TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
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Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
5213- PI,    Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation
- in-vitro, Cerv, HeLa
Apoptosis↑, TumCG↓, ROS↑, MMP↓, DNAdam↑, Casp3↑, TumCCA↑, *Inflam↓, *antiOx↓, *hepatoP↑, ChemoSen↑, CSCs↓,
2649- PL,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
AntiCan↑, ROS↑, GSH↓, TrxR↓, Trx↓, Apoptosis↑, TumCCA↑, ER Stress↑, DNAdam↑, ChemoSen↑, BioAv↓,
2957- PL,    Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells
- in-vitro, BC, MCF7
TumCP↓, TumCMig↓, TumCCA↑, ROS↑, H2O2↑, GSH↓, IKKα↓, NF-kB↓, P21↑, eff↓,
2942- PL,    Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
- in-vitro, CRC, CT26 - in-vitro, CRC, DLD1 - in-vivo, CRC, CT26
ROS↑, GSH↓, TrxR↓, RadioS↑, DNAdam↑, TumCCA↑, mitResp↓, GSTs↓, OS↑,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2947- PL,    Piperlongumine: the amazing amide alkaloid from Piper in the treatment of breast cancer
- Review, Var, NA
TumCP↓, Apoptosis↑, TumCCA↑, ROS↑,
2952- PL,    Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization
- in-vitro, Bladder, T24/HTB-9 - in-vivo, Bladder, NA
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, ROS↑, Slug↓, β-catenin/ZEB1↓, Zeb1↓, N-cadherin↓, F-actin↓, GSH↓, EMT↓, CLDN1↓, ZO-1↓,
1947- PL,    Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, NA
TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,
1942- PL,    Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines
- in-vitro, BC, MCF7
ROS↑, SOD1↑, Trx1↓, Catalase↓, PrxII↓, ROS↑, GADD45A↑, P21↑, DNAdam↑, TumCCA↑,
1944- PL,    Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress
- in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
ER Stress↑, TrxR1↓, ROS↑, eff↓, Bcl-2↓, proCasp3↓, BAX↓, cl‑Casp3↑, TumCCA↑, p‑PERK↑, ATF4↑, TumCG↓, lipid-P↑, selectivity↑,
1945- PL,  SANG,    The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer
- in-vitro, Lung, A549
toxicity∅, Apoptosis↑, TumMeta↓, ROS↑, TumCCA↑,
1948- PL,  BNL,    Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy
- in-vitro, GBM, NA
selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, Synergy↑,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
1953- PL,    Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation
- in-vitro, Lung, A549 - in-vitro, Nor, WI38
ROS↑, selectivity↑, TrxR↓, TumCCA↑, GSH?, H2O2↑,
1951- PL,    Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation
- in-vitro, Lung, A549
ROS↑, lipid-P↑, MMP↓, TumCCA↑, TrxR↓, eff↑,
5160- PLB,  VitK3,    Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
- in-vitro, Melanoma, U266
STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,
5163- PLB,    Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCP↓, NRF2↓, TumCCA↑, EMT↓, CSCs↓, eff↓, ROS↑, CycB/CCNB1↓, CDK1↓, CDK2↓, CDC25↓, Vim↓, OCT4↓, SOX2↓, Nanog↓, BMI1↓, NQO1↓, GSTA1↓, HSP90↓, toxicity↓,
5162- PLB,    Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
- vitro+vivo, Melanoma, A172
TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27/CDKN1B↑, P53↑, Casp9↑, Casp3↑,
2651- PLB,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, TrxR↓, GSR↓, ER Stress↓, TumCCA↑, MMP↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MKP1↓, MKP2↓, ChemoSen↑,
4967- PSO,    Psoralidin's Anti-Cancer Mechanisms: A Technical Guide
- Review, Var, NA
NF-kB↓, PI3K↓, Akt↓, ITGB1↓, FAK↓, BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, DR5↑, TumCCA↑, TumAuto↑, TumMeta↓,
1991- PTL,    A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability
- in-vitro, Liver, HUH7
TumCCA↑, Apoptosis↑, CSCs↓, ROS↑, OXPHOS↓, MMP↓, SLC25A1↓, IDH2↓,
1992- PTL,    Parthenolide induces ROS-dependent cell death in human gastric cancer cell
- in-vitro, BC, MGC803
TumCCA↑, Casp↑, Apoptosis↑, Necroptosis↑, RIP1↓, RIP3↑, MLKL↑, ROS↑, eff↓,
1994- PTL,    Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells
- in-vitro, Melanoma, A2058 - in-vitro, Nor, L929
tumCV↓, selectivity?, ROS?, BAX↑, TumCCA?, MMP2↓, MMP9↓, TumCMig↓, Synergy↑,
1238- PTS,    Pterostilbene suppresses gastric cancer proliferation and metastasis by inhibiting oncogenic JAK2/STAT3 signaling: In vitro and in vivo therapeutic intervention
- in-vitro, GC, NA - in-vivo, NA, NA
TumCCA↑, TumCP↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, Weight∅, JAK2↓, STAT3↓,
4693- PTS,    Pterostilbene in the treatment of inflammatory and oncological diseases
- Review, Var, NA
BioAv↑, *Inflam↓, *antiOx↑, AntiTum↑, BBB↑, Half-Life↝, *ROS↓, *NRF2↑, *NQO1↑, *HO-1↑, PTEN↑, miR-19b↓, TumCCA↑, ER Stress↑, PERK↑, ATF4↑, CHOP/DDIT3↑, Ca+2↝, EMT↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑, ChemoSen↑, toxicity∅, toxicity↝,
4697- PTS,    Pterostilbene and cancer: current review
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumMeta↑, toxicity↓, BioAv↑,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
- Review, Var, NA
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
4692- PTS,    Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol
- in-vitro, Cerv, HeLa
TumCG↓, TumMeta↓, TumCCA↑, ROS↑, Apoptosis↑, MMP2↓, MMP9↓, CD133↓, OCT4↓, SOX2↓, Nanog↓, STAT3↓, CSCs↓,
4689- PTS,    Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol
- in-vitro, Cerv, HeLa
eff↑, TumCCA↑, ROS↑, MMP2↓, MMP9↓, CSCs↓, CD133↓, OCT4↓, SOX2↓, Nanog↓, STAT3↓, BioAv↑, TumCI↓, ROS↑, Apoptosis↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
*antiOx↑, *lipid-P↓, *TNF-α↓, *NF-kB↓, *COX2/PTGS2↓, *IronCh↑, P53↓, TumCCA↑, HSPs↓, P21↓, RAS↓, ER(estro)↑, OS?,
3346- QC,    Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
TumCCA↑, Apoptosis↑, P53↑, TumCP↓, ROS↓, antiOx↑, HO-1↑, CDK1↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3372- QC,  FIS,  KAE,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2/PTGS2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
3371- QC,    Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways
- in-vitro, GBM, T98G
TIMP2↑, TumCG↓, TumCMig↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, Bax:Bcl2↑, cl‑Casp9↑, cl‑Casp3↑, DNAdam↑, γH2AX↑, MGMT↓, cl‑PARP↑,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
58- QC,  doxoR,    Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin
- in-vitro, CRC, HT-29 - in-vitro, NA, CD133+
Bcl-2↓, TumCCA↑, CD133↓, CSCs↓, ChemoSen↑, CycB/CCNB1↑, cycE/CCNE↓, cycD1/CCND1↓, E2Fs↓,
59- QC,    Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)
- in-vitro, BC, MDA-MB-231
ALDH1A1↓, CXCR4↓, MUC1↓, EpCAM↓, CSCs↓, TumCP↓, TumCI↓, CD44↓, CD24↓, Apoptosis↑, TumCCA↑,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2/KDR/Flk1↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP/DDIT3↑,
36- QC,    Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in HPV-positive human cervical cancer-derived cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa
P53↑, P21↑, BAX↑, Casp3↑, Casp7↑, TumCCA↑, ROS↑, TumCCA↑, Apoptosis↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, Var, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
40- QC,    Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells
- in-vitro, lymphoma, U937
cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, CycB/CCNB1↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓,
54- QC,    Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways
- in-vitro, BC, MCF7
EMT↓, E-cadherin↑, Vim↓, MMP2↓, NOTCH1↓, PI3K/Akt↓, PI3k/Akt/mTOR↓, p‑Akt↓, EZH2↓, H3K27ac↓, TumCCA↑, CSCs↓, CDK1↓, CycB/CCNB1↓, Bcl-xL↓, Bcl-2↓, Nanog↓, H3↓,
45- QC,    Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1 and Survivin Expression through Wnt/β-Catenin Signaling Pathway
- in-vitro, Colon, CX-1 - in-vitro, Colon, SW480 - in-vitro, Colon, HT-29 - in-vitro, Colon, HCT116
cycD1/CCND1↓, survivin↓, Wnt/(β-catenin)↓, tumCV↓, TumCCA↑, Apoptosis↑,
51- QC,    Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
- in-vitro, Ovarian, SKOV3
cycD1/CCND1↓, TumCCA↑,

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Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 6,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 14,   Catalase↑, 7,   Copper↑, 1,   DJ-1↓, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 5,   GPx1↓, 2,   GPx4↓, 20,   GPx4∅, 1,   GSH?, 1,   GSH↓, 65,   GSH↑, 10,   GSH⇅, 1,   GSH/GSSG↓, 3,   GSR↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 10,   HO-1↓, 6,   HO-1↑, 25,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 8,   Iron↝, 1,   i-Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 5,   lipid-P↑, 33,   MDA↓, 6,   MDA↑, 13,   i-MDA↑, 1,   NADH↓, 2,   mt-NADH↓, 1,   mt-NADH↑, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 4,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 34,   NRF2⇅, 1,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   Prx6↑, 1,   PrxII↓, 2,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 3,   ROS↓, 51,   ROS↑, 534,   ROS⇅, 11,   ROS↝, 4,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 9,   SOD?, 1,   SOD↓, 16,   SOD↑, 11,   SOD1↓, 2,   SOD1↑, 1,   SOD2↓, 5,   mt-SOD2↑, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 2,   TKT↓, 1,   Trx↓, 7,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 2,   ox-Trx1↑, 1,   TrxR↓, 12,   TrxR↑, 1,   TrxR1↓, 8,   TrxR1↑, 1,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 2,   IronCh↑, 3,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   BCR-ABL↓, 1,   CDC16↓, 1,   CDC2↓, 12,   p‑CDC2↓, 1,   CDC25↓, 30,   CDC25↑, 2,   CDC25↝, 1,   p‑CDC25↑, 1,   compI↓, 4,   compII↓, 2,   compIII↓, 1,   compV↓, 1,   EGF↓, 6,   EGF↑, 1,   ETC↓, 7,   HSP60/HSPD1↓, 2,   HSP60/HSPD1↑, 1,   IDH2↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↓, 3,   mtDam↑, 44,   OCR↓, 6,   OCR↑, 2,   mt-OCR↑, 1,   OXPHOS↓, 5,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PINK1↑, 1,   SIRT3↓, 3,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 5,   ACC↓, 1,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 10,   ALDOA↓, 2,   AMP↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 37,   AMPK↝, 1,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 40,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 4,   CholSyn↓, 1,   ECAR↓, 4,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   FABP4↓, 1,   FASN↓, 9,   G6PD↓, 2,   GAPDH↓, 2,   GLO-I↓, 2,   GLS↓, 2,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 18,   GlucoseCon∅, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 51,   GSK‐3β↓, 15,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 9,   H2S↑, 1,   Histones↑, 2,   HK1↓, 2,   HK2↓, 26,   HMG-CoA↓, 1,   IDH1↑, 1,   IDO1↓, 1,   lactateProd↓, 23,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 17,   LDL↓, 4,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NADPH↓, 4,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 1,   PKM1↑, 1,   PKM2↓, 21,   PKM2↑, 1,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyrim↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 2,   SCD1↓, 2,   SIRT1↓, 10,   SIRT1↑, 5,   SLC25A1↓, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   APAF1↑, 11,   Apoptosis?, 2,   Apoptosis↓, 12,   Apoptosis↑, 657,   mt-Apoptosis↑, 11,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 3,   p‑ASK1↑, 1,   BAD↓, 3,   BAD↑, 23,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 14,   BAX↓, 6,   BAX↑, 251,   BAX↝, 3,   Bax:Bcl2↑, 67,   Bcl-2↓, 276,   Bcl-2↑, 8,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 70,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 12,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 10,   BNIP3↑, 4,   BNIP3↝, 1,   BOK↑, 1,   BTG3↑, 1,   Casp↓, 4,   Casp↑, 73,   Casp↝, 2,   Casp∅, 1,   cl‑Casp↑, 3,   Casp1↓, 2,   Casp1↑, 3,   proCasp1↓, 1,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 5,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 2,   Casp3↓, 6,   Casp3↑, 295,   Casp3↝, 2,   cl‑Casp3↑, 65,   cl‑Casp3⇅, 1,   proCasp3↓, 3,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 32,   cl‑Casp7↑, 7,   Casp8↓, 3,   Casp8↑, 66,   Casp8∅, 1,   cl‑Casp8↑, 11,   proCasp8↑, 3,   Casp9↓, 2,   Casp9↑, 171,   p‑Casp9↑, 1,   cl‑Casp9↑, 21,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 8,   Cyt‑c↓, 4,   Cyt‑c↑, 162,   Cyt‑c↝, 5,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DR5↓, 1,   DR5↑, 36,   Endon↑, 2,   FADD↑, 9,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 34,   FasL↑, 18,   FasL⇅, 1,   Ferroptosis↑, 31,   GSDME↑, 1,   cl‑GSDME↑, 2,   HEY1↓, 1,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 18,   iNOS↑, 1,   Mcl-1↓, 34,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 16,   MLKL↑, 2,   MOMP↓, 1,   MOMP↑, 8,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 6,   NOXA↑, 6,   oncosis↑, 1,   P2X7↓, 1,   p38↓, 7,   p38↑, 31,   p‑p38↓, 5,   p‑p38↑, 7,   PUMA↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP1↓, 2,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 80,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 61,   TUNEL↑, 2,   XIAP?, 1,   XIAP↓, 38,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 245,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 69,   p‑Akt↑, 2,   AKT1↓, 6,   Akt2↓, 3,   AMPKα↑, 4,   BRAF↓, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 7,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERK↓, 67,   ERK↑, 18,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↑, 7,   p‑ERK⇅, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 23,   IGF-1R↓, 2,   IGFR↓, 3,   IKKα↓, 10,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 7,   JAK1?, 1,   JAK1↓, 6,   JAK1↑, 1,   p‑JAK1↓, 2,   JAK2↓, 20,   p‑JAK2↓, 5,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 42,   JNK↝, 2,   p‑JNK↓, 4,   p‑JNK↑, 5,   LATS1↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 57,   MAPK↑, 30,   MAPK↝, 4,   p‑MAPK↓, 2,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 2,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 116,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 15,   mTORC2↓, 5,   p42↓, 1,   p70S6↓, 6,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 2,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 176,   PI3K↑, 6,   PI3K↝, 2,   p‑PI3K↓, 8,   p‑PI3K↑, 1,   PI3K/Akt↓, 7,   PI3K/Akt↑, 1,   PI3k/Akt/mTOR↓, 6,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 1,   PTEN↑, 33,   p‑PTEN↓, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 17,   RET↓, 1,   RPS6KA1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 1,   Src↑, 1,   STAT↓, 5,   STAT3↓, 120,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 28,   p‑STAT3↑, 2,   STAT5↓, 4,   STAT6↓, 4,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 19,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 1,   BRD4↓, 1,   CBP↓, 3,   CBP↑, 1,   ChrMod↑, 3,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 4,   p‑cJun↑, 1,   cMyc↓, 65,   cMyc↑, 2,   DNMT1↓, 15,   DNMT1↑, 1,   DNMT3A↓, 3,   DNMT3B↓, 2,   DNMTs↓, 11,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 8,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   GATA3↓, 1,   H3↓, 2,   H3↑, 4,   p‑H3↓, 2,   p‑H3↑, 1,   ac‑H3↑, 10,   H3K27ac↓, 1,   H3K4↓, 1,   H4↑, 2,   ac‑H4↑, 7,   ac‑H4∅, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 48,   HDAC1↓, 9,   HDAC10↓, 1,   HDAC2↓, 7,   HDAC3↓, 7,   HDAC4↓, 2,   HDAC8↓, 4,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   KLF4↓, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 4,   miR-195↑, 1,   miR-199↓, 1,   miR-199↑, 1,   miR-19b↓, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-326-5p↑, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 11,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-422a↑, 2,   MTA2↓, 1,   Myc↓, 6,   Myc↑, 1,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 16,   other?, 2,   other↓, 9,   other↑, 7,   other↝, 25,   other∅, 2,   OV6↓, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 4,   PRC2↓, 1,   PRMT6↓, 1,   SBF2-AS1↓, 1,   Set9↑, 1,   sonoS↑, 1,   SOX2↓, 15,   SOX4↓, 4,   SOX4↑, 1,   SUV39H↓, 3,   TBX3↑, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 2,   tumCV↓, 152,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↑, 41,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   EDEM↑, 1,   eIF2α↓, 3,   eIF2α↑, 11,   p‑eIF2α↑, 6,   p‑eIF2α↝, 1,   ER Stress↓, 4,   ER Stress↑, 85,   ER Stress↝, 1,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 19,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 8,   HSP27↑, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↝, 1,   HSP90↓, 24,   HSP90↑, 2,   HSPs↓, 3,   IRE1↑, 4,   PDI↑, 1,   PERK↓, 1,   PERK↑, 12,   p‑PERK↑, 1,   p‑PERK↝, 1,   UPR↑, 16,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↓, 1,   ATG5↑, 11,   ATG7↑, 2,   AVOs↑, 1,   Beclin-1/ATG6↓, 6,   Beclin-1/ATG6↑, 20,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 2,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 13,   LC3s↑, 2,   LC3s↝, 1,   MitoP↓, 1,   p62↓, 9,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 4,   TumAuto↓, 4,   TumAuto↑, 84,   TumAuto⇅, 1,   TumAuto↝, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 11,   p‑ATM↑, 2,   ATR↑, 4,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↓, 6,   DNAdam↑, 160,   mt-DNAdam↑, 1,   DNArepair↓, 8,   ERCC3↑, 1,   m-FAM72A↓, 1,   G9a↓, 2,   HR↓, 1,   hTERT/TERT↓, 17,   MDMX↓, 1,   MGMT↓, 2,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 7,   P53?, 1,   P53↓, 9,   P53↑, 213,   P53↝, 3,   p‑P53↓, 2,   p‑P53↑, 5,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 9,   PARP↑, 36,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 143,   PARP1↓, 1,   PARP1↑, 5,   cl‑PARP1↑, 3,   PCNA↓, 48,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1?, 1,   TOP1↓, 8,   TOP2↓, 7,   TP53↑, 4,   TRF2↓, 2,   UHRF1↓, 2,   XRCC1↓, 1,   γH2AX↑, 26,   γH2AX↝, 1,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 45,   CDK1↑, 7,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 90,   CDK2↑, 6,   p‑CDK2↓, 1,   CDK4↓, 114,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 35,   CDK6↑, 6,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 2,   cellSen↑, 2,   CHK1↓, 4,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↑, 4,   Chk2↓, 2,   Chk2↑, 9,   p‑Chk2↑, 2,   ChrCon↑, 1,   Cyc↓, 8,   cycA1/CCNA1↓, 33,   cycA1/CCNA1↑, 5,   CycB/CCNB1↓, 74,   CycB/CCNB1↑, 10,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 220,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 4,   CycD3↑, 1,   cycE/CCNE↓, 63,   cycE/CCNE↑, 5,   cycE1↓, 4,   cycF↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   GADD45A↑, 5,   Ki-67↓, 49,   mitA↑, 4,   p19↑, 3,   P21?, 2,   P21↓, 10,   P21↑, 193,   P21↝, 1,   p27/CDKN1B↓, 7,   p27/CDKN1B↑, 75,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 5,   pRB↑, 1,   p‑pRB↓, 7,   RB1↑, 6,   p‑RB1↓, 10,   cl‑RB1↓, 1,   Securin↓, 2,   TumCCA?, 8,   TumCCA↓, 29,   TumCCA↑, 1128,   TumCCA⇅, 1,   TumCCA∅, 1,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↓, 1,   Axin2↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 3,   BMPs↑, 1,   CD133↓, 17,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 3,   CSCs?, 1,   CSCs↓, 68,   CSCs↑, 1,   Diff↓, 1,   Diff↑, 7,   EIF4E↓, 2,   EP300↑, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 12,   HH?, 1,   HH↓, 12,   HMGCR↓, 3,   IGF-1?, 1,   IGF-1↓, 12,   IGF-1↑, 1,   p‑IGF-1↓, 1,   IGFBP3↑, 4,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 49,   Let-7↑, 5,   LGR5↓, 1,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 3,   NF2↑, 1,   NKD2↑, 1,   NOTCH↓, 22,   NOTCH1↓, 17,   NOTCH1↑, 3,   NOTCH2↓, 1,   NOTCH3↓, 4,   OGFr↑, 1,   p300↓, 5,   PTCH1↓, 1,   SAL↑, 1,   SCF↓, 1,   Shh↓, 15,   Smo↓, 5,   Smo∅, 1,   STAT1↓, 1,   Sufu↑, 1,   TOPflash↓, 1,   TumCG?, 4,   TumCG↓, 244,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 396,   TumCP↑, 8,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 60,   Wnt↝, 1,   Wnt/(β-catenin)↓, 15,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

67LR↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 17,   APC↑, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 57,   Ca+2↝, 4,   i-Ca+2↑, 4,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCN2/CTGF↓, 2,   CD11b↑, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1↓, 1,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 12,   E-cadherin↑, 58,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 104,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 6,   F-actin↓, 2,   FAK↓, 19,   FAK↑, 1,   p‑FAK↓, 7,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 2,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 2,   KRAS↓, 2,   LAMs↓, 3,   LEF1↓, 3,   MALAT1↓, 1,   MET↓, 2,   MMP-10↓, 2,   MMP1↓, 8,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 124,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 152,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 47,   MTA1↓, 1,   MUC1↓, 1,   MUC1-C↓, 1,   MUC4↓, 4,   N-cadherin?, 1,   N-cadherin↓, 36,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 2,   NCAM↑, 1,   NEDD9↓, 2,   NFAT↑, 1,   p44↓, 1,   PAK1↓, 3,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 7,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 9,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 6,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 21,   STAC2↓, 1,   T-cadherin↑, 1,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 24,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 1,   THBS1↓, 1,   THBS1↑, 1,   TIMP1↓, 2,   TIMP1↑, 11,   TIMP2↓, 3,   TIMP2↑, 12,   TPM4↓, 1,   pol-TregCell↓, 1,   TRIB3↑, 1,   Trop2↓, 1,   TSC1↑, 2,   TSP-1↑, 4,   TumCA↓, 1,   TumCI↓, 152,   TumCI↑, 2,   TumCMig?, 1,   TumCMig↓, 161,   TumCMig↑, 2,   TumMeta↓, 129,   TumMeta↑, 9,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 25,   uPAR↓, 4,   Vim?, 1,   Vim↓, 42,   Vim↑, 1,   Zeb1↓, 13,   ZEB2↓, 2,   α-SMA↓, 2,   α-tubulin↓, 4,   β-catenin/ZEB1↓, 74,   β-catenin/ZEB1↑, 3,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 160,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   EGR1↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 10,   Hif1a↓, 90,   Hif1a↑, 2,   LOX1↓, 2,   NO↓, 6,   NO↑, 7,   VCAM-1↓, 3,   VEGF↓, 153,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 2,   CTR1↑, 1,   EPR↑, 14,   GLUT1↓, 16,   GLUT2↓, 2,   GLUT4↓, 6,   IBI↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 264,   MMP↑, 3,   MMP∅, 1,   MPT↑, 9,   NHE1↓, 2,   OATPs↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2∅, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPM7↑, 1,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 20,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 8,   p‑cDC2↓, 2,   p‑cDC2↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 109,   COX2/PTGS2↑, 4,   COX2/PTGS2↝, 2,   CXCL12↓, 2,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR2↑, 1,   CXCR4↓, 13,   DCells↑, 2,   DR4↑, 9,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 1,   FOXP3↑, 2,   Gal-3↓, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 6,   IFN-γ↓, 6,   IFN-γ↑, 2,   Igs↑, 2,   IL1↓, 7,   IL1↑, 1,   IL10↓, 3,   IL10↑, 3,   IL12↑, 1,   IL13↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 21,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 53,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 28,   Imm↝, 3,   Inflam↓, 53,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 2,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 220,   NF-kB↑, 8,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 11,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 2,   PD-L1↓, 12,   PD-L1↑, 3,   PGE2↓, 22,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 4,   Th1 response?, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 41,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   6IL↑, 1,   ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 22,   AR↑, 1,   COMT↓, 1,   ER-α36↓, 4,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 3,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   GR↑, 1,   PPARγ↓, 2,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 63,   BioAv↑, 58,   BioAv↝, 12,   BioEnh↑, 6,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 271,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↓, 5,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 3,   Dose↝, 98,   Dose∅, 12,   eff↓, 110,   eff↑, 148,   eff↝, 17,   eff∅, 3,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 19,   Half-Life↑, 4,   Half-Life↝, 16,   Half-Life∅, 2,   MDR1↓, 13,   MRP1/ABCC1↓, 6,   NAT↓, 1,   P-gp/ABCB1↓, 31,   P-gp/ABCB1∅, 1,   P450↓, 5,   P450↝, 1,   RadioS?, 1,   RadioS↓, 1,   RadioS↑, 84,   RadioS↝, 1,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 190,   selectivity∅, 1,   Synergy↑, 136,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 10,   ALP↓, 4,   AR↓, 22,   AR↑, 1,   AST↓, 7,   B2M↓, 1,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 4,   E7↓, 3,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERα/ESR1↓, 3,   EstroRS/ERS↓, 1,   EZH2↓, 2,   Ferritin↓, 2,   FOXM1↓, 8,   HER2/EBBR2↓, 23,   hTERT/TERT↓, 17,   IL6↓, 53,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 9,   LDH↑, 6,   LDH↝, 3,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 6,   Myc↑, 1,   PD-L1↓, 12,   PD-L1↑, 3,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 1,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 107,   AntiCan?, 1,   AntiDiabetic↑, 2,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 40,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 13,   CardioT↓, 2,   CardioT↑, 2,   chemoP↑, 43,   chemoPv↑, 33,   ChemoSideEff↓, 6,   cognitive↑, 1,   fatigue↓, 1,   fatigue∅, 1,   FTO↑, 1,   hepatoP↓, 2,   hepatoP↑, 15,   hepatoP∅, 1,   K17↓, 1,   kidSt↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 1,   Obesity↓, 1,   Obesity↑, 1,   OS?, 1,   OS↑, 26,   OS⇅, 1,   Pain↓, 4,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 10,   QoL∅, 2,   radioP↑, 11,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 25,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity?, 1,   toxicity↓, 31,   toxicity↑, 6,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 50,   TumVol↑, 2,   TumVol∅, 1,   TumW↓, 21,   TumW∅, 1,   Weight↑, 3,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 8,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 1394

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 6,   antiOx↑, 126,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 48,   Copper↓, 1,   GPx↓, 1,   GPx↑, 35,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 40,   GSR↑, 6,   GSSG↓, 1,   GSTs↑, 21,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 21,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 44,   MDA↓, 33,   MPO↓, 5,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 117,   ROS↑, 8,   ROS↝, 1,   ROS∅, 4,   mt-ROS?, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 51,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 3,   Trx1↑, 1,   uricA↓, 2,   VitC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   ALAT↓, 12,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↑, 4,   CRM↑, 1,   DGAT1↓, 1,   ECAR↓, 1,   ECAR∅, 1,   FASN↓, 2,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   H2S↑, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   NADPH↑, 2,   SIRT1↑, 4,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 6,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 8,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 11,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Cyt‑c↑, 1,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   IAP1↓, 1,   iNOS↓, 18,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 3,   Akt↝, 1,   p‑Akt↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↑, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 3,   JNK↑, 3,   MAPK↓, 8,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 2,   PKCδ↓, 1,   PTEN↑, 1,   STAT↓, 3,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↓, 2,   other↑, 5,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSPs↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   p16↓, 1,   P53↓, 3,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 3,   P21↑, 5,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   neuroG↑, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 12,   AP-1↓, 3,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↑, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP9↓, 5,   MUC1↑, 1,   Smad1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 10,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 9,   BBB↝, 2,   GastroP↑, 6,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 9,   MMP∅, 1,   MUC5AC↓, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 5,   IL12↓, 1,   IL17↓, 5,   IL18↓, 3,   IL1β↓, 21,   IL2↓, 1,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IL8↓, 8,   Imm↑, 6,   Imm⇅, 2,   Inflam?, 1,   Inflam↓, 121,   Inflam↑, 4,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 41,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 5,   NLRP3↑, 1,   PGE2↓, 15,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TLR2↓, 3,   TLR4↓, 7,   TNF-α?, 1,   TNF-α↓, 37,   TNF-α↑, 2,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   AChE↓, 17,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 10,   GABA↑, 3,   GABA↝, 1,   MAOA↓, 2,   NGF↑, 3,   TPH1↓, 1,   TrkB↑, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   Aβ↓, 19,   BACE/β-secretase↓, 6,   tau↓, 4,   p‑tau↓, 3,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   GPER↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 50,   BioAv↑, 45,   BioAv↝, 22,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 10,   eff↓, 1,   eff↑, 11,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 11,   Half-Life∅, 2,   P450↓, 3,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 4,   AST↓, 15,   BloodF↑, 1,   BMD↑, 5,   BP↓, 9,   creat↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 7,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 18,   AntiArt↑, 9,   AntiCan↓, 2,   AntiCan↑, 25,   antiCG↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 31,   antiNeop↑, 2,   antiPs↑, 1,   AntiTum↓, 2,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 53,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 7,   cognitive↑, 17,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 43,   Learn↑, 1,   memory↑, 19,   motorD↑, 3,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 82,   Obesity↓, 15,   OS↑, 1,   Pain↓, 9,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 12,   Risk↓, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity?, 2,   toxicity↓, 56,   toxicity↑, 6,   toxicity↝, 11,   toxicity∅, 10,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 17,   AntiFungal↓, 2,   AntiFungal↑, 7,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 13,   Bacteria↓, 28,   Diar↓, 3,   GutMicro↑, 15,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 443

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
30 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
21 Kaempferol
18 Radiotherapy/Radiation
18 Magnolol
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Magnetic Fields
14 Luteolin
14 Shikonin
13 Cisplatin
13 doxorubicin
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Lycopene
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
12 Licorice
11 Graviola
11 Licochalcone A
11 Linalool
10 Propolis -bee glue
9 5-fluorouracil
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 phytic acid, Inositol hexakisphosphate
9 Ivermectin
9 mebendazole
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Diindolylmethane
8 Indole-3-carbinol
8 Ferulic acid
8 Paclitaxel/Taxol
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
7 Chemotherapy
7 Melatonin
7 chitosan
7 Evodiamine
7 Fucoidan
7 Juglone
7 Phenylbutyrate
7 Pterostilbene
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Gambogic Acid
6 itraconazole
6 Matrine
6 Morin
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Laetrile B17 Amygdalin
5 lambertianic acid
5 methylseleninic acid
5 Methylsulfonylmethane
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Lemongrass Extract/Citral
4 Methyl Jasmonate
4 Magnetic Field Rotating
4 Moringa oleifera
4 Marjoram (Origanum majorana)
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Piperine
3 Flaxseed/Linseed
3 SDG/lignans
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Hyperthermia
3 Inositol
3 Isoliquiritigenin
3 Lasiodin
3 Metformin
3 Magnesium
3 Propyl gallate
3 Parthenolide
2 Gold NanoParticles
2 Photodynamic Therapy
2 Glucose
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 Echinacea
2 Electrical Pulses
2 Flaxseed Oil
2 carboplatin
2 Geraniol
2 isoflavones
2 isoquercitrin
2 Vitexin
2 Lactoferrin/Talactoferrin
2 Lutein
2 Methylene blue
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Mucuna pruriens/Velvet Bean
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Rutin
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Recombinant Methioninase
1 Lactobacillus
1 Lapachol
1 low dose naltrexone
1 Mung Bean Sprouts
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Methylglyoxal
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Purple Corn / Purple Maize
1 Sanguinarine
1 Psoralidin
1 Rhein
1 buckwheat sprouts
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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