radioP Cancer Research Results

radioP, RadioProtective: Click to Expand ⟱
Source:
Type:
Protect against the damaging effects of radiation therapy.
Scientific Papers found: Click to Expand⟱
2902- HNK,  Rad,    Honokiol Mitigates Ionizing Radiation-Induced Injury by Maintaining the Redox Balance of the TrxR/Trx System
- in-vitro, Nor, BEAS-2B
*TrxR1↑, *Trx↑, *radioP↑, *ROS↓,
7759- ISL,  Rad,    Isoliquiritigenin, a Bioactive Blood Component Derived from Licorice, Activates Nrf2 Enzymes to Confer Protection Against Radiation-Induced Nerve Injury
- vitro+vivo, Nor, PC12
*radioP↑, *LDH↓, *ROS↓, *SOD1↑, *GSH↑, *TAC↑, *NRF2↓, *cognitive↑, *Learn↑, *memory↑,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
8286- LE,  Rad,    Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients Under Head and Neck Radiotherapy: A Randomized Clinical Trial
- Trial, HNSCC, NA
Mucositis↓, radioP↑, Dose↝, Dose↝,
8273- LE,    A Systematic Review of the Effect of Licorice on Head and Neck Chemotherapy- and Radiotherapy-Induced Mucositis
- Review, HNSCC, NA
radioP↑, chemoP↑, *Pain↓, *Inflam↓, IL1β↓, PGE2↑, COX2/PTGS2↓, *toxicity↝, *Mucositis↓,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
8295- lign,    Distribution, biosynthesis and therapeutic potential of lignans
- Review, Var, NA
*Ingr?, *BioAv↝, *antiOx↑, *AntiCan↑, *Inflam↓, *other?, Dose↝, AntiTum↑, pS2/TFF1↓, Bcl-2↓, IGF-1R↓, *radioP↑, *HO-1↑, GSTM1↑, NQO1↑, ChemoSen↑, *AntiDiabetic↑, *glucose↓, *GSH↑, *SOD↑, *MDA↓, *NO↓, *Bacteria↓, *AntiFungal↑,
3280- Lyco,    Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview
- Review, Var, NA
*radioP↑, *antiOx↑, *lipid-P↓,
8423- Lyco,  Rad,    Tomato Juice Consumption Could Improve Breast Skin Adverse Effects of Radiotherapy in Breast Cancer Patients
- Trial, BC, NA
Dose↝, radioP↑, 8-oxo-dG↓,
8422- Lyco,  Rad,    Dietary and Serum Lycopene Levels in Prostate Cancer Patients Undergoing Intensity-Modulated Radiation Therapy
- Trial, Pca, NA
Weight↑, other?, Dose↝, Dose↝, *Half-Life↝, radioP?,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
8933- MBS,  Rad,    The evaluation of radio-sensitivity of mung bean proteins aqueous extract on MCF-7, hela and fibroblast cell line
- in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa
TumCP↓, selectivity?, RadioS↑, radioP↑,
8489- MF,    Pulsed electromagnetic fields induce ferroptosis in osteosarcoma cells and promote osteogenic differentiation
- in-vitro, OS, U2OS - in-vitro, OS, MG63
TumCP↓, TumCMig↓, Ferroptosis↑, GPx4↓, xCT/SLC7A11↓, BMD↑, selectivity↑, Dose↝, TumCG↓, Dose↝, OS↑, ROS↑, MDA↑, Iron↑, ChemoSen↑, TOP2↑, radioP↑,
3487- MF,  Rad,    High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field
- Review, Var, NA
radioP↑, *Ca+2↑, RAS↑, MAPK↓,
5245- MFrot,  Rad,    The hemoprotective effects of a rotary magnetic field in mice exposed to γ irradiation
- in-vivo, Nor, NA
*OS↑, *radioP↑,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
8692- MLT,    Melatonin as a Radio-Sensitizer in Cancer
- Review, Var, NA
RadioS↑, radioP↑, ROS↑, DNArepair↓, angioG↓, Inflam↓, Apoptosis↑, Telomerase↓, HSP70/HSPA5↑, P53↑, Glycolysis↓, Dose?, OS∅,
8686- MLT,  CAP,    Non-thermal plasma-treated melatonin inhibits the biological activity of HCC cells by increasing intracellular ROS levels and reducing RRM2 expression
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
Synergy↑, TumCI↓, TumCMig↓, Apoptosis↑, TumCP↓, TumMeta↓, radioP↑, ROS↑, RRM2↓,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
1775- MLT,  Chemo,  Rad,    A Systematic Review of the Chemo/Radioprotective Effects of Melatonin against Ototoxic Adverse Effects Induced by Chemotherapy and Radiotherapy
- Review, Var, NA
chemoP↑, radioP↑, antiOx↑, Inflam↑,
1776- MLT,    Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis
- Review, Var, NA
Remission↑, OS↑, neuroP↑, VEGF↓, KISS1↑, TumCP↓, ChemoSideEff↓, radioP↑, Dose∅, *ROS↓, DNArepair↑, ROS↑,
1779- MLT,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1783- MLT,    The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials
- Review, Var, NA
Dose∅, Remission↑, OS↑, radioP↑,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
2939- NAD,  Rad,    NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7
- in-vitro, Nor, NA
*SIRT6↑, *DNAdam↓, *radioP↑, *ROS↓,
2380- PBG,    Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy
- Review, Var, NA
Hif1a↓, Glycolysis↓, PKM2↓, LDHA↓, GLUT2↓, HK2↓, PFK1↓, PDK1 / PDPK1↓, chemoP↓, radioP↑,
1985- PTL,    KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of Parthenolide in Normal and Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Nor, PrEC - in-vivo, NA, NA
ROS↑, NADPH↑, RadioS↑, radioP↑, Trx↓, *ox-Keap1↑, ox-Keap1↓, rd-Keap1↑, *NRF2↑, NRF2∅, NF-kB↓,
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
5969- Rad,  CET,    Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
- Trial, HNSCC, NA
Dose↝, radioP↑, OS↑,
3075- RES,  Rad,    The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice
- in-vivo, Nor, NA
*SIRT1↑, *radioP↑, *NLRP3↓, *Weight↑, *IL1β↓,
3015- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROS/MYPT1/TGFβ1 Signaling Via miR-19b-3p
- in-vivo, Nor, IMR90
*radioP↑, *Inflam↓, *ROS↓, *NF-kB↓, *Rho↓, *ROCK1↓, *other↓,
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1/CCL2↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
4615- Se,  Rad,    Selenium as an adjuvant for modification of radiation response
- Review, Nor, NA
*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,
4613- Se,  Rad,    Effect of Selenium and Selenoproteins on Radiation Resistance
- Review, Nor, NA
*selenoP↑, *GPx1↑, *GPx4↑, *lipid-P↓, *DNAdam↓, *ROS↓, *radioP↑,
4737- Se,  Rad,    Nrf2-modulation by seleno-hormetic agents and its potential for radiation protection
- in-vivo, Var, NA
radioP↑, *NRF2↑, NRF2↓,
4717- Se,    A systematic review of Selenium as a complementary treatment in cancer patients
- Review, Var, NA
*antiOx↑, eff↝, radioP↑, chemoP↑, *selenoP↑, *GPx↑, TrxR↑, *ROS↓,
4715- Se,    The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells
- in-vitro, Var, NA
chemoP↑, radioP↑, selectivity↑, ChemoSen↑, GSH↓, *GSH↑, *DNAdam↓, DNAdam↑, eff↑,
4612- SeNPs,  Rad,    Histopathological Evaluation of Radioprotective Effects: Selenium Nanoparticles Protect Lung Tissue from Radiation Damage
- in-vivo, Nor, NA
*radioP↑, *Inflam↓, *antiOx↑, *Dose↝, *DNAdam↓, *ROS↓, *SOD↑, *GPx↑, *Dose↝, *Synergy↑,
4611- SeNPs,  Rad,    Radioprotective Effect of Selenium Nanoparticles: A Mini Review
- Review, Var, NA
*antiOx↑, *Inflam↓, *radioP↑, *ROCK1↓, *DNAdam↓, *Apoptosis↓, *RadioS↑, *Dose↝,
4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, Synergy↑, other↝, *Synergy↑, *Aβ↓, *Synergy↑,
3303- SIL,    Exploring the anti-cancer and antimetastatic effect of Silymarin against lung cancer
- Review, Var, NA
chemoP↑, radioP↑,
3306- SIL,  Rad,    Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation
- Review, Var, NA
radioP↑, RadioS↑, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, DNAdam↓, ROS↑, *ROS↓, *Inflam↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3297- SIL,  Rad,    Studies on radiation sensitization efficacy by silymarin in colon carcinoma cells
- in-vitro, CRC, HCT15 - in-vitro, CRC, RKO
TumCP↓, RadioS↑, TumCCA↑, DNAdam↓, MMP↓, ROS↓, *radioP↑,
3294- SIL,    Silymarin: a review on paving the way towards promising pharmacological agent
- Review, Nor, NA - Review, Arthritis, NA
*hepatoP↑, *Inflam↓, *chemoP↑, *glucose↓, *antiOx↑, *ROS↓, *ACC↓, *FASN↓, *radioP↑, *NF-kB↓, *TGF-β↓, *AST↓, *α-SMA↝, *Synergy↑, *neuroP↑, Synergy↑, ROS↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
4750- SSE,  Rad,    Selenium in Radiation Oncology—15 Years of Experiences in Germany
- Review, Var, NA
RadioS∅, radioP↑, eff↑,

Showing Research Papers: 51 to 100 of 120
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 120

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↓, 1,   Catalase↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 4,   GSH↑, 1,   H2O2↑, 2,   Iron↑, 1,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↑, 2,   MDA↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 1,   NRF2∅, 1,   ROS↓, 6,   ROS↑, 29,   ROS⇅, 2,   i-ROS↑, 1,   SOD↑, 2,   SOD2↓, 1,   TBARS↓, 1,   Trx↓, 2,   TrxR↑, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   ETC↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 2,   CAIX/CA9↑, 1,   glucose↓, 1,   Glycolysis↓, 3,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HK2↓, 1,   LDHA↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 1,   PFK1↓, 1,   PKM2↓, 1,   SCD1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 17,   BAX↑, 8,   BAX⇅, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 11,   Bcl-xL↓, 5,   Casp↑, 4,   cl‑Casp↑, 1,   Casp3↑, 11,   Casp8↑, 3,   Casp9↓, 2,   Casp9↑, 6,   Cyt‑c↑, 6,   DR5↑, 1,   Ferroptosis↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 3,   iNOS↓, 3,   Mcl-1↓, 2,   p38↑, 3,   p‑p38↓, 1,   p‑p38↑, 1,   pS2/TFF1↓, 1,   survivin↓, 5,   TumCD↓, 1,   TumCD↑, 1,   XIAP↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   Akt↑, 2,   p‑Akt↓, 2,   cMET↓, 1,   EGFR↓, 1,   ERK↓, 5,   p‑ERK↓, 2,   HER2/EBBR2↓, 1,   IGF-1R↓, 2,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 5,   MAPK↑, 1,   mTOR↓, 5,   PI3K↓, 9,   PI3K↑, 1,   p‑PI3K↓, 2,   PKCδ↓, 1,   PTEN↑, 1,   RAS↑, 1,   STAT3↓, 6,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   cJun↑, 2,   cMyc↓, 2,   DNMT1↓, 2,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   FOXO1↓, 1,   p‑FOXO3↓, 1,   HATs↓, 1,   HDAC↓, 4,   KISS1↑, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   MYCN↓, 1,   other?, 2,   other↓, 1,   other↝, 1,   PhotoS↑, 2,   sonoS↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 3,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATM?, 1,   DNAdam↓, 2,   DNAdam↑, 6,   DNArepair↓, 1,   DNArepair↑, 2,   P53↑, 7,   PARP↑, 1,   cl‑PARP↑, 5,   PCNA↓, 1,   Telomerase↓, 2,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   CDK2↓, 2,   CDK4↓, 4,   CDK6↑, 1,   Chk2↑, 1,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 4,   GADD45A↑, 1,   Ki-67↓, 1,   P21↑, 6,   p27/CDKN1B↑, 1,   RRM2↓, 1,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   IGF-1↓, 1,   Ki-67↓, 1,   mTORC1↓, 1,   TumCG↓, 7,   TumCG↑, 1,   TumCP↓, 16,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 3,   E-cadherin↑, 3,   EMT↓, 3,   p‑FAK↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 7,   MMP7↓, 1,   MMP9↓, 9,   MMPs↓, 3,   MUC4↓, 1,   N-cadherin↓, 1,   TGF-β↓, 2,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 8,   TumCMig↓, 9,   TumMeta↓, 12,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 13,   Hif1a↓, 6,   NO↓, 1,   VEGF↓, 13,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   MMP↓, 7,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 10,   CXCR4↓, 3,   DCells↑, 1,   FOXP3↓, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↓, 1,   IL6↓, 6,   IL8↓, 1,   IL8↑, 1,   Imm↑, 6,   Inflam↓, 11,   Inflam↑, 2,   NF-kB↓, 15,   NK cell↑, 4,   NLRP3↑, 1,   PD-1↝, 1,   PD-L1↓, 1,   PGE2↓, 2,   PGE2↑, 1,   PSA↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↓, 5,   TNF-α↑, 3,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 1,   CYP19↓, 1,   Estro↝, 1,   PPARγ↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 5,   BioAv↑, 5,   BioAv↝, 2,   ChemoSen↑, 30,   CompStab↓, 1,   Dose?, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 19,   Dose∅, 4,   eff↓, 1,   eff↑, 15,   eff↝, 5,   eff∅, 2,   GSTM1↑, 1,   Half-Life↝, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 2,   RadioS↑, 22,   RadioS∅, 2,   selectivity?, 1,   selectivity↑, 20,   Synergy↑, 15,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BMD↑, 1,   CRP↓, 1,   EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 6,   NLR↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8,   AntiTum↑, 7,   AntiTum∅, 1,   Appetite↑, 2,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 3,   chemoP↓, 1,   chemoP↑, 31,   chemoP↝, 1,   chemoPv↑, 4,   ChemoSideEff↓, 2,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↑, 5,   Mucositis↓, 2,   neuroP↑, 2,   NP/CIPN↓, 1,   OS↑, 10,   OS⇅, 1,   OS∅, 1,   Pain↓, 4,   PFS↑, 1,   QoL↑, 8,   radioP?, 1,   radioP↑, 69,   radioP↝, 2,   Remission↑, 2,   RenoP↑, 2,   Risk↓, 9,   Risk⇅, 1,   Sleep↑, 3,   Strength↑, 2,   toxicity↓, 3,   TumVol↓, 8,   TumW↓, 2,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   Sepsis↓, 1,  
Total Targets: 310

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 28,   ARE↑, 2,   Bil↓, 1,   Bil↑, 1,   Catalase↑, 16,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 13,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 15,   GSH/GSSG↑, 1,   GSR↑, 2,   GSTs↑, 6,   H2O2↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 12,   ox-Keap1↑, 1,   lipid-P↓, 11,   MDA↓, 14,   MDA↑, 1,   MPO↓, 2,   MPO↑, 1,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 16,   Prx↑, 1,   RNS↓, 2,   ROS↓, 45,   ROS∅, 1,   selenoP↑, 7,   SOD↓, 1,   SOD↑, 24,   SOD1↑, 1,   TAC↑, 3,   TBARS↓, 1,   Trx↑, 1,   TrxR1↑, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   ACC↓, 1,   ALAT↓, 4,   AMP↓, 1,   AMPK↑, 2,   ATP↑, 2,   cytoP450↓, 1,   FABP4↓, 1,   FASN↓, 1,   glucose↓, 2,   LDL↓, 2,   NADPH↓, 2,   NADPH↑, 1,   NADPH∅, 1,   PGC1A↑, 1,   SIRT1↑, 1,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 7,   Apoptosis↑, 1,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 6,   Casp3↑, 1,   cl‑Casp3↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 3,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 3,   p38↓, 3,   p38↑, 1,   p‑p38↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 5,   p‑Akt↑, 1,   AMPKα↑, 1,   ERK↑, 1,   JAK2↑, 1,   JNK↓, 3,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   p‑MAPK↓, 1,   Mst1↓, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 3,   PKCδ↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   p‑cJun↓, 1,   DNMTs↓, 1,   HDAC↑, 2,   other?, 1,   other↓, 3,   other↑, 2,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑BRCA1↑, 1,   DNAdam↓, 12,   P53↓, 3,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Cartilage↑, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MMP13↓, 1,   Rho↓, 2,   ROCK1↓, 3,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 2,   IBI↑, 2,   memfluid↑, 1,   MMP↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX1↓, 2,   COX2/PTGS2↓, 8,   DR4↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL10↑, 3,   IL12↓, 1,   IL1β↓, 10,   IL4↓, 2,   IL4↑, 2,   IL6↓, 14,   IL8↓, 1,   Imm↑, 6,   Imm↝, 1,   Inflam↓, 25,   LPS↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 3,   NF-kB↓, 9,   p‑NF-kB↓, 1,   NLRP3↓, 5,   PGE2↓, 3,   RANTES↓, 1,   TLR4↓, 1,   TNF-α↓, 16,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   BChE↓, 2,   BDNF↑, 3,   ChAT↑, 1,   MAOA↓, 1,   MAOB↓, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 6,   BACE/β-secretase↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 5,   BioAv↝, 6,   ChemoSen↑, 1,   CompStab↑, 1,   Dose↓, 2,   Dose↑, 2,   Dose↝, 16,   eff↑, 8,   Half-Life↓, 2,   Half-Life↝, 4,   RadioS↑, 1,   selectivity↑, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 5,   Bil↓, 1,   Bil↑, 1,   BMD↑, 1,   BP↓, 1,   p‑BRCA1↑, 1,   BUN↓, 2,   creat↓, 2,   CRP↓, 2,   IL6↓, 14,   LDH↓, 1,   LDH↑, 1,   NOS2↓, 1,   SpO2↑, 1,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 4,   antiPs↑, 1,   AntiTum↓, 1,   cardioP↑, 9,   chemoP↑, 8,   cognitive↓, 1,   cognitive↑, 7,   hepatoP↑, 13,   Learn↑, 1,   memory↑, 3,   motorD↑, 1,   Mucositis↓, 1,   neuroP↑, 11,   Obesity↓, 3,   OS↑, 3,   Pain↓, 3,   QoL↑, 1,   radioP↑, 50,   RenoP↑, 5,   Risk↓, 1,   Strength↑, 1,   Stroke↓, 2,   toxicity↓, 9,   toxicity↝, 3,   toxicity∅, 1,   Weight↑, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 1,   Bacteria↓, 5,   Diar↓, 2,   GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 287

Scientific Paper Hit Count for: radioP, RadioProtective
45 Radiotherapy/Radiation
8 Hydrogen Gas
8 Melatonin
8 Selenite (Sodium)
6 Chemotherapy
6 Curcumin
6 Silymarin (Milk Thistle) silibinin
6 Thymoquinone
5 Vitamin C (Ascorbic Acid)
5 Selenium
4 Diindolylmethane
4 Lycopene
3 Astaxanthin
3 Magnetic Fields
3 Selenium NanoParticles
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Aloe anthraquinones
2 γ-linolenic acid (Borage Oil)
2 Licorice
2 SDG/lignans
2 Magnetic Field Rotating
2 Parthenolide
2 Rosmarinic acid
2 Vitamin D3
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Atorvastatin
1 beta-glucans
1 Baicalein
1 Berberine
1 Gold NanoParticles
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Crocetin
1 diet Plant based
1 Indole-3-carbinol
1 Dandelion Root
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Ferulic acid
1 Fucoidan
1 Ginkgolide B
1 Honokiol
1 Isoliquiritigenin
1 isoflavones
1 Mung Bean Sprouts
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Moringa oleifera
1 nicotinamide adenine dinucleotide
1 Propolis -bee glue
1 Quercetin
1 cetuximab
1 Resveratrol
1 Rutin
1 buckwheat sprouts
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin A, Retinoic Acid
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1185  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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