NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.


Scientific Papers found: Click to Expand⟱
5147- AgNPs,    Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,
356- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF-7 - in-vitro, Bladder, HTB-22
Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, eff↑, Catalase↑, other↑,
402- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF-7
P53↑, iNOS↑, NF-kB↑, Bcl-2↓, miR-125b↓, ROS↑, SOD↑,
5340- Ajoene,    Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB
- in-vitro, AML, NA
Apoptosis↑, selectivity↑, H2O2↑, NF-kB↑,
252- Ajoene,    Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB
- in-vitro, AML, HL-60
H2O2↑, NF-kB↑, ROS↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
298- ALA,  Rad,    Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1
- in-vitro, BC, MDA-MB-231
Apoptosis↑, P53↑, p38↑, NF-kB↑, TumCCA↑,
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, E-cadherin↓, Snail↑, Twist↑, ZEB2↑, FAK↑, NF-kB↑, MMP2↓, MMP9↓, *EMT↑, TumCI↑,
3385- ART/DHA,    Interaction of artemisinin protects the activity of antioxidant enzyme catalase: A biophysical study
- Study, NA, NA
*NF-kB↑, *Catalase↑,
874- B-Gluc,    Potential promising anticancer applications of β-glucans: a review
- Review, NA, NA
AntiCan↑, TumCG↓, BAX↑, Bcl-2↓, IFN-γ↑, PI3K/Akt↑, MAPK↑, NFAT↑, NF-kB↑, ROS↑, NK cell↑, TumCCA↑, ERK↓, Telomerase↓,
5505- Ba,    Baicalein inhibits the progression of thyroid cancer by suppressing the TPL2/MEK2/ERK2 pathway
- in-vitro, Thyroid, NA
ERK↓, PI3K↓, Akt↓, Apoptosis↑, TumAuto↑, NF-kB↑, MEK↓,
5551- BBM,    Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis
- vitro+vivo, Bladder, NA
tumCV↓, TumCP↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, EMT↓, TumMeta↓, p65↓, p‑p65↓, IKKα↓, NF-kB↑, ROS↑, NRF2↓, HO-1↓, SOD2↓, GPx1↓, Bax:Bcl2↑, TumVol↓,
5582- BetA,    Targeting mitochondrial apoptosis by betulinic acid in human cancers
- Review, Var, NA
Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,
2722- BetA,    Betulinic Acid for Cancer Treatment and Prevention
- Review, Var, NA
MMP↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, ROS↑, NF-kB↑, TOP1↓,
2728- BetA,    Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy
- in-vitro, Var, NA
NF-kB↑, IKKα↑, eff↓,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP↑, *toxicity↓,
2752- BetA,    Betulinic acid: a natural product with anticancer activity
- Review, Var, NA
selectivity↑, ChemoSen↑, RadioS↑, MMP↓, cl‑Casp3↑, Cyt‑c↑, ROS↑, NF-kB↑, TOP1↓,
5650- BNL,    Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model
- in-vivo, Nor, NA
*P-gp↓, *NF-kB↑, *eff↓, *Dose↝,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5959- CEL,    Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-κB as a possible target
- in-vitro, Cerv, HeLa
Apoptosis↑, Casp8↑, Casp9↑, cl‑BID↑, MMP↓, NF-kB↑, Dose⇅, chemoPv⇅, COX2↓,
5986- Chit,    The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells
- Study, Var, NA
NK cell↑, IFN-γ↑, IL12↑, IL15↑, STAT4↑, NF-kB↑, DCells↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
1085- DHA,  EPA,    DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells
- in-vitro, Nor, HUVECs
*COX2↓, *NF-kB↓, *PGE2↓, *IL6↓, *NF-kB↑,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
3236- EGCG,  Buty,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
2082- HNK,    Revealing the role of honokiol in human glioma cells by RNA-seq analysis
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
4785- Lyco,    The Protective Anticancer Effect of Natural Lycopene Supercritical CO2 Watermelon Extracts in Adenocarcinoma Lung Cancer Cells
- in-vitro, Lung, A549
ROS↑, NF-kB↑, Apoptosis↑,
1780- MEL,    Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing
- Review, Var, NA
*antiOx↑, *toxicity↓, ChemoSen↑, *eff↑, *mitResp↑, *ATP↑, *ROS↓, *CardioT↓, *GSH↑, *NOS2↓, *lipid-P↓, eff↑, *HO-1↑, *NRF2↑, *NF-kB↑, TumCP↓, eff↑, neuroP↑,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
2987- RES,    Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1
- in-vivo, Nor, NA
*VEGF↑, *iNOS↑, *NF-kB↑, *Sp1/3/4↑, *cardioP↑,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
2093- TQ,    Regulation of NF-κB Expression by Thymoquinone; A Role in Regulating Pro-Inflammatory Cytokines and Programmed Cell Death in Hepatic Cancer Cells
- in-vitro, Liver, HepG2 - in-vitro, Nor, NA
TumCD↑, selectivity↑, Casp3↑, DLC1↑, NF-kB↑, LDH↑, *toxicity↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3113- VitC,    Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
- in-vitro, Nor, NA
TET2↑, NF-kB↑,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,

Showing Research Papers: 1 to 40 of 40

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 40

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

antiOx↑, 2,   Catalase↑, 1,   Ferroptosis↑, 2,   GPx1↓, 1,   GPx4↑, 1,   GSH↓, 1,   H2O2↑, 3,   HO-1↓, 2,   Iron↑, 1,   Keap1↓, 1,   lipid-P↑, 1,   NRF2↓, 2,   NRF2↑, 1,   ROS↑, 18,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↑, 2,   SOD2↓, 1,   Trx↓, 1,   TrxR1↓, 1,  

Metal & Cofactor Biology

Tf↑, 1,  

Mitochondria & Bioenergetics

AIF↑, 1,   CDC2↓, 2,   CDC25↓, 1,   EGF↓, 1,   MEK↓, 2,   MMP↓, 11,   mtDam↑, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis

ACC↑, 1,   AMPK↑, 1,   cMyc↓, 2,   p‑cMyc↑, 1,   Glycolysis↓, 2,   H2S↑, 1,   LDH↑, 1,   LDH↝, 1,   PI3K/Akt↑, 1,   PKM2↓, 1,  

Cell Death

Akt↓, 6,   Apoptosis↑, 16,   BAD↑, 1,   BAX↑, 7,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-2↑, 1,   cl‑BID↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 8,   cl‑Casp3↑, 3,   Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 3,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↑, 9,   Diablo↑, 1,   DR5↑, 2,   Fas↑, 2,   Ferroptosis↑, 2,   hTERT/TERT↓, 2,   iNOS↓, 2,   iNOS↑, 2,   JNK↑, 3,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 2,   MDM2↓, 1,   Necroptosis↑, 1,   NICD↓, 1,   p27↑, 2,   p38↑, 5,   survivin↓, 3,   Telomerase↓, 3,   TRAIL↑, 2,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction

Sp1/3/4↓, 1,  

Transcription & Epigenetics

cJun↓, 1,   cJun↑, 1,   ac‑H3↑, 1,   other↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress

CHOP↑, 2,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes

LC3B-II↑, 1,   LC3II↑, 1,   p62↓, 1,   p‑p62↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair

DNAdam↑, 9,   DNMT1↓, 1,   P53↑, 6,   p‑P53↑, 1,   cl‑PARP↑, 4,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence

CDK2↓, 3,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   P21↑, 5,   Securin↓, 1,   TumCCA?, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State

AR-V7?, 1,   cFos↓, 1,   EMT↓, 4,   ERK↓, 5,   p‑ERK↓, 1,   FOXM1↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   miR-125b↓, 1,   mTOR↓, 2,   NOTCH1↓, 1,   P90RSK↓, 1,   PI3K↓, 4,   PTEN↑, 1,   RAS↓, 1,   SCF↓, 1,   STAT3↓, 4,   STAT4↑, 1,   TAZ↓, 1,   TCF↑, 1,   TOP1↓, 3,   TumCG↓, 2,   Wnt↓, 2,  

Migration

5LO↓, 1,   AEG1↓, 1,   AntiAg↑, 1,   Ca+2↑, 2,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 1,   FAK↑, 1,   Fibronectin↓, 1,   MALAT1↓, 1,   MMP13↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 2,   MMPs↓, 2,   N-cadherin↓, 2,   NFAT↑, 1,   Snail↓, 1,   Snail↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 4,   TumCI↑, 1,   TumCMig↓, 3,   TumCP↓, 8,   TumCP↑, 2,   TumMeta↓, 2,   Twist↓, 1,   Twist↑, 1,   uPA↓, 1,   Vim↓, 1,   ZEB2↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature

angioG↓, 4,   angioG↑, 1,   EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 3,   NO↓, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling

COX2↓, 5,   CXCR4↓, 1,   DCells↑, 1,   IFN-γ↓, 1,   IFN-γ↑, 2,   IKKα↓, 1,   IKKα↑, 1,   IL12↑, 1,   IL15↑, 1,   IL1β↑, 1,   Inflam↓, 2,   NF-kB↓, 7,   NF-kB↑, 28,   p‑NF-kB↑, 3,   NK cell↑, 2,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors

AR↓, 2,   CDK6↓, 1,   CYP19?, 1,  

Drug Metabolism & Resistance

BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 10,   Dose?, 1,   Dose↑, 1,   Dose⇅, 1,   Dose∅, 1,   eff↓, 2,   eff↑, 8,   eff↝, 2,   MDR1↓, 1,   RadioS↑, 5,   selectivity↑, 10,   TET2↑, 1,  

Clinical Biomarkers

AR↓, 2,   EGFR↓, 1,   FOXM1↓, 1,   hTERT/TERT↓, 2,   LDH↑, 1,   LDH↝, 1,  

Functional Outcomes

AntiCan↑, 5,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   chemoPv⇅, 1,   ChemoSideEff↓, 1,   neuroP↑, 2,   TumVol↓, 1,  
Total Targets: 230

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress

antiOx↑, 6,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 2,   GSTA1↑, 1,   HO-1↑, 3,   lipid-P↓, 1,   MPO↓, 1,   NRF2↑, 4,   ROS↓, 4,   SOD↑, 2,  

Metal & Cofactor Biology

IronCh↑, 1,  

Mitochondria & Bioenergetics

ATP↑, 1,   mitResp↑, 1,  

Core Metabolism/Glycolysis

SIRT1↑, 1,  

Cell Death

Akt↑, 1,   BAX↓, 1,   Bcl-2↑, 1,   iNOS↑, 1,   MAPK↓, 1,  

Kinase & Signal Transduction

Sp1/3/4↑, 1,  

Transcription & Epigenetics

other↑, 1,  

Proliferation, Differentiation & Cell State

Choline↑, 1,   EMT↑, 1,   PI3K↑, 1,   STAT3↑, 1,  

Migration

MMP13↓, 1,  

Angiogenesis & Vasculature

NO↓, 1,   VEGF↑, 1,  

Barriers & Transport

BBB↑, 2,   P-gp↓, 1,  

Immune & Inflammatory Signaling

COX2↓, 4,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 4,   NF-kB↓, 1,   NF-kB↑, 9,   PGE2↓, 3,   TNF-α↓, 2,  

Synaptic & Neurotransmission

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,  

Protein Aggregation

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance

BioAv↓, 3,   BioAv↑, 5,   BioAv↝, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 1,   Half-Life↓, 1,   Half-Life↝, 2,  

Clinical Biomarkers

GutMicro↑, 1,   IL6↓, 2,   NOS2↓, 1,  

Functional Outcomes

cardioP↑, 1,   CardioT↓, 1,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 4,   toxicity↓, 5,  
Total Targets: 64

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
5 Betulinic acid
3 Silver-NanoParticles
2 Magnetic Fields
2 Ajoene (compound of Garlic)
2 Thymoquinone
2 Vitamin C (Ascorbic Acid)
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Radiotherapy/Radiation
1 alpha Linolenic acid
1 Artemisinin
1 beta-glucans
1 Baicalein
1 Berbamine
1 borneol
1 Boswellia (frankincense)
1 Carnosic acid
1 Celecoxib
1 chitosan
1 Chrysin
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 Disulfiram
1 Copper and Cu NanoParticles
1 EGCG (Epigallocatechin Gallate)
1 Butyrate
1 Fisetin
1 Honokiol
1 Luteolin
1 Lycopene
1 Melatonin
1 Mushroom Chaga
1 Propolis -bee glue
1 Piperlongumine
1 Resveratrol
1 Shikonin
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:%  Dir#:2
wNotes=0 sortOrder:rid,rpid

 

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