Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
461- CUR,    Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-30a-5p↑, PCLAF↓, Bcl-2↓, Casp3↓, BAX↑, cl‑Casp3↑,
460- CUR,    Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, TCCSUP - in-vitro, Bladder, J82
miR-7641↓, p16↑, Apoptosis↑, TumCI↓,
459- CUR,    Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, RT4
Trop2↓, Apoptosis↑, cycE1↓, p27↑, TumCCA↑,
458- CUR,    Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion
- vitro+vivo, GC, SGC-7901
Casp3↑, Apoptosis↑, TumCP↓,
405- CUR,  5-FU,    Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis
- vitro+vivo, CRC, HCT116
Apoptosis↑, TumCMig↓, NRF2↑, ROS↑, MET↑, miR-34a↑,
406- CUR,    Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2
- in-vitro, BC, MCF-7 - in-vitro, Hepat, HepG2
GSH↓, Apoptosis↑, Bcl-2↓, cMyc↓,
407- CUR,    Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress
- in-vitro, Melanoma, A375
Apoptosis↑, ROS↑, GSH↓, MMP↓,
477- CUR,    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
- in-vitro, Cerv, SiHa
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB/CCNB1↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,
483- CUR,  PDT,    Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin
- in-vivo, NA, A431
TumVol↓, TumCP↓, Apoptosis↑,
482- CUR,  PDT,    The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro
- in-vitro, Bladder, RT112 - in-vitro, Bladder, UMUC3
Apoptosis↑, TumCG↓, TumCP↓,
480- CUR,    Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells
- in-vitro, GBM, SNB19
TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, NEDD9↓, NOTCH1↓, p‑Akt↓,
435- CUR,    Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549
Apoptosis↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1↑, p62↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, p‑mTOR↓,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
455- CUR,    Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin
- in-vitro, GC, SGC-7901
Shh↓, Gli1↓, FOXM1↓, β-catenin/ZEB1↓, TumCMig↓, Apoptosis↑, TumCCA↑, Wnt↓, EMT↓, E-cadherin↑, Vim↓,
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,
448- CUR,    Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation
- in-vitro, CRC, HT-29
Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1↑, p62↑, GPx1↓, GPx4↓,
444- CUR,  Cisplatin,    LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells
- vitro+vivo, CRC, HCT8
TumVol↓, Apoptosis↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑PARP1↑, miR-497↑, KCNQ1OT1↓,
442- CUR,  5-FU,    Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress
- in-vitro, CRC, HCT116
Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,
439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
Apoptosis↑, TumAuto↑, GP1BB↓, COL9A3↓, COMP↓, AGRN↓, ITGB4↓, LAMA5↓, COL2A1↓, ITGB6↓, LGR5↓, TFAP2A↓, ECM/TCF↓,
137- CUR,    Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling
- in-vitro, Pca, DU145
NOTCH1↓, cycD1/CCND1↓, CDK2↓, P21↑, p27↑, P53↑, Bcl-2↓, Casp3↑, Casp9↑, TumCCA↑, TumCP↓, Apoptosis↑,
141- CUR,    Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer
- in-vivo, Pca, PC3
BAX↑, Bcl-2↓, TumCG↓, TumVol↓, TumW↓, Apoptosis↑, AR↓, Ca+2↑, MPT↑,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
117- CUR,    Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells
- in-vivo, Pca, RM-1 - in-vivo, Pca, DU145
ROS↑, tumCV↓, Apoptosis↑, TumCCA↑, Ca+2↑, eff↓, ER Stress↑,
123- CUR,    Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells
- in-vitro, Colon, LoVo - in-vitro, Colon, COLO205 - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
NF-kB↓, ATF3↑, HO-1↑, Wnt↓, Akt↓, mTOR↓, PTEN↑, Apoptosis↑, TGF-β↓, PPARγ↑,
124- CUR,    Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TGF-β↓, Wnt↓, PI3k/Akt/mTOR↓, NF-kB↓, PTEN↑, Apoptosis↑, TumCCA↑,
125- CUR,    Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway
- in-vitro, adrenal, H295R
CYP17A1↓, CYP19↓, *Nrf1↑, *NF-kB↓, angioG↓, Apoptosis↑, AR↓, toxicity↓, BioAv↑,
134- CUR,  RES,  MEL,  SIL,    Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Apoptosis↑, ROS↑, Trx1↓, TumCG↓, eff↓, TXNIP↑,
129- CUR,    Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation
- vitro+vivo, Pca, LNCaP
JNK↓, H3K4↓, TumCG↓, Apoptosis↑, eff↑,
131- CUR,    Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer
- vitro+vivo, Pca, LNCaP - vitro+vivo, Pca, 22Rv1
AKR1C2↓, CYP11A1↓, HSD3B↓, DHT↓, testos↓, StAR↓, SRD5A1↑, AR↓, tumCV↓, TumCG↓, Apoptosis↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
14- CUR,    Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway
- vitro+vivo, Pca, PC3
PI3K/mTOR/ETS2↓, MDM2↓, P21↑, Apoptosis↑, TumCP↓, eff↑, RadioS↑,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, eff↑,
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,
167- CUR,    Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
- in-vitro, Pca, PC3
MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,
6236- CUSP9,  EP,    Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro
- in-vitro, GBM, U251
Apoptosis↑, MOMP↓, Casp2↑, Bcl-2↓, Mcl-1↓, eff↑, OCR↓, OXPHOS↓, TumCMig↓,
6234- CUSP9,    In Vitro and Clinical Compassionate Use Experiences with the Drug-Repurposing Approach CUSP9v3 in Glioblastoma
- Human, GBM, NA
TumCP↓, Apoptosis↑, TumCMig↓, tumCV↓, TumCG↓, cl‑Casp3↑,
6249- Cyc,    Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
HH↓, OCR↓, TumCP↓, Apoptosis↑, ROS↑, MMP↑, mtDam↑,
6247- Cyc,    Sonic Hedgehog Pathway Contributes to Gastric Cancer Cell Growth and Proliferation
- vitro+vivo, GC, MKN45
Shh↓, TumCP↓, TumCCA↓, Apoptosis↓, TumCG↓, cycD1/CCND1↓,
6248- Cyc,    The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
- in-vitro, CRC, NA
HH↓, Apoptosis↑, Slug↓, Snail↓, Twist↓, EMT↓, β-catenin/ZEB1↓, E-cadherin↑, TumCI↓,
1871- DAP,    Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
- in-vitro, AML, U937 - in-vivo, AML, NA
TumCP↓, Apoptosis↑, TumCG↓, PDK1↓, cl‑PARP↑, Bcl-xL↓, Bcl-2↓, Beclin-1↓, ATG3↓, PI3K↓, Akt↓, eff↑,
5194- DCA,    Metabolic modulation of glioblastoma with dichloroacetate
- vitro+vivo, GBM, NA
MMP↓, mt-ROS↑, Apoptosis↑, CSCs↓, Hif1a↓, P53↑, angioG↓, toxicity↓, PDKs↓,
5196- DCA,    Dichloroacetate induces apoptosis in endometrial cancer cells
- in-vitro, Var, NA
selectivity↑, MMP↓, survivin↓, Ca+2↓, P53↑, PDK1↓, PDH↑, Glycolysis↓, OXPHOS↑, ROS↑, Cyt‑c↑, Apoptosis↑, Casp↑, tumCV↓, PUMA↑,
1874- DCA,    Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, MDAH-2774
Apoptosis↑, MPO↓, iNOS↓, Hif1a↓, SOD↑, Casp3↑,
1873- DCA,    Dual-targeting of aberrant glucose metabolism in glioblastoma
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
PDKs↓, eff↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, eff↑, Dose∅, toxicity∅,
1870- DCA,  Rad,    Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
- in-vitro, Pca, PC3
TumCCA↑, Apoptosis↑, MMP↓, eff↑, RadioS↑,
1868- DCA,  MET,    Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
- Case Report, NA, NA
eff↑, toxicity∅, MMP↓, Apoptosis↑, selectivity↑, pH↝, Dose↝, Dose↝, eff↑,
1889- DCA,    A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
- Review, Var, NA
PDKs↓, Glycolysis↓, mt-H2O2↑, Apoptosis↑, TumCP↓, TumCG↓, toxicity∅,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,

Showing Research Papers: 601 to 650 of 1398
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1398

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   GPx1↓, 1,   GPx4↓, 1,   GSH↓, 3,   mt-H2O2↑, 1,   HO-1↑, 1,   MPO↓, 1,   NRF2↑, 1,   NRF2↝, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   ROS↑, 13,   ROS↝, 1,   mt-ROS↑, 1,   SOD↑, 1,   Trx1↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   CDC25↓, 1,   MMP↓, 6,   MMP↑, 1,   MPT↑, 2,   mtDam↑, 2,   OCR↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMP↓, 1,   AMPK↑, 1,   cMyc↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 3,   lactateProd↓, 1,   PDH↑, 1,   PDK1↓, 2,   PDKs↓, 4,   PI3K/Akt↓, 2,   PI3k/Akt/mTOR↓, 1,   PI3K/mTOR/ETS2↓, 1,   PPARγ↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 5,   Akt↝, 1,   p‑Akt↓, 4,   Apoptosis↓, 1,   Apoptosis↑, 48,   Apoptosis↝, 1,   BAD↑, 1,   p‑BAD↓, 1,   BAX↑, 4,   BAX↝, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   Bcl-2↝, 1,   Bcl-xL↓, 2,   Bcl-xL↝, 1,   Casp↑, 2,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 6,   Casp3↝, 1,   cl‑Casp3↑, 5,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 3,   Cyt‑c↝, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 1,   JNK↝, 1,   MAPK↑, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   MDM2↓, 1,   miR-497↑, 1,   miR-7641↓, 1,   MOMP↓, 1,   p27↑, 3,   PUMA↑, 1,   survivin↓, 4,  

Transcription & Epigenetics ⓘ

COMP↓, 1,   H3K4↓, 1,   KCNQ1OT1↓, 1,   miR-30a-5p↑, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,   HSP27↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

ATG3↓, 1,   ATG3↑, 1,   ATG5↑, 1,   Beclin-1↓, 1,   Beclin-1↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3I↓, 1,   LC3II↑, 1,   LC3s↓, 1,   p62↓, 1,   p62↑, 3,   TumAuto↑, 5,  

DNA Damage & Repair ⓘ

ATR↑, 1,   DNAdam↑, 2,   GADD45A↑, 1,   p16↑, 1,   P53↑, 5,   P53↝, 1,   p‑P53↑, 1,   cl‑PARP↑, 4,   cl‑PARP1↑, 1,   PCLAF↓, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   Cyc↝, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 5,   P21↝, 1,   TFAP2A↓, 1,   TumCCA↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↓, 1,   CSCs↓, 2,   EMT↓, 5,   FOXM1↓, 2,   Gli1↓, 4,   HH↓, 5,   LGR5↓, 1,   miR-34a↑, 1,   mTOR↓, 5,   mTOR↝, 1,   p‑mTOR↓, 2,   n-MYC↓, 1,   NKD2↑, 1,   NOTCH1↓, 2,   PI3K↓, 3,   PI3K↝, 1,   PTCH1↓, 2,   PTEN↑, 2,   PTEN↝, 1,   Shh↓, 4,   STAT3↓, 1,   Sufu↓, 1,   TCF↓, 1,   TumCG↓, 13,   Wnt↓, 4,  

Migration ⓘ

AGRN↓, 1,   AKR1C2↓, 1,   AP-1↝, 1,   Ca+2↓, 1,   Ca+2↑, 2,   COL2A1↓, 1,   COL9A3↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   GP1BB↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,   MET↑, 1,   MMP2↓, 1,   MMP2↝, 1,   MMP9↓, 1,   NEDD9↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 2,   Trop2↓, 1,   TumCI↓, 4,   TumCMig↓, 9,   TumCP↓, 17,   Twist↓, 1,   TXNIP↑, 1,   Vim↓, 1,   Vim↑, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   ECM/TCF↓, 1,   EGFR↝, 1,   HIF-1↓, 1,   Hif1a↓, 3,   VEGF↓, 2,   VEGF↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↝, 1,   IKKα↓, 2,   IL6↝, 1,   NF-kB↓, 6,   NF-kB↝, 1,   PSA↝, 1,   TNF-α↝, 1,  

Cellular Microenvironment ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   AR↝, 1,   CYP11A1↓, 1,   CYP19↓, 1,   DHT↓, 1,   HSD3B↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   CYP17A1↓, 1,   Dose↝, 2,   Dose∅, 1,   eff↓, 3,   eff↑, 13,   RadioS↑, 4,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 3,   AR↝, 1,   EGFR↝, 1,   Ferritin↓, 1,   FOXM1↓, 2,   IL6↝, 1,   PSA↝, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   OS↑, 2,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 3,   TumVol↓, 3,   TumVol↑, 1,   TumW↓, 1,  
Total Targets: 226

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Nrf1↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Functional Outcomes ⓘ

toxicity↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: Apoptosis, Apoptosis
68 Curcumin
67 Silver-NanoParticles
43 Magnetic Fields
41 Quercetin
36 Thymoquinone
34 Berberine
31 Sulforaphane (mainly Broccoli)
31 EGCG (Epigallocatechin Gallate)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Shikonin
23 Betulinic acid
23 Phenethyl isothiocyanate
22 Resveratrol
20 Radiotherapy/Radiation
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Dandelion Root
18 Honokiol
18 Lycopene
18 Urolithin
17 Garcinol
16 Eugenol
15 Chemotherapy
15 Carvacrol
15 Nimbolide
14 Cisplatin
14 Astaxanthin
14 chitosan
14 Crocetin
14 Luteolin
13 Beta-Caryophyllene
13 salinomycin
13 Magnolol
12 Allicin (mainly Garlic)
12 Graviola
12 Selenium NanoParticles
11 Propolis -bee glue
11 Silymarin (Milk Thistle) silibinin
11 Gambogic Acid
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 Metformin
10 Chlorogenic acid
10 Phenylbutyrate
10 Piperlongumine
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Fisetin
9 Juglone
9 Rosmarinic acid
8 Photodynamic Therapy
8 5-fluorouracil
8 Coenzyme Q10
8 Auranofin
8 Paclitaxel
8 Bufalin/Huachansu
8 Citric Acid
8 Carvone
8 Electrical Pulses
8 Ursolic acid
8 Dichloroacetate
8 Magnetic Field Rotating
7 Gemcitabine (Gemzar)
7 Atorvastatin
7 doxorubicin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Caffeic acid
7 Carnosic acid
7 Cinnamon
7 Emodin
7 HydroxyTyrosol
7 Vitamin K2
6 Astragalus
6 Andrographis
6 Celecoxib
6 D-limonene
6 Ellagic acid
6 Hydrogen Gas
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Aflavin-3,3′-digallate
5 Genistein (soy isoflavone)
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 3-bromopyruvate
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Disulfiram
4 Eurycomanone
4 Ferulic acid
4 Ginkgo biloba
4 Geraniol
4 γ-linolenic acid (Borage Oil)
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Cat’s Claw
3 Cannabidiol
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Galloflavin
3 Orlistat
3 Hyperthermia
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Fenbendazole
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Aspirin
2 Sorafenib (brand name Nexavar)
2 Dipyridamole
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Chocolate
2 irinotecan
2 CUSP9
2 Deguelin
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 Fucoidan
2 Shilajit/Fulvic Acid
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Rutin
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 Hydroxycinnamic-acid
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 methylseleninic acid
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Mistletoe
1 Lemongrass Extract/Citral
1 Evodiamine
1 Exercise
1 Gallic acid
1 carboplatin
1 gefitinib, erlotinib
1 Grapeseed extract
1 hydrogen sulfide
1 Rapamycin
1 Huperzine A/Huperzia serrata
1 Indole-3-carbinol
1 Inoscavin A
1 Ivermectin
1 Licorice
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 isoflavones
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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