angioG Cancer Research Results

angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
Scientific Papers found: Click to Expand⟱
2797- CHr,    A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells
- in-vivo, BC, NA - in-vitro, BC, 4T1
tumCV↓, p‑STAT3↓, VEGF↓, Weight∅, angioG↓,
2802- CHr,    Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis
- in-vitro, Pca, DU145 - in-vivo, Pca, NA
Hif1a↓, VEGF↓, angioG↓,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2787- CHr,    Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics
- Analysis, Var, MCF7
TumCP↓, angioG↓, TumCI↓, TumMeta↓, TP53↑, Akt↓, Casp3↑, tumCV↓, TNF-α↓, BioAv↑, BioAv↑, AKT1↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
952- Cin,    Cinnamon Extract Reduces VEGF Expression Via Suppressing HIF-1α Gene Expression and Inhibits Tumor Growth in Mice
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U251 - in-vivo, Ovarian, SKOV3
VEGF↓, Hif1a↓, p‑STAT3↓, p‑Akt↓, angioG↓, TumCG↓, TumW↓, ascitic↓,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6143- Cin,    Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling
- in-vitro, Var, NA
VEGFR2↓, angioG↓,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, eff↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
3892- Cin,    Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *cardioP↑, angioG↓, VEGF↓, *LDL↓, COX2↓, Hif1a↓, *Aβ↓, *tau↓, *toxicity↓,
3890- Cin,    The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases
- Review, NA, NA
*cardioP↑, *Inflam↓, *ROS↓, *lipid-P↓, *AntiAg↑, *angioG↑, *GutMicro↑, *ER Stress↓,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
6370- CPLE,    Delving into the Therapeutic Potential of Carica papaya Leaf against Thrombocytopenia
- Review, Var, NA
CIT↓, *Imm↑, *AntiDiabetic↑, *AntiCan↑, angioG↓, *Bacteria↓, *antiOx↑,
6373- CPLE,    Anticancer Activity of Phytochemicals of the Papaya Plant Assessed: A Narrative Review
- Review, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumMeta↓, ROS↑, Dose↝,
6178- Cro,    Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, ChemoSen↑,
6305- Cro,    Bridging Preclinical and Clinical Evidence on Crocin in Breast Cancer
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, TumCG↓, ChemoSen↑,
6301- Cro,    Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways
- vitro+vivo, Colon, HT29 - in-vitro, Colon, Caco-2
tumCV↓, selectivity↑, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, NF-kB↓, VEGF↓, TumMeta↓,
6171- Cu,    Copper in the tumor microenvironment and tumor metastasis
- Review, Var, NA
*angioG↑, other↑, *ROS↑, CTR1↝, other↝, COX17↝, ATOX1↝,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
1639- Cu,  HCAs,    Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
angioG↓, tumCV↓, Dose↓, ROS↑,
1598- Cu,    Targeting copper in cancer therapy: 'Copper That Cancer'
- Review, NA, NA
eff↓, eff↑, Dose∅, eff↑, angioG↑, ROS↑,
1596- Cu,  CDT,    Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
- Review, NA, NA
TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,
6211- CUR,    The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer
- Review, Var, NA
HIF-1↓, VEGF↓, angioG↓, RadioS↑, ChemoSen↑, other↝, Apoptosis↑, TumCG↓, TumMeta↓, BioAv↓, COX2↓, CD31↓, IL8↓, TGF-β↓, NF-kB↓, JAK2↓, STAT3↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
TumCG↓, MDSCs↓, TLR4↓, NF-kB↓, IL6↓, IL1↓, PGE2↓, COX2↓, GM-CSF↓, angioG↓, VEGF↓, CD31↓, GM-CSF↓, α-SMA↓, p‑IKKα↓, MyD88↓,
155- CUR,    Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
- in-vitro, Pca, PC3
p‑ERK↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, angioS↑,
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓, AR↓, STAT3↓, p‑Akt↓, Mcl-1↓, Bcl-xL↓, cl‑PARP↑, miR-21↓, miR-205↑, TumCG↓, TumCP↓, TumCI↓, angioG↓, TumMeta↓,
125- CUR,    Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway
- in-vitro, adrenal, H295R
CYP17A1↓, CYP19↓, *Nrf1↑, *NF-kB↓, angioG↓, Apoptosis↑, AR↓, toxicity↓, BioAv↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
5194- DCA,    Metabolic modulation of glioblastoma with dichloroacetate
- vitro+vivo, GBM, NA
MMP↓, mt-ROS↑, Apoptosis↑, CSCs↓, Hif1a↓, P53↑, angioG↓, toxicity↓, PDKs↓,
1880- DCA,    A Novel Form of Dichloroacetate Therapy for Patients With Advanced Cancer: A Report of 3 Cases
- Case Report, Var, NA
OS↑, angioG↓, Hif1a↝, pH↝, QoL↑,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
6676- Deg,    Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry
- Review, Var, NA
TumCP↓, Apoptosis↑, NF-kB↓, Wnt↓, TumCCA↑, TumMeta↑, antiOx↑, Inflam↓, angioG↓, Half-Life↑, MMP2↓, MMP9↓, Casp9↑, Casp3↑, EMT↓, PTEN↑, ChemoSen↑, toxicity↑, *BBB↑,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
6692- DFC,    Diclofenac Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer by Modulation of VEGF Levels and Arginase Activity
- in-vivo, PC, Panc02
TumW↓, Apoptosis↑, VEGF↓, COX2↓, ARG1/2↑, TumCG↓, angioG↓, ARG↓, NO↓,
1850- dietFMD,    Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
- in-vivo, CRC, NA
TumCP↑, angioG↓, CD8+↑, GutMicro↑, eff↑,
6732- Dipy,    Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathway
- in-vivo, Nor, NA
*BloodF↑, *NO↑, *AntiAg↑, *AntiThr↑, *antiOx↑, *angioG↑,
6736- Dipy,    Nucleoside Transport Inhibition by Dipyridamole Prevents Angiogenesis Impairment by Homocysteine and Adenosine
*other↝, *p‑MEK↑, *ERK↑, *angioG↑,

Showing Research Papers: 101 to 150 of 343
Prev Page 3 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 343

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ARG↓, 1,   CIT↓, 1,   miR-375↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Fenton↑, 3,   Ferroptosis↑, 2,   GSH↓, 2,   GSTZ1↓, 1,   H2O2↑, 1,   HO-1↓, 1,   lipid-P↑, 3,   NRF2↓, 4,   OXPHOS↑, 1,   ROS↓, 2,   ROS↑, 19,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   mt-ATP↓, 1,   COX17↝, 1,   ETC↓, 1,   MMP↓, 7,   MMP↑, 1,   MPT↑, 1,   mtDam↑, 1,   OCR↑, 1,   SDH↓, 1,   XIAP↓, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   ALAT↓, 1,   AMP↓, 1,   AMPK↑, 2,   citrate↓, 1,   cMyc↓, 4,   CPT1A↓, 1,   FASN↑, 1,   Glycolysis↓, 3,   HK2↓, 2,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDH↓, 1,   LDL↓, 1,   lipoGen↓, 1,   PDH↓, 1,   PDK1↓, 3,   PDK3↑, 1,   PDKs↓, 1,   PFK2?, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPARα↓, 1,   TCA↓, 1,   Warburg↓, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 23,   BAD↑, 1,   Bak↑, 3,   BAX↑, 5,   Bcl-2↓, 5,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 7,   Casp2↑, 1,   Casp3↑, 8,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 5,   Cupro↑, 2,   Cyt‑c↑, 5,   Fas↑, 1,   Ferroptosis↑, 2,   hTERT/TERT↓, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   Mcl-1↓, 4,   NOXA↑, 1,   p27↑, 2,   p38↑, 1,   Paraptosis↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 6,   TRAIL↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   HATs↓, 1,   miR-205↑, 1,   miR-21↓, 1,   other↑, 2,   other↝, 4,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

p‑eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP90↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DNAdam↑, 4,   DNMTs↓, 2,   P53↑, 5,   PARP↑, 3,   cl‑PARP↑, 4,   PCNA↓, 2,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 3,   P21↑, 2,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   Axin2↑, 1,   CD133↑, 1,   cFos↓, 2,   CSCs↓, 3,   EMT↓, 5,   ERK↓, 4,   p‑ERK↓, 1,   FOXO1↓, 1,   GSK‐3β↓, 2,   HDAC↓, 3,   HDAC8↓, 2,   IGF-1R↓, 1,   mTOR↓, 9,   NOTCH↓, 2,   NOTCH1↑, 2,   PI3K↓, 7,   PI3K↑, 1,   PTEN↑, 3,   SCF↓, 1,   STAT↓, 1,   STAT3↓, 9,   STAT3↑, 1,   p‑STAT3↓, 2,   TOP1↓, 3,   TumCG↓, 12,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   ARG1/2↑, 1,   ATOX1↝, 1,   Ca+2↓, 1,   Ca+2↑, 3,   CD31↓, 2,   CLDN1↓, 1,   E-cadherin↑, 3,   FAK↓, 2,   p‑FAK↓, 2,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP-10↓, 1,   MMP2↓, 5,   MMP9↓, 7,   MMP9↑, 1,   MMPs↓, 4,   PDGF↓, 1,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 1,   TumCI↓, 9,   TumCI↑, 1,   TumCMig↓, 3,   TumCMig↑, 1,   TumCP↓, 12,   TumCP↑, 2,   TumMeta↓, 10,   TumMeta↑, 5,   Twist↓, 1,   uPA↓, 1,   VCAM-1↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 43,   angioG↑, 3,   angioS↑, 1,   EGFR↓, 2,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 10,   Hif1a↝, 1,   NO↓, 1,   VEGF↓, 20,   VEGFR2↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CTR1↝, 1,   GLUT1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 8,   COX2↑, 2,   GM-CSF↓, 2,   ICAM-1↓, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 4,   JAK↓, 2,   JAK2↓, 1,   MCP1↓, 1,   MDSCs↓, 1,   MyD88↓, 1,   NF-kB↓, 13,   PD-L1↓, 1,   PGE2↓, 4,   T-Cell↝, 1,   TLR4↓, 2,   TLR4↝, 1,   TNF-α↓, 4,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   e-pH↑, 1,   i-pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 8,   BioAv↝, 1,   ChemoSen↑, 15,   ChemoSen∅, 1,   CYP17A1↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 2,   Dose↝, 5,   Dose∅, 2,   eff↓, 5,   eff↑, 34,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 2,   RadioS↑, 4,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 3,   ascitic↓, 1,   BRCA1↓, 1,   EGFR↓, 2,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 1,   LDH↓, 1,   PD-L1↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   cardioP↑, 4,   chemoP↑, 2,   chemoPv↑, 4,   fatigue↓, 1,   neuroP↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 3,   TumVol↓, 1,   TumW↓, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 284

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 2,   HO-1↑, 3,   lipid-P↓, 1,   MDA↓, 2,   Nrf1↑, 1,   NRF2↑, 2,   ROS↓, 11,   ROS↑, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p‑MEK↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cytoP450↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,   LDL↓, 1,   lipidLev↓, 1,   NADPH↑, 1,   PPARα↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   iNOS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 4,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 3,   CRP↓, 1,   IL1↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 8,   Inflam↑, 1,   NF-kB↓, 6,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   GABA↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AST↓, 1,   BloodF↑, 1,   BMD↑, 1,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 3,   cardioP⇅, 1,   chemoPv↑, 1,   hepatoP↑, 4,   memory↑, 2,   neuroP↑, 5,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 3,   toxicity↑, 2,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 77

Scientific Paper Hit Count for: angioG, angiogenesis
14 Magnetic Fields
14 Thymoquinone
11 Curcumin
11 Chrysin
9 Sulforaphane (mainly Broccoli)
9 Silymarin (Milk Thistle) silibinin
8 Artemisinin
8 Propolis -bee glue
8 Copper and Cu NanoParticles
8 Resveratrol
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Cinnamon
7 Eugenol
7 Nimbolide
7 Quercetin
6 Capsaicin
6 Fisetin
5 Apigenin (mainly Parsley)
5 Berberine
5 chitosan
5 Ellagic acid
5 EGCG (Epigallocatechin Gallate)
5 Selenite (Sodium)
4 Silver-NanoParticles
4 immunotherapy
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Rosmarinic acid
4 Celastrol
4 D-limonene
4 Disulfiram
4 Radiotherapy/Radiation
4 Luteolin
4 Magnolol
4 Phenethyl isothiocyanate
3 Carvacrol
3 Chlorogenic acid
3 Hydroxycinnamic-acid
3 Coenzyme Q10
3 Crocetin
3 Dichloroacetate
3 Gambogic Acid
3 Lycopene
3 Piperlongumine
3 tetrathiomolybdate
2 3-bromopyruvate
2 chemodynamic therapy
2 Allicin (mainly Garlic)
2 Alpha-Lipoic-Acid
2 Chemotherapy
2 beta-glucans
2 Baicalein
2 Boron
2 Caffeic acid
2 Carnosic acid
2 Carica papaya leaf extract
2 Cucurbitacin
2 Deguelin
2 Diclofenac
2 Dipyridamole
2 Dandelion Root
2 Fucoidan
2 Ferulic acid
2 Honokiol
2 HydroxyTyrosol
2 itraconazole
2 metronomic chemo
2 Naringin
2 Piperine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Selenium
2 Selenium NanoParticles
2 Ursolic acid
1 Auranofin
1 Astragalus
1 Andrographis
1 Anethole/trans-Anethole
1 Aspirin
1 Ascorbyl Palmitate
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 borneol
1 urea
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Carnosine
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chocolate
1 Metformin
1 Citric Acid
1 Vitamin E
1 diet FMD Fasting Mimicking Diet
1 Zinc
1 Echinacea
1 Emodin
1 Electrical Pulses
1 flavonoids
1 Gallic acid
1 Ginkgo biloba
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 Juglone
1 Melatonin
1 Magnetic Field Rotating
1 Neem
1 Oroxylin-A
1 Oleuropein
1 Oleocanthal
1 Oregano
1 Phenylbutyrate
1 Plumbagin
1 Psoralidin
1 Ramucirumab (CYRAMZA)
1 Salvia officinalis
1 salinomycin
1 Shikonin
1 Theobromine
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:447  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page