| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 6300- | Cro, | Interaction of saffron and its constituents with Nrf2 signaling pathway: A review |
| - | Review, | Nor, | NA | - | Review, | Arthritis, | NA |
| 6294- | Cro, | Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention |
| - | Review, | Var, | NA |
| 6293- | Cro, | Crocetin: an agent derived from saffron for prevention and therapy for cancer |
| - | Review, | Var, | NA |
| 6292- | Cro, | Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | Lung, | A549 | - | in-vitro, | Ovarian, | SKOV3 |
| 3832- | Cro, | Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 6521- | CRV, | L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | Nor, | MCF10 |
| 6527- | CRV, | Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events |
| - | in-vivo, | Melanoma, | NA |
| 6520- | CRV, | Health Benefits and Pharmacological Properties of Carvone |
| - | Review, | Nor, | NA |
| 6523- | CRV, | Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion |
| - | in-vitro, | Melanoma, | NA |
| 6525- | CRV, | D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4) |
| - | in-vitro, | AML, | NA |
| 6526- | CRV, | Multi-targeted effects of D-carvone against Non-Small Cell Lung Cancer (NSCLC): A network pharmacology-based study |
| - | Review, | NSCLC, | NA |
| 6528- | CRV, | D-carvone inhibits growth, migration, cell cycle at G0/G1 phase and induces apoptosis in A431 cells by disrupting mitochondrial membrane potential |
| - | in-vitro, | Melanoma, | A431 |
| 6530- | CRV, | Monoterpenes as Anticancer Therapeutic Agents |
| - | Review, | Var, | NA |
| 7416- | CS, | Poly, | Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines |
| - | in-vitro, | Colon, | Caco-2 | - | in-vitro, | Colon, | HT29 |
| 7424- | CS, | CGA, | Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells |
| - | in-vitro, | Nor, | NA | - | in-vitro, | Liver, | HepG2 |
| 7414- | CS, | Pro-Apoptotic Activity of Artichoke Leaf Extracts in Human HT-29 and RKO Colon Cancer Cells |
| - | in-vitro, | Colon, | HT29 | - | in-vitro, | CRC, | RKO |
| 7413- | CS, | Poly, | Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines |
| - | in-vitro, | SCC, | SCC25 |
| 7412- | CS, | Chemo, | Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1 |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 |
| 7411- | CS, | Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | CRC, | HCT116 |
| 7410- | CS, | Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231 |
| - | in-vitro, | BC, | MDA-MB-231 |
| 7425- | CS, | Artichoke as a melanoma growth inhibitor |
| - | in-vitro, | Melanoma, | NA |
| 6176- | Cu, | Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells |
| - | in-vitro, | Liver, | HepG2 |
| 6182- | Cu, | Role of cuproptosis in digestive system tumors (Review) |
| - | Review, | Var, | NA |
| 1602- | Cu, | A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy† |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | 4T1 | - | in-vitro, | Lung, | A549 | - | in-vitro, | Liver, | HepG2 |
| 1571- | Cu, | Copper in cancer: From pathogenesis to therapy |
| - | Review, | Var, | NA |
| 1572- | Cu, | Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy |
| - | Review, | Var, | NA |
| 1596- | Cu, | CDT, | Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review |
| - | Review, | Var, | NA |
| 6196- | Cuc, | Cucurbitacins – A Promising Target for Cancer Therapy |
| - | Review, | Var, | NA |
| 6189- | Cuc, | Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells |
| - | in-vitro, | Lung, | A549 |
| 6190- | Cuc, | Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells |
| - | in-vitro, | Colon, | SW480 |
| 6191- | Cuc, | Growth inhibitory effect of Cucurbitacin E on breast cancer cells |
| - | in-vitro, | BC, | MDA-MB-231 |
| 6195- | Cuc, | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
| - | Review, | Var, | NA |
| 6184- | Cuc, | Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells |
| - | vitro+vivo, | PC, | NA |
| 6197- | Cuc, | Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells |
| - | in-vitro, | neuroblastoma, | SH-SY5Y |
| 6201- | Cuc, | Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 6204- | Cuc, | Preliminary investigation of the anti-colon cancer activity of cucurbitacin C from cucumber: A network pharmacological study and experimental validation |
| - | in-vitro, | Colon, | HCT116 |
| 4830- | CUR, | Curcumin and Its Derivatives Induce Apoptosis in Human Cancer Cells by Mobilizing and Redox Cycling Genomic Copper Ions |
| - | in-vitro, | Var, | NA |
| 4826- | CUR, | The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management |
| - | Review, | Var, | NA |
| 4652- | CUR, | Anticancer effect of curcumin on breast cancer and stem cells |
| - | Review, | BC, | NA |
| 4709- | CUR, | Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways |
| - | Review, | Var, | NA |
| 990- | CUR, | Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | HT-29 |
| 933- | CUR, | EP, | Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study |
| - | in-vitro, | BC, | NA |
| 475- | CUR, | Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway |
| - | in-vitro, | PC, | PANC1 |
| 474- | CUR, | Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | MIA PaCa-2 |
| 472- | CUR, | Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis |
| - | vitro+vivo, | Ovarian, | SKOV3 | - | vitro+vivo, | Ovarian, | A2780S |
| 471- | CUR, | Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells |
| - | in-vitro, | Ovarian, | SKOV3 | - | in-vitro, | Ovarian, | A2780S |
| 468- | CUR, | 5-FU, | Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability |
| - | vitro+vivo, | Liver, | HepG2 | - | vitro+vivo, | Liver, | 402 | - | vitro+vivo, | Liver, | Bel7 |
| 467- | CUR, | Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling |
| - | in-vitro, | Liver, | HepG2 |
| 461- | CUR, | Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 |
| 460- | CUR, | Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer |
| - | in-vitro, | Bladder, | T24/HTB-9 | - | in-vitro, | Bladder, | TCCSUP | - | in-vitro, | Bladder, | J82 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:14 State#:% Dir#:%
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