eff Cancer Research Results

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4384- ,    Silver nanoparticles: synthesis, properties, and therapeutic applications
- Review, Var, NA
AntiCan↑, RadioS↑, CellMemb↑, ROS↑, DNAdam↑, PhotoS↑, eff↑,
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑,
6474- 1,8-Cin,    Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation
- in-vitro, Nor, HT29 - in-vivo, Nor, NA - in-vivo, IBD, NA
*Inflam↓, *NRF2↑, *antiOx↑, *PPARγ↑, eff↑,
6468- 1,8-Cin,    Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *eff↑,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, eff↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
2325- 2DG,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, eff↑,
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
1340- 3BP,    Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
- Review, NA, NA
Glycolysis↓, HK2↓, LDH↓, OXPHOS↓, angioG↓, H2O2↑, eff↑,
1341- 3BP,    The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- Review, NA, NA
Glycolysis↓, OXPHOS↓, *toxicity↓, ROS↑, GSH↓, eff↑,
7857- 3BP,    A Mechanism of Isoorientin-Induced Apoptosis and Migration Inhibition in Gastric Cancer AGS Cells
- in-vitro, NA, AGS
tumCV↓, selectivity↑, *toxicity↓, Apoptosis↑, ROS↑, eff↓, TumCCA↑, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, TumCMig↓, Twist↓, N-cadherin↑, β-catenin/ZEB1↓, E-cadherin↑,
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,
5278- 3BP,    effect-of-3-bromopyruvate-on-human-colorectal">The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression
- in-vitro, CRC, HCT116 - in-vitro, CRC, Caco-2 - in-vitro, CRC, SW48
ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,
5263- 3BP,  CET,    3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
- in-vitro, CRC, DLD1 - NA, NA, HCT116
eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT/SLC7A11↑, GSH↓, eff↓, MDA↑,
5259- 3BP,    Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
- in-vivo, HCC, NA
ATP↓, TumCD↑, toxicity↓, eff↑, tumCV↓, Dose↝,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5261- 3BP,    The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH
- in-vitro, BC, NA
eff↑, eff↓,
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
5264- 3BP,    Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- Review, Var, NA
toxicity↑, Glycolysis↓, eff↑, OS↑, QoL↑, toxicity↝,
5266- 3BP,    3-bromopyruvate-based agent KAT-101
- Review, Var, NA
eff↑, Glycolysis↓, OXPHOS↓, ATP↓, TumCP↓, Apoptosis↑, HK2↓, MPT↑, LDH↓, PDH↓,
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
3941- 5HT,  dietMed,  VitB12,  FA,  VitC  Nutrition strategies that improve cognitive function
- Review, AD, NA
*other↑, *other↓, *cognitive↑, *eff↑, *eff↑,
3968- ACNs,    Enhanced Neuronal Activation with Blueberry Supplementation in Mild Cognitive Impairment
- Human, AD, NA
*BOLD↑, *cognitive?, *eff↑,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
3973- ACNs,    Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries
- Analysis, AD, NA
eff↑,
5459- AF,    Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells
- in-vitro, Ovarian, NA
ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
5460- AF,    Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
- vitro+vivo, Var, 4T1
RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,
5469- AF,    Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation
- in-vitro, CRC, HCT116
eff↑, Half-Life↑,
5458- AF,    Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
- in-vitro, NSCLC, NA
TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,
5472- AF,    Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion
- in-vitro, Cerv, HeLa
TrxR↓, AntiCan↑, TumCG↓, Apoptosis↑, necrosis↑, cl‑PARP↑, MMP↓, ROS↑, GSH↓, eff↓,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
5467- AF,    Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth
- in-vitro, Lung, NA
TrxR↓, eff↑, Dose↝, OS↑, eff↑,
1900- AF,    Potential Anticancer Activity of Auranofin
- Review, Var, NA
TrxR↓, ROS↑, Apoptosis↓, TumCP↓, eff↑,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
5432- AG,    Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies
- Review, Cerv, NA
ChemoSen↑, eff↑, RadioS↑, CEA↓, Wnt↓, β-catenin/ZEB1↓, γH2AX↑, ER Stress↑, mt-TumAuto↑, QoL↑, Imm↑,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5441- AG,  Chemo,    Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients
- Review, Lung, NA
eff↑, ChemoSen↑,
5236- AgNPs,    Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury
- in-vitro, Liver, HepG2 - in-vitro, Nor, L02
tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,
5237- AgNPs,    Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes
- in-vitro, Liver, HepG2
Ferroptosis↑, p62↑, NRF2↝, eff↓,
5975- AgNPs,  PDT,  CDT,  RF,    Recent Advances in the Application of Silver Nanoparticles for Enhancing Phototherapy Outcomes
- Review, Var, NA - Review, BPH, NA
ROS↑, EPR↓, eff↑, Bacteria↓, eff↑, eff↑, TumVol↓,
5976- AgNPs,    Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions
- Review, Vit, NA
*Bacteria↓, AntiCan↑, *Inflam↓, *Wound Healing↑, eff↑, ChemoSen↑, EGFR↓, ROS↑, P53↑, BAX↑, Casp3↑, toxicity↝,
5977- AgNPs,  CDT,    Silver Nitroprusside as an Efficient Chemodynamic Therapeutic Agent and a Peroxynitrite nanogenerator for Targeted Cancer Therapy
- in-vivo, Ovarian, A2780S - NA, Ovarian, SKOV3
Fenton↑, ROS↑, eff↑, angioG↓, p‑Akt↓, EPR↑, selectivity↑, selectivity↑, eff↑, Cyt‑c↑, HO-1↑,
1907- AgNPs,  GoldNP,  Cu,    In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands
- in-vitro, Lung, A549 - in-vitro, BC, MCF7 - in-vitro, Melanoma, A375 - in-vitro, Colon, HCT15 - in-vitro, Cerv, HeLa
TrxR↓, eff↓, eff↓, other∅,
1906- AgNPs,  GoldNP,  Cu,    Current Progresses in Metal-based Anticancer Complexes as Mammalian TrxR Inhibitors
- Review, Var, NA
TrxR↓, eff↓, eff↓,
1903- AgNPs,    Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Managemen
- in-vitro, Lung, U1285
TrxR↓, eff↝, ROS↑,
4403- AgNPs,    Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, GL26 - in-vitro, Cerv, HeLa - in-vitro, CRC, RKO
AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

Showing Research Papers: 1 to 50 of 1636
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1636

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Fenton↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 2,   GPx↓, 1,   GPx4↓, 3,   GSH↓, 7,   H2O2↑, 1,   HO-1↑, 1,   c-Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   MFN2↑, 1,   NRF2↝, 1,   OXPHOS↓, 4,   ROS↑, 21,   mt-ROS↑, 1,   TrxR↓, 11,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 7,   MMP↓, 5,   MPT↑, 1,   mt-OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   AMPK↑, 2,   ECAR↓, 2,   GAPDH↓, 2,   Glycolysis↓, 12,   HK2?, 1,   HK2↓, 7,   LDH↓, 3,   LDHA↓, 2,   NADPH↓, 1,   PDH↓, 1,   PDH↑, 1,   PKM2↓, 1,   PPP↓, 1,   PPP↑, 1,   SIRT1↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 2,   p‑Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 14,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 2,   Casp3↑, 5,   cl‑Casp3⇅, 1,   Casp7↑, 1,   Casp9↑, 2,   Cyt‑c↑, 6,   Fas↓, 1,   Fas↑, 1,   FasL↓, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 2,   JNK↓, 3,   MAPK↝, 1,   necrosis↑, 1,   p27/CDKN1B↑, 1,   p38↑, 1,   survivin↓, 2,   TumCD↑, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   other∅, 1,   PhotoS↑, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   p‑Beclin-1↑, 1,   p62↑, 1,   TumAuto↑, 2,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 9,   P53↑, 3,   cl‑PARP↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD44↓, 1,   CSCs↓, 2,   EMT↓, 3,   FOXO3↑, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   mTOR↓, 4,   mTOR↝, 1,   NOTCH1↓, 3,   NOTCH3↓, 1,   PI3K↓, 5,   PTEN↑, 1,   TumCG↓, 8,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

CEA↓, 1,   E-cadherin↑, 1,   fascin↓, 1,   miR-133a-3p↑, 1,   MMP2↓, 1,   MMP9↓, 4,   N-cadherin↑, 1,   TET1?, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 2,   Twist↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGFR↓, 2,   EPR↓, 1,   EPR↑, 2,   Hif1a↓, 2,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR4↓, 1,   IL12↑, 1,   IL2↑, 1,   IL6↓, 1,   Imm↑, 3,   Inflam↓, 1,   NF-kB↓, 3,   NK cell↑, 1,   PD-L1↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 9,   Dose↝, 8,   eff↓, 16,   eff↑, 45,   eff↝, 6,   Half-Life↓, 1,   Half-Life↑, 1,   MDR1↓, 1,   RadioS↑, 5,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

CEA↓, 1,   EGFR↓, 2,   IL6↓, 1,   LDH↓, 3,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 7,   AntiTum↑, 3,   chemoP↑, 2,   OS↑, 3,   QoL↑, 4,   toxicity↓, 8,   toxicity↑, 4,   toxicity↝, 3,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 169

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   TRPA1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 1,   GPx↑, 2,   GSH↑, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 1,   ROS↑, 1,   SOD↑, 2,   TAC↑, 1,   VitC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↓, 1,   LDL↓, 1,   NADPH↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   GSK‐3β↓, 2,  

Migration(tgid=13) ⓘ

VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   ICAM-1↓, 1,   IL1β↓, 4,   IL4↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 6,   MUC2↓, 1,   NF-kB↓, 2,   PGE2↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   eff↓, 3,   eff↑, 5,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   GutMicro↑, 1,   IL6↓, 2,   MUC19↓, 1,  

Functional Outcomes(tgid=23) ⓘ

BOLD↑, 2,   cardioP↑, 2,   cognitive?, 1,   cognitive↑, 2,   memory↑, 1,   neuroP↑, 3,   Risk↓, 3,   toxicity↓, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 2,  
Total Targets: 69

Scientific Paper Hit Count for: eff, efficacy
70 Silver-NanoParticles
65 Magnetic Fields
49 Curcumin
43 Sulforaphane (mainly Broccoli)
37 Vitamin C (Ascorbic Acid)
33 Chemotherapy
32 Thymoquinone
29 immunotherapy
29 EGCG (Epigallocatechin Gallate)
28 Shikonin
26 chitosan
26 Quercetin
25 Radiotherapy/Radiation
25 Piperlongumine
24 Artemisinin
23 Resveratrol
23 Selenium NanoParticles
23 Selenite (Sodium)
22 Copper and Cu NanoParticles
22 Baicalein
22 Dichloroacetate
20 Ashwagandha(Withaferin A)
20 Berberine
18 Metformin
18 Chlorogenic acid
18 Capsaicin
18 Chrysin
18 Magnetic Field Rotating
17 Apigenin (mainly Parsley)
17 Phenylbutyrate
17 Gambogic Acid
16 Lycopene
16 diet FMD Fasting Mimicking Diet
16 Exercise
16 Bicarbonate(Sodium)
15 Selenium
15 Fisetin
14 3-bromopyruvate
14 Folic Acid, Vit B9
14 Hyperthermia
14 Citric Acid
14 Caffeic acid
14 Propolis -bee glue
14 Hydrogen Gas
14 Phenethyl isothiocyanate
13 Gold NanoParticles
13 Cisplatin
13 Formononetin
13 Honokiol
12 Betulinic acid
12 Disulfiram
11 Auranofin
11 Fenbendazole
11 Melatonin
11 borneol
11 chaetocin
11 doxorubicin
11 salinomycin
11 Dandelion Root
11 Rosmarinic acid
10 Alpha-Lipoic-Acid
10 Luteolin
10 Atorvastatin
10 Boron
10 Vitamin D3
10 Choline
10 Vitamin K2
10 Silymarin (Milk Thistle) silibinin
10 diet Methionine-Restricted Diet
10 VitK3,menadione
10 Urolithin
9 Coenzyme Q10
9 Photodynamic Therapy
9 SonoDynamic Therapy UltraSound
9 Ellagic acid
9 Carvacrol
9 Electrical Pulses
9 Eugenol
8 Vitamin B12
8 isoquercitrin
8 Chlorophyllin
8 Docosahexaenoic Acid
8 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 Plumbagin
8 Parthenolide
7 5-fluorouracil
7 Gemcitabine (Gemzar)
7 Docetaxel
7 Carnosic acid
7 Piperine
7 Gossypol/AT-101
7 Juglone
6 Allicin (mainly Garlic)
6 Dipyridamole
6 beta-glucans
6 Bifidobacterium
6 Bortezomib
6 Celastrol
6 Diclofenac
6 Fucoidan
6 Ginger/6-Shogaol/Gingerol
6 HydroxyCitric Acid
6 Spermidine
6 Inositol
6 Terpinen-4-ol / Tea Tree Oil
5 1,8-Cineole
5 Astragalus
5 chemodynamic therapy
5 Akkermansia
5 Bevacizumab (brand Avastin)
5 Aspirin
5 Ascorbyl Palmitate
5 Astaxanthin
5 Berbamine
5 beta-carotene(VitA)
5 Boswellia (frankincense)
5 Thymol-Thymus vulgaris
5 Centella asiatica / Gotu kola → asiaticoside
5 Cynaropicrin
5 eicosapentaenoic acid
5 diet Plant based
5 Echinacea
5 Ginkgo biloba-EGb 761
5 Emodin
5 MCToil
5 Gallic acid
5 Gamma-aminobutyric acid
5 Ginkgolide B
5 Magnolol
5 isoorientin
5 Moringa oleifera
5 Nimbolide
4 2-DeoxyGlucose
4 cetuximab
4 EMF
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 almonertinib
4 Andrographis
4 Vitamin A, Retinoic Acid
4 α-Bisabolol / Chamomile oil
4 Butyrate
4 capecitabine
4 hydroxychloroquine
4 Cat’s Claw
4 Cannabidiol
4 CUSP9
4 erastin
4 diet Short Term Fasting
4 ferumoxytol
4 Ginseng
4 Isobavachalcone
4 iodine
4 Inulin Prebiotic
4 Propyl gallate
4 Pterostilbene
4 Sulfasalazine
4 Whole Body Vibration
3 Anthocyanins
3 Zinc
3 Anti-oxidants
3 Sorafenib (brand name Nexavar)
3 Arsenic trioxide
3 Aloe anthraquinones
3 D-limonene
3 Biochanin A
3 Beta-Caryophyllene
3 bempedoic acid
3 Lutein
3 Zeaxanthin
3 Bufalin/Huachansu
3 temozolomide
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Calorie Restriction Mimetics
3 Cysteamine
3 Oxygen, Hyperbaric
3 Paclitaxel/Taxol
3 Garcinol
3 Ginkgo biloba
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Hibiscus sabdariffa
3 HydroxyTyrosol
3 Isoliquiritigenin
3 isoflavones
3 Lecithin
3 nicotinamide adenine dinucleotide
3 Naringin
3 Radio Frequency
3 Taurine
3 Vitamin B1/Thiamine
2 5-Aminolevulinic acid
2 Trichostatin A
2 Glucose
2 Anethole/trans-Anethole
2 Aromatherapy
2 Trastuzumab
2 Baicalin
2 Huperzine A/Huperzia serrata
2 brusatol
2 Rutin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Caffeine
2 Calcium
2 carboplatin
2 Celecoxib
2 Cinnamon
2 Hydroxycinnamic-acid
2 Crocetin
2 Cucurbitacin
2 Cyclopamine
2 Dichloroacetophenone(2,2-)
2 Dasatinib/Phyrago
2 Deguelin
2 Date Fruit Extract
2 statins
2 Ferulic acid
2 Vitamin E
2 Geldanamycin
2 Kaempferol
2 Galloflavin
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Orlistat
2 Helleborus niger extracts – Christmas Rose
2 Hyperoside
2 Potassium
2 Methylene blue
2 metronomic chemo
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane
2 Niclosamide (Niclocide)
2 Phosphatidylserine
2 Rauwolfia serpentina/Indian Snakeroot
2 Aflavin-3,3′-digallate
2 tetrathiomolybdate
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 Anzaroot, Astragalus fasciculifolius Bioss
1 wortmannin
1 Resiquimod
1 Aidi injection
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Amodiaquine
1 DTS(dibenzyl trisulphide) from Anamu
1 Fennel Oil/Foeniculum vulgare
1 Acer okamotoanum
1 probiotics
1 Brucea javanica
1 Bacopa monnieri
1 Bromelain
1 Bruteridin(bergamot juice)
1 urea
1 Carnosine
1 Cannabichromene
1 Beta‐Lapachone
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Carvone
1 Polyphenols
1 Black phosphorus
1 gefitinib, erlotinib
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 diet Ketogenic
1 Mistletoe/Viscum album Extracts
1 Lemongrass Extract/Citral
1 Protocatechuic acid
1 PXD, phenoxodiol
1 Eurycomanone
1 Radicicol/monorden
1 flavonoids
1 Flickering Light Stimulation
1 olaparib/LYNPARZA
1 verapamil
1 Germanium inorganic
1 Geraniol
1 Germanium-Spirogermanium
1 Glabrescione B
1 Graviola
1 tamoxifen
1 High-Ozonide Oil
1 Indole-3-carbinol
1 entinostat
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Linalool
1 Matrine
1 Mung Bean Sprouts
1 Isovitexin
1 Vitexin
1 Methyl Jasmonate
1 methotrexate
1 Magnesium
1 Methylglyoxal
1 Mushroom Reishi
1 Myricetin
1 No Product/Mechanism Only
1 Oleocanthal
1 Peppermint
1 sericin
1 Psoralidin
1 enzalutamide
1 Rhein
1 Oxaliplatin
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 acetazolamide
1 Iron
1 Squalene
1 Glutathione
1 Sutherlandioside D
1 triptolide
1 Triphala
1 Tumor Treating Fields
1 Turmerones
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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