MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
2242- MF,    Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair
- in-vitro, Nor, NA
*MMP↑, *Diff↑, *OXPHOS↑, *BMD↑, ATP∅,
538- MF,    The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift
- in-vitro, BC, MDA-MB-231 - in-vitro, Melanoma, MSTO-211H
TumCG↓, Ca+2↑, COX2/PTGS2↓, ATP↑, MMP↑, ROS↑, OXPHOS↑, mitResp↑,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
532- MF,    A 50 Hz magnetic field influences the viability of breast cancer cells 96 h after exposure
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
TumCP↓, MMP↓, ROS↑, eff↝, selectivity↑,
507- MF,    Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism
- in-vitro, Liver, HepG2 - in-vitro, Lung, A549 - in-vitro, Nor, GP-293
MMP↓, TumCG↓, ROS↑, *Ca+2↓, Ca+2↑, selectivity↑, i-pH↑,
520- MF,    Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway
- in-vitro, Nor, NA
*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,
4147- MF,    PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration
- in-vitro, AD, PC12
*ROS↓, *Catalase↑, *MMP↑, *Casp3↓, *p‑ERK↓, *cAMP↑, *p‑CREB↑, *BDNF↑, *neuroP↑,
4568- MF,    Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria
- Study, NA, NA
*ETC↓, *OCR↑, *MMP↑, *ROS⇅, *MMP⇅,
3493- MFrot,  MF,    Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes
- in-vivo, GBM, NA
TumCD↑, MMP↓, Cyt‑c↑, Apoptosis↑, OS↑, DNAdam↑,
186- MFrot,  MF,    Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields
- in-vitro, GBM, GBM - in-vitro, Lung, NA
mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓, H2O2↑, eff↓, GSH↑, MMP↓,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
2259- MFrot,  MF,    Method and apparatus for oncomagnetic treatment
- in-vitro, GBM, NA
MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, eff↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,
1891- MGO,    Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma
- in-vitro, SCC, NA
NADH↓, MMP↓, Cyt‑c↑, selectivity↑, Apoptosis↑, ROS↑, ATP↓,
3839- Moringa,    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
5609- NaHCO3,    Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function
- in-vitro, Var, NA
eff↑, e-pH↑, MMP↓, OXPHOS↝, AMP↑, TumAuto↑, MPT↑, mtDam↑,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1↓, p62↑, PI3K↓, chemoPv↑,
4975- Nimb,    Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma
- in-vitro, Oral, NA
Apoptosis↑, ROS↑, Ca+2↑, ER Stress↑, Casp↑, MMP↓, tumCV↓,
6413- NoProd,    The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, HS587T
FIS1↓, ROS∅, MMP∅, OXPHOS∅,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
998- PB,    Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect
- in-vivo, NA, NA
p‑PDH↓, PDH↑, PDK1↓, HDAC↓, Glycolysis↓, MMP↓, Apoptosis↑,
2057- PB,    Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER–mitochondria crosstalk in SiHa cells
- in-vitro, Cerv, SiHa
ROS↓, tumCV∅, cl‑PARP↓, cl‑Casp3↓, MMP∅, ER Stress↓,
2065- PB,  TMZ,    Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells
- in-vitro, GBM, NA
eff↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, pro‑Casp12↓, eff↝, Ca+2↝,
2070- PB,    Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells
- in-vitro, CRC, HT-29
TumCG↓, Apoptosis↑, MMP↓, Casp3↑, PARP↓, NF-kB↓, eff↑,
2077- PB,    Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
- in-vitro, Liver, HUH7
miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,
2041- PB,    The Effect of Glucose Concentration and Sodium Phenylbutyrate Treatment on Mitochondrial Bioenergetics and ER Stress in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*mitResp↓, *ER Stress↓, MMP↓, GlucoseCon↓, OCR↓, CHOP/DDIT3↑,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1673- PBG,    An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms
- Review, Var, NA
TumCP↓, Apoptosis↑, TumCCA↑, MALAT1↓, P53↑, RadioS↑, OS↑, ROS↑, NF-kB↓, p65↑, MMP↓, ROS↑, MMP9↓, β-catenin/ZEB1↓, Vim↓, E-cadherin↓, VEGF↓, EMT↓,
1674- PBG,  SDT,  HPT,    Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
- in-vitro, PC, PANC1 - in-vitro, Nor, H6c7
tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,
1667- PBG,    Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis
- in-vitro, Pca, LNCaP
NF-kB↓, Apoptosis↑, MMP↓,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, eff↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
1677- PBG,    Propolis Inhibits UVA-Induced Apoptosis of Human Keratinocyte HaCaT Cells by Scavenging ROS
- in-vitro, Nor, HaCaT
*Dose∅, *AP-1↓, *MMP↑, *Casp3↓, *ROS↓,
1682- PBG,    Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits
- Review, Var, NA
i-LDH↓, Akt↓, MAPK↓, NF-kB↓, IL1β↓, IL6↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, ROS↓, Bcl-2↓, PARP↓, P53↑, BAX↑, Casp3↑, TumCCA↑, Cyt‑c↑, MMP↓, eff↑,
1684- PBG,    Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs
Apoptosis?, ANXA7↑, ROS↑, NF-kB↓, MMP↓, selectivity↑,
1685- PBG,    Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells
- in-vitro, BC, MCF7
ANXA7↑, ROS↑, NF-kB↓, MMP↓, selectivity↑, Dose⇅, ROS⇅,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1231- PBG,    Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,
2381- PBG,    Chinese Poplar Propolis Inhibits MDA-MB-231 Cell Proliferation in an Inflammatory Microenvironment by Targeting Enzymes of the Glycolytic Pathway
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, IL1β↓, IL6↓, NLRP3↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ROS↑, MMP↓,
2430- PBG,    The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation
- in-vitro, BC, MDA-MB-231
TumCP↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eff↓, MMP↓, LDH↑, ATP↓, Ca+2↑,
4947- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G0/G1   Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
AntiCan↑, chemoPv↑, TumCG↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
4950- PEITC,    Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
- vitro+vivo, Pca, PC3
MMP↓, Cyt‑c↑, Smad1↑, Diablo↑, ROS↑,
4956- PEITC,    Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells
- vitro+vivo, Lung, A549
GSH↓, ROS↑, mtDam↑, mitResp↓, MMP↓, CSCs↓, OCT4↓, ABC↓, SOX2↓, CD133↓, CD44↓, ALDH↓, Nanog↓, TumCG↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4944- PEITC,    Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations
- in-vitro, Oral, NA
TumCG↓, TumCCA↑, Apoptosis↑, ROS↑, NO↑, GSH↓, MMP↓, DNAdam↑, ATM↑, Chk2↑, P53↑, eff↓,
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,

Showing Research Papers: 451 to 500 of 672
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 672

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GPx↑, 1,   GSH↓, 5,   GSH↑, 1,   GSH/GSSG↓, 2,   H2O2↑, 3,   mt-H2O2↑, 1,   lipid-P↑, 2,   NADH↓, 1,   NOX4↑, 1,   OXPHOS↑, 1,   OXPHOS↝, 1,   OXPHOS∅, 1,   ROS↓, 2,   ROS↑, 37,   ROS⇅, 1,   ROS∅, 1,   i-ROS?, 1,   mt-ROS↑, 1,   SIRT3↓, 1,   SOD↓, 1,   SOD2↓, 1,   Thiols↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 4,   ATP↑, 1,   ATP∅, 1,   CDC25↓, 1,   EGF↓, 1,   ETC↓, 3,   FIS1↓, 1,   mitResp↓, 2,   mitResp↑, 1,   MMP?, 2,   MMP↓, 40,   MMP↑, 1,   MMP↝, 1,   MMP∅, 2,   MPT↑, 3,   mtDam↑, 7,   OCR↓, 4,   SDH↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMP↑, 1,   ANXA7↑, 2,   CYP3A4↓, 1,   FASN↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 4,   lactateProd↑, 1,   LDH↓, 4,   LDH↑, 1,   i-LDH↓, 1,   LDHA↓, 3,   PDH↑, 1,   p‑PDH↓, 1,   PDK1↓, 1,   PFK↓, 4,   PKM2↓, 4,   PPARγ↑, 1,   SIRT1↓, 2,   TCA?, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   Apoptosis?, 2,   Apoptosis↑, 18,   BAD↑, 1,   Bak↑, 2,   BAX↓, 2,   BAX↑, 9,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   BID↑, 2,   Casp↓, 1,   Casp↑, 3,   pro‑Casp12↓, 1,   Casp3↓, 2,   Casp3↑, 13,   cl‑Casp3↓, 1,   cl‑Casp3↑, 3,   Casp7↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   Chk2↑, 1,   Cyt‑c↑, 14,   Diablo↑, 1,   DR4↑, 2,   DR5↑, 1,   Fas↓, 1,   Fas↑, 1,   hTERT/TERT↓, 1,   iNOS↓, 2,   iNOS↑, 1,   JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 2,   Mcl-1↓, 1,   p27/CDKN1B↑, 3,   p38↑, 1,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 1,   Telomerase↓, 2,   TRAIL↑, 1,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1,   ChrMod↑, 1,   H3↓, 1,   other↝, 1,   tumCV↓, 5,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 5,   GRP78/BiP↑, 3,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3II↑, 2,   p62↓, 2,   p62↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 5,   DNArepair↓, 1,   P53↑, 9,   P53↝, 1,   PARP↓, 2,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 3,   PCNA↓, 1,   TP53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   p‑CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   P21?, 1,   P21↓, 2,   P21↑, 5,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD133↓, 1,   CD44↓, 2,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 2,   p‑ERK↓, 1,   FOXO3↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   mTOR↓, 1,   Nanog↓, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 2,   SOX2↓, 1,   STAT3↓, 4,   TumCG↓, 8,  

Migration(tgid=13) ⓘ

Ca+2↑, 7,   Ca+2↝, 1,   i-Ca+2↑, 1,   CLDN2↓, 1,   E-cadherin↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MALAT1↓, 1,   miR-22↑, 1,   MMP2↓, 2,   proMMP2↓, 1,   MMP9↓, 2,   MMPs↓, 2,   PAK1↓, 1,   PKCδ↓, 1,   Smad1↑, 1,   TIMP1↓, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 12,   TumMeta↓, 4,   Vim↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EGFR↓, 1,   eNOS↑, 1,   Hif1a↓, 4,   NO↑, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT3↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 4,   DCells↑, 1,   IL10↓, 2,   IL1β↓, 4,   IL1β↑, 1,   IL4↓, 1,   IL6↓, 5,   Imm↑, 1,   Inflam↓, 2,   IRAK4↓, 1,   JAK↓, 1,   NF-kB↓, 14,   NF-kB↑, 2,   p65↓, 2,   p65↑, 1,   TLR4↓, 4,   TNF-α↓, 5,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 2,   ChemoSen↓, 1,   ChemoSen↑, 7,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 2,   Dose∅, 4,   eff↓, 8,   eff↑, 20,   eff↝, 3,   Half-Life↓, 1,   Half-Life↝, 1,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 5,   LDH↓, 4,   LDH↑, 1,   i-LDH↓, 1,   TP53↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   Appetite↑, 1,   breath↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   OS↑, 4,   OS⇅, 1,   Pain↓, 2,   QoL↑, 1,   radioP↑, 1,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 275

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 3,   GPx1↑, 2,   GPx4↑, 1,   GSH↑, 2,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   ROS↓, 6,   ROS↑, 1,   ROS⇅, 1,   ROS∅, 1,   SOD↑, 3,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   mitResp↓, 1,   MMP↑, 5,   MMP⇅, 1,   MMP↝, 1,   MMP∅, 1,   MPT↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cAMP↑, 1,   p‑CREB↑, 1,   Glycolysis↑, 1,   HK2↑, 1,   PFKL↑, 1,   PFKM↑, 1,   PFKP↑, 1,   PKM2↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2∅, 1,   Casp3↓, 2,   Cyt‑c↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   p‑ERK↓, 1,   p‑GSK‐3β↑, 1,   mTOR↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↓, 2,   β-Endo↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   Dose↝, 2,   Dose∅, 1,   eff↓, 1,   eff↑, 1,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   chemoP↑, 1,   neuroP↑, 2,   OS↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 72

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
31 Silver-NanoParticles
25 Quercetin
21 Betulinic acid
21 Capsaicin
17 Baicalein
17 Propolis -bee glue
17 Fisetin
16 Curcumin
16 Berberine
15 Sulforaphane (mainly Broccoli)
15 Emodin
15 Shikonin
15 Thymoquinone
14 Magnetic Fields
13 Apigenin (mainly Parsley)
11 Chrysin
11 Resveratrol
10 Ashwagandha(Withaferin A)
10 Electrical Pulses
10 Gambogic Acid
10 Graviola
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Dichloroacetate
8 Honokiol
8 Phenethyl isothiocyanate
7 Cisplatin
7 Radiotherapy/Radiation
7 Dandelion Root
7 EGCG (Epigallocatechin Gallate)
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 Beta-Caryophyllene
6 Carvacrol
6 Juglone
6 Luteolin
6 Parthenolide
5 Alpha-Lipoic-Acid
5 Artemisinin
5 doxorubicin
5 Rosmarinic acid
5 Eugenol
5 Ferulic acid
5 Lycopene
5 Magnetic Field Rotating
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 Selenium
4 Copper and Cu NanoParticles
4 Date Fruit Extract
4 Ginkgo biloba-EGb 761
4 Evodiamine
4 Formononetin
4 Gallic acid
4 Garcinol
4 HydroxyTyrosol
4 Hyperoside
4 Indole-3-carbinol
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Boron
3 Thymol-Thymus vulgaris
3 Crocetin
3 Carvone
3 Cynaropicrin
3 Diclofenac
3 Ellagic acid
3 Fucoidan
3 Geraniol
3 Gossypol/AT-101
3 Hibiscus sabdariffa
3 Linalool
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Anethole/trans-Anethole
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorogenic acid
2 Cinnamon
2 Hydroxycinnamic-acid
2 Citric Acid
2 Coenzyme Q10
2 Fenbendazole
2 Paclitaxel/Taxol
2 Ginseng
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hydrogen Gas
2 Hyperthermia
2 Photodynamic Therapy
2 Magnolol
2 Nimbolide
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Angelica archangelica / Garden Angelica
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Cannabidiol
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Cyclopamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Mistletoe/Viscum album Extracts
1 Disulfiram
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Helleborus niger extracts – Christmas Rose
1 Isobavachalcone
1 Inositol
1 1,8-Cineole
1 Methylene blue
1 Methyl Jasmonate
1 Melatonin
1 Methylglyoxal
1 Moringa oleifera
1 Mushroom Chaga
1 Bicarbonate(Sodium)
1 No Product/Mechanism Only
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Kaempferol
1 Rauwolfia serpentina/Indian Snakeroot
1 Oxaliplatin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sulfasalazine
1 polyethylene glycol
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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