FOXO3 Cancer Research Results

FOXO3, Forkhead Box O3: Click to Expand ⟱
Source:
Type:
FOXO3 (Forkhead Box O3) is a transcription factor that plays a critical role in regulating apoptosis, cell cycle arrest, DNA repair, and cellular stress responses.

• Positive Prognostic Marker
– In several cancers, higher nuclear FOXO3 expression (denoting active, transcriptionally functional FOXO3) is generally associated with a more favorable prognosis.
– Active FOXO3 can promote cell cycle arrest and apoptosis, thereby inhibiting tumor progression.

• Negative Prognostic Implications
– Conversely, reduced or cytoplasmically sequestered FOXO3 (often due to hyperactivation of the PI3K/Akt signaling pathway) has been linked to aggressive disease and poorer survival
 – Loss of FOXO3 function can allow tumor cells to proliferate unchecked and resist apoptosis, which contributes to a worse outcome.
Scientific Papers found: Click to Expand⟱
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,
3433- ALA,    Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals
*ROS↓, *Apoptosis↓, *Hif1a↑, *FOXO1↑, *FOXO3↑, *ATM↑, *SIRT1↑, *SIRT3↑, *CD34↑,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
2702- BBR,    The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1
- in-vitro, Lung, A549 - in-vitro, Lung, H1975
TumCG↓, MAPK↓, FOXO3↑, TumCCA↑, TumCMig↓, TumCI↓, Sp1/3/4↓, PDK1↓, DNMT1↓, eff↑,
5202- CAP,    Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways
- vitro+vivo, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
antiOx↑, Inflam↓, AntiCan↓, TRPV1↑, TumCP↓, TumCCA↑, ROS↑, FOXO3↑, TumCMig↓,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3776- H2,    The role of hydrogen in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,
3372- QC,  FIS,  KaempF,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,

Showing Research Papers: 1 to 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   Catalase↓, 2,   Ferroptosis↓, 1,   GPx↓, 1,   GSH↓, 3,   GSR↑, 1,   HO-1↑, 2,   lipid-P↑, 1,   MDA↑, 1,   NOX4↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 2,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 11,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↓, 2,   SOD2↑, 1,   xCT↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   CDC2↓, 1,   MEK↓, 2,   mitResp↓, 1,   MMP↓, 6,   MMP↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 1,   cMyc↓, 1,   FASN↓, 1,   HK2↓, 1,   LDH↓, 1,   LDHA↓, 1,   NADPH↑, 3,   PDK1↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 6,   Apoptosis↑, 4,   Bak↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 3,   Bcl-xL↓, 1,   BIM↑, 1,   Casp12↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   proCasp3↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Chk2↓, 1,   CK2↓, 2,   Cyt‑c↑, 4,   DR4↑, 1,   DR5↑, 1,   Endon↑, 1,   Ferroptosis↓, 1,   HEY1↓, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 2,   Necroptosis↑, 1,   NOXA↑, 1,   p27↑, 1,   p38↓, 1,   p38↑, 3,   RIP1↑, 1,   survivin↓, 1,   Telomerase↓, 2,   TRPV1↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   H3↑, 1,   other↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   HSP90↓, 3,   HSPs↓, 1,  

Autophagy & Lysosomes ⓘ

p‑Beclin-1↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNMT1↓, 1,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   SIRT6↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 4,   EMT↓, 4,   ERK↓, 3,   p‑ERK↓, 1,   FOXO3↑, 12,   Gli↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 6,   RAS↓, 1,   STAT3↓, 4,   p‑STAT3↓, 1,   TumCG↓, 4,  

Migration ⓘ

AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 2,   E-cadherin↑, 1,   ER-α36↓, 1,   FAK↓, 3,   MMP-10↓, 1,   MMP2↓, 5,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 2,   N-cadherin↓, 2,   RIP3↑, 1,   ROCK1↑, 1,   Slug↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   SMAD4↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 2,   Twist↓, 1,   uPA↓, 3,   Vim↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↑, 1,   ECM/TCF↓, 1,   EGFR↓, 1,   EGR1↑, 1,   Hif1a↓, 2,   PDGFR-BB↓, 1,   VEGF↓, 4,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   NF-kB↓, 7,   p65↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   Dose∅, 1,   eff↓, 3,   eff↑, 16,   eff↝, 1,   Half-Life↓, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 2,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   chemoPv↑, 2,   neuroP↑, 1,   RenoP↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 197

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   Catalase↑, 2,   GPx1↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 2,   NRF2↑, 2,   Prx↑, 1,   ROS↓, 5,   mt-ROS↓, 1,   SIRT3↑, 2,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 4,   LDL↓, 1,   NADPH↓, 1,   p‑PPARγ↓, 1,   SIRT1↑, 4,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Casp3?, 1,   JNK↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD34↑, 1,   FOXO1↑, 1,   FOXO3↑, 5,   mTOR↓, 1,   PTEN↓, 1,  

Migration ⓘ

AntiAg↑, 1,   APP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   NO↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL18↓, 1,   IL1β↓, 3,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 5,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 3,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 1,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,   ER(estro)↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   Dose↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

BP∅, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 2,   chemoPv↑, 1,   cognitive↑, 3,   memory↑, 3,   neuroP↑, 2,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 62

Scientific Paper Hit Count for: FOXO3, Forkhead Box O3
4 Hydrogen Gas
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Capsaicin
1 3-bromopyruvate
1 cetuximab
1 Alpha-Lipoic-Acid
1 Andrographis
1 Berberine
1 Quercetin
1 Fisetin
1 Kaempferol
1 Sulforaphane (mainly Broccoli)
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:997  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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