cycE/CCNE Cancer Research Results

cycE/CCNE, Cyclin E: Click to Expand ⟱
Source:
Type:
Cyclin E regulates multiple downstream molecules, such as the retinoblastoma susceptibility gene (RB1) and the transcription factor E2F.
Cyclin E (Cyclin E1 and Cyclin E2) is the key regulator of the late G1 → S-phase transition.
Cyclin E is a prognostic marker in breast cancer, its altered expression increased with the increasing stage and grade of the tumor.
Cyclin E is a regulatory protein that plays a critical role in the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression levels can significantly influence cancer progression and patient prognosis.

Cyclin E expression is frequently elevated in various cancers and is generally associated with poor prognosis. Its role in promoting cell cycle progression makes it a potential biomarker for tumor aggressiveness and patient outcomes.


Scientific Papers found: Click to Expand⟱
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8282- LE,    Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, GC, MGC803 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
Ingr↝, TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, BAX↑, PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, Bcl-2↓, survivin↓, p65↓, p‑PI3K↓, p‑Akt↓,
8298- lign,    Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer
- in-vitro, BC, MDA-MB-231
Risk↓, TumCP↓, Ki-67↓, PCNA↓, FOXM1↓, TumCCA↑, cycE/CCNE↓, cycA1/CCNA1↓, CycB/CCNB1↓, FAK↓, pax↓, TumCMig↓, TumCI↓,
2928- LT,    Luteolin-mediated increase in miR-26a inhibits prostate cancer cell growth and induces cell cycle arrest targeting EZH2
- in-vitro, Pca, NA
EZH2↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4793- Lyco,    Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells
- in-vitro, GC, AGS
antiOx↑, AntiCan↑, ROS↓, JAK1↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, cycE/CCNE↓, TumCP↓, Risk↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
TumCCA↑, Apoptosis↑, ChemoSen↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
8899- MOR,    Morin Inhibits Proliferation, Migration, and Invasion of Bladder Cancer EJ Cells via Modulation of Signaling Pathways, Cell Cycle Regulators, and Transcription Factor-Mediated MMP-9 Expression
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p‑ERK↑, p‑JNK↓, p‑Akt↓, TumCMig↓, TumCI↓, MMP9↓, AP-1↓, Sp1/3/4↓, NF-kB↓,
8886- MOR,  doxoR,    Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNAdam↑, DNArepair↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CycB/CCNB1↓, PARP↓, Bcl-xL↓, p‑AMPK↑, p‑STK11/LKB1↑, p‑mTOR↓, p‑Akt↓, p‑GSK‐3β↓, tumCV↓,
8935- MushCha,    Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-10AT
Ingr↝, tumCV↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, ChemoSen↑, Imm↑, Dose↝, Ingr?,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, Synergy↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
58- QC,  doxoR,    Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin
- in-vitro, CRC, HT-29 - in-vitro, NA, CD133+
Bcl-2↓, TumCCA↑, CD133↓, CSCs↓, ChemoSen↑, CycB/CCNB1↑, cycE/CCNE↓, cycD1/CCND1↓, E2Fs↓,
40- QC,    Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells
- in-vitro, lymphoma, U937
cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, CycB/CCNB1↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
CDK2↓, cycE/CCNE↓, cycD1/CCND1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP/DDIT3↑, TumCCA↑, DNAdam↑, AIF↑, Ca+2↑, MMP↓,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27/CDKN1B↑,
3029- RosA,    Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, tumCV↓, Apoptosis↑, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21↑, DNAdam↑, Casp3↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3047- SK,    Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1/CCND1↓, cycE/CCNE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, Synergy↑, Synergy↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3415- TQ,    The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations
- in-vitro, Lung, H446
tumCV↓, TumCCA↑, ROS↓, CycB/CCNB1↑, CycD3↑, cycA1/CCNA1↓, cycE/CCNE↓, cDC2↓, antiOx↑, PARP↓, NRF2↓, ARE/EpRE↑, eff↓,

Showing Research Papers: 51 to 84 of 84
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 84

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 4,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↓, 2,   GSH↑, 3,   GSR↑, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 3,   HO-2↓, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 5,   ROS↓, 8,   ROS↑, 32,   ROS⇅, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↑, 3,   SOD2↑, 2,   Trx↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 2,   CDC25↓, 3,   compI↓, 2,   EGF↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 3,   OCR↓, 1,   OCR↑, 1,   OXPHOS↑, 1,   PDH↑, 1,   PINK1↑, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 3,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 3,   ATP↑, 1,   ECAR↓, 1,   ECAR↝, 1,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 2,   H2S↑, 1,   Histones↑, 1,   lactateProd↓, 3,   LDHA↓, 1,   LDL↓, 2,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PKM2↓, 1,   PPP↓, 1,   SIRT1↓, 2,   SIRT1↑, 3,   TS↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 6,   APAF1↑, 1,   Apoptosis↑, 33,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 23,   BAX⇅, 1,   Bax:Bcl2↑, 6,   Bcl-2↓, 24,   Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↑, 2,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 8,   Casp↝, 1,   Casp3↓, 1,   Casp3↑, 29,   cl‑Casp3↑, 4,   proCasp3↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↑, 12,   cl‑Casp8↑, 1,   proCasp8↑, 2,   Casp9↑, 20,   cl‑Casp9↑, 4,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 25,   Diablo↑, 6,   DR5↓, 1,   DR5↑, 5,   FADD↑, 1,   Fas↑, 6,   HEY1↓, 1,   ICD↑, 1,   iNOS↓, 4,   Mcl-1↓, 10,   MDM2↓, 3,   MDM2↑, 1,   NOXA↑, 1,   p38↑, 4,   PUMA↑, 2,   Pyro↑, 1,   survivin↓, 12,   TRAIL↑, 1,   TumCD↑, 3,   XIAP↓, 8,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 22,   Akt↑, 1,   p‑Akt↓, 7,   AKT1↓, 1,   CDC7↓, 1,   CK2↓, 1,   CREB↓, 1,   EGFR↓, 11,   ERK↓, 8,   p‑ERK↓, 2,   p‑ERK↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IKKα↓, 3,   JAK↓, 1,   JAK1?, 1,   JAK1↓, 2,   p‑JAK1↓, 1,   JAK2↓, 3,   p‑JAK2↓, 2,   JNK↓, 2,   JNK↑, 5,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 14,   mTOR↝, 1,   p‑mTOR↓, 2,   mTORC2↓, 1,   mTORC2↑, 1,   p70S6↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 17,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 4,   Raf↓, 2,   RAS↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 1,   STAT3↓, 11,   p‑STAT3↓, 5,   STAT5↓, 1,   STAT6↓, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 4,   ATFs↑, 1,   CBP↑, 1,   cJun↓, 4,   cMyc↓, 10,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   H3↑, 1,   HATs↓, 1,   HDAC↓, 1,   HDAC1↓, 2,   HDAC2↓, 2,   HDAC3↓, 1,   miR-200b↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 1,   SOX2↓, 2,   TCF-4↓, 2,   TFE3↑, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 12,   GRP78/BiP↓, 1,   GRP78/BiP↑, 7,   HSF1↓, 1,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   IRE1↑, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   p62↓, 1,   PARK2↑, 1,   TumAuto↑, 2,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   BRCA1↑, 3,   BRCA2↑, 1,   CUL4B↑, 1,   DNAdam↓, 2,   DNAdam↑, 17,   DNArepair↓, 1,   MSH2↑, 1,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 26,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 19,   PARP1↑, 1,   PCNA↓, 11,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 2,   TOP2↓, 2,   TOP2↑, 1,   TP53↑, 1,   γH2AX↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1/2/5/9∅, 1,   CDK2↓, 44,   CDK2↑, 2,   p‑CDK2↓, 1,   CDK4↓, 48,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 20,   CDK6↑, 3,   CDK8↓, 1,   CHK1↓, 2,   CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 2,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 7,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 68,   cycD1/CCND1↑, 1,   CycD3↓, 3,   CycD3↑, 1,   cycE/CCNE↓, 77,   cycE/CCNE↑, 5,   cycF↓, 1,   E2Fs↓, 4,   FBXO5/EMI1↓, 1,   Ki-67↓, 4,   mitA↓, 1,   P21?, 1,   P21↓, 1,   P21↑, 42,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 25,   pRB↑, 2,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   TumCCA↓, 2,   TumCCA↑, 67,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 2,   cFos↓, 3,   CSCs↓, 7,   Diff↓, 1,   EP300↑, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 4,   Let-7↑, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NF2↑, 1,   NOTCH↓, 4,   NOTCH1↓, 1,   TumCG↓, 11,   TumCP↓, 32,   TumCP↑, 1,   TumCP⇅, 1,   tyrosinase↓, 1,   Wnt↓, 8,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 6,   AXL↓, 1,   Ca+2↑, 10,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cdc42↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 6,   EMT↓, 9,   FAK↓, 3,   p‑FAK↓, 2,   MMP1↓, 2,   MMP2↓, 18,   MMP3↓, 2,   MMP7↓, 4,   MMP9↓, 24,   MMP9↑, 1,   MMPs↓, 6,   N-cadherin↓, 5,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   PDGF↓, 3,   Slug↓, 2,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 4,   TGF-β↓, 5,   TIMP1↑, 1,   TIMP2↑, 2,   TSC1↑, 1,   TumCA↓, 1,   TumCI↓, 14,   TumCMig↓, 15,   TumMeta↓, 10,   TumMeta↑, 2,   Twist↓, 4,   uPA↓, 8,   Vim↓, 6,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 10,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 18,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1,   GLUT1↓, 1,   MMP↓, 22,   NHE1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 1,   cDC2↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 18,   CXCR4↓, 4,   DR4↑, 2,   IFN-γ↓, 1,   IL1↓, 1,   IL1↑, 1,   IL12↓, 1,   IL1α↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 5,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 5,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 28,   NF-kB↑, 1,   NLRP3↑, 1,   p50↓, 1,   p65↓, 2,   PD-L1↓, 1,   PGE2↓, 7,   PSA↓, 3,   TCF↝, 1,   TLR4↝, 1,   TNF-α↓, 5,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 4,   ER-α36↓, 2,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 9,   BioEnh↑, 2,   ChemoSen↑, 23,   CYP1A1↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 6,   Dose∅, 1,   eff↓, 6,   eff↑, 9,   eff↝, 3,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↝, 2,   P-gp/ABCB1↓, 3,   P450↓, 1,   P450↝, 1,   RadioS↑, 10,   selectivity↑, 16,   Synergy↑, 27,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 4,   ascitic↓, 1,   AST↓, 1,   BRCA1↑, 3,   E6↓, 1,   E7↓, 1,   EGFR↓, 11,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 5,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 3,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 8,   AntiTum↑, 3,   chemoP↑, 3,   chemoPv↑, 5,   hepatoP↑, 2,   NP/CIPN↓, 1,   RenoP↑, 1,   Risk↓, 4,   TGFβR1↑, 1,   toxicity↓, 5,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 3,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 484

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 14,   Catalase↑, 3,   GPx↑, 4,   GSH↑, 5,   GSR↑, 2,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 3,   lipid-P↓, 6,   MDA↓, 1,   NRF2↑, 6,   Prx↑, 1,   ROS↓, 9,   ROS↑, 1,   SOD↑, 4,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   ECAR∅, 1,   FASN↓, 1,   LDL↓, 1,   lipidLev↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Bax:Bcl2↑, 1,   Casp3?, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Fas↓, 1,   Fas↑, 1,   Ferroptosis↓, 1,   iNOS↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CREB↑, 1,   ERK↑, 2,   IκB?, 1,   MAPK↑, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   other?, 1,   tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   IL10↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 13,   NF-kB↓, 4,   NLRP3↓, 1,   PGE2↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   GABA↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   CompStab↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 2,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 3,   cardioP↑, 6,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 3,   neuroP↑, 6,   Obesity↓, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   toxicity↑, 2,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 108

Scientific Paper Hit Count for: cycE/CCNE, Cyclin E
9 Fisetin
5 Lycopene
5 Quercetin
3 Berberine
3 Ferulic acid
3 Gallic acid
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalein
2 Boswellia (frankincense)
2 Capsaicin
2 Cucurbitacin
2 Emodin
2 Licorice
2 Morin
2 doxorubicin
2 Rosmarinic acid
2 Shikonin
2 Thymoquinone
1 Andrographis
1 Gemcitabine (Gemzar)
1 Ashwagandha(Withaferin A)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorophyllin
1 Deguelin
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Fenbendazole
1 Flaxseed/Linseed
1 Garcinol
1 Hibiscus sabdariffa
1 Honokiol
1 HydroxyTyrosol
1 Indole-3-carbinol
1 phytic acid, Inositol hexakisphosphate
1 Isoliquiritigenin
1 Ivermectin
1 Licochalcone A
1 SDG/lignans
1 Luteolin
1 Magnolol
1 Metformin
1 Magnetic Fields
1 Chemotherapy
1 Mushroom Chaga, Inonotus obliquus
1 Propolis -bee glue
1 Phenethyl isothiocyanate
1 Pterostilbene
1 Resveratrol
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:378  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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