MMP2 Cancer Research Results

MMP2, metalloproteinase-2: Click to Expand ⟱
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Matrix metalloproteinase-2 (MMP-2) is an enzyme that plays a significant role in the degradation of extracellular matrix components, which is crucial for various physiological processes, including tissue remodeling, wound healing, and angiogenesis.
Elevated levels of MMP-2 have been associated with poor prognosis in various cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5182- BBR,    Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9
- in-vitro, SCC, SCC4
TumCMig↓, TumCI↓, p‑JNK↝, p‑ERK↝, p‑p38↝, IKKα↝, NF-kB↝, MMP2↓, MMP9↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, Synergy↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP/DDIT3↑, *toxicity↓,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1 / PDPK1↓, PDK1 / PDPK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
2741- BetA,    Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress
- in-vitro, GC, SNU16 - in-vitro, GC, NCI-N87 - in-vivo, NA, NA
TumCG↓, TumCMig↓, TumCI↓, N-cadherin↓, E-cadherin↑, EMT↓, Ki-67↓, MMP2↓,
2742- BetA,    Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models
- in-vitro, BC, MDA-MB-231 - in-vivo, BC, 4T1 - in-vitro, BC, MCF7
tumCV↓, TumCMig↓, TumCI↓, STAT3↑, FAK↓, MMPs↓, MMP2↓, MMP9↓, TIMP2↑,
5688- BJ,    Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes
- vitro+vivo, PC, MIA PaCa-2
TumCG↓, TumCI↓, TumCCA↑, Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, MMP2↓, BACE/β-secretase↓, TOP2↓,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
5481- BM,    Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies
- in-vitro, HCC, HepG2
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, lipid-P↓,
3521- Bor,    A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway
- in-vitro, Obesity, 3T3
*CEBPA↓, *PPARγ↓, *FASN↓, *SREBP1/SREBF1↓, *FABP4↓, *GLUT4↓, *β-catenin/ZEB1↑, *MMP2↓, *FGF↑, *Ca+2?,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, Synergy↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, Synergy↑, MMP1↓, MMP2↓, Synergy↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑, *antiAll↑,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, Var, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2/PTGS2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
8972- BRice,    Cyanidin-3-O-Glucoside-Rich Black Rice Fraction Attenuates IL-1β/IL-6-Driven A549 Lung Cancer Cell Migration and Invasion and Modulates JAK1/STAT3 Signaling
- in-vitro, Lung, A549
Ingr↝, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, uPA↓, uPAR↓, p‑JAK1↓, p‑STAT3↓, Dose↝,
5752- CA,    Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma
- Review, HCC, NA
*ROS↓, angioG↓, STAT3↓, MMP2?, MMP9?,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, Synergy↑, ChemoSen↑, *memory↑, *ROS↓,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2/PTGS2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, Synergy↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, Synergy↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, Synergy↑, Synergy↑, Synergy↑,
1646- CA,    Caffeic acid: a brief overview of its presence, metabolism, and bioactivity
- Review, Nor, NA
*BioAv↓, ROS⇅, selectivity↑, other∅, VEGF↓, MMP2↓, MMP9↓,
1650- CA,    Adjuvant Properties of Caffeic Acid in Cancer Treatment
- Review, Var, NA
ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2/PTGS2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP/DDIT3↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
5845- CAP,    Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
- in-vivo, RCC, A498 - in-vitro, RCC, T24/HTB-9 - NA, Bladder, 5637
TRPV1↑, TumCP↓, Casp↑, Apoptosis↑, SIRT1↓, MMP2↓, MMP9↓, TumCMig↓, TumCCA↑, ROS↑, DNAdam↑, PD-L1↑, eff↓,
5204- CAP,    Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways
- in-vitro, Colon, SW480 - in-vitro, Colon, CT26
TumCP↓, TumCMig↑, TumCI↑, EMT↑, MMP2↓, MMP9↑, STAT3↑, TumMeta↑, ROS↑,
1264- CAP,    Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCCA↑, MMP∅, MMP2↓, MMP9↓, α-SMA↓, COL1A1↓, COL3A1↓, TIMP1↓,
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, Synergy↑,
5773- CAPE,    Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B
- in-vitro, HCC, SK-HEP-1
TumCI↓, MMP2↓, MMP9↓, NF-kB↓, TumMeta↓,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2/PTGS2↓, 5LO↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5912- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, p‑Cofilin↑, RAS↓, MEK↓, MAPK↓, PI3K↓, Akt↓,
6254- CBC/D,    Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Review, Var, NA
*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, MMP2↑, MMP9↓, BioAv↑,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
6652- Cen,    AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells
- in-vitro, GC, SGC-7901 - in-vitro, GC, HGC27
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, Bcl-2↓, BAX↑, cMyc↓, Casp3↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, tumCV↓,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, toxicity↓, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
6131- CHr,  Bor,  Z,    Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells
- in-vitro, Lung, A549
*BioAv↑, ROS↑, TumCD↑, TumCCA↑, MMP2↓, TumMeta↓, TumCI↓, GSH↓, eff↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, Synergy↑, Ca+2↑,
6142- Cin,    Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, SW48 - in-vitro, CRC, HCT116
E-cadherin↑, MMP2↓, MMP9↓, PI3K↓, Akt↓, IGF-1↓, Apoptosis↑, BAX↑, cl‑PARP↑, PARP↓, Bcl-2↓, TumCI↓,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
7415- CS,    Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells
- in-vitro, AML, THP1
AKR1B10↓, NF-kB↓, COX2/PTGS2↓, MMP2↓, ROS↓,
7410- CS,    Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231
- in-vitro, BC, MDA-MB-231
selectivity↑, other↝, Apoptosis↑, DR4↑, Casp9↑, Casp8↑, Bax:Bcl2↑, P21↑, MMP↓, TumCI↓, MMP2↓,

Showing Research Papers: 51 to 100 of 348
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 348

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 8,   Catalase↑, 2,   Copper↓, 1,   Copper↑, 1,   ENOX2↓, 1,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 4,   GSH↓, 21,   GSH↑, 4,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 2,   H2O2↑, 6,   HO-1↓, 11,   HO-1↑, 10,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 10,   MDA↓, 4,   MDA↑, 2,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 11,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   ROS?, 2,   ROS↓, 23,   ROS↑, 150,   ROS⇅, 6,   ROS↝, 2,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 2,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 5,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   CDC2↓, 8,   CDC25↓, 9,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 4,   ETC↓, 2,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 7,   OCR↓, 4,   OCR↑, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 4,   ACC↑, 2,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 11,   CAIX/CA9↑, 1,   ECAR↓, 3,   ECAR↝, 1,   FABP4↑, 1,   FASN↓, 4,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 6,   GlutMet↓, 2,   Glycolysis↓, 18,   GSK‐3β↓, 10,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   HK1↓, 1,   HK2↓, 8,   lactateProd↓, 9,   LDHA↓, 6,   LDL↓, 2,   NADPH↓, 3,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PIP3↑, 1,   PKM2↓, 8,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 9,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 122,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 4,   BAD↑, 7,   Bak↑, 7,   BAX↓, 2,   BAX↑, 79,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 20,   Bcl-2↓, 91,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 25,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 2,   BIM↑, 4,   BNIP3↑, 2,   Casp↑, 23,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 4,   Casp3↑, 100,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 14,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 65,   cl‑Casp9↑, 9,   proCasp9↓, 1,   CellShr↑, 2,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 62,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 12,   DR5↑, 21,   Endon↑, 2,   FADD↑, 3,   Fas?, 1,   Fas↓, 1,   Fas↑, 20,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↑, 5,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 8,   IAP2/BIRC3↓, 1,   iNOS↓, 14,   Mcl-1?, 1,   Mcl-1↓, 20,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 3,   Necroptosis↑, 1,   NOXA↑, 3,   oncosis↑, 1,   p38↓, 9,   p38↑, 8,   p‑p38↓, 5,   p‑p38↑, 3,   p‑p38↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 2,   survivin↓, 40,   TNFR 1↑, 3,   TRAIL↑, 3,   TRAILR↑, 3,   TumCD↑, 9,   XIAP↓, 22,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 115,   Akt↑, 3,   Akt↝, 1,   p‑Akt↓, 38,   AKT1↓, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 42,   ERK↑, 6,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↝, 1,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 12,   HGF/c-Met↓, 3,   Hippo↑, 1,   IGF-1R↓, 4,   IGFR↓, 2,   IKKα↓, 9,   IKKα↝, 1,   p‑IKKα↓, 2,   p‑IκB↓, 3,   JAK↓, 6,   p‑JAK↓, 1,   JAK1↓, 3,   JAK1↑, 1,   p‑JAK1↓, 1,   JAK2↓, 14,   p‑JAK2↓, 2,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 31,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 2,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 60,   mTOR↝, 2,   p‑mTOR↓, 10,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   P90RSK↓, 2,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 94,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 7,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 2,   PKA↓, 1,   PKCδ↓, 11,   PTEN↓, 1,   PTEN↑, 24,   PTEN↝, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 12,   RCC1↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 9,   p‑Src↓, 2,   STAT↓, 4,   p‑STAT2↓, 1,   STAT3↓, 71,   STAT3↑, 2,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 2,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 4,   CBP↓, 1,   cJun↓, 8,   cJun↑, 1,   cMyc↓, 29,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 7,   EZH2↓, 7,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↓, 2,   H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 1,   HDAC↓, 17,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   METTL7A↑, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-126↓, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 3,   miR-155↑, 1,   miR-17↓, 1,   miR-182-5p↓, 1,   miR-194↑, 1,   miR-195↑, 1,   miR-200b↑, 2,   miR-200c↓, 1,   miR-203↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↑, 1,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 4,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 2,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 4,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 13,   other↓, 4,   other↑, 1,   other↝, 5,   other∅, 1,   PAX2↓, 1,   PhotoS↑, 1,   RASSF1A↑, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX9?, 1,   SOX9↓, 1,   SOX9↑, 1,   TCF-4↓, 1,   tumCV↓, 35,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 16,   eIF2α↓, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 25,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↝, 1,   HSP90↓, 6,   HSPs↓, 1,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 9,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 8,   LC3s↑, 1,   p62↓, 6,   TumAuto↓, 1,   TumAuto↑, 27,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 42,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 11,   MGMT↓, 1,   p16↑, 5,   P53?, 2,   P53↓, 2,   P53↑, 57,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 19,   cl‑PARP↑, 40,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 26,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 5,   TOP2↓, 4,   TOP2↑, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 7,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 12,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 35,   CDK2↑, 2,   CDK4↓, 43,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 18,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 3,   p‑CHK1↑, 2,   Chk2↓, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 2,   Cyc↝, 1,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 16,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 67,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 18,   cycE1↓, 1,   E2Fs↓, 6,   GADD45A↓, 1,   Ki-67↓, 16,   MAD↓, 1,   P21↓, 3,   P21↑, 43,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 24,   pRB↑, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 2,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 118,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 2,   BMP2↓, 2,   BMPs↑, 1,   CD133↓, 8,   CD24↓, 3,   CD34↓, 1,   cFos↓, 7,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 34,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 2,   Gli1↓, 7,   HH↓, 7,   IGF-1↓, 6,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 16,   Let-7↑, 4,   LRP6↓, 1,   p‑LRP6↓, 1,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 9,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 18,   NOTCH1↓, 14,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 1,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 8,   Smo↓, 3,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 50,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 97,   TumCP↑, 4,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt↓, 38,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 11,   AP-1↝, 2,   ATPase↓, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↑, 30,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   p‑Cofilin↑, 2,   COL1↓, 3,   COL1A1↓, 1,   COL3A1↓, 2,   DLC1↑, 1,   E-cadherin↓, 14,   E-cadherin↑, 70,   EMT↓, 98,   EMT↑, 3,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 15,   FAK↑, 1,   p‑FAK↓, 3,   Fibronectin↓, 10,   GIT1↓, 1,   GLI2↓, 2,   IQGAP3↓, 1,   ITGA1∅, 1,   ITGA5↓, 1,   ITGA5∅, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB1∅, 1,   ITGB3↓, 1,   ITGB3∅, 1,   ITGB4∅, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 10,   MMP13↓, 5,   MMP14↓, 1,   MMP16↓, 3,   MMP2?, 2,   MMP2↓, 321,   MMP2↑, 3,   MMP2⇅, 1,   MMP2↝, 2,   MMP2∅, 1,   proMMP2↓, 1,   MMP3↓, 11,   MMP7↓, 14,   MMP7∅, 1,   MMP9?, 2,   MMP9↓, 262,   MMP9↑, 3,   MMP9⇅, 1,   MMP9↝, 1,   MMP9∅, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 29,   MTA1↓, 2,   N-cadherin↓, 48,   NCAM↓, 1,   NCAM↑, 1,   PAK1↓, 2,   pax↓, 1,   PDGF↓, 7,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 6,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 2,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 40,   Snail↑, 1,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 5,   TIMP1↑, 21,   TIMP2↓, 7,   TIMP2↑, 18,   TIMP3↑, 2,   TSP-1↑, 4,   TumCA↓, 5,   TumCA↑, 1,   TumCI↓, 122,   TumCI↑, 2,   TumCMig↓, 117,   TumCMig↑, 1,   TumMeta↓, 69,   TumMeta↑, 7,   TumPF↓, 1,   Twist↓, 26,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 34,   uPAR↓, 6,   Vim?, 1,   Vim↓, 53,   Vim↑, 1,   Zeb1↓, 18,   ZEB2↓, 1,   ZEB2↑, 1,   α-SMA↓, 5,   α-SMA↑, 1,   β-catenin/ZEB1↓, 44,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 74,   angioG↑, 1,   angioS↑, 1,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 2,   HIF-1↓, 7,   Hif1a↓, 50,   Hif1a↑, 1,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 8,   NO↑, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 114,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 3,   CLDN2↓, 1,   EPR↑, 5,   GLUT1↓, 7,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 75,   MMP↑, 1,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   TRPM7↓, 3,   TRPV1↑, 3,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 14,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 79,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 13,   DR4↑, 8,   FOXP3↓, 2,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 6,   IL1↑, 1,   IL10↓, 7,   IL10↑, 2,   IL12↓, 3,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 18,   IL1β↑, 2,   IL2↓, 3,   IL2↑, 4,   IL4↑, 2,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 2,   Imm↝, 3,   Inflam↓, 19,   IRAK1↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MIP-1β↑, 1,   MIP2↓, 2,   mPGES-1↓, 2,   NF-kB?, 1,   NF-kB↓, 127,   NF-kB↑, 3,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p50↓, 3,   p65↓, 12,   p‑p65↓, 4,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE2↓, 24,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 1,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 34,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,   WFDC10A↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   PPARα↓, 2,   PPARα↑, 2,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 8,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B10↓, 1,   BioAv↓, 32,   BioAv↑, 30,   BioAv↝, 9,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 100,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 6,   Dose↝, 28,   Dose∅, 8,   eff?, 1,   eff↓, 13,   eff↑, 41,   eff⇅, 1,   eff↝, 11,   GSTA1↑, 2,   Half-Life↓, 8,   Half-Life↑, 2,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 2,   RadioS↑, 35,   selectivity?, 1,   selectivity↑, 47,   Synergy?, 1,   Synergy↑, 68,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 6,   ALP↓, 2,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ascitic↓, 1,   AST↓, 4,   BRCA1↓, 2,   BRCA1↑, 1,   CEA↓, 1,   CRP↓, 4,   E6↓, 2,   E7↓, 2,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 7,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 12,   hTERT/TERT↓, 11,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 4,   Myc↓, 4,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 33,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 2,   AntiTum↑, 17,   cachexia↓, 3,   cardioP↑, 9,   chemoP?, 1,   chemoP↑, 20,   chemoPv↑, 14,   ChemoSideEff↓, 4,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 5,   OS↑, 5,   Pain↓, 1,   Pin1↓, 1,   radioP↑, 6,   RenoP↑, 6,   Risk↓, 6,   toxicity↓, 8,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 12,   TumVol∅, 1,   TumW↓, 3,   TumW∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 6,  
Total Targets: 1004

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 60,   Catalase↑, 20,   Copper↓, 1,   GPx↑, 17,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 21,   GSR↓, 1,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 10,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HO-1↑, 10,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 16,   MDA↓, 14,   MPO↓, 1,   NADH↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 23,   NRF2∅, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 71,   ROS∅, 1,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 1,   ALAT↓, 8,   AMPK↓, 1,   AMPK↑, 1,   DGAT1↓, 1,   FABP4↓, 1,   FASN↓, 3,   GSK‐3β↓, 2,   LDL↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 4,   Casp3?, 1,   Casp3↓, 6,   Casp3↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 8,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↓, 1,   p‑Akt↑, 1,   CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 1,   p‑LIMK1↑, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↑, 3,   PDGFR-BB↓, 1,   PI3K↑, 3,   PKCδ↑, 1,   PTEN↑, 1,   STAT3↓, 3,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 2,   other↝, 3,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↑, 2,   Ki-67↓, 2,   P21↓, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   FGF↑, 2,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↓, 2,   Ca+2↝, 1,   p‑Cofilin↑, 1,   COL1↓, 1,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   Fibronectin↓, 1,   LAMs↑, 1,   p‑MLC2/MYL9↑, 1,   MMP1↓, 1,   MMP2↓, 14,   MMP2↑, 6,   MMP3↓, 1,   MMP9↓, 7,   MMP9↑, 2,   MMPs↓, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   PAI-1/SERPINE1↓, 1,   Rac1↑, 1,   Rho↓, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Smad1↑, 1,   Smad7↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TregCell↑, 1,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 3,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 8,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGF↑, 3,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 8,   CLDN1↝, 1,   CLDN5↓, 1,   GastroP↑, 2,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 4,   OCLN↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 21,   Eos↓, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 3,   IL10↓, 1,   IL10↑, 4,   IL12↓, 2,   IL17↓, 2,   IL1β↓, 12,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 5,   Imm↑, 11,   Inflam↓, 62,   Inflam↑, 1,   MCP1/CCL2↓, 3,   MCP1/CCL2↑, 1,   NeuroI↓, 1,   NF-kB↓, 29,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 21,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 7,   AChE↑, 1,   BChE↓, 1,   BDNF↑, 4,   GABA↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 2,   tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   Estro↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24,   BioAv↑, 24,   BioAv↝, 14,   BioEnh↑, 2,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↓, 1,   eff↑, 8,   Half-Life↓, 1,   Half-Life↝, 6,   Half-Life∅, 1,   P450↓, 3,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 3,   AST↓, 11,   BMD↑, 1,   BP↓, 2,   BUN↓, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 11,   AntiArt↑, 6,   AntiCan↓, 1,   AntiCan↑, 12,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 14,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 28,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↑, 7,   diuretic↑, 3,   hepatoP↓, 1,   hepatoP↑, 21,   Learn↑, 1,   memory↑, 11,   motorD↑, 3,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 44,   Obesity↓, 5,   Pain↓, 4,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 5,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↓, 1,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 17,   Diar↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 3,  
Total Targets: 321

Scientific Paper Hit Count for: MMP2, metalloproteinase-2
14 Fisetin
14 Quercetin
10 Baicalein
10 Berberine
10 Matrine
10 Sulforaphane (mainly Broccoli)
8 Curcumin
8 Luteolin
8 Resveratrol
7 EGCG (Epigallocatechin Gallate)
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Eugenol
6 Garcinol
6 Kaempferol
6 Lycopene
6 Rosmarinic acid
5 Artemisinin
5 Betulinic acid
5 Caffeic acid
5 Propolis -bee glue
5 Capsaicin
5 Dandelion Root
5 Ellagic acid
5 Thymoquinone
4 Carvacrol
4 Chrysin
4 Formononetin
4 Magnolol
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Silver-NanoParticles
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Hydroxycinnamic-acid
3 Diindolylmethane
3 Emodin
3 Ferulic acid
3 Fucoidan
3 Gambogic Acid
3 Honokiol
3 Naringin
3 Nimbolide
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Selenite (Sodium)
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 alpha Linolenic acid
2 Andrographis
2 Radiotherapy/Radiation
2 Astaxanthin
2 Baicalin
2 Berbamine
2 Brucea javanica
2 Boron
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 CUSP9
2 Deguelin
2 Indole-3-carbinol
2 Ginkgetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Hyperoside
2 mebendazole
2 Melatonin
2 Morin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Shikonin
1 1,8-Cineole
1 Astragalus
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Cisplatin
1 Aspirin
1 Aloe anthraquinones
1 Biochanin A
1 Beta-Caryophyllene
1 Chemotherapy
1 brusatol
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 Carnosic acid
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenium NanoParticles
1 Zinc
1 Coenzyme Q10
1 Cucurbitacin
1 Ursolic acid
1 Cyclopamine
1 Cysteamine
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Sorafenib (brand name Nexavar)
1 Flaxseed/Linseed
1 5-fluorouracil
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Juglone
1 Lactobacillus
1 gefitinib, erlotinib
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 tamoxifen
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Oleuropein
1 Phenylbutyrate
1 Propyl gallate
1 temozolomide
1 Piperlongumine
1 Polyphenols
1 Parthenolide
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:201  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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