Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
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The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5903- CAR,  TV,    Combined Cytotoxic Effects of Carvacrol-Based Essential Oil Formulations
- in-vitro, BC, MDA-MB-231
BioAv↑, MPT↑, ROS↑, Casp↑, eff↑, PI3K↓, Akt↓, TumCCA↑, Apoptosis↑, Cyt‑c↑, cl‑PARP↑, MPT↑,
5921- Cats,    Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells
- in-vitro, Colon, HT29
ChemoSen↑, Casp↑, DNAdam↑, ROS↑,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
6188- Cuc,    Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation
TumCCA↑, p‑H3↓, cl‑PARP↑, Casp↑, AntiCan↑, JAK2↓, STAT3↓,
6190- Cuc,    Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells
- in-vitro, Colon, SW480
ROS↑, TumCCA↑, Apoptosis↑, CycB/CCNB1↓, CDC25↓, Casp↓, eff↓,
6200- Cuc,  GEM,    Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
- in-vivo, PC, NA
eff↑, TumCG↓, Bcl-xL↓, Bcl-2↓, cMyc↓, Casp↑, STAT3↓, JAK2↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
135- CUR,    Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TfR1/CD71↑, IRP1↑, IronCh↑, Casp↑, eff↑,
5196- DCA,    Dichloroacetate induces apoptosis in endometrial cancer cells
- in-vitro, Var, NA
selectivity↑, MMP↓, survivin↓, Ca+2↓, P53↑, PDK1↓, PDH↑, Glycolysis↓, OXPHOS↑, ROS↑, Cyt‑c↑, Apoptosis↑, Casp↑, tumCV↓, PUMA↑,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, NA, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27↑, P21↑,
2994- EGCG,    Nano-Engineered Epigallocatechin Gallate (EGCG) Delivery Systems: Overcoming Bioavailability Barriers to Unlock Clinical Potential in Cancer Therapy
- Review, Var, NA
BioAv↓, NF-kB↓, Casp↑, MMP9↑, Sp1/3/4↑,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
6336- Eug,    Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG
- in-vivo, GC, NA
Apoptosis?, Bcl-2↓, Cyt‑c↝, Casp↑, TumCI↓, angioG↓, MMPs↓, VEGF↓, VEGFR1↓, TIMP2↑, RECK↑,
3779- FA,    A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease
- Review, AD, NA
*antiOx↑, *neuroP↑, *Aβ↓, *Inflam↓, *COX2↓, *Casp↓, *NOS2↓, *HO-1↑, *AChE∅, *BChE∅, *memory↑,
2847- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,
2846- FIS,    Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity
- in-vitro, Nor, NA
*cardioP↑, *ROS↓, *Casp↓, *DNAdam↓,
2855- FIS,    Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells
- in-vitro, RCC, Caki-1
TumCCA↑, cl‑PARP↑, Apoptosis↑, Casp↑, P53↑, DR5↑, CHOP↑, ROS↑, ER Stress↑, ATF4↑, XBP-1↑, eff∅,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
1955- GamB,    Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp↓, survivin↓,
810- GAR,  GEM,    Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures
- in-vitro, PC, NA
TumCP↓, Apoptosis↑, PARP↝, VEGF↝, MMPs↝, Casp↝, NF-kB↝, miR-21↝,
1504- GEN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, P21↑, p16↑, ac‑H3↑, ac‑H4↑, TumCCA↑, Casp↑, Apoptosis↑, hTERT/TERT↓, BTG3↑,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1↓,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
858- Gra,    Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,
856- Gra,    https://pubmed.ncbi.nlm.nih.gov/33048613/
- in-vitro, BC, MCF-7
TumCCA↑, ROS↑, Casp↑,
5049- HPT,    Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
- vitro+vivo, PC, Panc02 - vitro+vivo, PC, Bxpc-3
tumCV↓, proCasp↑, ROS↑, Ki-67↓, TOP2↓, TumVol↓,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
1762- MF,  Fe,    Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane
- in-vitro, RCC, NA
Dose∅, Apoptosis↑, Casp↑, tumCV↓, Casp3↑, Casp7↑, Ca+2↑, Cyt‑c↑,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF-7
TumCCA↑, Apoptosis↑, eff↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4974- Nimb,    Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma
- in-vitro, OS, NA
Apoptosis↑, ER Stress↑, mtDam↑, ROS↑, Casp↑, TumCMig↓, TumMeta↓,

Showing Research Papers: 51 to 100 of 141
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 141

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx⇅, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Fenton↑, 1,   Ferroptosis↑, 3,   GPx4↓, 1,   GSH↓, 2,   HO-1↑, 2,   Iron↑, 1,   IRP1↑, 1,   lipid-P↓, 1,   lipid-P↑, 4,   MDA↑, 2,   NADH↓, 1,   NRF2↓, 1,   NRF2↑, 4,   OXPHOS↓, 1,   OXPHOS↑, 1,   ROS↓, 4,   ROS↑, 33,   mt-ROS↑, 1,   Trx↓, 1,   TrxR↓, 2,   TrxR1↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 3,   mt-ATP↓, 1,   CDC2↓, 1,   CDC25↓, 2,   ETC↓, 2,   mitResp↓, 1,   MMP↓, 13,   MPT↑, 3,   mtDam↑, 5,   e-Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AMP↓, 1,   AMPK↑, 5,   cMyc↓, 4,   FASN↓, 2,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   HK2↓, 2,   lactateProd↑, 1,   LDHA↓, 2,   NADPH↓, 1,   PCK1↓, 1,   PDH↑, 1,   PDK1↓, 4,   PDK3↑, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SREBP2↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 16,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 26,   BAD↑, 1,   Bak↑, 2,   BAX↑, 8,   Bax:Bcl2↑, 4,   Bcl-2↓, 12,   Bcl-2↑, 1,   Bcl-xL↓, 6,   BID↑, 2,   BIM↑, 2,   BTG3↑, 1,   Casp↓, 1,   Casp↑, 40,   Casp↝, 3,   Casp∅, 1,   cl‑Casp↑, 1,   proCasp↑, 1,   Casp3↓, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp7↑, 1,   cl‑Casp7↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 4,   cl‑Casp9↑, 2,   Chk2↑, 1,   Cupro↑, 1,   Cyt‑c↑, 13,   Cyt‑c↝, 1,   Diablo↑, 3,   DR4↑, 1,   DR5↑, 4,   FADD↑, 2,   Fas↓, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 3,   HGF/c-Met↓, 1,   hTERT/TERT↓, 2,   IAP2↓, 1,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 7,   MAPK↑, 1,   Mcl-1↓, 3,   MCT1↓, 1,   MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p27↓, 1,   p27↑, 6,   p38↓, 1,   p38↑, 1,   p‑p38↓, 1,   p‑p38↑, 1,   Proteasome↓, 1,   PUMA↑, 2,   survivin↓, 9,   TRAIL↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,   Sp1/3/4↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 2,   p‑H3↓, 2,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   miR-21↝, 1,   pRB↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 2,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   IRE1↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↓, 2,   Beclin-1↑, 1,   LC3s↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   CHK1↑, 1,   DNAdam↑, 7,   DNMTs↓, 4,   p16↑, 1,   P53↑, 11,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 2,   PARP↝, 1,   cl‑PARP↑, 12,   PCNA↓, 5,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 8,   p‑CDK2↓, 1,   CDK4↓, 4,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 6,   P21↑, 8,   TumCCA↑, 27,  

Proliferation, Differentiation & Cell State ⓘ

AR-V7?, 1,   cFos↓, 3,   Diff↓, 1,   EMT↓, 3,   EMT↝, 1,   ERK↓, 2,   p‑ERK↓, 1,   FOXO1↓, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   IGF-1↓, 1,   mTOR↓, 11,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC1↓, 3,   mTORC2↓, 1,   mTORC2↑, 1,   NOTCH1↑, 1,   PI3K↓, 11,   PTEN↑, 1,   RAS↓, 2,   SCF↓, 1,   STAT↓, 1,   STAT3↓, 11,   p‑STAT3↓, 1,   TCF-4↓, 1,   TOP1↓, 3,   TOP2↓, 3,   TumCG↓, 5,   TumCG↑, 1,   Wnt↓, 5,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 5,   E-cadherin↑, 4,   FAK↓, 1,   p‑FAK↓, 2,   Ki-67↓, 4,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP7↓, 2,   MMP9↓, 7,   MMP9↑, 2,   MMPs↓, 5,   MMPs↝, 1,   MUC4↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   PKCδ↓, 1,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TSC1↑, 1,   TumCI↓, 6,   TumCI↑, 1,   TumCMig↓, 4,   TumCMig↑, 1,   TumCP↓, 14,   TumCP↑, 1,   TumMeta↓, 9,   TumMeta↑, 3,   Twist↓, 2,   uPA↓, 5,   VCAM-1↓, 2,   VEGFR1↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 13,   angioG↑, 1,   ATF4↑, 3,   EGFR↓, 3,   Hif1a↓, 6,   NO↑, 1,   VEGF↓, 10,   VEGF↝, 1,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↓, 3,   GLUT4↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 7,   CXCR2↓, 1,   CXCR4↓, 1,   ICAM-1↓, 2,   IKKα↓, 2,   IL1β↓, 1,   IL2↑, 1,   Imm↑, 1,   JAK1↓, 1,   JAK2↓, 3,   NF-kB↓, 19,   NF-kB↑, 1,   NF-kB↝, 1,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 3,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 4,   CDK6↓, 2,   CYP19?, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 11,   CYP1A2↓, 1,   DDS↑, 1,   Dose↝, 2,   Dose∅, 3,   eff↓, 3,   eff↑, 17,   eff∅, 1,   Half-Life↓, 3,   Half-Life↝, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 4,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   GutMicro↑, 1,   hTERT/TERT↓, 2,   Ki-67↓, 4,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 317

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 10,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 3,   GSR↑, 1,   GSTA1↑, 1,   GSTs↑, 2,   HO-1↑, 5,   MDA↓, 2,   NRF2↑, 6,   ROS↓, 9,   SOD↑, 5,   TBARS↓, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   p‑cMyc↑, 1,   CRM↑, 1,   cytoP450↓, 1,   glucose↓, 2,   glyC↓, 1,   LDH↓, 1,   PPARα↝, 1,  

Cell Death ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp↓, 3,   iNOS↓, 1,   JNK↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   TRPC1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IL1↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 12,   Inflam↑, 1,   NF-kB↓, 4,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   AChE∅, 1,   BChE∅, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 2,   XO↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioEnh↑, 1,   eff↑, 2,   Half-Life↝, 1,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   IL6↓, 2,   LDH↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 3,   chemoPv↑, 1,   hepatoP↑, 3,   memory↑, 3,   neuroP↑, 6,   radioP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 76

Scientific Paper Hit Count for: Casp, caspase
7 Thymoquinone
6 Betulinic acid
6 Capsaicin
6 Fisetin
4 Silver-NanoParticles
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Carvacrol
4 Curcumin
4 Shikonin
3 Allicin (mainly Garlic)
3 Alpha-Lipoic-Acid
3 Anethole/trans-Anethole
3 Cisplatin
3 Apigenin (mainly Parsley)
3 Cucurbitacin
3 Gambogic Acid
3 Graviola
3 Nimbolide
3 α-Santalol/Sandalwood oil
3 Selenite (Sodium)
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
2 Berberine
2 Rosmarinic acid
2 Thymol-Thymus vulgaris
2 Selenium
2 Chrysin
2 Gemcitabine (Gemzar)
2 EGCG (Epigallocatechin Gallate)
2 Magnetic Fields
2 Parthenolide
2 Quercetin
2 Selenium NanoParticles
2 Urolithin
1 3-bromopyruvate
1 Astragalus
1 alpha Linolenic acid
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Cat’s Claw
1 Chlorogenic acid
1 chitosan
1 Selenate
1 Chlorophyllin
1 Cinnamon
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Deguelin
1 D-limonene
1 Docetaxel
1 Ellagic acid
1 Emodin
1 Eugenol
1 Ferulic acid
1 verapamil
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 Hyperthermia
1 HydroxyTyrosol
1 Luteolin
1 Metformin
1 Iron
1 Chemotherapy
1 Naringin
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Pterostilbene
1 salinomycin
1 irinotecan
1 Photodynamic Therapy
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:443  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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