PCNA Cancer Research Results

PCNA, Proliferating Cell Nuclear Antigen: Click to Expand ⟱
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Type:
Proliferating Cell Nuclear Antigen (PCNA) is a protein that plays a crucial role in DNA replication and repair. It acts as a processivity factor for DNA polymerase, helping to increase the efficiency of DNA synthesis. PCNA is also involved in various cellular processes, including cell cycle regulation, DNA damage response, and chromatin remodeling.
PCNA is often overexpressed in many types of tumors. This overexpression is associated with increased cell proliferation, which is a hallmark of cancer. The elevated levels of PCNA can serve as a biomarker for tumor growth and progression.
PCNA is called the “ringmaster of the genome” : it regulates the cell cycle and participates in DNA synthesis. PCNA is widely used as a cell proliferation marker in both healthy and malignant tissues.
Scientific Papers found: Click to Expand⟱
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
8599- FSO,    Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action
- in-vivo, CRC, NA
other↝, PCNA↓, AntiCan↑, toxicity↓, TumCP↓,
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, *PCNA↑, *SOD↑, *lipid-P↓, *NRF2↑, *Keap1↓, *chemoP↑,
1065- GA,    Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression
- vitro+vivo, Pca, NA
tumCV↓, MMP↓, DNAdam↑, HDAC1↓, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE1↓, P21↑, TumVol↓,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
6573- Ger,    Systematic elucidation of the mechanism of geraniol via network pharmacology
- Study, Nor, NA - Study, Var, NA
HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,
7201- GGB,    Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway
- vitro+vivo, GC, AGS - in-vitro, GC, HGC27
TumCI↓, TumCMig↓, Apoptosis↑, Pyro↑, BAX↑, GSDMD↑, Bcl-2↓, TumCG↓, EMT↓, PCNA↓, N-cadherin↓, E-cadherin↑, PI3K↓, Akt↓, mTOR↓, Dose↝,
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
7680- iod,  doxoR,    Iodine and doxorubicin, a good combination for mammary cancer treatment: antineoplastic adjuvancy, chemoresistance inhibition, and cardioprotection
- vitro+vivo, BC, NA
antiNeop↑, antiOx↑, Dose↝, TumVol↓, PCNA↓, Weight↑, cardioP↑, ChemoSen↑,
7728- IP6,    G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6)
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HT-29
AntiCan↑, TumCCA↑, Ki-67↓, PCNA↓,
7712- IP6,    Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice
- in-vivo, Pca, NA
toxicity↓, PCNA↓, TumCG↓, TumCP↓, Apoptosis↑, Risk↓,
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
8289- LE,  Cisplatin,    Effects of Glycyrrhizin in a Mouse Model of Lung Adenocarcinoma
- vitro+vivo, Lung, NA
TBXAS1/TxAS↓, PCNA↓, Weight?, RenoP↑, hepatoP↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8298- lign,    Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer
- in-vitro, BC, MDA-MB-231
Risk↓, TumCP↓, Ki-67↓, PCNA↓, FOXM1↓, TumCCA↑, cycE/CCNE↓, cycA1/CCNA1↓, CycB/CCNB1↓, FAK↓, pax↓, TumCMig↓, TumCI↓,
6481- LIN,    Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis
- in-vivo, Pca, 22Rv1
TumCP↓, Apoptosis↑, Ki-67↓, PCNA↓, TumCCA↑, MMP↓, TumCG↓,
8385- LT,    Luteolin regulates pyroptosis of triple-negative breast cancer cells through AKT signaling
- vitro+vivo, BC, MDA-MB-231
Pyro↑, Akt↓, GSDMD↑, NLRP3↑, IL1β↓, IL6↓, TNF-α↓, PCNA↓, Ki-67↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,
3276- Lyco,    Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma
- in-vivo, HCC, NA
G6PD↓, PCNA↓, cycD1/CCND1↓, P21↑, Hif1a↓, Glycolysis↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
8416- Lyco,    Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *Dose↝, *Aβ42↓, *IL1β↓, *TNF-α↓, *MDA↓, *Ach↑, *MAOA↓, *LDH↓, *AChE↓, *NRF2↑, *5HT↑, *TGF-β1↑, *IL10↑, *Ki-67↓, *PCNA↓,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8518- MAG,    Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway
- in-vitro, CCA, NA
TumCG↓, TumCMig↓, TumCI↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, p‑IκB↓, p‑p65↓, NF-kB↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8821- MCP,  Rad,    Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
Gal-3↓, TumCP↓, angioG↓, Apoptosis↑, RadioS?, BAX↓, DNArepair↓, PCNA↓, TumCI↓, TumCCA↑, ROS↑,
8720- MeJa,    Methyl jasmonate downregulates expression of proliferating cell nuclear antigen and induces apoptosis in human neuroblastoma cell lines
- in-vitro, neuroblastoma, SK-N-SH
PCNA↓, TumCCA↑, XIAP↓, survivin↓,
8687- MLT,    Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3
TumCP↓, TumCCA↑, Hif1a↓, NF-kB↓, Bcl-2↓, ROS↑, Akt↓, PCNA↓, cycD1/CCND1↓, BAX↓, Apoptosis?, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PI3K↓, Akt↓, P53↑, P21↑, *cardioP?, *NRF2↑, *HO-1↑, *RenoP↑, chemoP↑,
8675- MLT,    Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update
- Review, Var, NA
ChemoSen↑, TumCP↓, TumCMig↓, CSCs↓, MDR1↓, chemoP?, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Bcl-2↓, Mcl-1↓, IAP1↓, survivin↓, PCNA↓, Ki-67↓, CC(CDKs/cyclins)↓, TumCMig↓, TumCI↓, Fibronectin↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, Synergy↑, Synergy↑, OCT4↓, Nanog↓, ERCC1↓, P-gp/ABCB1↓, EMT↓, Synergy↑, ChemoSen↑,
1063- MLT,    HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
AntiCan↑, TumCMig↓, GSH↓, Casp3↑, Apoptosis↑, ROS↑, HDAC1↓, Ac-histone H3↑, PUMA↑, BAX↑, PCNA↓, Bcl-2↓,
8874- MOR,    The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives
- Review, Var, NA
AntiCan↑, selectivity↑, *ROS↓, *Inflam↓, *p‑Akt↓, *NF-kB↓, ChemoSen↑, chemoPv↑, *toxicity↓, BioAv↑, BioAv↓, MRP1/ABCC1↝, BioAv↑, PCNA↓, hepatoP↑, NF-kB↓, TNF-α↓, IL6↓, PGE2↓, MMP2↓, MMP9↓, Apoptosis↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, ROS↑, MMP↓, BAX↑, Bcl-xL↓, Casp9↑, Casp3↑, EMT↓, Akt↓, Hippo↑,
8951- mushLions,    Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL
- vitro+vivo, GC, NA
Apoptosis↑, ROS↑, selectivity↑, TumCG↓, FasL↑, TRAIL↑, PCNA↓, cycD1/CCND1↓, Casp3↑, Casp9↑, Casp8↑, Bcl-2↓, Bcl-xL↓, TumCCA↑, tumCV↓, TumVol↓, TumW↓,
8961- mushLions,    A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation
- in-vivo, CRC, NA
Apoptosis↑, TRAIL↑, TNFR 1↑, DR5↑, p‑Akt↓, p‑ERK↓, Hif1a↓, PCNA↓, NF-kB↓, TumCI↓, TumCMig↓, TumCP↓,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, Synergy↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,

Showing Research Papers: 51 to 100 of 112
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 112

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 5,   Catalase↓, 3,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 6,   GPx4↓, 1,   GSH↓, 12,   GSH↑, 4,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 2,   HO-1↓, 2,   HO-1↑, 4,   HO-1↝, 1,   lipid-P↓, 4,   lipid-P↑, 3,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 4,   NRF2↑, 7,   ROS↓, 8,   ROS↑, 49,   mt-ROS↑, 1,   SOD↓, 3,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 3,   Trx1↓, 1,   TrxR↓, 3,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 1,   CDC2↑, 1,   CDC25↓, 3,   CDC25↝, 1,   ETC↓, 2,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 2,   OCR↓, 1,   OXPHOS↓, 1,   PDH↝, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY↓, 1,   ALAT↓, 1,   ALDOB↑, 1,   AMPK↑, 4,   ATP↓, 4,   mt-ATP↓, 1,   ENO3↑, 1,   FASN↓, 2,   FBP1↑, 1,   G6PD↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 7,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 5,   HK2↓, 4,   HK3↑, 1,   lactateProd↓, 1,   LDL↓, 1,   PCK1↓, 1,   PCK1↑, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PGK2↑, 1,   PGM1↑, 1,   PGM3↑, 1,   PKLR↑, 1,   SIRT1↓, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 49,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↑, 3,   Bak↑, 2,   BAX↓, 3,   BAX↑, 42,   BAX⇅, 1,   Bax:Bcl2↑, 6,   Bcl-2↓, 49,   Bcl-2↑, 2,   Bcl-xL↓, 8,   BIM↓, 1,   BIM↑, 2,   Casp↓, 1,   Casp↑, 6,   Casp1↓, 1,   cl‑Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 38,   cl‑Casp3↑, 12,   Casp7↑, 6,   cl‑Casp7↑, 2,   Casp8↑, 13,   Casp9↑, 20,   cl‑Casp9↑, 7,   cFLIP↓, 2,   Cyt‑c↑, 23,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 8,   FADD↑, 3,   Fas↑, 6,   FasL↑, 4,   Ferroptosis↑, 1,   GSDMD↑, 2,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 5,   Mcl-1↓, 4,   Mcl-1↑, 1,   MDM2↓, 3,   MDM2↑, 1,   p‑MDM2↓, 2,   p38↓, 1,   p38↑, 4,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↑, 2,   Pyro↑, 2,   survivin↓, 17,   TNFR 1↑, 1,   TRAIL↑, 2,   TumCD↑, 3,   XIAP↓, 8,   XIAP↑, 1,   YAP/TEAD↓, 2,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 38,   p‑Akt↓, 6,   p‑Akt↑, 1,   AKT1↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   cMET↓, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 7,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 12,   p‑ERK↓, 6,   p‑ERK↑, 1,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↑, 1,   HRAS↓, 1,   IGFR↓, 1,   IKKα↓, 4,   ILK↓, 1,   p‑IκB↓, 1,   JAK1↓, 3,   JAK2↓, 3,   JNK↓, 2,   JNK↑, 6,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 10,   MAPK↑, 1,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 15,   p‑mTOR↓, 1,   mTORC2↓, 3,   p‑p70S6↑, 1,   P90RSK↓, 1,   PHKG1↑, 1,   PI3K↓, 28,   PI3K↑, 1,   p‑PI3K↓, 1,   PKCδ↓, 4,   PTEN↓, 1,   PTEN↑, 3,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 2,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT3↓, 20,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF4↑, 2,   CBP↑, 1,   cJun↓, 1,   cJun↑, 2,   cMyc↓, 19,   DNMT1↓, 1,   DNMTs↓, 2,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO3↑, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   H3K9↓, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 4,   HDAC2↓, 3,   HDAC3↓, 1,   HMTs↓, 1,   miR-200c↑, 1,   miR-320a↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-590-3p↑, 1,   OCT4↓, 6,   other↝, 3,   PAX2↓, 1,   PCAF↓, 1,   SOX2↓, 6,   SOX4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   cl‑CHOP/DDIT3↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 10,   GRP78/BiP↑, 2,   HSP90↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 5,   LC3s↑, 1,   p62↓, 2,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA2↓, 1,   CUL4B↑, 1,   DNAdam↓, 1,   DNAdam↑, 20,   DNArepair↓, 2,   ERCC1↓, 2,   ERCC4/XPF↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   MSH2↑, 1,   p16↑, 1,   P53↓, 3,   P53↑, 30,   p‑P53↑, 2,   PARP↑, 6,   cl‑PARP↑, 17,   PARP1↑, 1,   PCNA↓, 104,   PCNA↑, 1,   PCNA↝, 1,   RAD51↓, 1,   SIRT6↓, 1,   SMG1↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 2,   TRF2↓, 1,   γH2AX↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↝, 1,   CDK2↓, 17,   CDK2↑, 1,   CDK4↓, 14,   CDK4/6↓, 1,   CDK6↓, 4,   CDK8↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   CHK1↑, 1,   CHK1↝, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 1,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 43,   cycE/CCNE↓, 11,   cycE1↓, 1,   cycF↓, 1,   E2Fs↓, 2,   GADD45A↓, 1,   Ki-67↓, 32,   Ki-67↑, 1,   MAD↓, 1,   P21?, 2,   P21↓, 1,   P21↑, 26,   p27/CDKN1B↑, 10,   pRB↑, 2,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 1,   TumCCA↑, 50,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 3,   CD34↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 9,   CSCsMark↓, 1,   EIF4E↓, 1,   EP300↑, 1,   HH↓, 1,   IGF-1↓, 1,   Ki-67↓, 32,   Ki-67↑, 1,   MCM2↓, 1,   mTORC1↓, 3,   Nanog↓, 4,   Nestin↓, 1,   NF2↑, 1,   NOTCH↓, 4,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 1,   NOTCH3↓, 2,   p300↓, 1,   circ‑PLEKHM3↑, 1,   SCF↓, 1,   Shh↓, 1,   TumCG↓, 24,   TumCG↑, 1,   TumCP↓, 46,   Wnt↓, 6,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 8,   cal2↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   Cdc42↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 17,   EMT↓, 21,   EMT↝, 1,   EpCAM↓, 1,   FAK↓, 5,   p‑FAK↓, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 29,   MMP3↓, 1,   MMP7↓, 6,   MMP9↓, 26,   MMP9↑, 1,   MMPs↓, 4,   N-cadherin↓, 16,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   pax↓, 2,   PDGF↓, 3,   Rac1↓, 2,   Rho↓, 4,   ROCK1↓, 1,   Slug↓, 3,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail↓, 9,   TGF-β↓, 5,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↑, 7,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 23,   TumCMig↓, 24,   TumMeta↓, 22,   TumMeta↑, 2,   Twist↓, 4,   Tyro3↓, 1,   uPA↓, 10,   Vim↓, 11,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 11,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 19,   LOX1↓, 1,   NO↓, 1,   TBXAS1/TxAS↓, 1,   VEGF↓, 29,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 2,   CLDN2↓, 1,   GLUT1↓, 2,   IBI↑, 1,   MMP↓, 31,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 25,   CXCL12↓, 1,   CXCR4↓, 3,   DR4↑, 2,   Gal-3↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 2,   IL10↑, 1,   IL1β↓, 6,   IL2↑, 4,   IL4↑, 2,   IL5↓, 1,   IL6↓, 18,   IL8↓, 5,   Inflam↓, 9,   Inflam↝, 1,   MDSCs↓, 1,   NF-kB↓, 43,   NF-kB↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 4,   p‑p65↓, 2,   PD-1↓, 2,   PD-L1↓, 1,   PGE2↓, 7,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   TNF-α↓, 14,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 3,   AR-V7?, 1,   CYP19?, 1,   GR↑, 1,   cl‑PPARα↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 9,   ChemoSen↑, 33,   CYP1A1↓, 3,   CYP3A4↓, 1,   Dose↑, 2,   Dose↝, 13,   Dose∅, 1,   eff↓, 4,   eff↑, 9,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 4,   Half-Life↝, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 6,   RadioS?, 1,   RadioS↑, 4,   selectivity↓, 1,   selectivity↑, 20,   Synergy↑, 22,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 1,   ALP↓, 2,   AR↓, 3,   AST↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EGFR↑, 1,   p‑EGFR↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 18,   LDH↓, 5,   LDH↑, 1,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 17,   AntiCan∅, 1,   antiNeop↑, 2,   AntiTum↑, 4,   cachexia↓, 2,   cardioP↑, 4,   chemoP?, 1,   chemoP↑, 9,   chemoPv↑, 6,   ChemoSideEff↓, 1,   hepatoP↑, 6,   K17↓, 1,   neuroP↑, 4,   OS↑, 6,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 8,   TGFβR1↑, 1,   toxicity↓, 6,   toxicity↝, 1,   TumNum↓, 1,   TumVol↓, 11,   TumW↓, 5,   Weight?, 1,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,  
Total Targets: 577

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 19,   Catalase↓, 1,   Catalase↑, 8,   GPx↓, 1,   GPx↑, 9,   GSH↑, 9,   GSR↑, 2,   GSTs↑, 3,   H2O2↓, 1,   HDL↑, 1,   HO-1?, 1,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 10,   MDA↓, 7,   MPO↓, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 10,   ROS↓, 24,   SOD↑, 14,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 2,   ATP↓, 1,   ATP↑, 1,   FASN↓, 1,   glucose↓, 1,   lipidLev↓, 1,   NAD↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp↓, 1,   Casp3↓, 3,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 1,   GSDMD↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   CREB↑, 1,   ERK↑, 1,   IκB?, 1,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 2,   PTEN↑, 1,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   HDAC2↓, 1,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 2,   PCNA↓, 5,   PCNA↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   TGF-β↓, 1,   TGF-β1↑, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   CD31/PECAM-1↓, 1,   eNOS↑, 1,   Hif1a↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2?, 1,   COX2/PTGS2↓, 5,   Eos↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↓, 2,   IL10↑, 2,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 8,   IL22↓, 1,   IL6↓, 10,   IL8↓, 4,   Imm↓, 1,   Inflam↓, 26,   Inflam↑, 1,   NF-kB↓, 11,   PGE2↓, 3,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 3,   AChE↑, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   Aβ42↓, 1,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   Estro↓, 1,   GR↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 2,   BioAv↝, 3,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 4,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 2,   AST↓, 5,   BP↓, 2,   creat↓, 1,   IL6↓, 10,   LDH↓, 3,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 4,   cardioP?, 1,   cardioP↑, 10,   cardioP⇅, 1,   chemoP↑, 1,   chemoPv↑, 3,   cognitive↑, 1,   diuretic↑, 1,   hepatoP↑, 8,   Learn↑, 1,   memory↑, 4,   neuroP↑, 15,   Obesity↓, 1,   RenoP↑, 2,   Stroke↓, 2,   toxicity↓, 7,   toxicity↝, 3,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiViral↑, 2,   Bacteria↓, 5,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 176

Scientific Paper Hit Count for: PCNA, Proliferating Cell Nuclear Antigen
6 Chrysin
4 Lycopene
4 Quercetin
3 Apigenin (mainly Parsley)
3 Benzyl isothiocyanate
3 Curcumin
3 Ellagic acid
3 phytic acid, Inositol hexakisphosphate
3 Magnolol
3 Matrine
3 Melatonin
3 Silymarin (Milk Thistle) silibinin
2 Açaí, Euterpe oleracea
2 Silver-NanoParticles
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 chaetocin
2 Propolis -bee glue
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Eugenol
2 Fisetin
2 Hibiscus sabdariffa
2 Licorice
2 Luteolin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Piperlongumine
1 Alpha-Lipoic-Acid
1 Isovitexin
1 Artemisinin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Berberine
1 Bufalin/Huachansu
1 Boron
1 Black Rice, Oryza sativa
1 Caffeic acid
1 Carvacrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Eurycomanone
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Shilajit/Fulvic Acid
1 Chemotherapy
1 Gallic acid
1 Garcinol
1 Geraniol
1 Ginkgolide B
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Honokiol
1 iodine
1 doxorubicin
1 isoorientin
1 Cisplatin
1 SDG/lignans
1 Linalool
1 Lutein
1 Modified Citrus Pectin
1 Radiotherapy/Radiation
1 Methyl Jasmonate
1 Morin
1 Pterostilbene
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 Selenium NanoParticles
1 Shikonin
1 Gemcitabine (Gemzar)
1 Terpinen-4-ol / Tea Tree Oil
1 Tomatine
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:489  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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