Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5805- Sper,    The Effect of Spermidine Supplementation on Cognitive Function in Adults: A Mini-Review
- Review, AD, NA
*cognitive↝, *Dose↝,
5802- Sper,    Spermidine reduces cancer-related mortality in humans
- Review, Var, NA
EP300↓, Risk↓,
5782- Sper,    Cardioprotection and lifespan extension by the natural polyamine spermidine
- in-vivo, Nor, NA
cardioP↑, eff↓, AntiAge↑, BioAv↑, CRM↝,
5799- Sper,    The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial
- Trial, AD, NA
*cognitive↑, memory↑, *Dose↑, *Dose↑, *Dose↝, *Dose↝, BioAv↓, eff↑,
1512- Squ,    Combination therapy in combating cancer
- Review, NA, NA
ChemoSideEff↓, *ROS↓, *GSH↑, eff↑, chemoP↑,
107- SS,    Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway
- vitro+vivo, MB, LS174T
HH↓, Smo↓, Gli↓, Gli1↓, PTCH1↓, TumCG↓,
1017- SSE,    Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis
- vitro+vivo, CRC, NA
Akt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, survivin↓, Apoptosis↑, ROS↑,
1062- SSE,    Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells
- in-vitro, GBM, LN229 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HDAC↓, TumCP↓, TumCCA↑, Apoptosis↑, Casp3↝, MMP2↓, *BioAv↝,
1018- SSE,    Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, HCT116 - vitro+vivo, CRC, SW480
TumAuto↑, LC3s↑, TumW↓, Weight∅, Beclin-1↑, p62↓, ROS↑,
984- SSE,    Effects of selenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
ERα/ESR1↓, PR↑, pS2/TFF1↑, Catalase↑,
1002- SSE,  Osi,  Adag,    Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
- in-vitro, Lung, H1975 - in-vitro, Lung, H385
Apoptosis↑, Ferroptosis↑, DNMT1↓, TET1↑, TumCCA↑, cl‑PARP↑, cl‑Casp3↑, Cyt‑c↑, BIM↑, NOXA↑, Apoptosis↑, ROS↑, ER Stress↑, UPR↑,
1003- SSE,    Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression
- vitro+vivo, Lung, NA
NF-kB↓, PDK1↓, p‑p65↑, p‑IκB↑, BAX↑, lactateProd↓, MMP↓, Cyt‑c↑, mitResp↑, Apoptosis↑,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, eff↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,
1707- SSE,    A Diet Lacking Selenium, but Not Zinc, Copper or Manganese, Induces Anticancer Activity in Mice with Metastatic Cancers
- in-vivo, Ovarian, NA - in-vivo, BC, NA
OS↓,
1697- SSE,  Calc,    Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland
- Human, CRC, NA
Risk↓, Risk↓, Dose∅, AntiCan↑,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,
1687- SSE,    Selenium for preventing cancer
- Analysis, Var, NA
eff∅, AntiCan∅,
4216- SSE,    Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways
- in-vitro, NA, NA
*BDNF↑, *TrkB↓, *PI3K↑, *Akt↑, *neuroP↑,
4739- SSE,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,
4748- SSE,  Chemo,  antiOx,    Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in gastric cancer patients receiving adjuvant oxaliplatin and capecitabine after gastrectomy: a retrospective pilot study
- Trial, GC, NA
toxicity↓, chemoP∅, *neuroP↑, *Dose↝,
4727- SSE,    Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4
- in-vivo, Col, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,
4743- SSE,    Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients
- Review, Var, NA
eff↝, chemoP↝, radioP↝,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
4741- SSE,    Selenium in Oncological Intervention
- Review, Var, NA
Risk↓, *other↝, Risk↓, AntiTum↑, chemoR↓, chemoP↑,
4740- SSE,    Optimising Selenium for Modulation of Cancer Treatments
- Review, Var, NA
*selenoP↑, *Dose↓, Risk↓, *toxicity↝, Dose↑, chemoP↑, radioP↑,
4728- SSE,    Selective Impact of Selenium Compounds on Two Cytokine Storm Players
- NA, Covid, NA
*IL6↓, *TNF-α↓, *NRF2↑, *other↑, *eff↑,
4716- SSE,    Selenium Substitution During Radiotherapy of Solid Tumours – Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients
- in-vivo, HNSCC, NA
Dose↝, *GPx↑, *ROS↓,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
4733- SSE,    Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition
- NA, Nor, NA
*selenoP↑, *Trx↑, *GPx↑, *NRF2↑,
4732- SSE,    Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway
- in-vivo, Autism, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *other↝,
4731- SSE,    Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *H2O2↓, *Catalase↑, *GSH↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *other↝,
4718- SSE,    High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer
- in-vitro, Ovarian, NA
TumCP↑, ROS↑, GPx↓, lipid-P↑, Ferroptosis↑, Dose↑,
4750- SSE,  Rad,    Selenium in Radiation Oncology—15 Years of Experiences in Germany
- Review, Var, NA
RadioS∅, radioP↑, eff↑,
4753- SSE,  Chemo,    Selenium and Lung Cancer: A Systematic Review and Meta Analysis
- Review, Lung, NA
Risk⇅, chemoP↑, radioP↑,
5081- SSE,    Application Notes and Protocols: Selenite as a Selenium Source in Cell Culture Media Supplementation
- Review, Var, NA
Dose↝, ROS↑, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑,
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, HOXB-AS1↓, TumCP↓, TumCI↓, Apoptosis↑, BAD↓, Bcl-2↓, cl‑Casp3↑, MMP2↓, E-cadherin↑, N-cadherin↓, ROS↑, NF-kB↓,
5079- SSE,  Rad,    The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B
chemoP↑, eff↝, ROS↑, MMP↓, Cyt‑c↑, TumCG↓, RadioS↝, other↝,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5077- SSE,    Antitumor effects of sodium selenite on acute lymphocytic leukemia
- in-vitro, AML, NA
TumCD↑, Apoptosis↑,
5076- SSE,    Sodium selenite inhibits the growth of cervical cancer cells through the PI3K/AKT pathway
- in-vivo, Cerv, HeLa - in-vivo, Cerv, SiHa
TumCG↓, toxicity↓, tumCV↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, eff↑,
5075- SSE,    Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma
- vitro+vivo, RCC, 786-O
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, NF-kB↓, eff↓, E-cadherin↑, cl‑Casp3↑, VEGF↓, MMP9↓, EMT↓, MMP↓, mtDam↑, BAX↑, Bcl-2↓,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5073- SSE,    Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
- Trial, Var, NA
AntiTum↑, ChemoSen↑, Dose↑, Half-Life↝, toxicity↝, toxicity↝,
5091- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, GBM, U87MG - in-vitro, Cerv, HeLa - in-vitro, BC, MCF-7 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29 - in-vitro, Nor, SVGp12
Ferroptosis↑, xCT↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,
5093- SSE,    Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice
- in-vivo, Var, NA
AntiCan↑, eff↑, selectivity↑, ROS↑, Dose↝, Trx↓, GSH↓,
5111- SSE,    Sodium selenite induces apoptosis via ROS-mediated NF-κB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells
- in-vitro, BC, 4T1
ROS↑, NF-kB↓, p65↓, mtDam↑, Casp9↑, Casp3↑, Apoptosis↑, eff↓,
5110- SSE,    Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells
- in-vitro, AML, APL NB4
Apoptosis↑, selectivity↑, TumAuto↓, PI3K↓, Akt↓,
5109- SSE,    Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells
- in-vitro, CRC, HCT116
ROS↑, DNAdam↓, ATM↑, eff↓, TumCCA↑,
5108- SSE,    Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis
- in-vitro, AML, U937
p‑P53↑, Beclin-1↓, LC3I↓, Apoptosis↑, Casp↑,
5107- SSE,    Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells
- vitro+vivo, AML, APL NB4
PERK↑, eIF2α↑, ATF4↑, Apoptosis↑, AntiTum↑, ER Stress↑, p38↑,

Showing Research Papers: 5551 to 5600 of 6149
Prev Page 112 of 123 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6149

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↑, 4,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 3,   Iron↑, 2,   lipid-P↑, 2,   MDA↑, 1,   NRF2↓, 2,   PrxI↓, 1,   ROS↑, 19,   Trx↓, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↑, 1,   MMP↓, 5,   mtDam↑, 2,  

Core Metabolism/Glycolysis ⓘ

CRM↝, 1,   lactateProd↓, 1,   PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 16,   BAD↓, 1,   BAX↑, 2,   Bcl-2↓, 2,   BIM↑, 1,   Casp↑, 2,   Casp3↑, 1,   Casp3↝, 1,   cl‑Casp3↑, 3,   Casp9↑, 1,   Cyt‑c↑, 3,   Ferroptosis↑, 4,   necrosis↑, 1,   NOXA↑, 1,   p38↑, 1,   pS2/TFF1↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 3,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3I↓, 1,   LC3s↑, 1,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↓, 1,   DNAdam↑, 1,   DNArepair↑, 1,   DNMT1↓, 1,   p‑P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   EP300↓, 1,   Gli↓, 1,   Gli1↓, 1,   HDAC↓, 1,   HH↓, 1,   HOXB-AS1↓, 1,   mTOR↓, 1,   PI3K↓, 1,   p‑PI3K↓, 1,   PR↑, 1,   PTCH1↓, 1,   Smo↓, 1,   TumCG↓, 4,  

Migration ⓘ

E-cadherin↑, 2,   MMP2↓, 3,   MMP9↓, 2,   N-cadherin↓, 1,   TET1↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 6,   TumCP↑, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   angioG↑, 1,   ATF4↑, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

IL2↑, 1,   Imm↑, 1,   INF-γ↑, 1,   Inflam↓, 1,   p‑IκB↑, 1,   NF-kB↓, 4,   NK cell↑, 1,   p65↓, 1,   p‑p65↑, 1,   PSA↓, 1,   Th1 response↑, 1,   Th2↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   chemoR↓, 1,   ChemoSen↑, 7,   Dose↑, 7,   Dose⇅, 1,   Dose↝, 3,   Dose∅, 1,   eff↓, 6,   eff↑, 9,   eff↝, 2,   eff∅, 2,   Half-Life↝, 2,   RadioS↑, 2,   RadioS↝, 1,   RadioS∅, 1,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

AR↓, 1,   ERα/ESR1↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 3,   AntiCan∅, 2,   AntiTum↑, 5,   cardioP↑, 1,   chemoP↑, 7,   chemoP↝, 1,   chemoP∅, 1,   ChemoSideEff↓, 3,   memory↑, 1,   OS↓, 1,   OS↑, 1,   Pain↓, 1,   QoL↑, 1,   radioP↑, 5,   radioP↝, 1,   Risk↓, 10,   Risk↑, 2,   Risk⇅, 1,   Risk∅, 1,   toxicity↓, 2,   toxicity↝, 4,   TumW↓, 1,   Weight∅, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 151

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↑, 1,   Ferroptosis↓, 2,   GPx↑, 2,   GPx4↑, 2,   GSH↑, 2,   H2O2↓, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 6,   ROS↓, 3,   selenoP↑, 3,   Trx↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Bcl-2↑, 1,   Ferroptosis↓, 2,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↑, 1,   other↝, 3,  

DNA Damage & Repair ⓘ

GADD45A↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Imm↑, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   TrkB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 4,   eff↑, 2,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   cognitive↝, 1,   neuroP↑, 2,   Pain↓, 1,   toxicity↑, 1,   toxicity↝, 1,  
Total Targets: 42

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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