IronCh Cancer Research Results

IronCh, Iron Chelator: Click to Expand ⟱
Source:
Type:
Iron Chelator
Scientific Papers found: Click to Expand⟱
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
3038- RosA,    Prooxidant action of rosmarinic acid: transition metal-dependent generation of reactive oxygen species
- in-vitro, Nor, NA
IronCh↑, ROS↑,
6046- SeNPs,  CGA,    Anti-amyloidogenic properties of 5‑caffeoylquinic acid-capped selenium nanoparticles
- Study, AD, NA
*AChE↓, *BChE↓, *Aβ↓, *eff↑, *BBB↑, *Dose↝, *IronCh↑, *antiOx↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3295- SIL,    Hepatoprotective effect of silymarin
- Review, NA, NA
*hepatoP↑, *ROS↓, *GSH↑, *BioAv↝, ERK↓, NF-kB↓, STAT3↓, COX2↓, Inflam↓, IronCh↑, lipid-P↓, ALAT↓, AST↓, TNF-α↓, *α-SMA↓, *SOD↑,
3291- SIL,    Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
- Review, Nor, NA
*antiOx↑, *ROS↓, *cardioP↑, *BioAv↓, *Half-Life↝, *other↑, IronCh↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,

Showing Research Papers: 51 to 58 of 58
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 58

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

H2O2↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   ROS↑, 2,   i-ROS↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 4,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

APAF1↑, 1,   Apoptosis↑, 2,   BAX↑, 3,   Bcl-2↓, 2,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 2,   Gli1↓, 1,   HDAC2↓, 1,   p‑PI3K↑, 1,   STAT3↓, 1,  

Migration ⓘ

Ca+2↑, 2,   E-cadherin↑, 1,   MARK4↓, 1,   miR-155↓, 1,   MMP2↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   PKCδ↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   radioP↑, 1,   RenoP↑, 1,  
Total Targets: 52

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 2,   Ferroptosis↓, 1,   GPx↑, 3,   GPx4↑, 1,   GSH↑, 3,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   Iron↓, 1,   MDA↓, 1,   NADH↓, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 5,   ROS↑, 1,   SOD↑, 4,   Trx↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 4,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↓, 1,   LDL↓, 1,   NADPH↓, 1,   SIRT2↑, 1,  

Cell Death ⓘ

Ferroptosis↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

Migration ⓘ

AntiAg↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 1,   Imm↑, 1,   Inflam↓, 2,   NF-kB↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BChE↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 3,   Dose↝, 2,   eff↑, 2,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

BP↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   CardioT↓, 1,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↑, 1,   Obesity↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 59

Scientific Paper Hit Count for: IronCh, Iron Chelator
17 Alpha-Lipoic-Acid
9 Curcumin
7 Carnosine
4 Ferulic acid
4 Quercetin
4 Rosmarinic acid
3 Silymarin (Milk Thistle) silibinin
2 Chlorogenic acid
2 EGCG (Epigallocatechin Gallate)
2 Luteolin
1 Bacopa monnieri
1 Boron
1 Chlorophyllin
1 Vitamin C (Ascorbic Acid)
1 Silver-NanoParticles
1 Aflavin-3,3′-digallate
1 Huperzine A/Huperzia serrata
1 Selenium NanoParticles
1 Thymol-Thymus vulgaris
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:835  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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