PCNA Cancer Research Results

PCNA, Proliferating Cell Nuclear Antigen: Click to Expand ⟱
Source:
Type:
Proliferating Cell Nuclear Antigen (PCNA) is a protein that plays a crucial role in DNA replication and repair. It acts as a processivity factor for DNA polymerase, helping to increase the efficiency of DNA synthesis. PCNA is also involved in various cellular processes, including cell cycle regulation, DNA damage response, and chromatin remodeling.
PCNA is often overexpressed in many types of tumors. This overexpression is associated with increased cell proliferation, which is a hallmark of cancer. The elevated levels of PCNA can serve as a biomarker for tumor growth and progression.
PCNA is called the “ringmaster of the genome” : it regulates the cell cycle and participates in DNA synthesis. PCNA is widely used as a cell proliferation marker in both healthy and malignant tissues.
Scientific Papers found: Click to Expand⟱
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31↓, Hif1a↓, VEGFR2↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
5102- SK,  GEM,    Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway
TumCG↓, ChemoSen↑, NF-kB↓, PCNA↓, Ki-67↓, p‑EGFR↓, ROS↑, TumCCA↑, P53↑, JNK↑, Akt↓,
139- Tomatine,  CUR,    Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells
- in-vitro, Pca, PC3
NF-kB↓, Bcl-2↓, p‑Akt↓, p‑ERK↓, TumCG↓, Apoptosis↑, PCNA↓, BioAv↓,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2↓, MMP9↓,

Showing Research Papers: 51 to 56 of 56
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 56

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↓, 1,   GSH↓, 1,   GSH↑, 1,   lipid-P↓, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MMP↓, 2,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 3,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 2,   BAX↑, 2,   Bcl-2↓, 5,   Bcl-xL↓, 2,   BIM↓, 1,   Casp↑, 1,   Casp3↑, 2,   Casp9↑, 1,   Cyt‑c↑, 2,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   Mcl-1↓, 1,   p27↑, 1,   p‑p38↓, 1,   survivin↓, 3,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

HATs↑, 1,   p‑pRB↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 4,   PCNA↓, 6,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 1,   RB1↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 2,   ERK↓, 3,   p‑ERK↓, 2,   HDAC↓, 1,   mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 2,   STAT3↓, 2,   TumCG↓, 3,   Wnt↓, 1,  

Migration ⓘ

CD31↓, 1,   E-cadherin↑, 1,   Ki-67↓, 2,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,   TumMeta↓, 2,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 1,   p‑EGFR↓, 1,   Hif1a↓, 3,   LOX1↓, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   CXCR4↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 1,   Inflam↓, 3,   JAK2↓, 1,   MDSCs↓, 1,   NF-kB↓, 4,   p65↓, 1,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   ChemoSen↑, 1,   eff↑, 3,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   p‑EGFR↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   chemoP↑, 3,   hepatoP↑, 2,   neuroP↑, 1,   radioP↑, 1,  
Total Targets: 110

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   lipid-P↓, 1,   ROS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: PCNA, Proliferating Cell Nuclear Antigen
6 Chrysin
4 Quercetin
3 Curcumin
3 Ellagic acid
3 Lycopene
3 Silymarin (Milk Thistle) silibinin
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Propolis -bee glue
2 EGCG (Epigallocatechin Gallate)
2 Fisetin
2 Magnolol
2 Piperlongumine
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Berberine
1 Bufalin/Huachansu
1 Boron
1 Shilajit/Fulvic Acid
1 Chemotherapy
1 Gallic acid
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Honokiol
1 Luteolin
1 Melatonin
1 Pterostilbene
1 Rosmarinic acid
1 Selenium NanoParticles
1 Shikonin
1 Gemcitabine (Gemzar)
1 Tomatine
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:489  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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