MMP2 Cancer Research Results

MMP2, metalloproteinase-2: Click to Expand ⟱
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Matrix metalloproteinase-2 (MMP-2) is an enzyme that plays a significant role in the degradation of extracellular matrix components, which is crucial for various physiological processes, including tissue remodeling, wound healing, and angiogenesis.
Elevated levels of MMP-2 have been associated with poor prognosis in various cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP↑, *toxicity↓,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
2741- BetA,    Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress
- in-vitro, GC, SNU16 - in-vitro, GC, NCI-N87 - in-vivo, NA, NA
TumCG↓, TumCMig↓, TumCI↓, N-cadherin↓, E-cadherin↑, EMT↓, Ki-67↓, MMP2↓,
2742- BetA,    Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models
- in-vitro, BC, MDA-MB-231 - in-vivo, BC, 4T1 - in-vitro, BC, MCF-7
tumCV↓, TumCMig↓, TumCI↓, STAT3↑, FAK↓, MMPs↓, MMP2↓, MMP9↓, TIMP2↑,
5688- BJ,    Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes
- vitro+vivo, PC, MIA PaCa-2
TumCG↓, TumCI↓, TumCCA↑, Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, MMP2↓, BACE↓, TOP2↓,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1↓, RadioS↑, PhotoS↑, toxicity↝,
5481- BM,    Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies
- in-vitro, HCC, HepG2
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, lipid-P↓,
3521- Bor,    A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway
- in-vitro, Obesity, 3T3
*CEBPA↓, *PPARγ↓, *FASN↓, *SREBP1↓, *FABP4↓, *GLUT4↓, *β-catenin/ZEB1↑, *MMP2↓, *FGF↑, *Ca+2?,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
1646- CA,    Caffeic acid: a brief overview of its presence, metabolism, and bioactivity
- Review, Nor, NA
*BioAv↓, ROS⇅, selectivity↑, other∅, VEGF↓, MMP2↓, MMP9↓,
1650- CA,    Adjuvant Properties of Caffeic Acid in Cancer Treatment
- Review, Var, NA
ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,
5752- CA,    Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma
- Review, HCC, NA
*ROS↓, angioG↓, STAT3↓, MMP2?, MMP9?,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
5845- CAP,    Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
- in-vivo, RCC, A498 - in-vitro, RCC, T24/HTB-9 - NA, Bladder, 5637
TRPV1↑, TumCP↓, Casp↑, Apoptosis↑, SIRT1↓, MMP2↓, MMP9↓, TumCMig↓, TumCCA↑, ROS↑, DNAdam↑, PD-L1↑, eff↓,
5204- CAP,    Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways
- in-vitro, Colon, SW480 - in-vitro, Colon, CT26
TumCP↓, TumCMig↑, TumCI↑, EMT↑, MMP2↓, MMP9↑, STAT3↑, TumMeta↑, ROS↑,
1264- CAP,    Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCCA↑, MMP∅, MMP2↓, MMP9↓, α-SMA↓, COL1A1↓, COL3A1↓, TIMP1↓,
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,
5773- CAPE,    Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B
- NA, HCC, SK-HEP-1
TumCI↓, MMP2↓, MMP9↓, NF-kB↓, TumMeta↓,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2↓, 5LO↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2↓, *MDA↓,
5912- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, p‑Cofilin↑, RAS↓, MEK↓, MAPK↓, PI3K↓, Akt↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF-7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, eff↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, eff↑, Ca+2↑,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
155- CUR,    Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
- in-vitro, Pca, PC3
p‑ERK↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, angioS↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
TumCI↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, STAT3↓, miR-301a-3p↓, STAT↓, N-cadherin↓, Vim↓, Fibronectin↓, p‑JAK↓, p‑JAK2↓, p‑JAK3↓, p‑STAT1↓, p‑STAT2↓, E-cadherin↑,
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
TRAILR↑, BAX↑, P21↑, p27↑, NF-kB↓, cycD1/CCND1↓, VEGF↓, uPA↓, MMP2↓, MMP9↓, Bcl-2↓, Bcl-xL↓,
181- CUR,    The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo
- vitro+vivo, Pca, DU145
MMP2↓, MMP9↓, TumCP↓, TumCI↓,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,

Showing Research Papers: 51 to 100 of 241
Prev Page 2 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   GSH↓, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 4,   HO-1↑, 1,   HO-2↓, 1,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MAD↓, 1,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↝, 1,   ROS↑, 25,   ROS⇅, 1,   ROS↝, 1,   mt-ROS↑, 1,   SOD2↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   AIF↑, 1,   ATP↓, 2,   MEK↓, 2,   mitResp↑, 1,   MMP↓, 11,   MMP↑, 1,   MMP∅, 1,   MPT↑, 1,   OCR↓, 2,   XIAP↓, 4,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 3,   AMPK↑, 8,   cMyc↓, 3,   ECAR↓, 1,   ECAR↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 3,   lactateProd↓, 2,   LDH↓, 2,   LDHA↓, 1,   LDL↓, 1,   PDH↝, 1,   PDK1?, 2,   PDK1↓, 2,   p‑PDK1↓, 1,   PI3K/Akt↓, 1,   PPARα↓, 2,   PPARα↝, 1,   SIRT1↓, 3,  

Cell Death ⓘ

Akt↓, 10,   Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 21,   Apoptosis↝, 1,   BAX↑, 5,   BAX↝, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-2↝, 1,   Bcl-xL↓, 3,   Bcl-xL↝, 1,   Casp↑, 5,   Casp1↑, 1,   Casp3↑, 9,   Casp3↝, 1,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 2,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   Diablo↑, 2,   DR4↑, 2,   DR5↑, 2,   Fas↑, 2,   hTERT/TERT↓, 3,   iNOS↓, 2,   JNK↑, 1,   JNK↝, 1,   p‑JNK↑, 1,   MAPK↓, 5,   MAPK↑, 1,   Mcl-1↓, 2,   MDM2↓, 1,   Myc↓, 1,   NOXA↑, 1,   p27↑, 2,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TRAILR↑, 1,   TRPV1↑, 3,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

SOX9?, 1,   Sp1/3/4↓, 6,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   EZH2↓, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   other∅, 1,   PhotoS↑, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   p‑eIF2α↑, 2,   ER Stress↑, 7,   GRP78/BiP↑, 3,   GRP78/BiP↝, 1,   PERK↑, 2,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

LC3B↓, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 6,   DNMT1↓, 1,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 4,   P53↝, 1,   PARP↑, 2,   cl‑PARP↑, 5,   PCNA↓, 3,   SIRT6↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 3,   CDK2↑, 1,   CDK4↓, 4,   CDK4↑, 1,   Cyc↝, 1,   cycD1/CCND1↓, 10,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 2,   P21↑, 6,   P21↝, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State ⓘ

CD24↓, 1,   CDK8↓, 2,   CIP2A↓, 1,   CSCs↓, 3,   EMT↓, 14,   EMT↑, 1,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 3,   FOXO↑, 1,   Gli1↓, 2,   GSK‐3β↓, 1,   HDAC↓, 2,   HDAC4↓, 1,   HH↓, 1,   Let-7↑, 2,   LRP6↓, 1,   p‑LRP6↓, 1,   mTOR↓, 8,   mTOR↝, 1,   Nanog↓, 1,   NOTCH↓, 5,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH1↝, 1,   OCT4↓, 1,   P90RSK↓, 2,   PI3K↓, 11,   PI3K↑, 1,   PI3K↝, 1,   PTCH1↓, 2,   PTEN↑, 2,   PTEN↝, 1,   RAS↓, 1,   Shh↓, 1,   SOX2↓, 1,   STAT↓, 1,   p‑STAT1↓, 1,   p‑STAT2↓, 1,   STAT3↓, 13,   STAT3↑, 2,   p‑STAT3↓, 2,   p‑STAT3↑, 2,   Sufu↓, 1,   TOP1↓, 3,   TOP2↓, 1,   TOP2↑, 1,   TRPM7↓, 3,   TumCG↓, 9,   Wnt↓, 4,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

5LO↓, 2,   AP-1↝, 2,   AXL↓, 1,   Ca+2↑, 8,   Ca+2↝, 1,   CDKN1C↑, 1,   CLDN1↓, 2,   p‑Cofilin↑, 2,   COL1A1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 10,   F-actin↓, 2,   FAK↓, 2,   p‑FAK↓, 1,   Fibronectin↓, 2,   GLI2↓, 1,   Ki-67↓, 2,   LAMs↓, 1,   MALAT1↓, 1,   miR-200b↑, 1,   miR-301a-3p↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP2?, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP2↝, 1,   MMP9?, 1,   MMP9↓, 37,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 4,   PDGF↓, 1,   PKCδ↓, 2,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 2,   SMAD3↓, 1,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 21,   TumCI↑, 1,   TumCMig↓, 20,   TumCMig↑, 1,   TumCP↓, 12,   TumMeta↓, 9,   TumMeta↑, 1,   Twist↓, 5,   uPA↓, 2,   Vim↓, 6,   Zeb1↓, 1,   ZO-1↑, 1,   α-SMA↓, 2,   β-catenin/ZEB1↓, 10,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 9,   angioG↑, 1,   angioS↑, 1,   EGFR↓, 4,   EGFR↝, 1,   Endoglin↑, 1,   EPR↑, 1,   HIF-1↓, 2,   Hif1a↓, 7,   Hif1a↝, 1,   p‑PDGFR-BB↓, 1,   PHDs↓, 1,   VEGF↓, 19,   VEGF↝, 1,   VEGFR2↓, 2,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 3,   COX2↓, 9,   COX2↑, 1,   COX2↝, 1,   CXCR4↓, 3,   IKKα↓, 2,   IL10↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL6↓, 4,   IL6↝, 1,   Inflam↓, 4,   JAK↓, 1,   p‑JAK↓, 1,   JAK1↓, 1,   JAK2↓, 3,   p‑JAK2↓, 1,   p‑JAK3↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 17,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PGE2↓, 2,   PSA↝, 1,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↝, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   AR↑, 1,   AR↝, 1,   CDK6↓, 3,   CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 6,   ChemoSen↑, 17,   ChemoSen∅, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 3,   Dose∅, 5,   eff↓, 3,   eff↑, 30,   eff↝, 1,   Half-Life↓, 1,   MRP1↓, 1,   RadioS↑, 11,   selectivity↑, 11,  

Clinical Biomarkers ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 2,   AR↓, 2,   AR↑, 1,   AR↝, 1,   ascitic↓, 1,   AST↓, 1,   EGFR↓, 4,   EGFR↝, 1,   EZH2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 4,   IL6↝, 1,   Ki-67↓, 2,   LDH↓, 2,   Myc↓, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PSA↝, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 3,   chemoP↑, 1,   chemoPv↑, 4,   ChemoSideEff↓, 1,   NDRG1↑, 1,   neuroP↑, 3,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 3,   toxicity↝, 2,   TumVol↓, 2,   TumW↓, 1,   Weight↑, 1,  
Total Targets: 376

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   Catalase↑, 3,   GPx↑, 3,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 1,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 2,   MDA↓, 3,   NRF2↓, 1,   NRF2↑, 2,   ROS↓, 11,   SOD↑, 6,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   FABP4↓, 1,   FASN↓, 1,   LDH↓, 2,   LDH↑, 1,   PPARγ↓, 1,   SREBP1↓, 1,  

Cell Death ⓘ

iNOS↓, 1,   MAPK↓, 1,   MAPK↑, 1,   necrosis↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CEBPA↓, 1,   FGF↑, 1,   PTEN↑, 1,   TRPM7↓, 1,  

Migration ⓘ

5LO↓, 2,   AntiAg↑, 1,   Ca+2?, 1,   Ca+2↝, 1,   MMP2↓, 2,   MMP3↓, 1,   MMP9↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT4↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   CRP↓, 1,   IL1↓, 1,   IL12↓, 1,   IL2↑, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 9,   MCP1↓, 1,   NF-kB↓, 7,   PGE2↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Protein Aggregation ⓘ

BACE↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   Dose↝, 1,   eff↑, 1,   P450↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 2,   AST↓, 5,   CRP↓, 1,   IL6↓, 2,   LDH↓, 2,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 4,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 2,   hepatoP↑, 5,   memory↑, 3,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 5,   Obesity↓, 2,   Pain↓, 1,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 2,  
Total Targets: 87

Scientific Paper Hit Count for: MMP2, metalloproteinase-2
13 Quercetin
12 Fisetin
10 Baicalein
10 Berberine
10 Sulforaphane (mainly Broccoli)
8 Curcumin
8 Resveratrol
7 EGCG (Epigallocatechin Gallate)
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Lycopene
6 Rosmarinic acid
5 Artemisinin
5 Betulinic acid
5 Caffeic acid
5 Propolis -bee glue
5 Capsaicin
5 Ellagic acid
5 Garcinol
5 Thymoquinone
4 Carvacrol
4 Luteolin
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Chrysin
3 Honokiol
3 Magnolol
3 Naringin
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Selenite (Sodium)
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Silver-NanoParticles
2 Alpha-Lipoic-Acid
2 alpha Linolenic acid
2 Andrographis
2 Radiotherapy/Radiation
2 Astaxanthin
2 Baicalin
2 Berbamine
2 Brucea javanica
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Gambogic Acid
2 Grapeseed extract
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Shikonin
1 Astragalus
1 Allicin (mainly Garlic)
1 Cisplatin
1 Aspirin -acetylsalicylic acid
1 Aloe anthraquinones
1 Biochanin A
1 Chemotherapy
1 brusatol
1 Bacopa monnieri
1 Boron
1 Carnosic acid
1 Celecoxib
1 Chlorogenic acid
1 chitosan
1 Selenium NanoParticles
1 Coenzyme Q10
1 Ursolic acid
1 Deguelin
1 Emodin
1 Ferulic acid
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Proanthocyanidins
1 Juglone
1 Melatonin
1 Magnetic Field Rotating
1 Myricetin
1 Oleuropein
1 Phenylbutyrate
1 Propyl gallate
1 temozolomide
1 Piperlongumine
1 Parthenolide
1 Kaempferol
1 Aflavin-3,3′-digallate
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:201  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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