Synergy Cancer Research Results

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Synergy — Interaction in which two or more agents, treatments, or biological interventions produce a combined effect greater than would be expected from their individual effects. In pharmacology and cancer research, synergy commonly refers to enhanced therapeutic efficacy when a compound is combined with chemotherapy, radiation, targeted therapy, or another bioactive agent.

Typical modulation in cancer: ↑ synergy is generally favorable when it increases tumor-cell killing, suppresses proliferation, enhances apoptosis or ferroptosis, or improves sensitivity to anticancer therapy. Synergy should be distinguished from simple additive effects and ideally supported by quantitative combination analysis such as combination index, Bliss independence, Loewe additivity, or related methods.

Typical modulation in Alzheimer’s disease: Context-dependent. Synergy may describe enhanced neuroprotective, anti-inflammatory, antioxidant, or cognitive effects produced by combinations of compounds or treatments, but it is not a disease-specific molecular pathway.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
2325- 2DG,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, Synergy↑,
1340- 3BP,    Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
- Review, NA, NA
Glycolysis↓, HK2↓, LDH↓, OXPHOS↓, angioG↓, H2O2↑, Synergy↑,
1341- 3BP,    The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- Review, NA, NA
Glycolysis↓, OXPHOS↓, *toxicity↓, ROS↑, GSH↓, Synergy↑,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, Synergy↑,
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
Synergy↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1/ATG6↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT/SLC7A11↑, GSH↓, eff↓, MDA↑,
3941- 5HT,  dietMed,  VitB12,  FA,  VitC  Nutrition strategies that improve cognitive function
- Review, AD, NA
*other↑, *other↓, *cognitive↑, *Synergy↑, *Synergy↑,
5469- AF,    Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation
- in-vitro, CRC, HCT116
Synergy↑, Half-Life↑,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, Synergy↑, eff↑, MMP↓, AIF↑, toxicity↓,
5975- AgNPs,  PDT,  CDT,  RF,    Recent Advances in the Application of Silver Nanoparticles for Enhancing Phototherapy Outcomes
- Review, Var, NA - Review, BPH, NA
ROS↑, EPR↓, Synergy↑, Bacteria↓, eff↑, eff↑, TumVol↓,
5976- AgNPs,    Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions
- Review, Vit, NA
*Bacteria↓, AntiCan↑, *Inflam↓, *Wound Healing↑, Synergy↑, ChemoSen↑, EGFR↓, ROS↑, P53↑, BAX↑, Casp3↑, toxicity↝,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, Synergy↑,
4415- AgNPs,  SDT,  CUR,    Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells
- in-vitro, BC, MCF7
tumCV↓, BAX↑, Casp3↑, Bcl-2↓, Synergy↑, ROS↑, sonoS↑, Synergy↑, MMP↓, Cyt‑c↑,
4358- AgNPs,  HPT,  Rad,    Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells
- in-vitro, GBM, U251
RadioS↑, Synergy↑, TumCD↑,
326- AgNPs,  TSA,    Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles
- in-vitro, Cerv, HeLa
Apoptosis↑, ChrMod↝, Synergy↑,
356- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF7 - in-vitro, Bladder, HTB-22
Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, Synergy↑, Catalase↑, other↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, Synergy↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
1158- And,  GEM,    Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1/CCND1↓, cycE/CCNE↓, survivin↓, XIAP↓, Bcl-2↓, Synergy↑,
1348- And,    Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vivo, NA, NA
ERα/ESR1↓, TumCG↓, ROS↑, FOXM1↓, Synergy↑,
4759- antiOx,  Chemo,    Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization
- Review, Var, NA
TumCD↑, TumCG↓, ROS⇅, Synergy↑, RadioS↑, TumCG↓, OS↑, toxicity∅, toxicity↑,
2635- Api,  CUR,    Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
- in-vitro, Cerv, HeLa
TumCD↑, Synergy↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, Synergy↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, Synergy↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, ChemoSen↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, Synergy↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, Synergy↑, Synergy↑, Synergy↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3345- ART/DHA,    Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- in-vitro, GBM, NA
ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, Synergy↑, GPx4↑,
5377- ART/DHA,    Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein
- in-vitro, AML, NA
AntiCan↑, Ferroptosis↑, Iron↑, Mets↑, eff↑, GSH↝, Synergy↑, other↓, eff↑, other↓,
2574- ART/DHA,    Artemisinin: A Promising Adjunct for Cancer Therapy
- Review, Var, NA
selectivity↑, Synergy↑,
2576- ART/DHA,  AL,    The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo
- in-vitro, OS, MG63 - in-vivo, NA, NA
Synergy↑, tumCV↓, Casp3↑, Casp9↑, Apoptosis↑, TumCG↓,
2578- ART/DHA,  RES,    Synergic effects of artemisinin and resveratrol in cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa
Dose↝, TumCMig↓, Apoptosis↑, necrosis↑, ROS↑, Synergy↑,
2582- ART/DHA,  5-ALA,    Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity
- in-vivo, CRC, HCT116 - in-vitro, CRC, HCT116
Synergy↑, ROS↑, selectivity↑, TumCG↓, toxicity↓,
5409- ASA,    Role of aspirin in cancer prevention
- Review, Var, NA
Imm↑, *Inflam↓, *AntiAg↑, *GutMicro↑, Synergy↑, TumMeta↓, angioG↓, Risk↓, Risk↓,
3175- Ash,  SFN,    Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNMTs↓, HDAC↓, Synergy↑,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, Synergy↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, Synergy↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, Synergy↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, Synergy↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, Synergy↑, ChemoSen↑, ChemoSen↑, Synergy↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
1433- Ash,  SFN,    A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Synergy↑, Bcl-2↓, BAX↑, tumCV↓, DNMT1↓, DNMT3A↓, HDAC↓,
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, Synergy↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,
5175- Ash,    Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance
- in-vitro, Cerv, CCL-102
Inflam↓, AntiTum↑, Proteasome↓, ER Stress↑, HSPs↑, GRP94↑, Akt↑, Synergy↑, HSP70/HSPA5↑,
4818- ASTX,  MEL,    Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, Synergy↑, Dose↓,
4804- ASTX,    Astaxanthin in cancer therapy and prevention (Review)
- Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, ChemoSen⇅, chemoP↑, BioAv↑, TumCP↑, ROS⇅, Apoptosis↑, PI3K↑, Akt↑, GSK‐3β↑, NRF2↑, AntiCan↑, *neuroP↑, Synergy↑, AntiTum↑,
5424- ASTX,    Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity
- in-vivo, Nor, NA
*GutMicro↑, AntiCan↑, Synergy↑, AntiTum↑, ChemoSen↑,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, Synergy↑, OS↑, Remission↑,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, Synergy↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,

Showing Research Papers: 1 to 50 of 343
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 343

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CBR1↓, 1,   KAI1/CD82↑, 1,   miR-375↑, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 2,   compI↓, 1,   CYP1A1↑, 1,   Fenton↑, 5,   Ferroptosis↓, 1,   Ferroptosis↑, 12,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 3,   GPx4↑, 1,   GSH↓, 18,   GSH↑, 1,   GSH↝, 1,   GSR↑, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 2,   GSTs↓, 1,   GSTZ1↓, 1,   H2O2↑, 5,   HO-1↓, 3,   HO-1↑, 9,   hyperG↓, 1,   Iron↑, 5,   i-Iron↑, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 10,   MDA↓, 1,   MDA↑, 4,   Mets↑, 1,   MFN2↑, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 13,   OXPHOS↓, 6,   OXPHOS↑, 3,   OXPHOS↝, 1,   PARK2↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 16,   ROS↑, 159,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SIRT3↓, 1,   SIRT3↑, 2,   SOD↓, 4,   SOD↑, 3,   Trx↓, 3,   Trx1↓, 1,   TrxR↓, 3,   TrxR1?, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   KLF5↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   ATP↓, 13,   ATP↑, 1,   mt-ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 2,   CDC25↓, 1,   EGF↓, 2,   ETC↑, 1,   ETC↝, 1,   FGFR1↓, 1,   Insulin↓, 1,   MEK↓, 4,   mitResp↓, 1,   mitResp↑, 3,   MMP↓, 50,   MMP↑, 2,   Mortalin↓, 1,   MPT↑, 3,   mtDam↑, 8,   OCR↓, 1,   OCR↑, 2,   PINK1↑, 1,   Raf↓, 2,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 10,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 4,   AMP↑, 1,   AMPK↑, 15,   ATG7↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 2,   cMyc↓, 20,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   FASN↓, 4,   FASN↑, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 5,   GlucoseCon↑, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 30,   Glycolysis↑, 1,   Histones↝, 1,   HK2↓, 13,   HMG-CoA↓, 9,   KeyT↑, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDH↓, 8,   p‑LDH↓, 1,   LDHA↓, 5,   LDL↓, 3,   lipoGen↓, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   NADPH↑, 2,   PDH↓, 1,   PDH↑, 5,   p‑PDH↑, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 7,   PDK3↑, 1,   PDKs↓, 9,   PFK↓, 2,   PFK2?, 1,   PI3K/Akt↓, 1,   PKM2↓, 10,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 3,   p‑S6K↓, 1,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP2↓, 2,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 8,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 96,   ASK1↑, 1,   BAD↑, 4,   BAD↝, 1,   Bak↑, 4,   BAX↓, 3,   BAX↑, 52,   BAX↝, 2,   Bax:Bcl2↑, 12,   Bcl-2↓, 56,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 13,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 6,   Casp↑, 18,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 70,   cl‑Casp3↑, 7,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 7,   cl‑Casp8↑, 2,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 36,   cl‑Casp9↑, 5,   proCasp9↑, 1,   cFLIP↓, 2,   Chk2↓, 1,   CK2↓, 4,   Cupro↑, 1,   Cyt‑c↑, 33,   Diablo↑, 4,   DR4↑, 2,   DR5↑, 11,   FADD↑, 2,   Fas↑, 9,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 12,   GSDME-N↑, 1,   HEY1↓, 1,   hTERT/TERT↓, 9,   IAP1↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 5,   iNOS↑, 2,   JNK↓, 2,   JNK↑, 8,   p‑JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 4,   MAPK↝, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   MDM2↓, 3,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 1,   Myc↓, 4,   Myc↑, 1,   Necroptosis↑, 3,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↑, 7,   p38↓, 1,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 2,   Proteasome?, 1,   Proteasome↓, 3,   PUMA↑, 2,   Pyro↑, 2,   survivin↓, 19,   Telomerase↓, 6,   TRAIL↑, 1,   TRPV1↑, 1,   TumCD↓, 1,   TumCD↑, 16,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 51,   Akt↑, 10,   p‑Akt↓, 13,   Akt2↓, 1,   AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 5,   miR-25-5p↓, 1,   p70S6↓, 1,   SOX9?, 1,   Sp1/3/4↓, 7,   TRPV2↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↓, 7,   cJun↑, 3,   EZH2↓, 2,   H3↑, 2,   ac‑H3↑, 3,   H3K4↓, 1,   H4↑, 1,   ac‑H4↑, 3,   HATs↓, 2,   HATs↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↓, 5,   other↑, 7,   other↝, 10,   PhotoS↑, 3,   p‑pRB↓, 1,   sonoS↑, 2,   tumCV↓, 24,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 32,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   HSP72↑, 1,   HSP90↓, 7,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 3,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   p‑Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 7,   LC3s↓, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 4,   p62↑, 6,   SESN2↑, 1,   TumAuto↑, 24,   TumAuto⇅, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 2,   DNA-PK↑, 2,   DNAdam↑, 34,   DNArepair↓, 1,   DNArepair↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMTs↓, 5,   m-FAM72A↓, 1,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 29,   p‑P53↑, 2,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↑, 30,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 11,   SIRT6↓, 1,   TP53↓, 2,   TP53↑, 3,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK2↓, 20,   CDK4↓, 25,   CDK4↑, 3,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 9,   cycD1/CCND1↓, 37,   CycD3↓, 3,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 2,   mitA↑, 1,   P21?, 2,   P21↓, 1,   P21↑, 20,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 68,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 1,   CD44↓, 6,   cFos↓, 7,   cMYB↓, 2,   CSCs↓, 31,   CSCsMark↓, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↓, 3,   Diff↑, 2,   EMT↓, 41,   EMT↑, 2,   ERK↓, 11,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 9,   FGF↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 7,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 3,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HDAC↓, 18,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 5,   HMGCR↓, 1,   HMGCR↑, 1,   HMGCR⇅, 1,   HMTs↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 1,   KLF4↓, 1,   Let-7↑, 2,   LRP6↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   mTOR↓, 33,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC1↓, 4,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 2,   Nanog↓, 7,   Nestin↓, 3,   NOTCH↓, 5,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 4,   NOTCH3↓, 3,   OCT4↓, 5,   P70S6K↓, 2,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 39,   PI3K↑, 4,   p‑PI3K↓, 2,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↑, 10,   RAS↓, 5,   SAL↑, 1,   Shh↓, 3,   SHP1↑, 1,   Smo↓, 1,   SOX2↓, 4,   Src↓, 1,   STAT↓, 2,   STAT3↓, 37,   STAT3↝, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 4,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 2,   TCF↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 5,   TOP2↓, 2,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 60,   TumCG↑, 2,   tyrosinase↓, 1,   Wnt↓, 16,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 4,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 5,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 11,   CAFs/TAFs↓, 1,   cal2↑, 1,   CDKN1C/p57↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   CXCL12↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 21,   ER-α36↓, 2,   FAK↓, 3,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 5,   GLI2↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 15,   Ki-67↑, 1,   KLF2↓, 1,   KRAS↓, 2,   L-sel↑, 1,   LAMs↓, 2,   MALAT1↓, 2,   MET↓, 1,   miR-200b↑, 1,   miR-29b↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP15↓, 1,   MMP2↓, 35,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 5,   MMP9↓, 41,   MMP9↑, 2,   MMPs↓, 17,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 13,   PAK1↓, 1,   PDGF↓, 2,   PKA↓, 1,   PKA↑, 1,   PKCδ↓, 4,   RECK↑, 1,   Rho↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 2,   Slug↓, 9,   Smad1↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 12,   SOX4↓, 1,   STAC2↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 4,   Treg lymp↓, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 41,   TumCMig↓, 30,   TumCMig↑, 1,   TumCP↓, 46,   TumCP↑, 2,   TumMeta↓, 33,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 9,   uPAR↓, 1,   Vim?, 1,   Vim↓, 18,   Zeb1↓, 10,   Zeb1↑, 1,   ZEB2↓, 2,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 22,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 49,   angioG↑, 1,   ATF4↓, 1,   ATF4↑, 6,   ECM/TCF↓, 1,   EGFR↓, 17,   eNOS↓, 2,   eNOS↑, 1,   EPR↓, 1,   EPR↑, 1,   HIF-1↓, 4,   Hif1a↓, 31,   Hif1a↑, 1,   miR-126↑, 1,   NO↓, 4,   NO↑, 2,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 51,   VEGFR2/KDR/Flk1↓, 7,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   CellMemb↑, 1,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↑, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↝, 1,   SMCT1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 3,   CRP↓, 2,   CXCR4↓, 9,   FOXP3↓, 1,   HCAR2↑, 1,   HMGB1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 3,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 19,   IL8↓, 5,   Imm↑, 11,   INF-γ↑, 1,   Inflam↓, 15,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 1,   JAK2↓, 7,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MIP2↓, 1,   NF-kB↓, 53,   NF-kB↑, 4,   NF-kB↝, 1,   NK cell↑, 4,   p65↓, 4,   PD-1↓, 3,   PD-L1↓, 5,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 15,   PSA↓, 4,   PSA∅, 1,   T-Cell↑, 1,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 2,   TNF-α↓, 13,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↑, 1,   e-pH↑, 4,   i-pH↓, 1,   TIM-3↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   PP2A↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 9,   CDK6↓, 8,   CDK6↑, 3,   COMT↓, 2,   CYP19↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   RANKL↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 17,   BioAv↑, 30,   BioAv↝, 10,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 3,   ChemoSen↑, 115,   ChemoSen⇅, 2,   CYP1A2↓, 1,   CYP2C9↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 5,   Dose↑, 7,   Dose↝, 33,   Dose∅, 15,   eff↓, 30,   eff↑, 83,   eff↝, 5,   eff∅, 1,   Half-Life↓, 7,   Half-Life↑, 4,   Half-Life↝, 5,   Half-Life∅, 1,   MDR1↓, 4,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 42,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 62,   Synergy↑, 364,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALP↓, 2,   AR↓, 9,   ascitic↓, 1,   AST↓, 2,   BG↓, 3,   BRCA1↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 17,   ERα/ESR1↓, 1,   EZH2↓, 2,   Ferritin↓, 2,   FOXM1↓, 2,   GutMicro↑, 5,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 9,   IL6↓, 19,   Ki-67↓, 15,   Ki-67↑, 1,   KRAS↓, 2,   LDH↓, 8,   p‑LDH↓, 1,   Myc↓, 4,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 4,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 27,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↓, 2,   AntiTum↑, 14,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 1,   chemoP↑, 14,   chemoPv↑, 7,   ChemoSideEff↓, 10,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 5,   memory↑, 1,   NDRG1↑, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 25,   PDE4↓, 1,   Pin1↓, 1,   QoL↑, 3,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 3,   Risk↓, 18,   Risk↑, 2,   Risk∅, 1,   toxicity↓, 14,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 5,   TumVol↓, 13,   TumW↓, 7,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 5,   Sepsis↓, 2,  
Total Targets: 808

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,   diuretic↑, 2,   Stroke↓, 1,   TRPA1↑, 1,   UFR↑, 1,   UR↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 5,   antiOx↑, 53,   Catalase↑, 21,   Copper↓, 1,   Fenton↓, 1,   Ferroptosis↓, 2,   GPx↑, 17,   GSH↑, 23,   GSR↑, 3,   GSSG↓, 1,   GSSG∅, 1,   GSTA1↑, 1,   GSTs↑, 7,   H2O2↑, 1,   H2O2∅, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 16,   Iron↓, 1,   Keap1↓, 3,   Keap1↝, 1,   lipid-P↓, 20,   MDA↓, 14,   MDA↑, 1,   MPO↓, 3,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 31,   PARK2↑, 1,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 61,   ROS↝, 1,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 31,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 1,   Trx↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↓, 1,   ATP↑, 5,   ATP↝, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 2,   Insulin↑, 1,   MMP↑, 3,   mtDam↓, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ALAT↓, 7,   AMPK↓, 1,   AMPK↑, 6,   p‑cMyc↑, 1,   CREB↑, 1,   CYP3A2↓, 1,   cytoP450↓, 1,   FASN↓, 1,   glucose↓, 5,   GlucoseCon↑, 2,   GLUT2↑, 1,   H2S↑, 1,   LDH↓, 2,   LDL↓, 5,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PONs↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 2,   BAX↑, 1,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Casp3?, 1,   Casp3↓, 5,   Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 2,   GADD34↓, 1,   iNOS↓, 9,   JNK↓, 2,   MAPK↓, 6,   MAPK↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 1,   TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 2,   other↓, 3,   other↑, 10,   other↝, 4,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 3,   GRP78/BiP↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   GADD45A↑, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Diff↝, 1,   ERK↓, 2,   ERK↑, 2,   GSK‐3β↓, 5,   HDAC↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 2,   mTOR↑, 1,   neuroG↑, 1,   PI3K↓, 5,   PI3K↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   TumCG∅, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↑, 7,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↑, 1,   Ca+2↝, 3,   Cartilage↑, 2,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 3,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 2,   RAGE↓, 1,   serineP↓, 1,   TGF-β↓, 2,   VCAM-1↓, 4,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   ATF4↓, 1,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO?, 1,   NO↓, 9,   NO↑, 1,   TXA2↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 12,   GastroP↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   CRP↓, 6,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 16,   IL2↓, 2,   IL33↓, 1,   IL4↓, 1,   IL6↓, 28,   IL8↓, 3,   Imm↓, 1,   Imm↑, 5,   Inflam↓, 74,   Inflam↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↝, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 25,   PGE2↓, 7,   PSA↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 33,   TNF-α↑, 1,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 8,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 1,   NGF↑, 1,   tau↓, 5,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 14,   BACE/β-secretase↓, 5,   NLRP3↓, 7,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 23,   BioAv↑, 40,   BioAv⇅, 2,   BioAv↝, 11,   BioEnh↑, 3,   Dose↑, 4,   Dose↝, 16,   eff↓, 1,   eff↑, 13,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 7,   MRP1/ABCC1↓, 1,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 59,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 2,   AST↓, 10,   BloodF↑, 2,   BMD↑, 2,   BMPs↑, 1,   BP↓, 6,   BP↝, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 6,   GutMicro↑, 11,   Hcy/homoC↝, 1,   hs-CRP↓, 1,   IL6↓, 28,   LDH↓, 2,   Mag↑, 1,   MUC19↓, 1,   PSA↓, 1,   RAGE↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   AntiArt↑, 2,   AntiCan↑, 5,   AntiDiabetic↑, 11,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↓, 1,   cardioP↑, 24,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 20,   cognitive↝, 1,   hepatoP↑, 17,   memory↑, 16,   Mood↑, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 45,   Obesity↓, 4,   Pain↓, 3,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 8,   Risk↓, 4,   Strength↑, 1,   toxicity↓, 21,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 5,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 4,   Bacteria↓, 11,   Diar↓, 1,   IRF3↓, 1,  
Total Targets: 319

Scientific Paper Hit Count for: Synergy, Synergy
22 Curcumin
13 Vitamin C (Ascorbic Acid)
13 Quercetin
12 Sulforaphane (mainly Broccoli)
12 Chrysin
12 Dichloroacetate
10 EGCG (Epigallocatechin Gallate)
9 Metformin
9 Resveratrol
8 Silver-NanoParticles
8 Ashwagandha(Withaferin A)
8 Lycopene
8 Fisetin
7 Chemotherapy
7 Artemisinin
7 Atorvastatin
7 Berberine
6 Magnetic Fields
6 Vitamin K2
6 Silymarin (Milk Thistle) silibinin
6 Bicarbonate(Sodium)
6 Thymoquinone
5 Radiotherapy/Radiation
5 Hyperthermia
5 Apigenin (mainly Parsley)
5 Melatonin
5 Dipyridamole
5 immunotherapy
5 diet FMD Fasting Mimicking Diet
5 Gambogic Acid
5 Rosmarinic acid
4 3-bromopyruvate
4 Alpha-Lipoic-Acid
4 Gemcitabine (Gemzar)
4 Propolis -bee glue
4 Capsaicin
4 Carvacrol
4 salinomycin
4 Dandelion Root
4 Disulfiram
4 Fenbendazole
4 Formononetin
4 Phenethyl isothiocyanate
4 Piperlongumine
4 Urolithin
4 VitK3,menadione
3 1,8-Cineole
3 Auranofin
3 Photodynamic Therapy
3 Astaxanthin
3 beta-carotene(VitA)
3 borneol
3 Caffeic acid
3 Carnosic acid
3 chitosan
3 Copper and Cu NanoParticles
3 Piperine
3 diet Methionine-Restricted Diet
3 Emodin
3 Hydrogen Gas
3 Selenium NanoParticles
2 2-DeoxyGlucose
2 cetuximab
2 Vitamin B12
2 Folic Acid, Vit B9
2 chemodynamic therapy
2 Allicin (mainly Garlic)
2 Andrographis
2 Aspirin
2 Baicalein
2 Biochanin A
2 Betulinic acid
2 Lutein
2 Zeaxanthin
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Chlorogenic acid
2 5-fluorouracil
2 Citric Acid
2 Coenzyme Q10
2 Ellagic acid
2 Bortezomib
2 Docosahexaenoic Acid
2 erastin
2 Exercise
2 Ferulic acid
2 ferumoxytol
2 doxorubicin
2 Genistein (soy isoflavone)
2 HydroxyCitric Acid
2 Spermidine
2 Honokiol
2 Lecithin
2 Niclosamide (Niclocide)
2 Selenite (Sodium)
2 Terpinen-4-ol / Tea Tree Oil
2 Vitamin D3
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 SonoDynamic Therapy UltraSound
1 Trichostatin A
1 Anti-oxidants
1 5-Aminolevulinic acid
1 almonertinib
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Bufalin/Huachansu
1 Bifidobacterium
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Beta‐Lapachone
1 Chlorophyllin
1 Rutin
1 Cinnamon
1 Hydroxycinnamic-acid
1 Selenium
1 Cucurbitacin
1 Dasatinib/Phyrago
1 Diclofenac
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 Vitamin A, Retinoic Acid
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Electrical Pulses
1 Eugenol
1 temozolomide
1 Geldanamycin
1 Radicicol/monorden
1 verapamil
1 hydroxychloroquine
1 Calorie Restriction Mimetics
1 Juglone
1 Linalool
1 Luteolin
1 Matrine
1 methotrexate
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Naringin
1 Phenylbutyrate
1 Paclitaxel/Taxol
1 Phosphatidylserine
1 Psoralidin
1 Cisplatin
1 Parthenolide
1 Pterostilbene
1 Sulfasalazine
1 acetaminophen
1 acetazolamide
1 Shikonin
1 statins
1 triptolide
1 Turmerones
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1849  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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