Hif1a Cancer Research Results

Hif1a, HIF1α/HIF1a: Click to Expand ⟱
Source:
Type:
Hypoxia-Inducible-Factor 1A (HIF1A gene, HIF1α, HIF-1α protein product)
-Dominantly expressed under hypoxia(low oxygen levels) in solid tumor cells
-HIF1A induces the expression of vascular endothelial growth factor (VEGF)
-High HIF-1α expression is associated with Poor prognosis
-Low HIF-1α expression is associated with Better prognosis

-Functionally, HIF-1α is reported to regulate glycolysis, whilst HIF-2α regulates genes associated with lipoprotein metabolism.
-Cancer cells produce HIF in response to hypoxia in order to generate more VEGF that promote angiogenesis

Key mediators of aerobic glycolysis regulated by HIF-1α.
-GLUT-1 → regulation of the flux of glucose into cells.
-HK2 → catalysis of the first step of glucose metabolism.
-PKM2 → regulation of rate-limiting step of glycolysis.
-Phosphorylation of PDH complex by PDK → blockage of OXPHOS and promotion of aerobic glycolysis.
-LDH (LDHA): Rapid ATP production, conversion of pyruvate to lactate;

HIF-1α Inhibitors:
-Curcumin: disruption of signaling pathways that stabilize HIF-1α (ie downregulate).
-Resveratrol: downregulate HIF-1α protein accumulation under hypoxic conditions.
-EGCG: modulation of upstream signaling pathways, leading to decreased HIF-1α activity.
-Emodin: reduce HIF-1α expression. (under hypoxia).
-Apigenin: inhibit HIF-1α accumulation.
Scientific Papers found: Click to Expand⟱
2289- Ba,  Rad,    Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A
- in-vitro, ESCC, KYSE150
TumCP↓, TumCMig↓, Glycolysis↓, cycD1/CCND1↓, CDK4↓, ECAR↓, TumCCA↑, HK1↓, ALDH↓, ALDOA↓, PKM2↓, Hif1a↓,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
2291- Ba,  BA,    Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Melanoma, A375
LDHA↓, ENO1↓, PKM2↓, GLUT1↓, GLUT3↓, HK2↓, PFK1↓, GPI↓, TPI↓, GlucoseCon↓, TumCG↓, TumCP↓, mTORC1↓, Hif1a↓, Ki-67↓,
2293- Ba,    Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling
- in-vitro, Nor, MH-S - in-vivo, NA, NA
*Hif1a↓, *Glycolysis↓, *Inflam↓, *HK2↓, *PFK1↓, *PKM2↓,
2295- Ba,  5-FU,    Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway
- in-vitro, GC, AGS
ChemoSen↑, HK2↓, LDHA↓, PDK1 / PDPK1↓, Akt↓, PTEN↑, Hif1a↓, Glycolysis↓, ROS↑, CHOP/DDIT3↑,
2297- Ba,    Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine
- Review, Var, NA
Glycolysis↓, Hif1a↓, PKM2↓, RadioS↑,
2298- Ba,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCG↓, TumCP↓, Hif1a↓, VEGF↓, ChemoSen↑, Glycolysis↓, HK2↓, PDK1 / PDPK1↓, LDHA↓, p‑Akt↓, PTEN↑,
1392- BBR,    Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress
- in-vitro, GC, AGS - in-vitro, GC, MKN45
TumCG↓, TumCMig↓, ROS↑, MDA↑, SOD↓, NRF2↓, HO-1↓, Hif1a↓, EMT↓, Snail↓, Vim↓,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, Var, NA
*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,
2695- BBR,    The effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial
- Trial, BC, NA
IGF-1↓, PPARγ↓, VEGF↓, Hif1a↓, angioG↓,
2708- BBR,    Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells
- in-vitro, CRC, HCT116
TumCG↓, GlucoseCon↓, GLUT1↓, LDHA↓, HK2↓, Hif1a↓, mTOR↓, Glycolysis↓,
2709- BBR,    Berberine inhibits the glycolysis and proliferation of hepatocellular carcinoma cells by down-regulating HIF-1α
- in-vitro, HCC, HepG2
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PKM2↓, LDHA↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
956- BBR,    Berberine inhibits HIF-1alpha expression via enhanced proteolysis
- in-vitro, Nor, HUVECs - in-vitro, GC, SCM1
Hif1a↓, angioG↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, Synergy↑, chemoPv↑, BioAv↓,
5180- BBR,    Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- in-vitro, NSCLC, NA
TumCMig↓, TumCP↓, Apoptosis↑, TFAP2A↓, hTERT/TERT↓, NF-kB↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, Akt↓, p‑ERK↓, Cyt‑c↑, cl‑Casp↑, cl‑PARP↑, PI3K↓, Akt↓, Raf↓, MEK↓, ERK↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5586- BetA,    Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer
- in-vitro, Cerv, HeLa
Hif1a↓, VEGF↓, GLUT1↓, PDK1 / PDPK1↓,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, Synergy↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP/DDIT3↑, *toxicity↓,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2766- BetA,    Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy
- Review, Var, NA
Hif1a↓, VEGF↓, GLUT1↓,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1 / PDPK1↓, PDK1 / PDPK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
5686- BJ,  BRU,    A review of Brucea javanica: metabolites, pharmacology and clinical application
- Review, Var, NA
AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2/PTGS2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,
5689- BJ,    Brucea javanica oil inhibited the proliferation, migration, and invasion of oral squamous carcinoma by regulated the MTFR2 pathway
- vitro+vivo, Oral, CAL27
TumCP↓, TumCMig↓, TumCI↓, SOD2↓, H2O2↓, OXPHOS↑, Glycolysis↓, ROS↑, RadioS↑, Hif1a↓, TumCG↓,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, Beclin-1/ATG6↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
5673- Bor,    Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice
- in-vivo, Nor, NA
HRAS↓, Hif1a↓, Akt↓, PTEN↓,
715- Bor,    Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1alpha inhibitors
- in-vitro, Pca, HeLa
Hif1a↓,
3522- Bor,    The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry
- Review, Var, NA
Hif1a↓, HDAC↓, *CXCR2↑, ROS↑,
5697- BRU,    Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
- in-vitro, HNSCC, NA
NRF2↓, STAT3↓, proCasp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, Hif1a↓, cMyc↓, JNK↑, MAPK↑, tumCV↓, ROS∅,
5699- BRU,  BJ,    Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay
- in-vitro, Lung, A549
EGFR↓, ChemoSen↑, NRF2↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ROCK1↓, Hif1a↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2/PTGS2↓, ROS↑,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
1259- CAP,    Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, H2009
Hif1a↓, PDK1 / PDPK1↓, GLUT1↓, ROS↑, mitResp↓, ATP↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5892- CAR,  SRF,    Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study
- in-vivo, HCC, NA
Hif1a↓, AFP↑, hepatoP↑, STAT3↓, JAK2↓, *CD8+↑, ChemoSen↑, Dose↝, angioG↓,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, CRC, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
955- CEL,    Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells
- in-vitro, RPE/RB, D407
TumCP↓, VEGF↓, Hif1a↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6009- CGA,    Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment
- Review, Var, NA
TumCCA↑, TumCI↓, TumMeta↓, angioG↓, ROS↑, ChemoSen↑, BioAv↓, Half-Life↓, PI3K↓, Akt↓, mTOR↓, Apoptosis↑, NOTCH↓, Hif1a↓, VEGF↓, Casp3↑, MMP↓, Ferroptosis↑, ATP↓,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
954- CGA,    Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway
- in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
Hif1a↓, VEGF↓, angioG↓, Akt↓,
7180- CHA,    Chaetocin: A review of its anticancer potentials and mechanisms
- Review, Var, NA
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumCMig↓, SUV39H↓, TrxR↓, Hif1a↓, HSP90↓, ox-Trx1↑, ROS↑, PI3K↓, Akt↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, DR5↑, CHOP/DDIT3↑, ATF3↑, angioG↓, VEGF↑, LDHA↓, ENO1↓,
7168- CHA,    The anticancer effect of chaetocin is enhanced by inhibition of autophagy
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HepG3 - in-vitro, Liver, HUH7
Apoptosis↓, TumAuto↑, ROS↑, Hif1a↓, SUV39H↓, cl‑PARP↑, eff↑, eff↑,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
6133- CHr,    Chrysin in PI3K/AKT and other apoptosis signalling pathways, and its effect on HeLa cells.
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, eff↑, CYP19↓, Hif1a↓, VEGF↓, NF-kB↓, PI3K↓, Akt↓,

Showing Research Papers: 51 to 100 of 359
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 359

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 7,   antiOx⇅, 1,   Catalase↓, 4,   Catalase↑, 3,   Fenton↑, 3,   frataxin↑, 1,   GPx↓, 1,   GPx↑, 4,   GPx4↓, 3,   GPx4↑, 1,   GSH↓, 12,   GSH↑, 5,   GSH/GSSG↓, 1,   GSTs↑, 2,   H2O2↓, 3,   H2O2↑, 4,   HO-1↓, 7,   HO-1↑, 9,   HO-2↓, 1,   Iron↑, 3,   Iron∅, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA?, 1,   MDA↓, 1,   MDA↑, 3,   MPO↓, 3,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 16,   NRF2↑, 21,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   Prx↓, 1,   PrxI↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 19,   ROS↑, 127,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↓, 1,   mt-ROS↑, 2,   RPM↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   TKT↝, 1,   Trx↓, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 1,   CDC25↓, 2,   compI↓, 1,   EGF↓, 1,   ETC↓, 3,   ETC↝, 1,   MCU↓, 1,   mitResp↓, 4,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 8,   OCR↓, 6,   OCR↑, 4,   OXPHOS↓, 1,   OXPHOS↑, 7,   mt-OXPHOS↓, 2,   PDH↓, 3,   PDH↑, 5,   PDH↝, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   AApath↓, 1,   ACC↓, 2,   ACLY↓, 1,   Alanine↓, 1,   ALAT↓, 1,   ALAT↝, 1,   ALDOA↓, 1,   AMACR↓, 1,   AMP↓, 1,   AMPK↑, 18,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 21,   ATP↑, 2,   ATP↝, 1,   i-ATP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   citrate↓, 2,   i-citrate↑, 1,   CPT1A↓, 1,   ECAR↓, 8,   ECAR↝, 1,   ENO1↓, 2,   FASN↓, 7,   FASN↑, 1,   FDG↓, 1,   G6PD↓, 5,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 3,   glucoNG↓, 1,   GlucoseCon↓, 24,   GlucoseCon↑, 3,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 2,   Glycine↓, 1,   Glycolysis↓, 75,   Glycolysis↑, 3,   GPI↓, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 5,   HAGH/GLO2↓, 1,   HK1↓, 1,   HK2↓, 34,   HK2↑, 2,   HMG-CoA↓, 2,   IDH1↑, 1,   lact/pyru↓, 1,   lactateProd↓, 22,   lactateProd↑, 4,   e-lactateProd↓, 1,   LAR↓, 1,   LDHA↓, 26,   LDHA↑, 1,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   NADPH↓, 4,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 19,   p‑PDK1 / PDPK1↓, 1,   PDK3↓, 1,   PDKs↓, 2,   PFK↓, 5,   PFK1↓, 3,   PFK1↑, 1,   PFK2?, 1,   PFKP?, 1,   PFKP↓, 1,   PKM2↓, 39,   PKM2:PKM1↓, 1,   PPP↓, 1,   Pyruv↓, 2,   R5P↝, 1,   p‑S6↓, 2,   SCD1↓, 2,   SHARP↑, 1,   SIRT1↓, 4,   SIRT1↑, 8,   SIRT2↓, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 3,   TCA↑, 1,   TPI↓, 1,   Warburg↓, 14,   Warburg↑, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 5,   Apoptosis↑, 101,   mt-Apoptosis↑, 1,   ASK1↑, 1,   aSmase↝, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 5,   BAX↓, 2,   BAX↑, 51,   BAX⇅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 56,   Bcl-2↑, 2,   Bcl-xL↓, 20,   BID↓, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   BNIP3↝, 1,   BOK↑, 1,   Casp↑, 13,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 80,   cl‑Casp3↑, 8,   proCasp3↑, 2,   Casp6↑, 1,   Casp7↑, 8,   cl‑Casp7↑, 3,   Casp8↑, 8,   cl‑Casp8↑, 3,   pro‑Casp8↑, 1,   Casp9↑, 45,   cl‑Casp9↑, 5,   cFLIP↓, 5,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 44,   Diablo↑, 5,   DR5↑, 12,   FADD↑, 3,   Fas↓, 1,   Fas↑, 11,   FasL↑, 3,   Ferroptosis↓, 1,   Ferroptosis↑, 10,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 12,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 18,   Mcl-1↑, 1,   MDM2↓, 3,   MDM2↑, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   oncosis↑, 1,   p38↓, 3,   p38↑, 4,   p‑p38↓, 1,   PUMA↑, 3,   Pyro↑, 1,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 25,   TNFR 1↑, 1,   TRAIL↑, 3,   TumCD↑, 5,   TUNEL↑, 1,   XIAP↓, 14,   XIAP↝, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↑, 7,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 30,   p‑Akt↑, 2,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 2,   Brk/PTK6↓, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 5,   cMET↓, 2,   p‑cMET↑, 1,   DDIT4?, 1,   EF-1α↓, 1,   EGFR↓, 29,   EphB4↓, 2,   ERK↓, 29,   ERK↑, 2,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 10,   p‑ERK↑, 1,   FLT4↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   HGF/c-Met↓, 1,   HRAS↓, 1,   IGF-1R↓, 5,   IKKα↓, 5,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   JAK↓, 3,   p‑JAK1↓, 1,   JAK2↓, 4,   p‑JAK2↓, 1,   JNK↓, 2,   JNK↑, 12,   p‑JNK↓, 2,   MAPK↓, 19,   MAPK↑, 3,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 1,   mTOR↓, 50,   p‑mTOR↓, 11,   p70S6↓, 2,   p‑p70S6↓, 2,   P70S6K↓, 3,   P70S6K↑, 1,   p‑P70S6K↓, 3,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PAK↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 65,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 2,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 9,   PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 22,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 8,   Src↓, 1,   STAT↓, 2,   STAT3↓, 55,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT5↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ARNT?, 1,   ATF3↑, 1,   ATF4↑, 3,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 27,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMTs↓, 7,   EZH2↓, 3,   FOXM1↓, 2,   FOXO↑, 2,   FOXO3↓, 3,   FOXO3↑, 3,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 3,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 3,   HDAC↓, 22,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 2,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-126↑, 1,   miR-155↓, 2,   miR-195↑, 1,   miR-199↑, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-34a↑, 1,   miR-34b-5p↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-590-3p↑, 1,   Myc↓, 4,   n-MYC↓, 1,   OCT4↓, 4,   other↓, 2,   other↑, 1,   other↝, 6,   SOX2↓, 4,   SOX4↓, 1,   SOX9?, 1,   SPP1↓, 1,   SUV39H↓, 3,   TFAP2A↓, 1,   tumCV?, 1,   tumCV↓, 17,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 22,   GRP78/BiP↓, 1,   GRP78/BiP↑, 8,   Hsc70↓, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 15,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 2,   ATG5↝, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   Beclin-1/ATG6↝, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 6,   LC3s↑, 1,   p62↓, 4,   p62↑, 2,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 21,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   DFF45↓, 1,   DNA-PK↓, 1,   DNAdam↓, 3,   DNAdam↑, 29,   DNArepair↓, 3,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 7,   importin α/β↓, 1,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 3,   P53?, 2,   P53↓, 3,   P53↑, 50,   P53↝, 1,   P53∅, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 8,   PARP∅, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 29,   PARP1↓, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 18,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 16,   TOP1↓, 5,   TOP2↓, 4,   TP53↑, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1/2/5/9↓, 1,   CDK2↓, 18,   CDK2↑, 1,   CDK4↓, 23,   CDK4/6↓, 1,   CDK6↓, 11,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 2,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 11,   cycD1/CCND1↓, 43,   CycD3↓, 1,   cycE/CCNE↓, 8,   cycE/CCNE↑, 2,   cycE1↓, 2,   E2Fs↑, 1,   Ki-67↓, 11,   MAD↓, 1,   mitA↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 35,   p27/CDKN1B↑, 17,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 3,   TumCCA↓, 4,   TumCCA↑, 88,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 1,   AXIN1↑, 1,   BMPs↑, 1,   CD133↓, 5,   CD24↓, 2,   CD34↓, 1,   cFos↓, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 24,   Diff↓, 1,   EIF4E↓, 3,   FBXW7↝, 1,   FGF↓, 1,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 7,   HH↓, 3,   IGF-1↓, 10,   IGFBP1↑, 1,   IGFBP3↑, 2,   Ki-67↓, 11,   Let-7↑, 1,   MCM2↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 11,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH3↓, 2,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 6,   Smo↓, 5,   TumCG?, 1,   TumCG↓, 47,   TumCG↑, 2,   TumCP↓, 83,   TumCP↑, 3,   Wnt↓, 14,   Wnt/(β-catenin)↓, 8,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 6,   AP-1↝, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 4,   Ca+2↑, 16,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   CAFs/TAFs↝, 1,   cal2↑, 1,   CD11b↓, 1,   COL4A3↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 28,   EMT?, 1,   EMT↓, 50,   EMT↝, 1,   FAK↓, 10,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 2,   GnT-V↝, 1,   heparanase↝, 1,   ITGA2↓, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB1↓, 4,   ITGB1↑, 1,   ITGB3↓, 3,   ITGB4↓, 2,   ITGB6↓, 1,   LAMs↓, 2,   MALAT1↓, 3,   MMP-10↓, 2,   MMP1↓, 2,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 54,   MMP3↓, 4,   MMP7↓, 5,   MMP9↓, 61,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 24,   MUC4↓, 2,   N-cadherin↓, 18,   NCAM↑, 1,   NM23↑, 1,   PAK1↓, 1,   PDGF↓, 6,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 1,   Slug↓, 4,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 4,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 19,   talin↓, 1,   TET1↑, 2,   TGF-β↓, 12,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 1,   TIMP2↑, 3,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 56,   TumCMig↓, 50,   TumMeta↓, 39,   TumMeta↑, 3,   Twist↓, 10,   uPA↓, 12,   uPAR↓, 1,   Vim?, 1,   Vim↓, 24,   Zeb1↓, 7,   ZEB2↓, 1,   α-SMA↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 24,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 86,   angioG↑, 1,   CD31/PECAM-1↓, 6,   CD31/PECAM-1↑, 1,   Endoglin↑, 1,   eNOS↓, 2,   HIF-1↓, 2,   Hif1a↓, 314,   Hif1a↑, 12,   Hif1a↝, 4,   HIF2a↓, 1,   Hypoxia↑, 1,   LOX1↓, 2,   NO↓, 4,   NO↑, 2,   PHDs↑, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 3,   VEGF↓, 142,   VEGF↑, 2,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 17,   VHL↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CLDN1↓, 1,   CLDN2↓, 1,   CTR1↑, 1,   EPR↑, 2,   EPR↝, 1,   GLUT1↓, 41,   GLUT1↑, 3,   GLUT2↓, 1,   GLUT3↓, 3,   GLUT3↑, 1,   GLUT4↓, 4,   MMP↓, 50,   MMP↑, 2,   MPT↑, 2,   NHE1↓, 3,   SVCT-2∅, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ALC∅, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 44,   COX2/PTGS2↑, 3,   CXCL12↓, 3,   CXCL6/GCP-2↓, 1,   CXCR4↓, 8,   DR4↑, 3,   FOXP3↓, 1,   Gal-3↓, 2,   HCAR1↓, 1,   HMGB1↓, 3,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 5,   IL10↑, 2,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 27,   IL8↓, 7,   IL8↑, 1,   Imm↑, 5,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 11,   M2 MC↓, 1,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 82,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 5,   NLRP3↓, 2,   p50↓, 1,   p65↓, 3,   PD-1↓, 3,   PD-L1↓, 7,   PGE2↓, 10,   PSA↓, 7,   PSA∅, 1,   RAGE↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   TCF↓, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 3,   TNF-α↓, 16,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   pH↝, 1,   e-pH↑, 1,   i-pH↓, 1,   PLC↓, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↑, 1,   Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 8,   ARNT?, 1,   CYP19↓, 1,   ER(estro)↓, 2,   Estro↝, 1,   GR↑, 1,   PPARα↓, 1,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 27,   BioAv↑, 21,   BioAv↝, 4,   BioEnh↑, 5,   chemoR↓, 1,   ChemoSen↑, 85,   ChemoSen⇅, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 4,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   Dose?, 3,   Dose↓, 4,   Dose↑, 9,   Dose↝, 31,   Dose∅, 10,   eff↓, 22,   eff↑, 46,   eff⇅, 1,   eff↝, 12,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 7,   Half-Life↑, 1,   Half-Life↝, 7,   Half-Life∅, 1,   MDR1↓, 4,   P-gp/ABCB1↓, 7,   P-gp/ABCB1↑, 1,   P450↓, 4,   RadioS↑, 34,   selectivity↑, 35,   Synergy↑, 65,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↑, 1,   ALAT↓, 1,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 8,   ascitic↓, 1,   AST↝, 1,   BRCA1↓, 1,   BRCA1↝, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 29,   EZH2↓, 3,   FOXM1↓, 2,   HEC1↓, 1,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 7,   IL6↓, 27,   LDH↓, 9,   LDH↑, 1,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 7,   PSA↓, 7,   PSA∅, 1,   RAGE↑, 1,   TP53↑, 2,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 28,   AntiCan∅, 2,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↓, 1,   chemoP↑, 17,   chemoPv↑, 15,   ChemoSideEff↓, 9,   fatigue↓, 3,   hepatoP↑, 6,   IMPDH1↓, 1,   IMPDH2↓, 1,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 12,   PFS↑, 2,   QoL↑, 4,   radioP↑, 5,   RenoP↑, 2,   Risk↓, 6,   Risk↑, 1,   Sleep↑, 1,   toxicity↓, 13,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 15,   TumW↓, 12,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 3,   GutMicro↝, 1,  
Total Targets: 942

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 30,   Catalase↓, 1,   Catalase↑, 15,   GPx↑, 12,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 14,   GSR↑, 1,   GSTs↑, 5,   H2O2↓, 1,   HO-1↓, 2,   HO-1↑, 9,   Iron↓, 2,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 7,   MDA↓, 12,   MDA↑, 1,   MPO↓, 3,   NOX4↓, 1,   NRF2↑, 24,   RNS↓, 1,   ROS↓, 61,   ROS↑, 1,   mt-ROS?, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 20,   SOD1↑, 2,   SOD2↑, 2,   TAC↑, 2,   TBARS↓, 2,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mtDam↓, 1,   OXPHOS↑, 1,   PDH↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 5,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 4,   ECAR↓, 1,   glucose↓, 4,   GlucoseCon↑, 4,   Glycolysis↓, 2,   Glycolysis↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   HK2↓, 2,   lactateProd↓, 2,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↑, 1,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 4,   PPP↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 3,   BAX↓, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 4,   Casp3↑, 1,   Casp9↓, 1,   Casp9↑, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 12,   p38↓, 2,   Pyro↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 4,   p‑Akt↓, 1,   ERK↓, 1,   IGF-1R↓, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 3,   mTOR↓, 2,   mTOR↑, 1,   p‑P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 6,   PI3K↑, 3,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ARNT↑, 1,   ATF2↑, 1,   ATF4↓, 2,   FOXO1↑, 1,   FOXO3↑, 2,   HDAC↓, 1,   other↓, 3,   other↑, 6,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,   PERK↓, 1,   p‑PERK↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNArepair↑, 1,   P53↓, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 2,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↑, 1,   FGF↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Jun↑, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   Ca+2↓, 2,   EMT↓, 1,   ITGB1↑, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 1,   MMP9↑, 1,   NFAM1↑, 1,   NFAT↑, 2,   Rho↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TumCI∅, 1,   TumCMig∅, 1,   Vim↓, 1,   α-SMA↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 5,   Hif1a↓, 19,   Hif1a↑, 14,   Hif1a↝, 1,   Hif1a∅, 2,   NO↓, 8,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 7,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   GLUT1↓, 1,   GLUT3↑, 2,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 5,   TRPC1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   CXCc↑, 1,   CXCR2↑, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 5,   IL2↑, 1,   IL4↓, 1,   IL6↓, 10,   IL6↑, 1,   IL8↓, 4,   Imm↑, 3,   Inflam↓, 46,   LIF↑, 1,   LPS↓, 1,   pol-M2 MC↑, 1,   MyD88↓, 1,   NF-kB↓, 20,   NF-kB↑, 1,   NLRP3↓, 3,   OSM↑, 1,   PGE2↓, 4,   TLR4↓, 3,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 2,   ChAT↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 5,   BACE/β-secretase↓, 2,   tau↓, 3,   p‑tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 1,   ARNT↑, 1,   CYP19↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 23,   BioAv↑, 13,   BioAv↝, 7,   BioAv∅, 1,   Dose⇅, 1,   Dose↝, 7,   Dose∅, 1,   eff↓, 1,   eff↑, 4,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 1,   Half-Life↝, 4,   Half-Life∅, 4,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 1,   AST↓, 7,   BG↓, 1,   BMD↑, 1,   BP↓, 3,   creat↓, 2,   CRP↓, 1,   IL6↓, 10,   IL6↑, 1,   IRes↝, 1,   LDH↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   antiAll↑, 5,   AntiCan↓, 1,   AntiCan↑, 5,   AntiDiabetic↑, 8,   antiPs↑, 3,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 16,   cardioP⇅, 1,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↑, 9,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 18,   memory↑, 11,   motorD↓, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 34,   Obesity↓, 7,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 7,   Stroke↓, 5,   toxicity↓, 19,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 6,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiViral↑, 2,   Bacteria↓, 7,   GutMicro↑, 7,   Sepsis↓, 1,  
Total Targets: 324

Scientific Paper Hit Count for: Hif1a, HIF1α/HIF1a
14 Apigenin (mainly Parsley)
14 Baicalein
14 Resveratrol
14 Sulforaphane (mainly Broccoli)
12 Silymarin (Milk Thistle) silibinin
10 EGCG (Epigallocatechin Gallate)
9 Vitamin C (Ascorbic Acid)
9 Berberine
9 Metformin
8 Curcumin
8 Melatonin
8 Shikonin
7 Honokiol
6 Thymoquinone
6 Alpha-Lipoic-Acid
6 Chrysin
6 Quercetin
5 Silver-NanoParticles
5 Artemisinin
5 Radiotherapy/Radiation
5 Betulinic acid
5 Dichloroacetate
5 Magnetic Fields
5 Propolis -bee glue
5 Phenethyl isothiocyanate
4 Ashwagandha(Withaferin A)
4 Chlorogenic acid
4 Deguelin
4 Ellagic acid
4 Emodin
4 Graviola
4 Vitexin
4 Rosmarinic acid
4 Vitamin K2
3 Brucea javanica
3 brusatol
3 borneol
3 Boron
3 Capsaicin
3 chaetocin
3 Cinnamon
3 Citric Acid
3 Formononetin
3 Hydrogen Gas
3 HydroxyTyrosol
3 Isoliquiritigenin
3 Kaempferol
3 Licochalcone A
3 Licorice
3 Luteolin
3 Magnolol
3 MCT, metronomic chemo
3 methylseleninic acid
2 5-fluorouracil
2 Allicin (mainly Garlic)
2 Caffeic acid
2 Carvacrol
2 Celastrol
2 Electrical Pulses
2 Cisplatin
2 Fucoidan
2 Gambogic Acid
2 Isovitexin
2 Lutein
2 Lycopene
2 mebendazole
2 Modified Citrus Pectin
2 Oxygen, Hyperbaric
2 Proanthocyanidins
2 Piperlongumine
2 Sanguinarine
2 Wogonin
1 Coenzyme Q10
1 Annona atemoya Seed Extract
1 Auranofin
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Atorvastatin
1 tamoxifen
1 Baicalin
1 Biochanin A
1 Thymol-Thymus vulgaris
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Celecoxib
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Bortezomib
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Diindolylmethane
1 Ormeloxifene (Centchroman)
1 Ferulic acid
1 Fenbendazole
1 Fisetin
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Gallic acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgolide B
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 phytic acid, Inositol hexakisphosphate
1 itraconazole
1 Ivermectin
1 Juglone
1 Lactobacillus
1 Paclitaxel/Taxol
1 Methylglyoxal
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Niclosamide (Niclocide)
1 Oroxylin-A
1 Oleuropein
1 doxorubicin
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:143  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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