ChemoSen Cancer Research Results

ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Possible Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-Caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-Ursolic acid
-butein
-Betulinic acid
Scientific Papers found: Click to Expand⟱
5249- Ba,  BA,    Baicalein and baicalin in cancer therapy: Multifaceted mechanisms, preclinical evidence, and translational challenges
- Review, Var, NA
Apoptosis↑, Inflam↓, TumCCA↑, ChemoSen↑, RadioS↑, TumCG↓, toxicity↓, BioAv↓, Half-Life↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, Synergy↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
2608- Ba,    Baicalein sensitizes hepatocellular carcinoma cells to 5-FU and Epirubicin by activating apoptosis and ameliorating P-glycoprotein activity
- in-vitro, HCC, Bel-7402
Apoptosis↑, TumAuto↑, P-gp/ABCB1↓, Bcl-xL↓, ChemoSen↑,
2606- Ba,    Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma
- Review, HCC, NA
ChemoSen↑, TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, MMPs↓, MAPK↓, TGF-β↓, ZFX↓, p‑MEK↓, ERK↓, MMP2↓, MMP9↓, uPA↓, TIMP1↓, TIMP2↓, NF-kB↓, p65↓, p‑IKKα↓, Fas↑, Casp2↑, Casp3↑, Casp8↑, Casp9↑, Bcl-xL↓, BAX↑, ER Stress↑, Ca+2↑, JNK↑, P53↑, ROS↑, H2O2↑, cMyc↓, CD24↓, 12LOX↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2597- Ba,    Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer
- Review, PC, NA
chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2295- Ba,  5-FU,    Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway
- in-vitro, GC, AGS
ChemoSen↑, HK2↓, LDHA↓, PDK1 / PDPK1↓, Akt↓, PTEN↑, Hif1a↓, Glycolysis↓, ROS↑, CHOP/DDIT3↑,
2298- Ba,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCG↓, TumCP↓, Hif1a↓, VEGF↓, ChemoSen↑, Glycolysis↓, HK2↓, PDK1 / PDPK1↓, LDHA↓, p‑Akt↓, PTEN↑,
5554- BBM,  SRF,    Berbamine (BBM), a Natural STAT3 Inhibitor, Synergistically Enhances the Antigrowth and Proapoptotic Effects of Sorafenib on Hepatocellular Carcinoma Cells
- in-vitro, HCC, NA
ChemoSen↑, STAT3↓,
5536- BBM,    Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers
- Review, Var, NA
JAK↝, STAT3↓, p‑CaMKII ↓, TGF-β↑, Smad1↑, ChemoSen↑, RadioS↑, TumCI↓, TumCMig↓, ROS↑, NRF2↓, SOD2↓, GPx1↓, HO-1↓,
5556- BBM,    Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells
- in-vitro, Melanoma, NA
TumCP↓, ChemoSen↑, TumCCA↑, IKKα↓, p65↓, Bcl-xL↓, BID↓, survivin↓,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
1385- BBR,  5-FU,    Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↓, ROS↑, TumCP↑, NRF2↑, ChemoSen↓,
1393- BBR,  EPI,    Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest
- in-vitro, Bladder, T24/HTB-9
ChemoSen↑, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, P53↑, P21↑, Bcl-2↓, ROS↑,
1389- BBR,  Lap,    Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS
- in-vitro, BC, BT474 - in-vitro, BC, AU-565
ChemoSen↑, Apoptosis↑, ROS↑, NRF2↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5181- BBR,  Cisplatin,    Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
tumCV↓, MDR1↓, ChemoSen↑, PI3K↓, Akt↓, mTOR↓,
4658- BBR,    Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
CSCs↓, TumCP↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, TumCCA↑, Apoptosis↑, ChemoSen↑, β-catenin/ZEB1↓, FTO↑, CD44↓, CD133↓, ChemoSen↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5635- BCA,    Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
- vitro+vivo, Lung, NA
AntiCan↑, ChemoSen↑, Zeb1↓, TumMeta↓,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
- in-vitro, Var, NA
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2/PTGS2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
6497- BCP,  Cisplatin,    Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules
- in-vitro, Lung, NA
TumCG↓, TumCP↓, Apoptosis↑, toxicity↓, ChemoSen↑, P21↑, Bcl-xL↑, Bcl-2↓, EMT↓, E-cadherin↑, eff↑, MMP↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
5582- BetA,    Targeting mitochondrial apoptosis by betulinic acid in human cancers
- Review, Var, NA
Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
2737- BetA,    Multiple molecular targets in breast cancer therapy by betulinic acid
- Review, Var, NA
TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, Synergy↑,
2727- BetA,    Betulinic acid in the treatment of breast cancer: Application and mechanism progress
- Review, BC, NA
mt-ROS↑, Sp1/3/4↓, TumMeta↓, GlucoseCon↓, NF-kB↓, ChemoSen↑, chemoP↑, m-Apoptosis↑, TOP1↓,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, Synergy↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP/DDIT3↑, *toxicity↓,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2732- BetA,  Chemo,    Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
ChemoSen↑, selectivity↑, GRP78/BiP↑, ER Stress↑, PERK↑, Ca+2↑, Cyt‑c↑, BAX↑, Bcl-2↓,
2735- BetA,    Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
- Review, Var, NA
mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,
2759- BetA,    Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies
- Review, Var, NA
chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2/PTGS2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,
2763- BetA,    Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization
- in-vitro, GC, NA
GRP78/BiP↓, TGF-β↓, ChemoSen↑, CSCs↓, SMAD2↓, SMAD3↓, OCT4↓,
2747- BetA,    Betulinic acid, a natural compound with potent anticancer effects
- Review, Var, NA
selectivity↑, Cyt‑c↑, *toxicity↓, TOP1↓, NF-kB↓, ROS↑, RadioS↑, ChemoSen↑,
2750- BetA,  GEM,    Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation
- in-vitro, PC, Bxpc-3 - in-vitro, Lung, H1299
CHK1↓, ChemoSen↑, tumCV↓, Apoptosis↑, DNAdam↑,
2752- BetA,    Betulinic acid: a natural product with anticancer activity
- Review, Var, NA
selectivity↑, ChemoSen↑, RadioS↑, MMP↓, cl‑Casp3↑, Cyt‑c↑, ROS↑, NF-kB↑, TOP1↓,
5686- BJ,  BRU,    A review of Brucea javanica: metabolites, pharmacology and clinical application
- Review, Var, NA
AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2/PTGS2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
5677- BML,    Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis
- in-vitro, Melanoma, A431 - in-vitro, Melanoma, A375
TumCP↓, Inflam↓, Akt↓, NF-kB↓, COX2/PTGS2↓, GSH↓, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *Synergy↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp/ABCB1↓, Synergy↑, other↝,
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
5660- BNL,    Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
- Review, Var, NA
TumMeta↓, BBB↑, EPR↑, toxicity↓, BioAv↑, ChemoSen↑, eff↑, other↑, P-gp/ABCB1↓, MDR1↓, ROS↑, TumCCA↑, other↝, BioAv↓, DNAdam↑, BioEnh↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,

Showing Research Papers: 101 to 150 of 880
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 880

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 25,   antiOx⇅, 1,   ARE↑, 1,   Bil↝, 1,   Catalase↓, 5,   Catalase↑, 8,   Fenton↑, 11,   frataxin↑, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 2,   GPx↑, 8,   GPx1↓, 1,   GPx4↓, 18,   GSH↓, 66,   GSH↑, 7,   GSH∅, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 1,   GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 16,   HO-1↓, 17,   HO-1↑, 18,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 11,   Iron↝, 1,   i-Iron↓, 2,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 2,   Keap1↑, 2,   lipid-P?, 1,   lipid-P↓, 5,   lipid-P↑, 29,   MDA↓, 4,   MDA↑, 7,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NQO1?, 1,   NQO1↓, 3,   NQO1↑, 4,   NRF2↓, 41,   NRF2↑, 36,   NRF2⇅, 1,   NRF2↝, 1,   NRF2∅, 1,   Prx↓, 2,   Prx3↑, 1,   Prx4↑, 1,   Prx6↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 1,   ROS↓, 36,   ROS↑, 376,   ROS⇅, 11,   ROS↝, 5,   i-ROS↓, 1,   i-ROS↑, 4,   mt-ROS↓, 1,   mt-ROS↑, 8,   RPM↑, 1,   SOD↓, 10,   SOD↑, 11,   SOD1↓, 2,   SOD1↑, 2,   SOD2↓, 2,   SOD2↑, 2,   TBARS↑, 1,   Thiols↓, 2,   Trx↓, 5,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 15,   TrxR1↓, 4,   TrxR1⇅, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 5,   FTH1↓, 1,   FTL↑, 1,   IronCh↑, 3,   IronCh∅, 1,   NCOA4↑, 2,   STEAP3↑, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 7,   CDC25↑, 1,   compI↓, 4,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 4,   ETC↓, 4,   ETC↑, 1,   ETC↝, 1,   HSP60/HSPD1↓, 3,   HSP60/HSPD1↑, 1,   Insulin↓, 5,   mitResp↓, 6,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↓, 1,   mtDam↑, 33,   OCR↓, 8,   OCR↑, 2,   OXPHOS↓, 6,   OXPHOS↑, 6,   OXPHOS↝, 1,   mt-OXPHOS↓, 3,   PDH↓, 3,   PDH↝, 1,   PGC-1α↑, 1,   SDH↓, 1,   SDH↑, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 2,   5LO↓, 4,   ACC↑, 2,   p‑ACC↑, 1,   ACC-α↓, 1,   ACLY↓, 6,   ACSL4↑, 3,   ACSL5↑, 2,   adiP↑, 1,   ADO↓, 1,   ALAT↓, 2,   ALAT↑, 1,   AminoA↓, 1,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 35,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 37,   ATP↑, 2,   i-ATP↓, 1,   ATP:AMP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   citrate↓, 1,   CPT1A↓, 1,   CRM↑, 1,   ECAR↓, 2,   ECAR∅, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 6,   FASN↑, 2,   FBPase↑, 2,   G6PD↓, 1,   GAPDH↓, 5,   GLS↓, 1,   glucoNG↓, 2,   glucoNG↑, 2,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 21,   GlucoseCon↑, 1,   GlucoseCon∅, 1,   GlutaM↓, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 60,   Glycolysis↝, 1,   Glycolysis∅, 1,   GSK‐3β↓, 15,   GSK‐3β↑, 6,   p‑GSK‐3β↓, 8,   H2S↑, 1,   Histones↑, 1,   HK1↓, 2,   HK2↓, 31,   HK2∅, 1,   HMG-CoA↓, 4,   KeyT↑, 1,   lactateProd↓, 18,   lactateProd↑, 4,   lactateProd∅, 1,   LDHA↓, 11,   LDHA∅, 1,   LDL↓, 4,   LDL↑, 1,   lipoGen↓, 2,   MATs↓, 1,   MCT4↓, 2,   MethCyc↓, 1,   NAD↓, 2,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 5,   NADPH↑, 2,   PDK1 / PDPK1↓, 8,   PDKs↓, 1,   PFK↓, 6,   PFK1↓, 8,   PFK2?, 1,   PFK2↓, 2,   PFKP↓, 2,   PKM2↓, 25,   PKM2↑, 1,   polyA↓, 1,   Pyrim↓, 1,   Pyruv↓, 3,   SAT1↑, 1,   SCD1↓, 2,   SIRT1↓, 9,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 3,   TCA?, 1,   TCA↓, 6,   TCA↑, 2,   TS↓, 5,   Warburg↓, 12,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 15,   APAF1↑, 9,   Apoptosis?, 3,   Apoptosis↓, 9,   Apoptosis↑, 323,   Apoptosis∅, 1,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 5,   ASC↓, 1,   BAD↓, 2,   BAD↑, 7,   p‑BAD↓, 1,   Bak↑, 6,   BAX↓, 5,   BAX↑, 122,   BAX⇅, 1,   Bax:Bcl2↑, 31,   Bcl-2↓, 131,   Bcl-2↑, 3,   Bcl-xL↓, 36,   Bcl-xL↑, 2,   BID↓, 3,   BID↑, 3,   p‑BID↓, 1,   BIM↑, 7,   BNIP3↑, 2,   Casp↓, 2,   Casp↑, 52,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12↑, 1,   Casp2↑, 4,   Casp3↓, 6,   Casp3↑, 162,   cl‑Casp3↑, 26,   proCasp3↑, 1,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↑, 1,   Casp7↓, 1,   Casp7↑, 20,   cl‑Casp7↑, 3,   Casp8↑, 32,   Casp8∅, 1,   cl‑Casp8↑, 8,   Casp9↓, 2,   Casp9↑, 101,   cl‑Casp9↑, 11,   proCasp9↓, 1,   cFLIP↓, 3,   Cupro↑, 2,   Cyt‑c↓, 3,   Cyt‑c↑, 93,   mt-Cyt‑c↓, 1,   Diablo↑, 7,   DR5↑, 27,   Endon↑, 1,   FADD↑, 4,   Fap1↓, 1,   Fas↓, 3,   Fas↑, 16,   FasL↓, 2,   FasL↑, 6,   Ferroptosis↑, 39,   GSDME↑, 1,   IAP1↓, 11,   IAP2/BIRC3↓, 6,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 13,   iNOS↑, 1,   Mcl-1↓, 31,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 10,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↓, 1,   MOMP↑, 4,   Necroptosis↑, 3,   necrosis↑, 5,   NOXA↑, 1,   p38↓, 5,   p38↑, 18,   p‑p38↓, 1,   p‑p38↑, 5,   Paraptosis↑, 3,   pS2/TFF1↓, 1,   PUMA↑, 7,   Pyro↑, 5,   survivin↓, 64,   TRAIL↑, 7,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 32,   TUNEL↑, 1,   XIAP↓, 30,   XIAP↑, 1,   YAP/TEAD↓, 7,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 178,   Akt↑, 7,   p‑Akt↓, 43,   AKT1↓, 2,   AMPKα↑, 1,   BRAF↓, 1,   CaMKII ↓, 2,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 5,   cMET↓, 4,   CREB↓, 1,   cSrc↓, 4,   DDIT4↑, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 3,   ERK↓, 49,   ERK↑, 8,   ERK↝, 1,   p‑ERK↓, 20,   p‑ERK↑, 1,   e-ERK↑, 1,   FGFR1↓, 1,   FOXD3↑, 3,   HCAR2↑, 1,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↑, 1,   IGF-1R↓, 9,   p‑IGF-1R↓, 1,   IGFR↓, 2,   IKKα↓, 6,   p‑IKKα↓, 1,   IκB↓, 4,   p‑IκB↓, 1,   JAK↓, 7,   JAK↝, 1,   JAK1↓, 8,   JAK2↓, 22,   JNK↓, 8,   JNK↑, 24,   p‑JNK↓, 2,   p‑JNK↑, 4,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 50,   MAPK↑, 19,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 5,   MEK↑, 1,   p‑MEK↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 104,   mTOR↑, 3,   p‑mTOR↓, 6,   mTORC2↓, 3,   mTORC2↑, 1,   p42↓, 1,   p70S6↓, 2,   P70S6K↓, 4,   P70S6K↑, 1,   p‑P70S6K↓, 2,   P90RSK↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 133,   PI3K↑, 4,   p‑PI3K↓, 6,   PI3K/Akt↓, 4,   PI3K/mTOR/ETS2↓, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 2,   PKCδ↓, 9,   p‑PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 3,   PTEN↑, 37,   p‑PTEN↓, 1,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 12,   RTK-RAS↓, 1,   p‑S6K↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 15,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 86,   STAT3↑, 2,   STAT3↝, 2,   p‑STAT3↓, 10,   p‑STAT3↑, 3,   mt-STAT3↓, 1,   STAT5↓, 4,   STAT6↓, 2,   p‑STAT6↓, 1,   TK1↓, 2,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AFAP1-AS1↓, 1,   ATF2↓, 1,   ATF3↓, 1,   ATF4↓, 1,   ATF4↑, 8,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 7,   cJun↑, 2,   cMyc↓, 41,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 9,   DNMT3A↓, 2,   DNMT3B↓, 2,   DNMTs↓, 7,   EZH2↓, 3,   FOXM1↓, 3,   FOXO↑, 2,   FOXO1↓, 3,   FOXO1↑, 2,   FOXO3↓, 6,   FOXO3↑, 6,   p‑FOXO3↓, 2,   FOXO4↓, 1,   FOXO4↑, 2,   GATA3↑, 1,   H3↓, 2,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   H3K4↓, 1,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 30,   HDAC1↓, 4,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 3,   HES1↓, 2,   miR-106b↓, 1,   miR-107↑, 1,   miR-124-3p↓, 1,   miR-130a↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-143↑, 1,   miR-155↓, 2,   miR-192-5p↑, 1,   miR-195↑, 1,   miR-199↓, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-21↓, 7,   miR-218↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 3,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 8,   miR-384↑, 1,   miR-422a↑, 1,   miR-429↑, 1,   miR-490↑, 1,   miR-545↑, 1,   miR-99↑, 1,   Myc↓, 6,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 14,   other?, 1,   other↓, 7,   other↑, 11,   other↝, 26,   PAX2↓, 1,   PhotoS↑, 3,   SALL4↓, 1,   sonoS↑, 2,   SOX2↓, 9,   SOX4↓, 3,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   TCF-4↓, 1,   TFE3↑, 1,   TLE1↓, 1,   tumCV?, 1,   tumCV↓, 78,   tumCV↑, 2,   tumCV∅, 1,   YMcells↓, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 5,   ER Stress↓, 1,   ER Stress↑, 62,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 10,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   HSP70/HSPA5↝, 1,   HSP72↑, 1,   HSP90↓, 13,   HSPs↓, 1,   HSPs↑, 1,   HTRA↓, 1,   IRE1↑, 4,   PERK↑, 8,   Proteasome?, 1,   Proteasome↓, 1,   UPR↑, 9,   XBP-1↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 7,   ATG7↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 17,   Beclin-1/ATG6⇅, 1,   CTSK↓, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 1,   LC3B↑, 1,   LC3B-II↑, 4,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 17,   LC3s↓, 2,   lysoMP↑, 1,   MitoP↓, 1,   p62↓, 8,   p62↑, 6,   p‑p62↑, 1,   SESN2↑, 3,   TumAuto↓, 3,   TumAuto↑, 65,   TumAuto↝, 2,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 3,   ATR↑, 1,   BRCA1↓, 4,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 2,   BRCA2↑, 1,   DFF45↑, 1,   DNAdam↓, 3,   DNAdam↑, 99,   DNArepair↓, 4,   DNArepair↑, 3,   ERCC1↓, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   FEN1↓, 1,   HR↓, 1,   hTERT/TERT↓, 13,   Ku70/XRCC6↓, 1,   MGMT↓, 2,   p16↑, 3,   P53?, 1,   P53↓, 6,   P53↑, 106,   P53↝, 1,   P53∅, 1,   p‑P53↑, 5,   PARP↓, 2,   PARP↑, 21,   PARP↝, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 76,   PARP1↓, 1,   PARP1↑, 3,   PCNA↓, 29,   RAD51↓, 2,   SIRT6↓, 3,   SIRT6↑, 1,   Telomerase↓, 14,   TOP1↓, 10,   TOP2↓, 6,   TOP2↑, 3,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 2,   γH2AX↓, 1,   γH2AX↑, 10,   γH2AX↝, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CC(CDKs/cyclins)↓, 2,   CDK1?, 1,   CDK1↓, 13,   CDK1↑, 4,   p‑CDK1↓, 2,   CDK2↓, 37,   CDK2↑, 4,   p‑CDK2↓, 1,   CDK4↓, 50,   CDK4↑, 3,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 20,   CDK6↑, 4,   CDK7↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   p‑CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 10,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 25,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 94,   cycD1/CCND1↑, 3,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 21,   cycE/CCNE↑, 1,   cycE1↓, 1,   cycF↑, 1,   E2Fs↓, 5,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 34,   MAD↓, 1,   mitA↑, 5,   p19↑, 1,   P21?, 2,   P21↓, 4,   P21↑, 81,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 31,   PLK1↓, 1,   pRB↓, 2,   p‑pRB↓, 3,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 6,   Securin↓, 2,   TubPol↓, 1,   TumCCA?, 2,   TumCCA↓, 12,   TumCCA↑, 252,   TumCCA⇅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 11,   ALDH1A1↓, 5,   Axin2↑, 1,   CD133↓, 13,   CD24↓, 2,   CD34↓, 2,   cFos↓, 10,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 70,   CSCs↑, 2,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 9,   EIF4E↓, 3,   EP4/PTGER4↑, 1,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 11,   HH↓, 15,   HH↝, 1,   HMGCR↓, 2,   HMGCR⇅, 1,   IGF-1↓, 16,   IGF-2↓, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 34,   Let-7↑, 2,   LRP6↓, 2,   mTORC1↓, 11,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 19,   NOTCH↑, 1,   NOTCH1↓, 14,   NOTCH1↑, 1,   NOTCH3↓, 3,   OGF↑, 1,   OGFr↑, 3,   p300↓, 1,   PTCH1↓, 4,   PTCH2↓, 1,   SAL↑, 1,   SCF↓, 2,   Shh↓, 9,   Smo↓, 6,   Smo∅, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 149,   TumCG↑, 4,   TumCG∅, 2,   TumCP?, 1,   TumCP↓, 214,   TumCP↑, 5,   Wnt↓, 55,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   ASAP2↓, 1,   ATPase↑, 1,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 3,   Ca+2↑, 38,   Ca+2↝, 1,   i-Ca+2?, 1,   i-Ca+2↓, 1,   i-Ca+2↑, 1,   cal2↓, 1,   cal2↑, 2,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   Chl↑, 1,   i-Chl↑, 1,   Cofilin↓, 1,   COL4A3↓, 1,   DLC1↑, 1,   E-cadherin↓, 6,   E-cadherin↑, 46,   EMT?, 1,   EMT↓, 95,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 21,   p‑FAK↓, 2,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 4,   Furin↓, 1,   GLI2↓, 2,   ITGA2↓, 1,   ITGA5↓, 3,   ITGA6↓, 1,   ITGB1↓, 7,   ITGB3↓, 3,   ITGB4↓, 2,   ITGB6↓, 1,   KRAS↓, 4,   LAMs↓, 2,   LEF1↓, 1,   MALAT1↓, 4,   MET↓, 2,   p‑MET↓, 1,   MMP1↓, 7,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 88,   MMP2⇅, 1,   MMP3↓, 6,   MMP7↓, 8,   MMP9↓, 112,   MMP9↑, 1,   MMP9⇅, 1,   MMPs↓, 36,   MUC4↓, 3,   N-cadherin↓, 30,   Na+↝, 1,   NEDD9↓, 1,   PAK1↓, 5,   pax↓, 1,   PDGF↓, 4,   Rac1↓, 3,   Rho↓, 5,   ROCK1↓, 6,   Sharpin↓, 1,   Slug↓, 9,   Smad1↓, 1,   Smad1↑, 2,   SMAD2↓, 1,   SMAD3↓, 2,   SMAD3↑, 1,   SMAD4↓, 1,   SMAD4↑, 1,   Snail↓, 26,   STAC2↓, 1,   TET1↑, 1,   TGF-β↓, 20,   TGF-β↑, 4,   TIMP1↓, 3,   TIMP1↑, 14,   TIMP2↓, 2,   TIMP2↑, 9,   TIMP3↑, 1,   TRIB3↑, 3,   TSP-1↑, 2,   TumCA↓, 2,   TumCA↑, 1,   TumCI↓, 105,   TumCMig↓, 97,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 107,   TumMeta↑, 9,   TumPF↓, 1,   Twist↓, 13,   Tyro3↓, 1,   uPA↓, 13,   uPAR↓, 1,   Vim↓, 34,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 13,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 70,   β-catenin/ZEB1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 147,   angioG↑, 4,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 4,   ECM/TCF↓, 1,   eNOS↓, 3,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 77,   Hif1a↑, 2,   Hypoxia↓, 2,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 5,   NO↑, 3,   NO↝, 1,   PHDs↓, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 4,   VEGF↓, 123,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   BBB↓, 1,   BBB↑, 12,   CellMemb↑, 2,   CLDN1↓, 3,   CLDN2↓, 2,   CLDN2↑, 1,   CTR1↑, 2,   EPR↑, 21,   GLUT1↓, 16,   GLUT1↑, 1,   GLUT2↓, 3,   GLUT3↑, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 138,   MMP↑, 2,   MMP↝, 1,   MPT↑, 6,   Na+↝, 1,   OATPs↓, 2,   TRPC1↑, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↑, 3,   TRPV1↝, 1,   TRPV2↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 2,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 17,   CD47↓, 1,   CD8+↑, 6,   p‑cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 96,   COX2/PTGS2↑, 1,   CR3↝, 1,   CXCL1↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCL6/GCP-2↓, 1,   CXCR4↓, 11,   DR4↑, 8,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 1,   Gal-3↓, 3,   HCAR1↓, 1,   HCAR2↑, 1,   HLA↑, 1,   HMGB1↓, 6,   ICAM-1↓, 6,   IFN-γ↓, 3,   IFN-γ↑, 2,   Igs↑, 2,   IL1↓, 5,   IL1↑, 2,   IL10↓, 5,   IL10↑, 4,   IL12↓, 2,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 19,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 6,   IL4↓, 4,   IL4↑, 2,   IL6↓, 43,   IL8↓, 11,   IL8↑, 1,   Imm↑, 36,   Imm↝, 6,   INF-γ↑, 1,   Inflam↓, 55,   Inflam↑, 1,   Inflam↝, 1,   LPS↓, 1,   LRIG1↑, 1,   M2 MC↓, 4,   MCP1/CCL2↓, 5,   MCT1↓, 2,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 2,   NF-kB↓, 191,   NF-kB↑, 8,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NK cell↑, 14,   NLRP3↓, 4,   NLRP3↑, 1,   p50↓, 2,   p65↓, 9,   p‑p65↓, 3,   PAF↓, 1,   PD-1↓, 4,   PD-L1↓, 7,   PGE2↓, 26,   PSA↓, 9,   PSA∅, 1,   RAGE↓, 1,   T-Cell↑, 4,   T-Cell↝, 1,   TCF↓, 1,   TCF↑, 1,   TCF7/TCF1↓, 1,   Th1 response↑, 2,   Th2↑, 1,   TLR4↓, 4,   TLR4↑, 1,   TNF-α↓, 38,   TNF-α↑, 6,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRAF1↓, 1,   Treg lymp↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↑, 3,   pH↝, 2,   e-pH↓, 1,   e-pH↑, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   PTN↓, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 14,   ER-α36↓, 4,   ER(estro)↓, 1,   Estro↝, 1,   GR↑, 1,   PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 7,   PRL↓, 1,   PXR, NR1I2↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCC2↓, 1,   ABCG2↓, 3,   BioAv↓, 69,   BioAv↑, 80,   BioAv↝, 20,   BioEnh?, 1,   BioEnh↑, 6,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen?, 5,   ChemoSen↓, 17,   ChemoSen↑, 871,   ChemoSen⇅, 3,   ChemoSen↝, 2,   ChemoSen∅, 7,   CompStab?, 1,   CompStab↓, 4,   CompStab↑, 4,   CompStab↝, 2,   CYP1A1↓, 4,   CYP1A1↑, 3,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP1B1↑, 2,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 5,   DDS↑, 2,   Dose?, 8,   Dose↓, 5,   Dose↑, 17,   Dose⇅, 1,   Dose↝, 98,   Dose∅, 18,   eff↓, 77,   eff↑, 182,   eff⇅, 1,   eff↝, 21,   eff∅, 3,   GSTA1↓, 1,   GSTA1↑, 2,   GSTM1↑, 1,   GSTP1/GSTπ↓, 2,   GSTZ1↝, 1,   Half-Life↓, 18,   Half-Life↑, 4,   Half-Life↝, 17,   Half-Life∅, 3,   MDR1↓, 20,   MRP↓, 1,   MRP1/ABCC1↓, 9,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 42,   P-gp/ABCB1↑, 1,   P-gp/ABCB1↝, 1,   P450↓, 5,   P450↝, 1,   RadioS?, 1,   RadioS↓, 3,   RadioS↑, 150,   RadioS↝, 1,   selectivity?, 2,   selectivity↑, 154,   Synergy↑, 197,   Synergy↝, 1,   TET2↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   AFP↑, 1,   ALAT↓, 2,   ALAT↑, 1,   ALP↓, 2,   AR↓, 14,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   BG↓, 4,   Bil↝, 1,   BloodF↑, 1,   BMD↑, 2,   BRAF↓, 1,   BRCA1↓, 4,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CEA↓, 2,   CEC↝, 1,   creat↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 3,   EZH2↓, 3,   Ferritin↓, 5,   FOXM1↓, 3,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 13,   IL6↓, 43,   KeyT↑, 1,   KRAS↓, 4,   LDH↓, 8,   LDH↑, 1,   LDH↝, 1,   Myc↓, 6,   NOS2↑, 1,   NSE↓, 1,   PD-L1↓, 7,   PSA↓, 9,   PSA∅, 1,   RAGE↓, 1,   RBC↑, 1,   TG/TAG↓, 1,   TP53↓, 1,   TP53↑, 3,   TRIB3↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 3,   AntiCan↑, 93,   AntiCan?, 1,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 5,   antiNeop∅, 1,   AntiTum↓, 1,   AntiTum↑, 42,   Appetite↑, 1,   cachexia↓, 5,   cardioP↑, 19,   CardioT↓, 3,   chemoP?, 1,   chemoP↑, 91,   chemoPv↑, 27,   ChemoSideEff↓, 19,   ChemoSideEff∅, 1,   cognitive↑, 2,   fatigue↓, 2,   fatigue∅, 1,   FTO↓, 1,   FTO↑, 1,   hepatoP↑, 16,   hepatoP↝, 1,   hepatoP∅, 1,   kidSt↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 12,   NP/CIPN↓, 3,   NP/CIPN↑, 1,   NP/CIPN↝, 1,   ORR↑, 1,   OS↓, 1,   OS↑, 50,   OS∅, 1,   Pain↓, 5,   PFS↓, 1,   PFS↑, 2,   PFS∅, 1,   QoL↑, 28,   QoL∅, 2,   radioP↑, 22,   Remission↑, 6,   RenoP↑, 9,   RenoP∅, 1,   Risk↓, 41,   Risk↑, 2,   Risk∅, 1,   Sleep↑, 2,   toxicity↓, 35,   toxicity↑, 8,   toxicity⇅, 1,   toxicity↝, 24,   toxicity∅, 8,   TumVol↓, 37,   TumVol⇅, 1,   TumW↓, 20,   TumW⇅, 1,   Weight↓, 1,   Weight↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 11,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 4,  
Total Targets: 1251

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 9,   antiOx↑, 105,   ARE↑, 1,   Catalase↑, 42,   Copper↓, 1,   Fenton↓, 3,   GPx↑, 35,   GPx1↑, 3,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 45,   GSR↑, 7,   GSSG↓, 1,   GSSG∅, 1,   GSTs↑, 16,   H2O2↓, 3,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 3,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 27,   Iron↓, 2,   Iron↑, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 36,   MDA↓, 28,   MDA↑, 1,   MPO↓, 5,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 2,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 5,   ROS?, 4,   ROS↓, 121,   ROS↑, 2,   ROS↝, 1,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS?, 1,   selenoP↑, 3,   SOD↓, 1,   SOD↑, 51,   SOD1↑, 5,   SOD2↑, 3,   TAC↑, 6,   TBARS↓, 2,   Trx↑, 1,   Trx1↑, 1,   VitC↑, 1,   VitE↓, 1,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 3,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   EGF↓, 1,   Insulin↓, 2,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 2,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 5,   adiP↑, 1,   ALAT↓, 14,   AMPK↓, 1,   AMPK↑, 7,   ATP↓, 1,   ATP↑, 4,   CRM↑, 1,   cytoP450↓, 1,   FABP4↓, 1,   glucose↓, 9,   GlucoseCon↑, 2,   glyC↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   LDL↓, 8,   lipidLev↓, 3,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 2,   NH3↓, 1,   SIRT1↑, 4,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 9,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 4,   Bcl-xL↑, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 12,   Casp3∅, 1,   Casp9↓, 5,   Cyt‑c↓, 1,   Cyt‑c∅, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 7,   p38↓, 4,   p38↑, 1,   p‑p38↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 8,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 2,   IGF-1R↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↑, 2,   JNK↓, 3,   p‑JNK↓, 4,   MAPK↓, 8,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 2,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 4,   PKCδ?, 1,   PKCδ↓, 3,   PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT3↓, 3,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 2,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 3,   HDAC↑, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 3,   other↑, 5,   other↝, 5,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   DNArepair↑, 2,   P53↓, 4,   PARP1↓, 1,   PCNA↓, 3,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 10,   AP-1↓, 3,   Ca+2↓, 3,   Ca+2↝, 2,   Cartilage↑, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP3↓, 1,   MMP9↓, 2,   MUC1↑, 1,   TGF-β↓, 2,   TGF-β↑, 2,   TGF-β1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   Hif1a↑, 2,   NO↓, 9,   NO↑, 2,   VCAM-1↓, 3,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 13,   EPR↑, 1,   GastroP↑, 2,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 2,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 5,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   CD8+↑, 2,   COX1↓, 4,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 5,   IFN-γ↑, 1,   IL1?, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 8,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 21,   IL2↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 2,   IL6?, 2,   IL6↓, 34,   IL8↓, 3,   Imm↓, 1,   Imm↑, 9,   Imm↝, 1,   Inflam?, 2,   Inflam↓, 121,   Inflam↑, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 5,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 36,   NF-kB↑, 1,   NLRP3↓, 6,   NLRP3↑, 1,   PGE2↓, 7,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 4,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 42,   Treg lymp↝, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 11,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 7,   GABA↑, 3,   MAOA↓, 4,   MAOB↓, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   Aβ↓, 18,   Aβ42↓, 1,   BACE/β-secretase↓, 3,   tau↓, 4,   p‑tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   Estro↓, 1,   GR↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 44,   BioAv↑, 50,   BioAv⇅, 1,   BioAv↝, 32,   BioEnh↑, 1,   ChemoSen↑, 5,   CompStab↑, 2,   CompStab↝, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 4,   Dose↝, 21,   eff↑, 18,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 14,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 3,   Synergy↑, 15,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 14,   ALP↓, 3,   anemia↓, 1,   AST↓, 16,   BG↓, 2,   BloodF↑, 1,   BMD↑, 2,   BP↓, 7,   BUN?, 1,   BUN↓, 1,   CK/CK-MB↓, 1,   creat↓, 4,   CRP↓, 5,   Ferritin↓, 1,   HemoG↑, 1,   HOMA↓, 1,   hs-CRP↓, 2,   IL6?, 2,   IL6↓, 34,   IRes↝, 1,   LDH↓, 4,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 2,   RBC↑, 1,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 1,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 4,   AntiAge↑, 6,   antiAll↑, 15,   AntiArt↑, 10,   AntiCan↓, 2,   AntiCan↑, 23,   AntiDiabetic↑, 29,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP?, 2,   cardioP↑, 46,   cardioP⇅, 1,   CardioT↓, 2,   chemoP↑, 16,   chemoPv↑, 10,   cognitive↓, 1,   cognitive↑, 18,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 46,   Learn↑, 1,   memory?, 1,   memory↑, 15,   motorD↓, 1,   motorD↑, 1,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 68,   Obesity↓, 12,   OS↑, 3,   Pain↓, 5,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 10,   Risk↓, 2,   Sleep↑, 1,   SoreThr?, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 8,   toxicity?, 1,   toxicity↓, 49,   toxicity↑, 4,   toxicity↝, 18,   toxicity∅, 9,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 11,   Bacteria↓, 26,   Diar↓, 2,   GutMicro↑, 19,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 4,   Ingr↝, 7,  
Total Targets: 465

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
53 Cisplatin
40 Chemotherapy
39 doxorubicin
31 Curcumin
20 Magnetic Fields
20 Thymoquinone
18 Resveratrol
17 5-fluorouracil
16 Sulforaphane (mainly Broccoli)
15 Luteolin
15 Quercetin
13 Apigenin (mainly Parsley)
13 Docetaxel
13 Artemisinin
13 Baicalein
13 Betulinic acid
13 Chrysin
13 Eugenol
13 Lycopene
12 Radiotherapy/Radiation
12 Fisetin
12 Kaempferol
12 Melatonin
12 Morin
11 Propolis -bee glue
11 Capsaicin
11 Paclitaxel/Taxol
11 Gambogic Acid
11 Honokiol
10 Vitamin C (Ascorbic Acid)
10 diet FMD Fasting Mimicking Diet
10 diet Methionine-Restricted Diet
10 Ivermectin
9 Citric Acid
9 Metformin
9 EGCG (Epigallocatechin Gallate)
9 Flaxseed/Linseed
9 phytic acid, Inositol hexakisphosphate
8 Sorafenib (brand name Nexavar)
8 Silver-NanoParticles
8 Copper and Cu NanoParticles
8 Ashwagandha(Withaferin A)
8 brusatol
8 Boswellia (frankincense)
8 Selenium NanoParticles
8 salinomycin
8 Formononetin
8 Matrine
8 Shikonin
7 Astragalus
7 Berberine
7 Disulfiram
7 Emodin
7 Pterostilbene
7 Selenite (Sodium)
7 Vitamin K2
6 Allicin (mainly Garlic)
6 Selenium
6 Gemcitabine (Gemzar)
6 borneol
6 chitosan
6 Fucoidan
6 Linalool
6 Magnolol
6 methylseleninic acid
6 Phenethyl isothiocyanate
6 Piperlongumine
6 Rosmarinic acid
5 2-DeoxyGlucose
5 Anti-oxidants
5 Astaxanthin
5 Atorvastatin
5 Beta-Caryophyllene
5 Cinnamon
5 Coenzyme Q10
5 Crocetin
5 Docosahexaenoic Acid
5 diet Short Term Fasting
5 Indole-3-carbinol
5 Hydrogen Gas
5 Hyperthermia
5 Inositol
5 itraconazole
5 VitK3,menadione
5 Urolithin
4 Alpha-Lipoic-Acid
4 Berbamine
4 Caffeic acid
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Cucurbitacin
4 Dichloroacetate
4 Oxygen, Hyperbaric
4 Dandelion Root
4 Ellagic acid
4 tamoxifen
4 isoorientin
4 low dose naltrexone
4 mebendazole
4 Bicarbonate(Sodium)
4 Phenylbutyrate
3 3-bromopyruvate
3 Auranofin
3 Andrographis
3 Isovitexin
3 beta-glucans
3 immunotherapy
3 Baicalin
3 Brucea javanica
3 Boron
3 Trastuzumab
3 Piperine
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Carvacrol
3 carboplatin
3 Celastrol
3 Chlorophyllin
3 Hydroxycinnamic-acid
3 Electrical Pulses
3 Gallic acid
3 Garcinol
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyCitric Acid
3 isoflavones
3 Methylsulfonylmethane
3 Silymarin (Milk Thistle) silibinin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Dipyridamole
2 Biochanin A
2 Bromelain
2 erastin
2 Bortezomib
2 Carnosic acid
2 capecitabine
2 Thymol-Thymus vulgaris
2 Cat’s Claw
2 Cannabidiol
2 chemodynamic therapy
2 Celecoxib
2 Folic Acid, Vit B9
2 Calorie Restriction Mimetics
2 Carvone
2 Cynaropicrin
2 Diclofenac
2 Diindolylmethane
2 D-limonene
2 Lemongrass Extract/Citral
2 Exercise
2 Flaxseed Oil
2 Shilajit/Fulvic Acid
2 Ginkgo biloba
2 Genistein (soy isoflavone)
2 Geraniol
2 Ginkgolide B
2 Ginseng
2 Spermidine
2 iodine
2 Isoliquiritigenin
2 Recombinant Methioninase
2 Licorice
2 SDG/lignans
2 Lutein
2 Methyl Jasmonate
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Naringin
2 Niclosamide (Niclocide)
2 Plumbagin
2 Psoralidin
2 Rutin
2 Oxaliplatin
2 Terpinen-4-ol / Tea Tree Oil
1 Gold NanoParticles
1 Photodynamic Therapy
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 temozolomide
1 Aspirin
1 Aloe anthraquinones
1 epirubicin
1 Lapatinib
1 Ras-selective lethal 3
1 Butyrate
1 urea
1 Centella asiatica / Gotu kola → asiaticoside
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cyclopamine
1 Deguelin
1 diet Ketogenic
1 Zinc
1 Echinacea
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Fenbendazole
1 Ginkgolic acids
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 Hibiscus sabdariffa
1 HydroxyTyrosol
1 Hyperoside
1 MCT, metronomic chemo
1 Licochalcone A
1 Lactoferrin/Talactoferrin
1 Bevacizumab (brand Avastin)
1 Dordaviprone; Modeyso
1 Modified Citrus Pectin
1 vp16, etoposide
1 Magnetic Field Rotating
1 Methylglyoxal
1 Moringa oleifera
1 Lemon Balm/Melissa officinalis
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Reishi
1 Nimbolide
1 nelfinavir/Viracept
1 Proanthocyanidins
1 SonoDynamic Therapy UltraSound
1 Propyl gallate
1 Ramucirumab (CYRAMZA)
1 Rhein
1 buckwheat sprouts
1 Sulfasalazine
1 irinotecan
1 cetuximab
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Vitexin
1 Wogonin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1106  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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