angioG Cancer Research Results

angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
Scientific Papers found: Click to Expand⟱
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSPD1 / HSP60↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
5582- BetA,    Targeting mitochondrial apoptosis by betulinic acid in human cancers
- Review, Var, NA
Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP↑, *toxicity↓,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
2737- BetA,    Multiple molecular targets in breast cancer therapy by betulinic acid
- Review, Var, NA
TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, eff↑,
2748- BetA,    Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy
- Review, Var, NA
Bcl-2↓, MMP↓, Cyt‑c↑, Casp↑, Diablo↑, AIF↑, angioG↓, BioAv↓, NF-kB↓,
2754- BetA,    Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
- in-vitro, Pca, LNCaP
VEGF↓, survivin↓, Sp1/3/4↓, Casp↑, PARP↑, survivin↓, angioG↓,
5715- BF,    Bufalin for an innovative therapeutic approach against cancer
- Review, Var, NA
selectivity↑, TumCP↓, TumCCA↓, TumCD↑, Apoptosis↑, TumAuto↑, TumMeta↓, TumCMig↓, TumCI↓, angioG↓, CSCs↓,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
5752- CA,    Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma
- Review, HCC, NA
*ROS↓, angioG↓, STAT3↓, MMP2?, MMP9?,
5872- CA,    Nrf2/ARE-Mediated Antioxidant Actions of Pro-Electrophilic Drugs
- Review, Nor, NA
*NRF2↑, *GSH↑, *neuroP↑, *Inflam↓, *cardioP↑, *Obesity↓, *angioG↓, chemoP↑, *NF-kB↓,
5923- CA,  RosA,    Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study
- Review, Var, NA
TumCD↑, ROS↑, Akt↓, ATG3↑, MMP↓, Casp↑, TumCP↓, TumCCA↑, DNAdam↑, angioG↓,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5856- CAP,    Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumAuto↑, angioG↓, TumCG↓, TumMeta↓, P-gp↝, ERK↝, NF-kB↝, STAT3↝, eff↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp↓, ChemoSen↑,
1260- CAP,    Capsaicin inhibits in vitro and in vivo angiogenesis
- vitro+vivo, NA, NA
VEGF↓, angioG↓, TumCCA↑, cycD1/CCND1↓, Akt↓,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,
2020- CAP,    Capsaicinoids and Their Effects on Cancer: The “Double-Edged Sword” Postulate from the Molecular Scale
- Review, Var, NA
AntiTum↑, selectivity↑, TRPV1↑, MMP↓, Ca+2↑, ER Stress↑, angioG↓, Casp3?, cl‑PARP↑, selectivity↑, ROS↑, *ROS∅, selectivity↑,
5764- CAPE,    Caffeic Acid Phenethyl Ester (CAPE), Derived from a Honeybee Product Propolis, Exhibits a Diversity of Anti-tumor Effects in Preclinical Models of Human Breast Cancer
- vitro+vivo, BC, MCF7 - NA, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, NF-kB↓, MDR1↓, VEGF↓, angioG↓,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5892- CAR,  SRF,    Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study
- in-vivo, HCC, NA
Hif1a↓, AFP↑, hepatoP↑, STAT3↓, JAK2↓, *CD8+↑, ChemoSen↑, Dose↝, angioG↓,
5890- CAR,    Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways
- Review, Var, NA
selectivity↑, TumCG↓, *Inflam↓, *antiOx↑, TumCCA↑, TumCMig↓, TumCI↓, angioG↓,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
5964- CEL,    Celecoxib pathways: pharmacokinetics and pharmacodynamics
- Review, Var, NA
COX2↓, *Pain↓, *Inflam↓, Apoptosis↑, TumCCA↑, angioG↓, ER Stress↑, VEGF↓, MMP9↓, PDK1↓, Akt↓, CA↓, CardioT↑,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓,
5940- Cela,    Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
- in-vivo, Pca, PC3
Dose↝, TumVol↓, TumW↓, angioG↓, VEGF↓, TumCMig↓, TumCP↓, TumCI↓, Akt↓, mTOR↓, P70S6K↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
6642- Cen,    Asiaticoside inhibits breast cancer progression and tumor angiogenesis via YAP1/VEGFA signal pathway
- vitro+vivo, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, TumCI↓, angioG↓, TumCG↓, YAP/TEAD↓, VEGF↓, TumCCA↑,
6009- CGA,    Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment
- Review, Var, NA
TumCCA↑, TumCI↓, TumMeta↓, angioG↓, ROS↑, ChemoSen↑, BioAv↓, Half-Life↓, PI3K↓, Akt↓, mTOR↓, Apoptosis↑, NOTCH↓, Hif1a↓, VEGF↓, Casp3↑, MMP↓, Ferroptosis↑, ATP↓,
6014- CGA,    Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research
- Review, Var, NA
AntiCan↑, *hepatoP↑, *Bacteria↓, *antiOx↓, *AntiDiabetic↑, Apoptosis↓, TumCG↓, angioG↓, TumCI↓, TumCMig↓, ROS↝, Inflam↝,
954- CGA,    Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway
- in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
Hif1a↓, VEGF↓, angioG↓, Akt↓,
5983- Chit,    Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy
- Review, BC, NA
DDS↑, BioAv↑, EPR↑, TumCP↓, angioG↓, TumMeta↓, other↑,
5984- Chit,    Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system
- Review, Var, NA
DDS↑, BioAv↑, TumCP↓, angioG↓, TumMeta↓, Apoptosis↑, eff↑,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
5990- Chit,    Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies
- Review, Var, NA
DDS↑, eff↓, *Bacteria↓, *antiOx↑, *Wound Healing↑, *Imm↑, TumCP↓, TumMeta↓, angioG↓, Apoptosis↑, ROS↑, ER Stress↑, BioAv↑, Half-Life↑, eff↑, EPR↑, ChemoSen↑, eff↑,
4477- Chit,    Recent Advances in Chitosan and its Derivatives in Cancer Treatment
- Review, NA, NA
*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
6133- CHr,    Chrysin in PI3K/AKT and other apoptosis signalling pathways, and its effect on HeLa cells.
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, eff↑, CYP19↓, Hif1a↓, VEGF↓, NF-kB↓, PI3K↓, Akt↓,
6132- CHr,  MET,    Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression
- in-vitro, BC, T47D
eff↑, cycD1/CCND1↓, hTERT/TERT↓, TumCP↓, Apoptosis↑, TumCI↓, TumMeta↓, angioG↓, selectivity↑,
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, eff↑, eff↑, *eff↑, RadioS↑, eff↑, ChemoSen↑, eff↑,

Showing Research Papers: 51 to 100 of 343
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 343

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↓, 1,   CBR1↓, 1,   HSPD1 / HSP60↓, 1,   HTRA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   CYP1A1↑, 1,   Ferroptosis↑, 1,   GSH↓, 1,   HO-1↑, 2,   lipid-P?, 1,   lipid-P↑, 2,   NRF2↑, 1,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 1,   ROS↑, 22,   ROS↝, 1,   mt-ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 1,   CDC25↓, 1,   ETC↓, 1,   MMP↓, 9,   MMP↑, 1,   MPT↑, 1,   mtDam↑, 3,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   AMPK↑, 3,   cMyc↓, 2,   ECAR↓, 1,   Glycolysis↓, 4,   lactateProd↓, 1,   LDHA↓, 1,   PDK1↓, 2,   p‑PDK1↓, 1,   PPARα↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 10,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 22,   mt-Apoptosis↑, 1,   BAX↑, 6,   Bax:Bcl2↑, 3,   Bcl-2↓, 6,   Bcl-xL↓, 1,   Casp↑, 7,   Casp3?, 1,   Casp3↑, 8,   Casp7↑, 1,   Casp8↑, 4,   Casp9↑, 4,   Cyt‑c↑, 8,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 2,   FADD↑, 1,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   ICAD↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 1,   MOMP↓, 1,   p38↑, 1,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 4,   TRPV1↑, 2,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

SOX9↓, 1,   Sp1/3/4↓, 5,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 4,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP?, 1,   GRP78/BiP↑, 3,   HSP90↓, 3,   PERK↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   BNIP3↝, 1,   LC3B↓, 1,   LC3II↑, 1,   p62↓, 1,   SESN2↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   DNArepair↓, 1,   P53↑, 6,   PARP↑, 1,   cl‑PARP↑, 6,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 3,   CDK4↑, 1,   Cyc↓, 2,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 3,   P21↑, 4,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 2,   TumCCA↑, 20,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 3,   EMT↓, 3,   ERK↓, 1,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 3,   FOXM1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   Let-7↑, 2,   mTOR↓, 4,   NOTCH↓, 1,   NOTCH1↑, 1,   P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 3,   STAT3↓, 10,   STAT3↝, 1,   TOP1↓, 4,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 9,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   CA↓, 1,   Ca+2↑, 3,   cal2↓, 1,   E-cadherin↑, 3,   FAK↓, 1,   Ki-67↓, 2,   MALAT1↓, 1,   miR-200b↑, 1,   MMP1↓, 1,   MMP2?, 1,   MMP2↓, 6,   MMP9?, 1,   MMP9↓, 10,   MMPs↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   TET1↑, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TIMP3↑, 1,   TSP-1↑, 1,   TumCI↓, 14,   TumCMig↓, 11,   TumCP↓, 16,   TumCP↑, 1,   TumMeta↓, 19,   Vim↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 47,   angioG↑, 1,   EPR↑, 6,   HIF-1↓, 2,   Hif1a↓, 7,   p‑PDGFR-BB↓, 1,   VEGF↓, 21,   VEGFR2↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   P-gp↓, 2,   P-gp↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   COX2↓, 5,   CXCR4↓, 4,   IKKα↓, 1,   IL1↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 3,   Imm↝, 1,   Inflam↓, 6,   Inflam↝, 1,   JAK2↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 13,   NF-kB↑, 2,   NF-kB↝, 1,   NK cell↑, 1,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 1,   CDK6↑, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 10,   BioEnh↑, 1,   ChemoSen↑, 22,   DDS↑, 4,   Dose↑, 1,   Dose↝, 5,   Dose∅, 2,   eff↓, 3,   eff↑, 30,   eff↝, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life∅, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 7,   selectivity↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AFP↑, 1,   AR↓, 2,   ascitic↓, 1,   FOXM1↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiTum↑, 4,   CardioT↑, 2,   chemoP↑, 2,   chemoPv↑, 4,   hepatoP↓, 1,   hepatoP↑, 2,   NDRG1↑, 1,   neuroP↑, 1,   OS↑, 1,   Pain↓, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity↑, 1,   TumVol↓, 4,   TumW↓, 2,  
Total Targets: 252

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 8,   Catalase↑, 6,   GPx↑, 4,   GSH↑, 2,   GSR↑, 2,   HNE↓, 1,   lipid-P↓, 4,   MDA↓, 1,   NOX4↓, 1,   NRF2↑, 3,   ROS↓, 9,   ROS∅, 1,   SAM-e↑, 1,   SOD↑, 7,   TOS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↝, 1,   MMP↑, 1,   MMP∅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   LDH↓, 1,   NAD↝, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 2,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 2,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Ca+2↓, 1,   Ca+2↝, 2,   COL1↑, 1,   MMP3↓, 1,   MMP9↓, 1,   serineP↓, 1,   TGF-β↑, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   NO↓, 1,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2↓, 4,   CRP↓, 1,   CXCR4↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 3,   IL6↓, 4,   Imm↑, 2,   Inflam↓, 11,   JAK2↓, 1,   NF-kB↓, 2,   PGE2↓, 3,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 5,   TNF-α↑, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   GABA↑, 1,   GABA↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioEnh↑, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 1,   eff↑, 3,   eff↝, 1,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BMD↑, 2,   BMPs↑, 1,   Calcium↑, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 4,   LDH↓, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 3,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 2,   neuroP↑, 7,   Obesity↓, 2,   Pain↓, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 5,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 122

Scientific Paper Hit Count for: angioG, angiogenesis
14 Magnetic Fields
14 Thymoquinone
11 Curcumin
11 Chrysin
9 Sulforaphane (mainly Broccoli)
9 Silymarin (Milk Thistle) silibinin
8 Artemisinin
8 Propolis -bee glue
8 Copper and Cu NanoParticles
8 Resveratrol
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Cinnamon
7 Eugenol
7 Nimbolide
7 Quercetin
6 Capsaicin
6 Fisetin
5 Apigenin (mainly Parsley)
5 Berberine
5 chitosan
5 Ellagic acid
5 EGCG (Epigallocatechin Gallate)
5 Selenite (Sodium)
4 Silver-NanoParticles
4 immunotherapy
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Rosmarinic acid
4 Celastrol
4 D-limonene
4 Disulfiram
4 Radiotherapy/Radiation
4 Luteolin
4 Magnolol
4 Phenethyl isothiocyanate
3 Carvacrol
3 Chlorogenic acid
3 Hydroxycinnamic-acid
3 Coenzyme Q10
3 Crocetin
3 Dichloroacetate
3 Gambogic Acid
3 Lycopene
3 Piperlongumine
3 tetrathiomolybdate
2 3-bromopyruvate
2 chemodynamic therapy
2 Allicin (mainly Garlic)
2 Alpha-Lipoic-Acid
2 Chemotherapy
2 beta-glucans
2 Baicalein
2 Boron
2 Caffeic acid
2 Carnosic acid
2 Carica papaya leaf extract
2 Cucurbitacin
2 Deguelin
2 Diclofenac
2 Dipyridamole
2 Dandelion Root
2 Fucoidan
2 Ferulic acid
2 Honokiol
2 HydroxyTyrosol
2 itraconazole
2 metronomic chemo
2 Naringin
2 Piperine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Selenium
2 Selenium NanoParticles
2 Ursolic acid
1 Auranofin
1 Astragalus
1 Andrographis
1 Anethole/trans-Anethole
1 Aspirin
1 Ascorbyl Palmitate
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 borneol
1 urea
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Carnosine
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chocolate
1 Metformin
1 Citric Acid
1 Vitamin E
1 diet FMD Fasting Mimicking Diet
1 Zinc
1 Echinacea
1 Emodin
1 Electrical Pulses
1 flavonoids
1 Gallic acid
1 Ginkgo biloba
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 Juglone
1 Melatonin
1 Magnetic Field Rotating
1 Neem
1 Oroxylin-A
1 Oleuropein
1 Oleocanthal
1 Oregano
1 Phenylbutyrate
1 Plumbagin
1 Psoralidin
1 Ramucirumab (CYRAMZA)
1 Salvia officinalis
1 salinomycin
1 Shikonin
1 Theobromine
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:447  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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