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Cinnamon
1 Vitamin E
1 Camptothecin
1 methylseleninic acid
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 diet Short Term Fasting
1 Evodiamine
1 Gallic acid
1 carboplatin
1 gefitinib, erlotinib
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Rapamycin
1 Indole-3-carbinol
1 Inoscavin A
1 Ivermectin
1 Licorice
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Proanthocyanidins
1 isoflavones
1 Vorinostat
1 Oxaliplatin
1 Sulfasalazine
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

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