survivin Cancer Research Results

survivin, BIRC5: Click to Expand ⟱
Source:
Type: antiapoptosis protein
Survivin, BIRC5 (Baculoviral IAP Repeat Containing 5) is a potent anti-apoptosis protein that is differentially expressed in cancer and therefore constitutes an important anti-cancer target [49]. Moreover, high expression of survivin plays important role in resistance to chemo- and radiotherapy and has been shown to be related to unfavorable outcome for medulloblastomas.
"Survivin" is a protein that plays a crucial role in regulating cell division and inhibiting apoptosis (programmed cell death). It is part of the inhibitor of apoptosis (IAP) family and is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, Synergy↑,
1262- CAP,    Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
- vitro+vivo, BC, NA
FBI-1↓, Ki-67↓, Bcl-2↓, survivin↓, BAX↑, Casp3↑, TumCP↓, Apoptosis↑,
5771- CAPE,  PBG,    Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma
- in-vitro, HNSCC, NA
MMP↓, Casp3↑, survivin↓, XIAP↓,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
1055- Cin,    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
- vitro+vivo, Melanoma, NA - vitro+vivo, CRC, NA - vitro+vivo, lymphoma, NA
TumCP↓, NF-kB↓, AP-1↓, Bcl-2↓, Bcl-xL↓, survivin↓,
2315- Citrate,  immuno,    Why and how citrate may sensitize malignant tumors to immunotherapy
- Review, Var, NA
Bcl-2↓, Mcl-1↓, survivin↓, Casp3↑, Casp9↑, Ferroptosis↑, lipid-P↑, Ca+2↓, Akt↓, mTOR↓, Hif1a↓, MCU↓, ATP↓, ROS↑, eff↑,
7425- CS,    Artichoke as a melanoma growth inhibitor
- in-vitro, Melanoma, NA
AntiCan↑, tumCV↓, PCNA↓, Casp3↑, P21↑, p27/CDKN1B↑, CDK4↓, survivin↓, TumCP↓, Apoptosis↑,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6199- Cuc,    Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells
- in-vitro, BC, MCF7
TumCCA↑, survivin↓,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
453- CUR,    Cellular uptake and apoptotic properties of gemini curcumin in gastric cancer cells
- in-vitro, GC, AGS
Bcl-2↓, survivin↓, BAX↑, TumCCA↑,
441- CUR,    Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p
- in-vitro, CRC, HCT116
ERCC1↓, Bcl-2↓, GSTP1/GSTπ↓, MRP↓, P-gp/ABCB1↓, miR-409-3p↑, survivin↓,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, Synergy↑,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑, CompStab↓,
6226- CUR,  Rad,    Analysis of Curcumin as a Radiosensitizer in Cancer Therapy with Serum Survivin Examination: Randomised Control Trial
- Trial, Cerv, NA
survivin↓, RadioS↑, toxicity↓,
7448- CYN,    Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs
- in-vitro, Pca, DU145
GSH↓, STAT3↓, Bcl-2↓, survivin↓, cl‑PARP↑, ChemoSen↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1 / PDPK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, Synergy↑, Synergy↑, other↝, RadioS↑, toxicity↓, Dose↝, Synergy↑, Synergy↑, Synergy↑, toxicity↝, eff↓,
5196- DCA,    Dichloroacetate induces apoptosis in endometrial cancer cells
- in-vitro, Var, NA
selectivity↑, MMP↓, survivin↓, Ca+2↓, P53↑, PDK1 / PDPK1↓, PDH↑, Glycolysis↓, OXPHOS↑, ROS↑, Cyt‑c↑, Apoptosis↑, Casp↑, tumCV↓, PUMA↑,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27/CDKN1B↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
1443- Deg,    Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, BT549
EGFR↓, Akt↓, p‑ERK↓, NF-kB↓, p‑STAT3↓, survivin↓, Myc↓, TumCG↓, cMET↓,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
3236- EGCG,  Buty,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
4682- EGCG,    Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate
- Review, Var, NA
CSCs↓, EMT↓, ChemoSen↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, TumCP↓, Apoptosis↑, p‑GSK‐3β↓, GSK‐3β↑, β-catenin/ZEB1↓, cMyc↓, XIAP↓, Bcl-2↓, survivin↓, Vim↓, Slug↓, Snail↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, Synergy↑,
685- EGCG,  CUR,  SFN,  RES,  GEN  The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
- Analysis, Var, NA
Bcl-2↓, survivin↓, XIAP↓, EMT↓, Apoptosis↑, Nanog↓, cMyc↓, OCT4↓, Snail↓, Slug↓, Zeb1↓, TCF↓,
5225- EMD,    Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
STAT3↓, Akt↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCP↓, Casp3↑, cl‑PARP↑, ChemoSen↑, XIAP↓,
6833- EMD,    Anticancer potential of emodin
- Review, Var, NA
Inflam↓, angioG↓, TumCCA↑, Apoptosis↑, HIF-1↓, TumCI↓, TumCMig↓, HER2/EBBR2↓, CK2↓, ROS↑, AR↓, JAK2↓, STAT3↓, Mcl-1↓, NAT↓, ChemoSen↑, survivin↓, XIAP↓, NF-kB↓, *neuroP↑, *hepatoP↑,
6583- EU,    Inactivation of AKT/NF-κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, Calu-1
tumCV↓, TumCCA↑, Casp3↑, PARP↑, Bcl-xL↓, survivin↓, Akt↓, NF-kB↓, ChemoSen↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6340- Eug,    Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
tumCV↓, E2Fs↓, survivin↓, NF-kB↓, cycD1/CCND1↓, P21↑, TumCP↓, Apoptosis↑, TumCI↓, angioG↓,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,
6427- FEO,    Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma
- vitro+vivo, HCC, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCG↓, survivin↓, mtDam↑, Casp3↑,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2842- FIS,    Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells
- in-vitro, GC, AGS
TumCCA↑, CDK2↓, P53↑, selectivity↑, MMP↓, DNAdam↑, cl‑PARP↑, mt-ROS↑, eff↓, survivin↓,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, Var, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
1972- GamB,  doxoR,    Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression
- in-vitro, BC, NA
ChemoSen↑, P-gp/ABCB1↓, ROS↑, survivin↓, p38↑,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,

Showing Research Papers: 51 to 100 of 241
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   antiOx⇅, 1,   Catalase↓, 1,   Copper↑, 1,   Fenton↑, 1,   frataxin↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 14,   GSH↑, 2,   GSTs↑, 2,   HO-1↓, 5,   HO-1↑, 9,   HO-2↓, 1,   lipid-P↓, 3,   lipid-P↑, 3,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 3,   NRF2↓, 7,   NRF2↑, 13,   Prx4↑, 1,   ox-PrxI↑, 1,   ROS↓, 9,   ROS↑, 97,   ROS⇅, 5,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   mt-ROS↑, 3,   SOD↓, 2,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC?, 1,   TAC↑, 1,   Thiols↓, 1,   Trx2↓, 1,   TrxR↓, 3,   TrxR1↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 7,   CDC25↓, 11,   compI↓, 1,   compIII↓, 1,   ETC↓, 1,   HSP60/HSPD1↓, 3,   HTRA2/Omi/PARK13↑, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 2,   PDH↝, 1,   PHB↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 2,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 10,   ATP↓, 11,   ECAR↝, 1,   FASN↓, 1,   FBI-1↓, 1,   GLO-I↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 11,   GSK‐3β↓, 10,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   HK2↓, 7,   HMG-CoA↓, 1,   lactateProd↓, 3,   LDHA↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↓, 4,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 6,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 116,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 70,   BAX⇅, 1,   Bax:Bcl2↑, 16,   Bcl-2↓, 115,   Bcl-2↑, 4,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 57,   Bcl-xL↝, 1,   BID↓, 3,   BID↑, 6,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 1,   Casp↑, 22,   Casp↝, 2,   cl‑Casp↑, 1,   Casp10↑, 3,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 90,   cl‑Casp3↑, 14,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↝, 1,   Casp7?, 1,   Casp7↑, 17,   cl‑Casp7↑, 3,   Casp8↑, 24,   cl‑Casp8↑, 5,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 56,   cl‑Casp9↑, 8,   proCasp9↑, 1,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 50,   Cyt‑c↝, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 11,   DR5↓, 1,   DR5↑, 21,   FADD↑, 4,   Fas↓, 1,   Fas↑, 13,   FasL↑, 7,   Ferroptosis↑, 4,   IAP1↓, 21,   IAP1↑, 1,   IAP2/BIRC3↓, 9,   IAP2/BIRC3↑, 1,   ICAD↓, 2,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 33,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 2,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 5,   p38↑, 15,   p‑p38↓, 2,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 6,   Pyro↑, 1,   survivin↓, 238,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAILR↑, 2,   TumCD↑, 1,   XIAP?, 1,   XIAP↓, 63,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 63,   Akt↑, 6,   p‑Akt↓, 14,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CIP2A↓, 2,   CK2↓, 2,   cMET↓, 5,   p‑cMET↑, 1,   p‑CREB↑, 1,   cSrc↓, 3,   EF-1α↓, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   ERK↓, 21,   ERK↑, 3,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   IGFR↓, 1,   IKKα↓, 12,   IκB↓, 2,   IκB↑, 1,   JAK↓, 4,   JAK1↓, 5,   JAK2↓, 17,   p‑JAK2↓, 1,   JNK↓, 6,   JNK↑, 14,   p‑JNK↓, 1,   p‑JNK↑, 1,   cl‑JNK↑, 1,   MAPK↓, 12,   MAPK↑, 6,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 1,   mTOR↓, 39,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 1,   NIK↓, 1,   p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   PI3K↓, 42,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PIAS-3↑, 1,   PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 17,   PTPN6↑, 1,   Raf↓, 2,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 5,   RIP1↓, 1,   p‑RSK↑, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 3,   c-Src↓, 1,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 61,   p‑STAT3↓, 12,   p‑STAT3↑, 1,   STAT5↓, 3,   STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 2,   ATF4↝, 1,   CBP↓, 1,   cJun↑, 2,   cMyc↓, 42,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 5,   DNMTs↓, 7,   EZH2↓, 2,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↑, 2,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 2,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 4,   HATs↑, 2,   HDAC↓, 18,   HDAC1↓, 4,   HDAC2↓, 1,   HDAC3↓, 3,   HDAC6↓, 2,   HDAC8↓, 2,   HES1↓, 2,   IRF1↑, 1,   miR-134↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-375↑, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 11,   OCT4↑, 1,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 5,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 2,   SOX9↓, 2,   tumCV↓, 39,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 13,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP27↑, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 9,   HTRA↓, 2,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 3,   LC3II↑, 5,   LC3s↑, 2,   p62↓, 3,   p62↑, 1,   RUBCN↓, 1,   TumAuto↑, 19,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 22,   DNArepair↓, 1,   ERCC1↓, 2,   HR↓, 1,   hTERT/TERT↓, 4,   MGMT↓, 1,   p16↑, 4,   P53↓, 1,   P53↑, 58,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↑, 12,   cl‑PARP↑, 61,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 17,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 1,   TOP2↓, 3,   UHRF1↓, 1,   γH2AX↑, 6,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1?, 1,   CDK1↓, 9,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 17,   CDK2↑, 2,   p‑CDK2↓, 1,   CDK4↓, 17,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 16,   cycD1/CCND1↓, 83,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 5,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 19,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 4,   P21↑, 44,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 19,   PLK1↓, 1,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 4,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 82,   WEE1↑, 4,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 3,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 5,   CD34↓, 1,   cFos↓, 2,   CSCs↓, 22,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 6,   HH↓, 4,   IGF-1↓, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 19,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 3,   Nanog↓, 9,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH2↓, 1,   NOTCH3↓, 1,   OGFr↑, 2,   p300↓, 2,   PTCH1↓, 5,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 4,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 50,   TumCG↑, 1,   TumCP↓, 74,   Wnt↓, 19,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   Ca+2↓, 3,   Ca+2↑, 9,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   Cav1↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 15,   EM↑, 1,   EMT↓, 32,   EMT↑, 1,   EpCAM↓, 1,   FAK↓, 10,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB6↓, 1,   LEF1↓, 3,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 40,   MMP3↓, 4,   MMP7↓, 7,   MMP9↓, 55,   MMPs↓, 17,   MUC4↓, 3,   N-cadherin↓, 11,   NCAM↑, 1,   pax↓, 1,   PDGF↓, 2,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 12,   Smad1↓, 1,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 1,   SMAD4↑, 1,   Snail↓, 22,   TET1↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TIMP1↑, 6,   TIMP2↑, 9,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 39,   TumCI↑, 1,   TumCMig↓, 30,   TumMeta↓, 37,   TumMeta↑, 3,   Twist↓, 14,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 19,   Zeb1↓, 8,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 29,   β-catenin/ZEB1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 1,   CD31/PECAM-1↓, 3,   Endoglin↑, 1,   HIF-1↓, 3,   Hif1a↓, 26,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 71,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 48,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 8,   COX1↓, 1,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 2,   CXCR4↓, 16,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↑, 1,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 5,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 6,   IL2↑, 2,   IL6↓, 23,   IL7↓, 1,   IL8↓, 4,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 17,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 87,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NLRP3↑, 1,   p50↓, 1,   p65↓, 6,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 8,   PSA↓, 3,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   TCF↓, 2,   TLR4↝, 1,   TNF-α↓, 17,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 9,   ER-α36↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 14,   BioAv↑, 19,   BioAv↝, 7,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 71,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 3,   Dose↓, 1,   Dose↝, 29,   Dose∅, 2,   eff↓, 24,   eff↑, 34,   eff↝, 4,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 7,   MDR1↓, 5,   MRP↓, 1,   MRP1/ABCC1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 14,   P450↓, 2,   RadioS↑, 17,   selectivity?, 1,   selectivity↑, 32,   Synergy↑, 38,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AR↓, 9,   ascitic↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 23,   LDH↓, 1,   Myc↓, 5,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 3,   PSADT↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 17,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 3,   cachexia↓, 1,   cardioP↑, 3,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 13,   chemoPv↑, 11,   ChemoSideEff↓, 1,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 2,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 1,   QoL∅, 1,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 5,   TGFβR1↓, 1,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 3,   TumVol↓, 20,   TumW↓, 10,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 4,  
Total Targets: 776

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 24,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 8,   GPx1↑, 1,   GSH↑, 7,   GSTs↑, 4,   HO-1?, 1,   HO-1↑, 4,   lipid-P↓, 8,   MDA↓, 4,   MPO↑, 1,   NQO1↑, 2,   NRF2?, 1,   NRF2↑, 8,   ROS↓, 26,   ROS↑, 1,   ROS∅, 3,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   5LO↝, 1,   ALAT↓, 2,   AMPK↑, 1,   FASN↓, 1,   glucose↝, 1,   GSK‐3β↓, 1,   NAD↑, 1,   NADPH↑, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Cyt‑c↓, 1,   Fas↓, 1,   FasL↓, 1,   IAP1↓, 1,   iNOS↓, 3,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↑, 1,   JAK2↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↑, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP27↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   MMP13↓, 1,   MMP3↓, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   NO↓, 4,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MUC5AC↓, 1,   TRPA1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 8,   HMGB1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 8,   IL4↓, 1,   IL5↓, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 26,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 4,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 10,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 6,   BioAv↝, 6,   CompStab↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 1,   GSTA1↑, 1,   Half-Life↝, 5,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   CRP↓, 1,   IL6↓, 9,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 8,   AntiArt↑, 4,   AntiCan↑, 5,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 7,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 7,   memory↑, 1,   neuroP↑, 17,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 3,   Stroke↓, 1,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 6,   Bacteria↓, 5,   Bacteria↑, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 151

Scientific Paper Hit Count for: survivin, BIRC5
19 Thymoquinone
8 Resveratrol
7 Curcumin
7 EGCG (Epigallocatechin Gallate)
7 Quercetin
6 Sulforaphane (mainly Broccoli)
6 Gambogic Acid
6 Ginkgetin
6 Silymarin (Milk Thistle) silibinin
5 Matrine
4 Artemisinin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Boswellia (frankincense)
4 Fisetin
4 Garcinol
4 Honokiol
4 Licochalcone A
4 Nimbolide
4 Marjoram (Origanum majorana)
4 Piperlongumine
3 Cisplatin
3 Apigenin (mainly Parsley)
3 Docetaxel
3 Berbamine
3 Berberine
3 Beta-Caryophyllene
3 Betulinic acid
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 Capsaicin
3 Deguelin
3 Eugenol
3 Ginger/6-Shogaol/Gingerol
3 Magnolol
3 Luteolin
3 Magnetic Fields
3 Morin
2 1,8-Cineole
2 5-fluorouracil
2 Silver-NanoParticles
2 Allyl isothiocyanate
2 Alpha-Lipoic-Acid
2 immunotherapy
2 Carnosic acid
2 Chemotherapy
2 Cucurbitacin
2 Dichloroacetate
2 Ellagic acid
2 Emodin
2 Fucoidan
2 doxorubicin
2 Geraniol
2 Isoliquiritigenin
2 lambertianic acid
2 low dose naltrexone
2 Licorice
2 Lycopene
2 Mangiferin
2 Naringin
2 Terpinen-4-ol / Tea Tree Oil
2 Rosmarinic acid
2 salinomycin
2 Aflavin-3,3′-digallate
1 Coenzyme Q10
1 Açaí, Euterpe oleracea
1 Andrographis
1 Gemcitabine (Gemzar)
1 chitosan
1 Bufalin/Huachansu
1 Isothiocyanates
1 brusatol
1 Bruteridin(bergamot juice)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Propolis -bee glue
1 Celastrol
1 chaetocin
1 Chlorophyllin
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Radiotherapy/Radiation
1 Cynaropicrin
1 Dandelion Root
1 Butyrate
1 Genistein (soy isoflavone)
1 Eurycomanone
1 Fennel Oil/Foeniculum vulgare
1 Flaxseed/Linseed
1 Grapeseed extract
1 HydroxyTyrosol
1 Indole-3-carbinol
1 Isobavachalcone
1 iodine
1 MCT, metronomic chemo
1 Juglone
1 Vitamin C (Ascorbic Acid)
1 Kaempferol
1 Methyl Jasmonate
1 Moringin
1 Melatonin
1 Mushroom Shiitake, AHCC
1 Neem
1 Oleuropein
1 Phenylbutyrate
1 Purple Corn / Purple Maize
1 Piperine
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Shikonin
1 Selenite (Sodium)
1 Ursolic acid
1 Urolithin
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:299  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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