TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.
Scientific Papers found: Click to Expand⟱
2432- 2DG,    Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- in-vitro, Lung, H23 - in-vitro, Lung, KP2 - in-vivo, NA, NA
HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,
5270- 5-ALA,  PDT,    5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
- Review, Var, NA
other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,
5430- AG,    Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation
- Review, Stroke, NA
*cardioP↑, *MitoP↑, *ROS↓, *mtDam↓, *neuroP↓, TumAuto↓, *AntiDiabetic↑,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
5432- AG,    Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies
- Review, Cerv, NA
ChemoSen↑, eff↑, RadioS↑, CEA↓, Wnt↓, β-catenin/ZEB1↓, γH2AX↑, ER Stress↑, mt-TumAuto↑, QoL↑, Imm↑,
4559- AgNPs,    Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation
- in-vitro, BC, SkBr3 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
MMP2↓, MMP9↓, ROS↑, TumAuto↑, Apoptosis↑, ER Stress↑,
5146- AgNPs,    Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent
- in-vitro, Liver, HepG2
TumAuto↑, EPR↑, LC3B↑, CHOP↑, ER Stress↑, NLRP3↑, Casp1↓,
328- AgNPs,  Rad,    Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
- vitro+vivo, GBM, U251
Apoptosis↑, TumAuto↑,
343- AgNPs,    Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma
- in-vitro, PC, PANC1
BAX↑, Bcl-2↓, P53↑, TumAuto↑,
330- AgNPs,  Rad,    Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
- in-vitro, GBM, U251
TumAuto↑, ROS↑,
329- AgNPs,  Rad,    Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells
- in-vitro, GBM, U251
Apoptosis↑, TumAuto↑,
327- AgNPs,  MS-275,    Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells
- in-vitro, Lung, A549
Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,
318- AgNPs,    Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells
- in-vitro, Pca, PC3
lysoM↓, lysosome↓, AMPKα↑, TumAuto↑, mTOR↑,
317- AgNPs,    Autophagic effects and mechanisms of silver nanoparticles in renal cells under low dose exposure
- in-vitro, Kidney, HEK293
TumAuto↑, p62↑,
312- AgNPs,  wortm,    Inhibition of autophagy enhances the anticancer activity of silver nanoparticles
- vitro+vivo, Cerv, HeLa
APA↑, p62↓, PIK3CA↑, TumVol↓, TumAuto↑, eff↑,
400- AgNPs,  MF,    Polyvinyl Alcohol Capped Silver Nanostructures for Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field
- in-vitro, Laryn, HEp2
TumCP↓, Casp3↑, P53↑, Beclin-1↑, TumAuto↑, GSR↑, ROS↑, MDA↑, ROS↑, SIRT1↑, Ca+2↑, Endon↑, DNAdam↑, Apoptosis↑, NF-kB↓,
2648- AL,    Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway
- in-vitro, OS, SaOS2 - in-vivo, OS, NA
ROS↑, TumCG↓, TumAuto↑, Wnt↓, β-catenin/ZEB1↓, MALAT1↓,
2666- AL,    Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
- Review, Var, NA
Inflam↓, AntiCan↑, ROS↑, MAPK↑, JNK↑, TumAuto↑, other↑, Dose↝, MALAT1↓, Wnt↓, β-catenin/ZEB1↓,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
250- AL,    Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells
- in-vitro, Liver, HepG2
P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,
280- ALA,    Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
- in-vivo, Lung, A549
p‑mTOR↑, TumCG↓, TumAuto↓, p‑P70S6K↑,
1354- And,    Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,
1553- Api,    Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
- Review, NA, NA
Dose∅, TumVol↓, Dose∅, COX2↓, Hif1a↓, TumCCA↑, P53↑, P21↑, Casp3↑, DNAdam↑, TumAuto↝,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
2631- Api,    Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
- in-vivo, GC, NA - in-vitro, GC, AGS
ER Stress↑, Hif1a↓, EZH2↓, HDAC↓, TumAuto↑, p‑mTOR↓, AMPKα↑, GRP78/BiP↑, ROS↑, MMP↓, Ca+2↑, ATF4↑, CHOP↑,
2635- Api,  CUR,    Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
- in-vitro, Cerv, HeLa
TumCD↑, eff↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,
2638- Api,    Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
- in-vitro, lymphoma, PEL
TumCD↑, TumAuto↑, ROS↓, P53↑, Catalase↑, STAT3↓,
1008- Api,    Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
Wnt/(β-catenin)↓, β-catenin/ZEB1↓, TumAuto↑, Akt↓, mTOR↓, tumCV↓, TumCCA↑, TumAuto↑, p‑Akt↓, p‑p70S6↓, p‑4E-BP1↓,
313- Api,    Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
- in-vitro, Thyroid, BCPAP
LC3s↝, p62↓, ROS↑, TumCCA↑, CDC25↓, TumAuto↑, Beclin-1↑, AVOs↑, DNAdam↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
5380- ART/DHA,    Artemisinin and Its Derivatives as Potential Anticancer Agents
- Review, Var, NA
TumCG↓, angioG↓, Ferroptosis↑, TumCP↑, TumAuto↑, CSCs↑, eff↑, YAP/TEAD↓, TumCCA↑, ROS↑, ChemoSen↑, N-cadherin↓, Vim↓, MMP9↓, eff↑, STAT3↓, CD133↓, CD44↓, Nanog↓, cMyc↓, OCT4↓, Akt↓, mTOR↓,
5376- ART/DHA,    Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, SW48 - in-vitro, BC, MDA-MB-453
Ferroptosis↑, Ferritin↓, Iron↑, eff↑, TumAuto↑, LC3II↑, ROS↑,
5137- ART/DHA,    Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin
- vitro+vivo, ESCC, Eca109
tumCV↓, TumCCA↑, ROS↑, TumAuto↑, eff↓, TRF2↓, TumCP↓,
5134- ART/DHA,    Dihydroartemisinin induces autophagy by suppressing NF-κB activation
- in-vitro, Var, NA
TumAuto↑, NF-kB↓, ChemoSen↑,
5133- ART/DHA,    Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,
1076- ART/DHA,    The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer
- Review, NA, NA
Ferroptosis↑, ROS↑, ER Stress↑, i-Iron↓, TumAuto↑, AMPK↑, mTOR↑, P70S6K↑, Fenton↑, lipid-P↑, ROS↑, ChemoSen↑, NRF2↑, NRF2↓,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, eff↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,
5451- ATV,    In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U87MG - in-vitro, GBM, A172
TumAuto↑, CSCs↓, HMG-CoA↓, TumCP↓, tumCV↓, TumCCA↑, TumCG↓, HMGCR↓,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
5505- Ba,    Baicalein inhibits the progression of thyroid cancer by suppressing the TPL2/MEK2/ERK2 pathway
- in-vitro, Thyroid, NA
ERK↓, PI3K↓, Akt↓, Apoptosis↑, TumAuto↑, NF-kB↑, MEK↓,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp↓, BioAv↑, selectivity↑,

Showing Research Papers: 1 to 50 of 185
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 185

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   DJ-1↓, 1,   Fenton↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 8,   GPx4↓, 3,   GSH↓, 3,   GSR↑, 1,   Iron↑, 3,   i-Iron↓, 1,   lipid-P↑, 2,   MDA↑, 3,   NRF2↓, 2,   NRF2↑, 1,   NRF2↝, 1,   mt-OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 29,   xCT↓, 1,   xCT↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 3,   FTH1↓, 1,   NCOA4↑, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 3,   BCR-ABL↓, 1,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 7,   Mortalin↓, 1,   mtDam↑, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMP↓, 1,   AMPK↑, 5,   p‑AMPK↑, 1,   ATG7↑, 2,   cMyc↓, 4,   GAPDH↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   Histones↝, 1,   HK2↓, 3,   HMG-CoA↓, 2,   lactateProd↓, 1,   LDH↓, 1,   p‑LDH↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↓, 1,   PIK3CA↑, 1,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,   SIRT1↑, 2,   SREBP1↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 9,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 21,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Bcl-xL↓, 1,   BIM↑, 1,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 5,   p‑Chk2↑, 1,   Cyt‑c↑, 5,   DR5↑, 1,   Endon↑, 1,   FADD↑, 1,   Fas↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 8,   JNK↓, 1,   JNK↑, 2,   MAPK↑, 1,   Mcl-1↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   Myc↓, 1,   Necroptosis↑, 1,   oncosis↑, 2,   p27↑, 1,   p38↑, 1,   Paraptosis↑, 1,   survivin↓, 3,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 3,   p‑p70S6↓, 1,   Sp1/3/4↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   other↑, 1,   other↝, 3,   tumCV↓, 7,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   eIF2α↑, 1,   ER Stress↑, 10,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

APA↑, 1,   ATG5↑, 1,   autoF↓, 1,   AVOs↑, 1,   Beclin-1↑, 5,   p‑Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3II↑, 2,   LC3s↝, 1,   lysoM↓, 1,   lysosome↓, 2,   p62↓, 5,   p62↑, 2,   TumAuto↓, 2,   TumAuto↑, 47,   TumAuto↝, 1,   mt-TumAuto↑, 1,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   p‑CHK1↑, 1,   DNAdam↑, 8,   m-FAM72A↓, 1,   HR↓, 1,   p16↑, 2,   P53↓, 1,   P53↑, 6,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 1,   p‑PARP↑, 1,   cl‑PARP↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 1,   RAD51↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 2,   CDK4↑, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 2,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State ⓘ

p‑4E-BP1↓, 1,   CD133↓, 2,   CD44↓, 2,   cMET↓, 1,   cMYB↓, 1,   CREBBP↓, 1,   CSCs↓, 5,   CSCs↑, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↑, 1,   EMT↓, 4,   ERK↓, 2,   FOXO3↑, 1,   HDAC↓, 3,   HH↓, 1,   HMGCR↓, 2,   mTOR↓, 9,   mTOR↑, 3,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   Nanog↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   P70S6K↑, 1,   p‑P70S6K↑, 1,   PI3K↓, 6,   STAT3↓, 2,   p‑STAT3↓, 1,   TRF2↓, 1,   TumCG↓, 8,   TumCG↑, 1,   Wnt↓, 5,   Wnt/(β-catenin)↓, 2,   Wnt/(β-catenin)↑, 1,  

Migration ⓘ

annexin II↓, 1,   AXL↓, 1,   Ca+2↑, 4,   CAFs/TAFs↓, 1,   CDK4/6↓, 1,   CEA↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   ITGB1↑, 1,   Ki-67↓, 2,   LysoPr↑, 1,   MALAT1↓, 2,   miR-133a-3p↑, 1,   MMP2↓, 4,   MMP9↓, 5,   N-cadherin↓, 1,   NCAM↑, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 1,   Slug↓, 1,   SMAD4↓, 1,   Snail?, 1,   TGF-β↓, 3,   TIMP2↑, 1,   TumCA↑, 1,   TumCI↓, 4,   TumCMig↓, 2,   TumCP↓, 10,   TumCP↑, 1,   TumMeta↓, 4,   Twist↓, 1,   uPA↓, 2,   Vim↓, 3,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   ATF4↑, 1,   EGFR↓, 3,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   KDR/FLK-1↓, 1,   NO↓, 1,   VEGF↓, 6,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   IL1↓, 1,   IL1β↓, 2,   IL4↓, 1,   IL6↓, 2,   IL8↓, 2,   Imm↑, 3,   Inflam↓, 2,   M2 MC↓, 1,   MIP2↓, 1,   NF-kB↓, 8,   NF-kB↑, 1,   PGE2↓, 2,   TNF-α↓, 2,   TNF-α↑, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 14,   Dose↝, 4,   Dose∅, 3,   eff↓, 4,   eff↑, 22,   eff↝, 1,   Half-Life↓, 1,   RadioS↑, 3,   selectivity↓, 1,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

CEA↓, 1,   EGFR↓, 3,   EZH2↓, 1,   Ferritin↓, 3,   IL6↓, 2,   Ki-67↓, 2,   LDH↓, 1,   p‑LDH↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   cardioP↑, 1,   OS↑, 1,   QoL↑, 2,   toxicity↓, 1,   toxicity↑, 1,   TumVol↓, 4,   TumW↓, 4,  
Total Targets: 294

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSTs↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↓, 1,  

Autophagy & Lysosomes ⓘ

MitoP↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   neuroP↓, 1,   toxicity↓, 1,  
Total Targets: 13

Scientific Paper Hit Count for: TumAuto, Tumor autophagy
13 Silver-NanoParticles
13 Curcumin
11 Artemisinin
9 salinomycin
7 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Baicalein
5 EGCG (Epigallocatechin Gallate)
5 Gambogic Acid
5 Shikonin
5 Selenite (Sodium)
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Juglone
4 Phenethyl isothiocyanate
4 Spermidine
4 Urolithin
4 Vitamin K2
3 Astragalus
3 Atorvastatin
3 Betulinic acid
3 diet Short Term Fasting
3 hydroxychloroquine
3 Luteolin
3 Quercetin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Ashwagandha(Withaferin A)
2 Boron
2 Resveratrol
2 Dichloroacetate
2 diet Methionine-Restricted Diet
2 Chemotherapy
2 Emodin
2 Honokiol
2 itraconazole
2 Propolis -bee glue
2 Psoralidin
2 Sulforaphane (mainly Broccoli)
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Alpha-Lipoic-Acid
1 Andrographis
1 Metformin
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Capsaicin
1 Celastrol
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Ellagic acid
1 Estrogen
1 Graviola
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Hydroxycinnamic-acid
1 immunotherapy
1 Magnetic Field Rotating
1 Mushroom Chaga
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Nimbolide
1 Phenylbutyrate
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 Cisplatin
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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