Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱
Source:
Type: pro-survival proteins
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.
Scientific Papers found: Click to Expand⟱
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
9273- CRAN,    Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation
- vitro+vivo, ESCC, NA
AntiCan↑, Casp↑, TumAuto↑, necrosis↑, PI3K↓, Akt↓, mTOR↓, BAX↑, Bcl-xL↑, Cyt‑c↑, PARP↑, TumCG↓, toxicity↓,
6184- Cuc,    Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells
- vitro+vivo, PC, NA
TumCG↓, TumCCA↑, Apoptosis↑, JAK2↓, STAT3↓, STAT5↓, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, Bcl-xL↓, ChemoSen↑, TumVol↓, toxicity↓,
6200- Cuc,  GEM,    Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
- in-vivo, PC, NA
Synergy↑, TumCG↓, Bcl-xL↓, Bcl-2↓, cMyc↓, Casp↑, STAT3↓, JAK2↓,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1/ATG6↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
136- CUR,  docx,    Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, BAX↑, BID↑, PARP↑, NF-kB↓, CDK1↓, COX2/PTGS2↓, RTK-RAS↓, PI3K/Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, ChemoSen↑,
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓, AR↓, STAT3↓, p‑Akt↓, Mcl-1↓, Bcl-xL↓, cl‑PARP↑, miR-21↓, miR-205↑, TumCG↓, TumCP↓, TumCI↓, angioG↓, TumMeta↓,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2/PTGS2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
TRAILR↑, BAX↑, P21↑, p27/CDKN1B↑, NF-kB↓, cycD1/CCND1↓, VEGF↓, uPA↓, MMP2↓, MMP9↓, Bcl-2↓, Bcl-xL↓,
1871- DAP,    Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
- in-vitro, AML, U937 - in-vivo, AML, NA
TumCP↓, Apoptosis↑, TumCG↓, PDK1 / PDPK1↓, cl‑PARP↑, Bcl-xL↓, Bcl-2↓, Beclin-1/ATG6↓, ATG3↓, PI3K↓, Akt↓, eff↑,
6672- Deg,    Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice
- vitro+vivo, CRC, COLO205 - in-vitro, CRC, HCT116
Akt↑, AntiTum↑, IL8↓, p‑IKKα↓, NF-kB↓, TumCD↑, Apoptosis↑, cFLIP↓, Bcl-2↓, Bcl-xL↓, TumVol↓,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, Synergy↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*Dose∅, *Half-Life∅, *BioAv∅, *BBB↑, *toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
651- EGCG,    Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications
- Review, Var, NA
ROS↑, p‑AMPK↑, mTOR↓, FAK↓, Smo↓, Gli1↓, HH↓, TumCMig↓, TumCI↓, NOTCH↓, JAK↓, STAT↓, Bcl-2↓, Bcl-xL↓, BAX↑, Casp9↑,
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, Lung, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2/PTGS2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,
5225- EMD,    Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
STAT3↓, Akt↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCP↓, Casp3↑, cl‑PARP↑, ChemoSen↑, XIAP↓,
6583- EU,    Inactivation of AKT/NF-κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, Calu-1
tumCV↓, TumCCA↑, Casp3↑, PARP↑, Bcl-xL↓, survivin↓, Akt↓, NF-kB↓, ChemoSen↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
1057- EVO,    Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
- in-vitro, Var, NA
NF-kB↓, TNF-α↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2/BIRC3↓, cFLIP↓, Bfl-1↓,
6902- FIS,    Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
P53↑, NF-kB↓, TumCP↓, Apoptosis↑, TumCCA↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK4↓, CDK2↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6993- Form,  ISL,    Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell
- in-vitro, CRC, HCT116
AntiTum↑, TumCG↓, Apoptosis↑, Casp↑, Bcl-2↓, Bcl-xL↓,
5150- GamB,    Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
- in-vitro, CLL, KBM-5 - in-vitro, Nor, HEK293
Apoptosis↑, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7245- Gink,    Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116 - in-vitro, Nor, MCF10
STAT3↓, cycD1/CCND1↓, survivin↓, Bcl-2↓, Bcl-xL↓, TumCG↓, Dose↝, TumCCA↑, Apoptosis↑, TumVol↓, TumW↓,
7259- Gink,    Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells
- in-vitro, Pca, PC3
tumCV↓, TumCCA↑, Casp3↑, Bcl-2↓, Bcl-xL↓, survivin↓, cycD1/CCND1↓, cl‑PARP↑,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7319- Gos,    BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides
- in-vitro, PC, NA
eff↑, Ca+2↑, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, RadioS↑,
7317- Gos,    A phase II study of AT-101 (gossypol) in chemotherapy-sensitive recurrent extensive stage small cell lung cancer (ES-SCLC)
- Trial, Lung, NA
Bcl-2↓, Bcl-xL↓, Mcl-1↓, NOXA↑, PUMA↑, Dose↝, eff↓,
7316- Gos,  PacT,  carbop,  Chemo,    A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors
- Trial, Var, NA
Bcl-2↓, Bcl-xL↓, Mcl-1↓, Dose↝, toxicity↝,
7315- Gos,    Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
- vitro+vivo, CRC, HT29 - in-vitro, CRC, COLO205
TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,
7312- Gos,    A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
- vitro+vivo, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
eff↑, TumAuto↑, TumCG↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Apoptosis↑, eff↑,
7309- Gos,    Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
- vitro+vivo, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, TumCG↓, Apoptosis↓, ChemoSen↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
5052- HPT,    Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- in-vitro, OS, U2OS
Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7608- I3C,    Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells
- in-vitro, Pca, PC3
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, Akt↓, EGF↓, PI3K↓, Bcl-xL↓, BAD↓,
7612- I3C,    Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
- in-vitro, Nor, MCF10
selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,

Showing Research Papers: 51 to 100 of 180
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 180

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 1,   Copper↑, 1,   frataxin↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 9,   GSH↑, 2,   GSR↑, 1,   H2O2↓, 1,   H2O2↑, 1,   i-H2O2↑, 1,   HO-1↓, 4,   HO-1↑, 1,   HO-2↓, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↑, 2,   NRF2↓, 4,   NRF2↑, 5,   NRF2↝, 1,   ROS?, 1,   ROS↓, 3,   ROS↑, 73,   ROS⇅, 2,   ROS↝, 1,   ROS∅, 1,   mt-ROS↑, 3,   SAM-e↝, 1,   SOD↓, 5,   SOD↑, 1,   TAC↓, 1,   Trx↑, 1,   ox-Trx1↑, 1,   TrxR↓, 1,   TrxR↑, 1,   TrxR1↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Bfl-1↓, 1,   CDC2↓, 2,   CDC25↓, 7,   compI↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC↓, 2,   mtDam↑, 7,   OCR↓, 2,   PHB↑, 1,   PINK1↑, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 1,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 1,   AMPK↓, 2,   AMPK↑, 7,   p‑AMPK↑, 2,   ATP↓, 3,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 2,   FASN↑, 1,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 6,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 4,   lactateProd↓, 3,   LDHA↓, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↝, 1,   NADPH↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PFK1↓, 1,   PFK2↓, 1,   PKM2↓, 3,   PLA2↓, 1,   p‑S6↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TCA↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 6,   Apoptosis↓, 4,   Apoptosis↑, 71,   Apoptosis↝, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   BAD?, 1,   BAD↓, 1,   BAD↑, 15,   Bak↑, 13,   BAX↓, 2,   BAX↑, 66,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 117,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 166,   Bcl-xL↑, 8,   Bcl-xL↝, 2,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 6,   cl‑BID↑, 2,   BIM↓, 1,   BIM↑, 7,   BNIP3↑, 1,   Casp↑, 19,   cl‑Casp↑, 2,   Casp1↓, 1,   Casp10↑, 1,   Casp2↑, 2,   Casp3↓, 1,   Casp3↑, 72,   Casp3↝, 1,   cl‑Casp3↑, 16,   proCasp3↑, 1,   pro‑Casp3↝, 1,   Casp6↑, 3,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↑, 17,   cl‑Casp8↑, 4,   proCasp8↑, 1,   Casp9↓, 1,   Casp9↑, 48,   cl‑Casp9↑, 9,   cFLIP↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 42,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 10,   FADD↑, 3,   Fas↑, 8,   FasL↑, 5,   IAP1↓, 19,   IAP2/BIRC3↓, 9,   IAP2/BIRC3↑, 1,   iNOS↓, 6,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 32,   cl‑Mcl-1↑, 1,   MDM2↓, 11,   MOMP↑, 1,   necrosis↑, 1,   NOXA↑, 6,   p38↓, 1,   p38↑, 4,   p‑p38↓, 1,   p‑p38↑, 3,   PUMA↑, 6,   survivin↓, 57,   survivin↝, 1,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 5,   XIAP?, 1,   XIAP↓, 30,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 43,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 14,   BRAF↝, 1,   CaMKII ↓, 1,   p‑cMET↑, 1,   cSrc↓, 4,   EGFR↓, 7,   EGFR↝, 1,   ERK↓, 12,   ERK↑, 1,   p‑ERK↓, 7,   p‑ERK↑, 2,   HCAR2↑, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 2,   IKKα↓, 6,   IKKα↑, 1,   p‑IKKα↓, 3,   IκB↓, 2,   IκB↑, 1,   JAK↓, 2,   JAK1↓, 4,   JAK2↓, 9,   p‑JAK2↓, 3,   JNK↓, 1,   JNK↑, 9,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAP2K1/MEK1↓, 1,   MAPK↓, 11,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 2,   p‑MEK↓, 3,   p‑MEK↑, 1,   mTOR↓, 20,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 5,   NIK↓, 1,   p70S6↑, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 28,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 3,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 13,   PTEN↝, 2,   Raf↓, 3,   RAS↓, 2,   RTK-RAS↓, 1,   SHP1↓, 1,   SHP1↑, 4,   Sp1/3/4↓, 3,   Src↓, 2,   STAT↓, 2,   STAT3↓, 35,   STAT3↑, 2,   p‑STAT3↓, 10,   STAT5↓, 2,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↑, 5,   cJun↓, 1,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 21,   cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 3,   EZH2↓, 2,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO3↑, 2,   GATA3↑, 1,   H3↓, 2,   ac‑H3↑, 1,   H3K27ac↓, 1,   ac‑H4∅, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 17,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 1,   HES1↓, 1,   miR-134↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-205↑, 1,   miR-21↓, 2,   miR-210↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-384↑, 1,   Myc↓, 2,   OCT4↓, 1,   other↓, 3,   other↝, 1,   Prot↓, 1,   SOX2↓, 1,   SUV39H↓, 1,   TCF-4↓, 1,   tumCV↓, 22,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 4,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 10,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 2,   ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   p‑Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 1,   LC3I↓, 1,   LC3II↑, 4,   p62↓, 2,   p62↑, 1,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↑, 14,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   DNAdam↓, 1,   DNAdam↑, 15,   DNArepair↓, 1,   hTERT/TERT↓, 3,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 49,   P53↝, 1,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 9,   cl‑PARP↑, 47,   PARP1↑, 1,   PCNA↓, 8,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 4,   TOP2↓, 2,   TRF2↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   CDK2↓, 8,   CDK4↓, 12,   CDK6↓, 5,   CDK8↓, 1,   Chk2↓, 1,   ChrCon↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 15,   cycD1/CCND1↓, 57,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE1↓, 1,   GADD45A↑, 1,   Ki-67↓, 7,   P21↓, 4,   P21↑, 35,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 14,   pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 72,   TumCCA⇅, 1,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   BMI1↓, 1,   CD24↓, 1,   cFos↓, 2,   CSCs↓, 5,   Diff↑, 2,   Gli1↓, 2,   HH↓, 2,   IGF-1↓, 4,   IGF-2↓, 1,   IGFBP3↑, 2,   Ki-67↓, 7,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 5,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH2↑, 1,   PTCH1↓, 1,   Shh↓, 2,   Smo↓, 1,   TumCG?, 1,   TumCG↓, 38,   TumCP?, 1,   TumCP↓, 49,   Wnt↓, 5,   Wnt/(β-catenin)↓, 3,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 4,   AP-1↝, 1,   AXL↓, 1,   Ca+2↑, 8,   Ca+2↝, 3,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cav1↓, 1,   E-cadherin↑, 12,   EMT↓, 18,   EMT↑, 1,   FAK↓, 6,   p‑FAK↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   LRP1↓, 1,   MMP-10↓, 2,   MMP1↓, 2,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 26,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 3,   MMP9↓, 36,   MMPs↓, 14,   MTA1↓, 1,   MUC4↓, 3,   N-cadherin↓, 5,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 3,   Slug↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   Snail↓, 8,   TET1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 2,   TSC1↑, 1,   TumCI?, 1,   TumCI↓, 13,   TumCI↑, 1,   TumCMig↓, 11,   TumMeta↓, 17,   TumMeta↑, 2,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 8,   Vim↓, 12,   Zeb1↓, 6,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29,   angioG↑, 1,   CD31/PECAM-1↓, 5,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 20,   Hif1a↑, 1,   NO↑, 2,   VEGF↓, 43,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   CTR1↑, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP?, 1,   MMP↓, 40,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   SLC12A5↝, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   cDC2↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 30,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCR2↓, 1,   CXCR4↓, 7,   CXCR4↑, 1,   DR4↑, 3,   HCAR2↑, 1,   ICAM-1↓, 6,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL1α↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL2↑, 1,   IL6↓, 16,   IL6↑, 1,   IL6↝, 1,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 12,   MCP1/CCL2↓, 1,   MDSCs↓, 1,   NAF1↓, 1,   NF-kB↓, 65,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 1,   p65↓, 4,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-L1↓, 5,   PGE1↓, 1,   PGE2↓, 8,   PSA↓, 3,   PSA↝, 1,   TLR4↓, 3,   TNF-α↓, 14,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,   TRAF1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 5,   AR↝, 1,   PPARα↓, 1,   PPARγ↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 9,   BioAv↑, 12,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 41,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A2↓, 1,   CYP3A4↓, 1,   Dose?, 3,   Dose↑, 1,   Dose↝, 12,   Dose∅, 1,   eff↓, 25,   eff↑, 22,   Half-Life↓, 2,   Half-Life↝, 2,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 6,   P450↓, 2,   RadioS↑, 10,   selectivity↑, 23,   selectivity↝, 1,   Synergy↑, 28,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   ALP↓, 1,   AR↓, 5,   AR↝, 1,   ascitic↓, 1,   BRAF↝, 1,   BRCA1↑, 1,   EGFR↓, 7,   EGFR↝, 1,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IL6↓, 16,   IL6↑, 1,   IL6↝, 1,   LDH↓, 1,   Maspin↑, 1,   Myc↓, 2,   PD-L1↓, 5,   PSA↓, 3,   PSA↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8,   AntiTum↑, 6,   cardioP↑, 3,   chemoP↑, 8,   chemoPv↑, 4,   hepatoP↑, 8,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 6,   toxicity↝, 1,   TumVol↓, 14,   TumW↓, 7,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 1,  
Total Targets: 645

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 12,   Catalase↑, 8,   Fenton↓, 1,   GPx↑, 4,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 3,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 2,   MPO↓, 1,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 4,   RNS↓, 3,   ROS↓, 17,   ROS∅, 1,   SOD↓, 1,   SOD↑, 8,   SOD1↑, 1,   SOD2↑, 1,   TBARS↓, 1,   VitE↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ALAT↓, 1,   AMPK↑, 1,   NAD↑, 1,   NADPH↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAD↓, 1,   BAX↓, 1,   BAX↑, 1,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   Casp3↓, 3,   Casp9↓, 1,   Cyt‑c↑, 1,   iNOS↓, 2,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   p‑ERK↑, 1,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↑, 1,   PDGFR-BB↓, 1,   PI3K↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   UPR↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↝, 1,   cal2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

HIF-1↓, 1,   NO↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 4,   FOXP3↑, 1,   HMGB1↓, 2,   IL10↑, 1,   IL1β↓, 3,   IL2↑, 1,   IL4↑, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 13,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   NLRP3↓, 1,   PGE2↓, 2,   TNF-α↓, 3,   Treg lymp↝, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 2,   BioAv↝, 2,   BioAv∅, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 2,   Dose∅, 1,   eff↑, 3,   GSTA1↑, 1,   Half-Life↝, 2,   Half-Life∅, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 2,   BP↓, 1,   BUN↓, 1,   CRP↓, 1,   IL6↓, 4,   LDH↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 5,   AntiArt↑, 2,   AntiCan↑, 4,   antiD↓, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↓, 1,   hepatoP↑, 2,   memory↑, 2,   neuroP?, 1,   neuroP↑, 8,   Obesity↓, 2,   OS↑, 1,   radioP↑, 3,   RenoP↑, 1,   Stress↓, 1,   Stroke↓, 2,   toxicity↓, 5,   toxicity∅, 2,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↓, 1,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 3,   Bacteria↑, 1,   Sepsis↓, 1,  
Total Targets: 161

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL
14 Thymoquinone
9 Apigenin (mainly Parsley)
6 Curcumin
6 Gossypol/AT-101
6 Morin
5 Baicalein
5 Quercetin
4 Alpha-Lipoic-Acid
4 EGCG (Epigallocatechin Gallate)
4 Sulforaphane (mainly Broccoli)
3 Cisplatin
3 Benzyl isothiocyanate
3 Boswellia (frankincense)
3 Fisetin
3 Gambogic Acid
3 Ginkgetin
3 Indole-3-carbinol
3 Phenethyl isothiocyanate
3 lambertianic acid
3 Luteolin
3 Mangiferin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Nimbolide
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Silver-NanoParticles
2 Paclitaxel/Taxol
2 Artemisinin
2 Berbamine
2 Beta-Caryophyllene
2 Boron
2 Butyrate
2 Carnosic acid
2 Capsaicin
2 chaetocin
2 Cucurbitacin
2 Docetaxel
2 Ursolic acid
2 Ellagic acid
2 Garcinol
2 Honokiol
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Linalool
2 doxorubicin
2 Phenylbutyrate
2 Plumbagin
2 VitK3,menadione
1 Astragalus
1 Camptothecin
1 Anethole/trans-Anethole
1 Berberine
1 Betulinic acid
1 brusatol
1 Black turtle bean
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Cranberry
1 Gemcitabine (Gemzar)
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 D-limonene
1 Emodin
1 Eurycomanone
1 Eugenol
1 Evodiamine
1 Formononetin
1 Isoliquiritigenin
1 Ginger/6-Shogaol/Gingerol
1 carboplatin
1 Chemotherapy
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Hyperthermia
1 Hyperoside
1 Isobavachalcone
1 Isothiocyanates
1 Allyl isothiocyanate
1 Juglone
1 Kaempferol
1 Licorice
1 Magnolol
1 mebendazole
1 Magnetic Fields
1 Moringin
1 Melatonin
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 Neem
1 Radiotherapy/Radiation
1 Piperine
1 Piperlongumine
1 Rosmarinic acid
1 Shikonin
1 Taurine
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:28  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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