Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
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The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5903- CAR,  TV,    Combined Cytotoxic Effects of Carvacrol-Based Essential Oil Formulations
- in-vitro, BC, MDA-MB-231
BioAv↑, MPT↑, ROS↑, Casp↑, Synergy↑, PI3K↓, Akt↓, TumCCA↑, Apoptosis↑, Cyt‑c↑, cl‑PARP↑, MPT↑,
5921- Cats,    Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells
- in-vitro, Colon, HT29
ChemoSen↑, Casp↑, DNAdam↑, ROS↑,
6653- Cen,    Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway
- in-vitro, Melanoma, KM3/BTZ
TumCG↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, Casp↑, ROS↑, TumCMig↓, TumCI↓, STAT3↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
7172- CHA,    Chaetocin enhances tumor necrosis factor‑related apoptosis‑inducing ligand‑mediated apoptosis by enhancing DR5 stabilization and reactive oxygen species generation in human glioblastoma cells
- in-vitro, GBM, U343 - in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, T98G - in-vitro, Nor, HEK293
Casp↑, Apoptosis↑, selectivity↑, DR5↑, ROS↑,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, Synergy↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2/PTGS2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
9273- CRAN,    Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation
- vitro+vivo, ESCC, NA
AntiCan↑, Casp↑, TumAuto↑, necrosis↑, PI3K↓, Akt↓, mTOR↓, BAX↑, Bcl-xL↑, Cyt‑c↑, PARP↑, TumCG↓, toxicity↓,
7411- CS,    Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
6188- Cuc,    Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation
- in-vitro, Var, NA
TumCCA↑, p‑H3↓, cl‑PARP↑, Casp↑, AntiCan↑, JAK2↓, STAT3↓,
6190- Cuc,    Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells
- in-vitro, Colon, SW480
ROS↑, TumCCA↑, Apoptosis↑, CycB/CCNB1↓, CDC25↓, Casp↓, eff↓,
6200- Cuc,  GEM,    Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
- in-vivo, PC, NA
Synergy↑, TumCG↓, Bcl-xL↓, Bcl-2↓, cMyc↓, Casp↑, STAT3↓, JAK2↓,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
135- CUR,    Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TfR1/CD71↑, IRP1↑, IronCh↑, Casp↑, eff↑,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *CompStab↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, Synergy↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1 / PDPK1↓, Beclin-1/ATG6↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
9092- CV,  I3C,    Anticancer and Antimicrobial Activity of Chlorella vulgaris BA02 Algae Extract Containing Indole-3-Acetic Acid
- in-vitro, BC, MCF7 - in-vitro, BC, ZR-75-1 - in-vitro, BC, MDA-MB-231
ROS↑, Apoptosis↑, tumCV↓, Casp↑,
9093- CV,    Microalga Chlorella sp. extract induced apoptotic cell death of cholangiocarcinoma via AKT/mTOR signaling pathway
- in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, BC, MCF7 - in-vitro, Liver, HUH7 - in-vitro, CCA, KKU-100
Apoptosis↑, Casp↑, Bcl-2↓, Dose↝, Akt↓, mTOR↓, Ingr↝,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1 / PDPK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, Synergy↑, Synergy↑, other↝, RadioS↑, toxicity↓, Dose↝, Synergy↑, Synergy↑, Synergy↑, toxicity↝, eff↓,
6681- DCA,    Dichloroacetate (DCA) in Cancer Care
- Review, Var, NA
PDK1 / PDPK1↓, Apoptosis↑, ROS↑, lactateProd↓, Dose↝, eff↝, toxicity↓, NP/CIPN↑, Dose↝, *BioAv↑, *Half-Life↓, GSTZ1↝, Glycolysis↓, OXPHOS↑, MPT↑, Cyt‑c↑, AIF↑, Casp↑, CSCs↓, Remission↑, ChemoSen↑, RadioS↑, toxicity↑,
5196- DCA,    Dichloroacetate induces apoptosis in endometrial cancer cells
- in-vitro, Var, NA
selectivity↑, MMP↓, survivin↓, Ca+2↓, P53↑, PDK1 / PDPK1↓, PDH↑, Glycolysis↓, OXPHOS↑, ROS↑, Cyt‑c↑, Apoptosis↑, Casp↑, tumCV↓, PUMA↑,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27/CDKN1B↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
8841- DIM,    3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Casp↑, EMT↓, UPR↓, Ca+2↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, IRE1↑, PERK↑, PDI↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Slug↓, Snail↓, chemoPv↑,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1 / PDPK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
2994- EGCG,    Nano-Engineered Epigallocatechin Gallate (EGCG) Delivery Systems: Overcoming Bioavailability Barriers to Unlock Clinical Potential in Cancer Therapy
- Review, Var, NA
BioAv↓, NF-kB↓, Casp↑, MMP9↑, Sp1/3/4↑,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, Var, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
6336- Eug,    Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG
- in-vivo, GC, NA
Apoptosis?, Bcl-2↓, Cyt‑c↝, Casp↑, TumCI↓, angioG↓, MMPs↓, VEGF↓, VEGFR1↓, TIMP2↑, RECK↑,
3779- FA,    A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease
- Review, AD, NA
*antiOx↑, *neuroP↑, *Aβ↓, *Inflam↓, *COX2/PTGS2↓, *Casp↓, *NOS2↓, *HO-1↑, *AChE∅, *BChE∅, *memory↑,
6862- FBZ,    Research: The Urgent Need for Clinical Studies to Evaluate the Anti-Tumor Efficacy of Fenbendazole
- Review, Var, NA
mitA↑, Apoptosis↑, GLUT4↓, HK2↓, Warburg↓, TumCCA↑, P53↑, Casp↑, TumCP↓, ROS↑, Ferroptosis↑, TumVol↓, Dose↝, BioAv↓, RadioS↝, ChemoSen↑,
2847- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,
2846- FIS,    Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity
- in-vitro, Nor, NA
*cardioP↑, *ROS↓, *Casp↓, *DNAdam↓,
2855- FIS,    Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells
- in-vitro, RCC, Caki-1
TumCCA↑, cl‑PARP↑, Apoptosis↑, Casp↑, P53↑, DR5↑, CHOP/DDIT3↑, ROS↑, ER Stress↑, ATF4↑, XBP-1↑, eff∅,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6993- Form,  ISL,    Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell
- in-vitro, CRC, HCT116
AntiTum↑, TumCG↓, Apoptosis↑, Casp↑, Bcl-2↓, Bcl-xL↓,
8596- FSO,    Treatment with flaxseed oil induces apoptosis in cultured malignant cells
- in-vitro, BC, MCF7 - in-vitro, Melanoma, B16-BL6
TumCG↓, selectivity↑, Apoptosis↑, DNAdam↑, Casp↑, mtDam↑, cl‑PARP↑, MMP↓,
7016- Fuc,    Therapies from Fucoidan: New Developments
- Review, Var, NA
*Bacteria↓, *BioAv↓, *Dose↝, *GutMicro↑, PD-1↝, ROS⇅, cl‑Casp↑, cl‑PARP↑, RadioS↑, *radioP↑, *neuroP↑, *Aβ↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,

Showing Research Papers: 51 to 100 of 205
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 205

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 1,   GPx4↓, 3,   GSH↓, 10,   GSH↑, 2,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 3,   Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA↓, 1,   MDA↑, 3,   NADH↓, 2,   mt-NADH↓, 1,   NQO1↓, 1,   NRF2↓, 7,   NRF2↑, 7,   ROS↓, 11,   ROS↑, 131,   ROS⇅, 3,   ROS↝, 1,   i-ROS?, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 1,   SOD↑, 2,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   Trx↓, 1,   Trx↑, 1,   TrxR↓, 2,   TrxR↑, 1,   TrxR1↓, 4,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IRP1↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   compI↓, 4,   compII↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC↓, 4,   mitResp↓, 3,   mtDam↑, 16,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 4,   PDH↑, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ACSL4↑, 1,   AMP↓, 1,   AMPK?, 1,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↓, 16,   mt-ATP↓, 1,   FASN↓, 5,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 11,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   H2S↑, 1,   HK2↓, 7,   HMG-CoA↓, 2,   lactateProd↓, 3,   lactateProd↑, 2,   LDHA↓, 3,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 10,   PDK3↑, 1,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 126,   mt-Apoptosis↑, 4,   BAD↑, 4,   Bak↑, 4,   BAX↑, 44,   Bax:Bcl2↑, 13,   Bcl-2↓, 56,   Bcl-2↑, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 19,   Bcl-xL↑, 2,   BID↑, 3,   BIM↓, 1,   BIM↑, 4,   BNIP3↓, 1,   BTG3↑, 1,   Casp↓, 5,   Casp↑, 184,   Casp↝, 3,   Casp∅, 1,   cl‑Casp↑, 6,   proCasp↑, 1,   Casp3↓, 1,   Casp3↑, 24,   cl‑Casp3↑, 5,   Casp6↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 3,   Casp8↑, 3,   cl‑Casp8↑, 3,   Casp9↑, 9,   cl‑Casp9↑, 6,   Cupro↑, 1,   Cyt‑c↑, 63,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↑, 9,   Endon↑, 1,   FADD↑, 2,   Fas?, 1,   Fas↓, 2,   Fas↑, 9,   FasL↑, 4,   Ferroptosis↑, 7,   GSDME↑, 1,   cl‑GSDME↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 6,   Mcl-1↓, 5,   MDM2↓, 3,   MLKL↑, 1,   MOMP↑, 3,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   p38↓, 5,   p38↑, 7,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP3↑, 1,   survivin↓, 25,   TNFR 1↑, 2,   TRAIL↑, 3,   TumCD↑, 8,   XIAP↓, 8,   XIAP↑, 1,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 55,   p‑Akt↓, 7,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 10,   ERK↓, 14,   ERK↑, 4,   p‑ERK↓, 4,   HCAR2↑, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   Hippo↓, 1,   IKKα↓, 2,   IκB↓, 1,   JAK1↓, 1,   JAK2↓, 8,   JAK3↓, 1,   JNK↓, 2,   JNK↑, 8,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK?, 1,   MAPK↓, 17,   MAPK↑, 9,   MEK↓, 3,   mTOR↓, 33,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 1,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   PDGFRA↓, 1,   PI3K↓, 38,   p‑PI3K↓, 1,   PI3K/Akt↓, 2,   PKCδ↓, 2,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 6,   Raf↓, 3,   e-Raf↓, 1,   RAS↓, 4,   RIP1↓, 1,   Sp1/3/4↓, 5,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3↓, 29,   p‑STAT3↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF4↑, 5,   cJun↓, 2,   cJun↑, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 4,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   p‑H3↓, 2,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 11,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC6↓, 1,   miR-148a↑, 1,   miR-203↑, 1,   miR-21↝, 1,   miR-34a↑, 1,   miR-375↑, 1,   NDRG1↑, 1,   OCT4↓, 4,   other↑, 3,   other↝, 5,   PhotoS↑, 1,   SOX2↓, 4,   TCF-4↓, 2,   TFAP2A↓, 1,   TFE3↑, 1,   tumCV↓, 30,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 17,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 2,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 2,   LC3I↓, 1,   LC3II↑, 5,   LC3s↑, 1,   lysoMP↑, 1,   p62↓, 4,   p62↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 15,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   DNAdam↓, 1,   DNAdam↑, 34,   DNArepair↓, 2,   hTERT/TERT↓, 4,   p16↑, 2,   P53↓, 2,   P53↑, 38,   P53↝, 2,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 6,   PARP↝, 1,   cl‑PARP↑, 36,   cl‑PARP1↑, 2,   PCNA↓, 8,   SIRT6↓, 1,   Telomerase↓, 6,   TOP1↓, 6,   TOP2↓, 4,   γH2AX↑, 4,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 11,   p‑CDK2↓, 1,   CDK4↓, 12,   CDK4↑, 1,   CDK6↓, 4,   CDK6↑, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   CycB/CCNB1↓, 4,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 23,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 10,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 8,   mitA↓, 1,   mitA↑, 2,   P21↑, 28,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 11,   PLK1↓, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 88,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH1A1↓, 1,   BMI1↓, 1,   CD133↓, 2,   cFos↓, 3,   CSCs↓, 13,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 2,   IGFBP3↑, 2,   Ki-67↓, 8,   mTORC1↓, 5,   Nanog↓, 4,   NOTCH↓, 2,   NOTCH1↓, 3,   NOTCH1↑, 1,   NOTCH2↑, 1,   SCF↓, 1,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 39,   TumCG↑, 2,   TumCP↓, 60,   TumCP↑, 3,   Wnt↓, 13,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 6,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 22,   cal2↑, 1,   CCN2/CTGF↓, 2,   COL1↓, 1,   E-cadherin↑, 13,   EMT↓, 19,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   GLI2↓, 1,   ITGB4↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 26,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 29,   MMP9↑, 2,   MMPs↓, 10,   MMPs↝, 1,   MUC4↓, 1,   N-cadherin↓, 7,   PAK1↑, 1,   PDGF↓, 2,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Slug↓, 1,   Snail↓, 2,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TSC1↑, 2,   TSP-1↑, 1,   TumCI↓, 23,   TumCI↑, 1,   TumCMig↓, 22,   TumCMig↑, 1,   TumMeta↓, 25,   TumMeta↑, 3,   Twist↓, 4,   uPA↓, 8,   Vim↓, 10,   Zeb1↓, 3,   β-catenin/ZEB1↓, 17,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 37,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 3,   HIF-1↓, 2,   Hif1a↓, 17,   Hif1a↑, 1,   NO↓, 1,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 41,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   EPR↑, 4,   GLUT1↓, 4,   GLUT4↓, 2,   MMP?, 2,   MMP↓, 78,   MMP↝, 1,   MPT↑, 10,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↑, 1,   CD44↓, 3,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCR2↓, 1,   CXCR4↓, 5,   DR4↑, 3,   Eos↑, 1,   HCAR2↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL12↑, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 10,   IL8↓, 1,   Imm↑, 8,   Inflam↓, 11,   M2 MC↓, 1,   MCT1↓, 1,   MDSCs↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 55,   NF-kB↑, 3,   NF-kB↝, 1,   NK cell↑, 1,   NLRP3↓, 2,   p50↓, 1,   p65↓, 3,   PD-1↝, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 5,   PSA↓, 2,   TCF↝, 1,   TLR4↓, 1,   TNF-α↓, 15,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 16,   BioAv↑, 16,   BioAv↝, 4,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 64,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↑, 2,   Dose↝, 25,   Dose∅, 5,   eff↓, 33,   eff↑, 37,   eff↝, 6,   eff∅, 1,   GSTA1↑, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 6,   Half-Life↝, 2,   MDR1↓, 4,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   P450↓, 2,   RadioS↑, 20,   RadioS↝, 1,   selectivity?, 1,   selectivity↑, 40,   selectivity↝, 1,   Synergy↑, 41,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 8,   BMD↑, 1,   BRCA1↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 10,   EZH2↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 4,   IL6↓, 10,   LDH↓, 1,   LDH↑, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 21,   AntiTum↑, 9,   AntiTum↝, 1,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 5,   ChemoSideEff↓, 1,   fatigue↓, 2,   hepatoP↑, 5,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 2,   NP/CIPN↑, 1,   Obesity↓, 1,   OS↑, 4,   Pain↓, 2,   QoL↑, 1,   radioP↑, 4,   Remission↑, 2,   RenoP↑, 1,   Risk↓, 7,   Sleep↑, 1,   toxicity↓, 12,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 2,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 629

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 23,   Catalase↑, 11,   GPx↑, 9,   GSH↑, 7,   GSR↑, 2,   GSTs↑, 2,   HO-1↑, 8,   Keap1↓, 2,   lipid-P↓, 6,   MDA↓, 4,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 14,   ROS↓, 27,   ROS↝, 1,   ROS∅, 2,   SOD↑, 12,   SOD2↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   ETC↑, 1,   Insulin↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↓, 1,   ALAT↓, 3,   AMPK↑, 2,   ATP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   glucose↓, 2,   glyC↓, 1,   NAD↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp↓, 5,   Ferroptosis↓, 1,   iNOS↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↑, 1,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 2,   PKCδ↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 1,   p‑cMyc↑, 1,   other↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   Ca+2↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   MMP↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   HMGB1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 3,   IL6↓, 8,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 33,   Inflam↑, 1,   NeuroI↓, 1,   NF-kB↓, 7,   NK cell↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   AChE∅, 1,   BChE∅, 1,   BDNF↑, 1,   proBDNF↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 5,   tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 2,   CompStab↑, 1,   Dose↝, 2,   eff↑, 2,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 3,   Half-Life∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   CRP↓, 2,   IL6↓, 8,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 3,   AntiArt↑, 3,   AntiCan↑, 4,   antiD↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   ANXi↓, 1,   cardioP↑, 8,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 4,   hepatoP↑, 6,   memory↑, 3,   Mood↑, 1,   neuroP↑, 15,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 1,   Sleep↑, 1,   Stroke↓, 3,   toxicity?, 1,   toxicity↓, 5,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   GutMicro↑, 4,  
Total Targets: 149

Scientific Paper Hit Count for: Casp, caspase
7 Thymoquinone
6 Betulinic acid
6 Capsaicin
6 Fisetin
4 Silver-NanoParticles
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Carvacrol
4 Curcumin
4 Graviola
4 Sulforaphane (mainly Broccoli)
4 Shikonin
3 Allicin (mainly Garlic)
3 Alpha-Lipoic-Acid
3 Anethole/trans-Anethole
3 Cucurbitacin
3 Dichloroacetate
3 Gambogic Acid
3 Ginkgetin
3 Licochalcone A
3 Melatonin
3 Nimbolide
3 α-Santalol/Sandalwood oil
3 Selenite (Sodium)
3 Silymarin (Milk Thistle) silibinin
2 Berberine
2 Rosmarinic acid
2 Thymol-Thymus vulgaris
2 chaetocin
2 Selenium
2 Chrysin
2 Gemcitabine (Gemzar)
2 Chlorella (Chlorella vulgaris)
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Isoliquiritigenin
2 Garcinol
2 HydroxyTyrosol
2 Isobavachalcone
2 iodine
2 isoquercitrin
2 Phenethyl isothiocyanate
2 Kaempferol
2 Luteolin
2 Matrine
2 methylseleninic acid
2 Magnetic Fields
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Parthenolide
2 Quercetin
2 Selenium NanoParticles
2 Urolithin
1 3-bromopyruvate
1 Astragalus
1 alpha Linolenic acid
1 Isovitexin
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Cat’s Claw
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenate
1 Chlorophyllin
1 Cinnamon
1 Cranberry
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Indole-3-carbinol
1 Deguelin
1 Diindolylmethane
1 D-limonene
1 Docetaxel
1 Ellagic acid
1 Eugenol
1 Ferulic acid
1 Fenbendazole
1 Formononetin
1 Flaxseed Oil
1 Fucoidan
1 verapamil
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginseng
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperthermia
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Ivermectin
1 Geldanamycin
1 Licorice
1 Linalool
1 Methylene blue
1 Magnolol
1 mebendazole
1 Paclitaxel/Taxol
1 Metformin
1 Chemotherapy
1 Magnetic Field Rotating
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Naringin
1 Phenylbutyrate
1 Phycocyanin
1 Pterostilbene
1 Rhein
1 salinomycin
1 irinotecan
1 Photodynamic Therapy
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:443  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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