IronCh Cancer Research Results

IronCh, Iron Chelator: Click to Expand ⟱
Source:
Type:
Iron Chelator
Scientific Papers found: Click to Expand⟱
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
7828- Myr,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *cognitive↑, *Aβ↓, *ADAM10↑, *BACE/β-secretase↝, *IronCh↑, *Iron↓, *AChE↓, *ROS↓,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
*antiOx↑, *lipid-P↓, *TNF-α↓, *NF-kB↓, *COX2/PTGS2↓, *IronCh↑, P53↓, TumCCA↑, HSPs↓, P21↓, RAS↓, ER(estro)↑, OS?,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, eff↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
3038- RosA,    Prooxidant action of rosmarinic acid: transition metal-dependent generation of reactive oxygen species
- in-vitro, Nor, NA
IronCh↑, ROS↑,
3618- RosA,    Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
- Review, AD, NA
*hepatoP↑, *antiOx↑, *angioG↓, *other↓, *Inflam↓, *ROS↓, *IronCh↑, *lipid-P↓, *antiOx↑,
6046- SeNPs,  CGA,    Anti-amyloidogenic properties of 5‑caffeoylquinic acid-capped selenium nanoparticles
- Study, AD, NA
*AChE↓, *BChE↓, *Aβ↓, *eff↑, *BBB↑, *Dose↝, *IronCh↑, *antiOx↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3295- SIL,    Hepatoprotective effect of silymarin
- Review, NA, NA
*hepatoP↑, *ROS↓, *GSH↑, *BioAv↝, ERK↓, NF-kB↓, STAT3↓, COX2/PTGS2↓, Inflam↓, IronCh↑, lipid-P↓, ALAT↓, AST↓, TNF-α↓, *α-SMA↓, *SOD↑,
3291- SIL,    Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
- Review, Nor, NA
*antiOx↑, *ROS↓, *cardioP↑, *BioAv↓, *Half-Life↝, *other↑, IronCh↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,

Showing Research Papers: 51 to 66 of 66
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 66

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

H2O2↑, 1,   HO-1↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↑, 6,   i-ROS↑, 1,   SOD↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   BOK↑, 1,   CDC2↓, 1,   MMP↓, 3,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   ALAT↓, 1,   cMyc↓, 2,   p‑cMyc↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 1,   APAF1↑, 1,   Apoptosis↑, 2,   BAD↑, 1,   BAX↑, 6,   Bcl-2↓, 3,   BID↑, 1,   cl‑Casp12↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 3,   DR5↓, 1,   DR5↑, 2,   FADD↑, 1,   Fas↑, 1,   hTERT/TERT↓, 2,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   NAIP↓, 1,   NICD↓, 1,   p27/CDKN1B↑, 1,   survivin↓, 2,   Telomerase↓, 2,   YAP/TEAD↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   ER Stress↑, 3,   HSPs↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   P53↓, 1,   P53↑, 2,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 3,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 2,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   ERK↓, 4,   Gli1↓, 1,   p‑GSK‐3β↓, 1,   HDAC2↓, 1,   mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 4,   p‑PI3K↑, 1,   RAS↓, 2,   STAT3↓, 2,   TAZ↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AEG1↓, 1,   Akt2↓, 1,   Ca+2↑, 4,   E-cadherin↑, 3,   MARK4↓, 1,   miR-155↓, 1,   MMP2↓, 2,   MMP9↓, 3,   N-cadherin↓, 3,   PKCδ↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCMig↓, 1,   TumCP↓, 3,   Vim↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   ATF4↑, 1,   HIF-1↑, 1,   Hif1a↓, 2,   VEGF↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CXCR4↓, 1,   IFN-γ↓, 1,   Inflam↓, 1,   NF-kB↓, 3,   p‑NF-kB↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   ChemoSen↑, 3,   eff↑, 1,   MDR1↓, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 1,   AST↓, 1,   hTERT/TERT↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   OS?, 1,   radioP↑, 1,   RenoP↑, 1,  
Total Targets: 136

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Catalase↑, 3,   Fenton↓, 1,   Ferroptosis↓, 1,   GPx↑, 3,   GPx4↑, 1,   GSH↑, 6,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   Iron↓, 2,   lipid-P↓, 4,   MDA↓, 2,   MDA↑, 1,   NADH↓, 1,   NRF2↑, 4,   RNS↓, 1,   ROS↓, 11,   ROS↑, 1,   SOD↑, 6,   Trx↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 10,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   FASN↓, 1,   LDHA↑, 1,   LDL↓, 1,   NADPH↓, 1,   SIRT2↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 2,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 5,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   ADAM10↑, 1,   BChE↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 4,   BioAv↝, 3,   Dose↝, 2,   eff↑, 2,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   IL6↓, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 3,   CardioT↓, 1,   cognitive↑, 2,   hepatoP↑, 4,   neuroP↑, 3,   Obesity↓, 1,   RenoP↑, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 76

Scientific Paper Hit Count for: IronCh, Iron Chelator
17 Alpha-Lipoic-Acid
9 Curcumin
7 Carnosine
5 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
4 Ferulic acid
4 Quercetin
4 Rosmarinic acid
3 Silymarin (Milk Thistle) silibinin
2 Chlorogenic acid
2 EGCG (Epigallocatechin Gallate)
2 Luteolin
1 Bacopa monnieri
1 Boron
1 buckwheat sprouts
1 Chlorophyllin
1 Vitamin C (Ascorbic Acid)
1 Silver-NanoParticles
1 Aflavin-3,3′-digallate
1 Huperzine A/Huperzia serrata
1 Inositol
1 isoquercitrin
1 Myricetin
1 Mung Bean Sprouts
1 Selenium NanoParticles
1 Thymol-Thymus vulgaris
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:835  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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