| 5583- | BetA, | Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells |
| - | vitro+vivo, | NA, | NA |
| 1305- | BetA, | Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells |
| - | in-vitro, | UEC, | NA |
| 1285- | BetA, | Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells |
| - | in-vitro, | Var, | NA |
| 2722- | BetA, | Betulinic Acid for Cancer Treatment and Prevention |
| - | Review, | Var, | NA |
| 2723- | BetA, | Betulinic acid and oleanolic acid modulate CD81 expression and induce apoptosis in triple-negative breast cancer cells through ROS generation |
| - | in-vitro, | BC, | MDA-MB-231 |
| 2718- | BetA, | The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis |
| - | in-vitro, | AML, | U937 |
| 2721- | BetA, | Proteomic Investigation into Betulinic Acid-Induced Apoptosis of Human Cervical Cancer HeLa Cells |
| - | in-vitro, | Cerv, | HeLa |
| 2720- | BetA, | Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo |
| - | in-vitro, | Cerv, | HeLa |
| 2719- | BetA, | Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential |
| - | in-vitro, | CRC, | T24/HTB-9 | - | in-vitro, | Bladder, | UMUC3 | - | in-vitro, | Bladder, | 5637 |
| 2734- | BetA, | Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | SW480 |
| 2724- | BetA, | Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice |
| - | in-vivo, | Nor, | NA | - | in-vivo, | Stroke, | NA |
| 2725- | BetA, | Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice |
| - | in-vivo, | Nor, | NA |
| 2726- | BetA, | Betulinic acid induces DNA damage and apoptosis in SiHa cells |
| - | in-vitro, | Cerv, | SiHa |
| 2727- | BetA, | Betulinic acid in the treatment of breast cancer: Application and mechanism progress |
| - | Review, | BC, | NA |
| 2728- | BetA, | Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy |
| - | in-vitro, | Var, | NA |
| 2729- | BetA, | Betulinic acid in the treatment of tumour diseases: Application and research progress |
| - | Review, | Var, | NA |
| 2730- | BetA, | Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells |
| - | in-vitro, | Bladder, | T24/HTB-9 |
| 2731- | BetA, | Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives |
| - | Review, | GBM, | NA | - | Review, | Park, | NA | - | Review, | AD, | NA |
| 2717- | BetA, | Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma |
| - | in-vitro, | Melanoma, | U266 | - | in-vivo, | Melanoma, | NA | - | in-vitro, | Melanoma, | RPMI-8226 |
| 2716- | BetA, | Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment |
| - | Review, | Var, | NA |
| 2732- | BetA, | Chemo, | Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78 |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | Nor, | MCF10 |
| 2733- | BetA, | Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling |
| - | in-vitro, | Oral, | KB | - | in-vivo, | NA, | NA |
| 2735- | BetA, | Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications |
| - | Review, | Var, | NA |
| - | Review, | Var, | NA |
| 2757- | BetA, | Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways |
| - | in-vitro, | GBM, | U251 |
| 2738- | BetA, | Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | BT549 | - | in-vivo, | NA, | NA |
| 2758- | BetA, | Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway |
| - | in-vivo, | Nor, | NA |
| 2759- | BetA, | Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies |
| - | Review, | Var, | NA |
| 2760- | BetA, | A Review on Preparation of Betulinic Acid and Its Biological Activities |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA |
| 2761- | BetA, | Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans |
| - | in-vivo, | Nor, | NA |
| 2762- | BetA, | Targeting Effect of Betulinic Acid Liposome Modified by Hyaluronic Acid on Hepatoma Cells In Vitro |
| - | in-vitro, | Liver, | HepG2 |
| 2763- | BetA, | Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization |
| - | in-vitro, | GC, | NA |
| 2764- | BetA, | In silico profiling of histone deacetylase inhibitory activity of compounds isolated from Cajanus cajan |
| - | Analysis, | Var, | NA |
| 2765- | BetA, | Unveiling Betulinic Acid as a Potent CDK4 Inhibitor for Cancer Therapeutics |
| - | in-vitro, | Lung, | A549 |
| 2766- | BetA, | Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy |
| - | Review, | Var, | NA |
| 2737- | BetA, | Multiple molecular targets in breast cancer therapy by betulinic acid |
| - | Review, | Var, | NA |
| 2771- | BetA, | Cardioprotective Effect of Betulinic Acid on Myocardial Ischemia Reperfusion Injury in Rats |
| - | in-vivo, | Nor, | NA | - | in-vivo, | Stroke, | NA |
| 2755- | BetA, | Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines |
| - | in-vitro, | Colon, | HT29 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | Lung, | H460 |
| 2739- | BetA, | Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells |
| - | in-vitro, | Nor, | HUVECs | - | in-vitro, | Nor, | MEF |
| 2740- | BetA, | Effects and mechanisms of fatty acid metabolism-mediated glycolysis regulated by betulinic acid-loaded nanoliposomes in colorectal cancer |
| - | in-vitro, | CRC, | HCT116 |
| 2741- | BetA, | Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress |
| - | in-vitro, | GC, | SNU16 | - | in-vitro, | GC, | NCI-N87 | - | in-vivo, | NA, | NA |
| 2742- | BetA, | Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vivo, | BC, | 4T1 | - | in-vitro, | BC, | MCF7 |
| 2743- | BetA, | Betulinic acid and the pharmacological effects of tumor suppression |
| - | Review, | Var, | NA |
| 2744- | BetA, | Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential |
| - | Review, | Var, | NA |
| 2745- | BetA, | Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors |
| - | in-vitro, | CRC, | RKO | - | in-vitro, | CRC, | SW480 | - | in-vivo, | NA, | NA |
| 2746- | BetA, | Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo |
| - | in-vitro, | CRC, | HCT116 | - | in-vivo, | CRC, | NA |
| 2747- | BetA, | Betulinic acid, a natural compound with potent anticancer effects |
| - | Review, | Var, | NA |
| 2748- | BetA, | Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy |
| - | Review, | Var, | NA |
| 2749- | BetA, | Anti-Inflammatory Activities of Betulinic Acid: A Review |
| - | Review, | Nor, | NA |
| 2750- | BetA, | GEM, | Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation |
| - | in-vitro, | PC, | Bxpc-3 | - | in-vitro, | Lung, | H1299 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid