CDK2 Cancer Research Results

CDK2, Cyclin-dependent kinase 2: Click to Expand ⟱
Source:
Type:
(CDK2) complex is significantly over-activated in many cancers.
CDK2 (Cyclin-Dependent Kinase 2) is a serine/threonine kinase that regulates late G1 and S phase of the cell cycle.
CDK2 interacts with and phosphorylates proteins in pathways such as DNA damage, intracellular transport, protein degradation, signal transduction, DNA and RNA metabolism and translation.
Scientific Papers found: Click to Expand⟱
8610- MO,    Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species
- in-vitro, CRC, HT-29 - in-vitro, Colon, T84
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, CDKN2C/p18↑, P21↑, cl‑Casp3↑, cl‑Casp7↑, Apoptosis↑, ROS↑, eff↓,
8899- MOR,    Morin Inhibits Proliferation, Migration, and Invasion of Bladder Cancer EJ Cells via Modulation of Signaling Pathways, Cell Cycle Regulators, and Transcription Factor-Mediated MMP-9 Expression
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p‑ERK↑, p‑JNK↓, p‑Akt↓, TumCMig↓, TumCI↓, MMP9↓, AP-1↓, Sp1/3/4↓, NF-kB↓,
3256- PBG,    Mechanisms of Apoptosis and Cell Cycle Arrest Induced by Propolis in Cancer Therapy
- Review, Var, NA
TumCCA↑, CDK2↓, CDK4↓, cycA1/CCNA1↓, CycB/CCNB1↓,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
5163- PLB,    Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCP↓, NRF2↓, TumCCA↑, EMT↓, CSCs↓, eff↓, ROS↑, CycB/CCNB1↓, CDK1↓, CDK2↓, CDC25↓, Vim↓, OCT4↓, SOX2↓, Nanog↓, BMI1↓, NQO1↓, GSTA1↓, HSP90↓, toxicity↓,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
CDK2↓, cycE/CCNE↓, cycD1/CCND1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP/DDIT3↑, TumCCA↑, DNAdam↑, AIF↑, Ca+2↑, MMP↓,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27/CDKN1B↑,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
1453- SFN,    Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, TumCP↓, TumCCA↑, H3↑, H4↑, HDAC↓, CDK1↑, CDK2↑, p19↑, *BioAv↑,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, Synergy↑, Synergy↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3133- VitC,    Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells
- in-vitro, Ovarian, NA
*SVCT-2↑, *GLUT1↓, SVCT-2↓, GLUT1↑, TumCP↓, CDK2↓, PARP↓, selectivity↑,

Showing Research Papers: 101 to 125 of 125
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 125

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 3,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 2,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx1↓, 1,   GSH↓, 6,   GSH↑, 4,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 5,   HO-1↑, 7,   HO-2↓, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 2,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 9,   NRF2↑, 13,   ROS↓, 13,   ROS↑, 61,   ROS⇅, 2,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 4,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 3,   TBARS↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 8,   CDC25↓, 13,   compI↓, 2,   EGF↓, 3,   ETC↓, 1,   mitResp↓, 3,   MKK7↓, 1,   mtDam↑, 7,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 2,   ALAT↓, 2,   ALDOA↓, 1,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 8,   ATP↓, 5,   mt-ATP↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 2,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 8,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   HK2↓, 3,   lactateProd↓, 4,   LDHA↓, 2,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 5,   Apoptosis↓, 1,   Apoptosis↑, 45,   mt-Apoptosis↑, 2,   BAD↑, 5,   Bak↑, 4,   BAX↓, 2,   BAX↑, 41,   BAX⇅, 1,   Bax:Bcl2↑, 9,   Bcl-2↓, 47,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 4,   BIM↑, 5,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 9,   Casp↝, 1,   Casp1↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 47,   cl‑Casp3↑, 9,   Casp7↑, 3,   cl‑Casp7↑, 5,   Casp8↑, 15,   cl‑Casp8↑, 4,   proCasp8↑, 1,   Casp9↓, 1,   Casp9↑, 33,   cl‑Casp9↑, 7,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 36,   Diablo↑, 9,   DR5↓, 1,   DR5↑, 15,   FADD↑, 3,   Fas↑, 13,   FasL↑, 1,   Ferroptosis↑, 2,   HEY1↓, 2,   IAP1↑, 1,   IAP2/BIRC3↓, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 7,   Mcl-1↓, 14,   Mcl-1↑, 1,   MDM2↓, 7,   MDM2↑, 1,   p‑MDM2↓, 1,   NAIP↓, 1,   NOXA↑, 2,   p38↓, 2,   p38↑, 9,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 3,   survivin↓, 20,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 7,   XIAP↓, 13,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 45,   Akt↑, 2,   p‑Akt↓, 11,   AKT1↓, 3,   Akt2↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 2,   cMET↓, 2,   CREB↓, 1,   p‑CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 16,   p‑EGFR↓, 2,   ERK↓, 15,   ERK↑, 1,   p‑ERK↓, 4,   p‑ERK↑, 1,   FGFR1↓, 3,   FGFR2↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGFR↓, 1,   IKKα↓, 4,   IκB↑, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 5,   JNK↓, 2,   JNK↑, 11,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 13,   MAPK↑, 6,   MEK↓, 2,   MKK4↓, 1,   mTOR↓, 28,   mTOR↑, 1,   p‑mTOR↓, 2,   mTORC2↓, 3,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 41,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PKCδ↓, 6,   PTEN↓, 1,   PTEN↑, 6,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 5,   RSK2/RPS6KA3/p90RSK2↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 4,   STAT↓, 2,   STAT3↓, 21,   STAT3↑, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT6↓, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 6,   ATFs↑, 1,   CBP↓, 2,   CBP↑, 1,   cJun↓, 7,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 16,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMTs↓, 3,   EZH2↓, 2,   FOXM1↓, 2,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↑, 2,   p‑FOXO3↓, 1,   H3↓, 1,   H3↑, 3,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 9,   HDAC1↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   miR-200b↑, 1,   miR-21↑, 1,   Myc↓, 3,   n-MYC↓, 1,   OCT4↓, 3,   other↝, 1,   PCAF↓, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 4,   SOX4↓, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV↓, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 8,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 17,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   IRE1↑, 3,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 4,   LC3s↑, 1,   p62↓, 1,   PARK2↑, 1,   TumAuto↑, 6,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↓, 1,   DNAdam↓, 1,   DNAdam↑, 22,   hTERT/TERT↓, 6,   MSH2↑, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 42,   p‑P53↑, 2,   PARP↓, 3,   PARP↑, 7,   cl‑PARP↑, 33,   PARP1↑, 1,   PCNA↓, 17,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 7,   TOP1↓, 5,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 12,   CDK1↑, 2,   CDK1/2/5/9↓, 1,   CDK2↓, 114,   CDK2↑, 8,   p‑CDK2↓, 2,   CDK4↓, 74,   CDK4↑, 3,   CDK4/6↓, 4,   CDK6↓, 27,   CDK6↑, 4,   CDK8↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 15,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 22,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 79,   cycD1/CCND1↑, 1,   CycD3↓, 5,   cycE/CCNE↓, 45,   cycE/CCNE↑, 2,   cycE1↓, 1,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   Ki-67↓, 10,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 1,   P21↑, 57,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 37,   pRB↑, 2,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 6,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 95,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   BMPs↑, 1,   CD133↓, 3,   cFos↓, 7,   CSCs↓, 9,   Diff↓, 1,   Diff↑, 1,   EP300↑, 1,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 2,   HH↓, 2,   IGF-1↓, 5,   IGFBP3↑, 1,   Ki-67↓, 10,   Let-7↑, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 10,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH3↓, 2,   p300↓, 2,   SCF↓, 1,   Shh↓, 2,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 19,   TumCP↓, 54,   TumCP↑, 1,   tyrosinase↓, 2,   Wnt↓, 12,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AP-1↓, 7,   AXL↓, 1,   Ca+2↑, 14,   Ca+2↝, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 19,   EMT↓, 25,   EMT↝, 1,   FAK↓, 6,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 1,   ITGA5↓, 1,   KRAS↓, 1,   MET↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP2↓, 35,   MMP3↓, 4,   MMP7↓, 9,   MMP9↓, 40,   MMP9↑, 3,   MMPs↓, 10,   N-cadherin↓, 14,   PAK1↑, 1,   pax↓, 1,   PDGF↓, 7,   Rac1↓, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 7,   Smad1↑, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 14,   TET1↓, 1,   TGF-β↓, 5,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↑, 4,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 23,   TumCMig↓, 21,   TumMeta↓, 21,   TumMeta↑, 2,   Twist↓, 12,   uPA↓, 16,   uPAR↓, 1,   Vim↓, 14,   Zeb1↓, 6,   ZEB2↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 10,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 19,   LOX1↓, 1,   NO↓, 1,   NO↑, 2,   VEGF↓, 37,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 5,   GLUT1↑, 1,   GLUT4↓, 1,   MMP↓, 38,   NHE1↓, 1,   SVCT-2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 1,   cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 3,   CXCL1↓, 1,   CXCR4↓, 5,   DR4↑, 4,   ICAM-1↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 3,   IL10↓, 2,   IL10↑, 1,   IL12↓, 1,   IL1α↓, 1,   IL1β↓, 3,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 11,   IL8↓, 5,   Imm↑, 2,   Inflam↓, 8,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 52,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 4,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 11,   PSA↓, 4,   PSA∅, 1,   TCF↑, 1,   TCF↝, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 1,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 2,   AR↓, 8,   ER-α36↓, 2,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 13,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 43,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 5,   Dose↝, 12,   Dose∅, 1,   eff↓, 9,   eff↑, 14,   eff↝, 2,   GSTA1↓, 1,   Half-Life↓, 7,   Half-Life↝, 3,   MDR1↓, 1,   P-gp/ABCB1↓, 5,   P450↓, 1,   P450↝, 1,   RadioS↑, 16,   selectivity↑, 32,   Synergy↑, 38,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 8,   ascitic↓, 1,   AST↓, 2,   BRCA1↓, 2,   BRCA1↑, 2,   CRP↓, 1,   E6↓, 3,   E7↓, 3,   EGFR↓, 16,   p‑EGFR↓, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 6,   IL6↓, 11,   KRAS↓, 1,   LDH↓, 2,   LDH↑, 1,   Myc↓, 3,   PD-L1↓, 3,   PSA↓, 4,   PSA∅, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 12,   AntiTum↑, 3,   cardioP↑, 5,   chemoP↑, 5,   chemoPv↑, 6,   ChemoSideEff↓, 1,   hepatoP↑, 3,   neuroP↑, 2,   NP/CIPN↓, 1,   OS↑, 4,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 4,   TGFβR1↑, 1,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 6,   TumW↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 666

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 24,   Catalase↑, 10,   GPx↑, 5,   GSH↑, 11,   GSR↑, 3,   GSTs↑, 5,   H2O2↓, 1,   HDL↑, 2,   HO-1↑, 7,   Keap1↑, 1,   lipid-P↓, 5,   MDA↓, 6,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 12,   Prx↑, 1,   RNS↓, 1,   ROS↓, 23,   ROS↑, 1,   SOD↓, 1,   SOD↑, 11,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ALAT↓, 1,   AMPK↑, 2,   FASN↓, 2,   glucose↓, 1,   GSK‐3β↓, 1,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bax:Bcl2↑, 1,   Casp↓, 1,   Casp3?, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↓, 1,   Fas↑, 1,   IAP1↓, 1,   iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 2,   IκB?, 1,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   mTOR↑, 1,   PI3K↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   p‑cMyc↑, 1,   other↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 1,   P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   Ca+2↓, 2,   Ca+2↝, 1,   MMP2↑, 1,   Rho↓, 1,   ROCK1↓, 1,   TregCell↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 2,   VCAM-1↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↓, 1,   MMP↓, 1,   MMP↑, 1,   SVCT-2↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   ICAM-1↓, 1,   IL10↓, 2,   IL17↓, 1,   IL1β↓, 1,   IL22↓, 1,   IL4↑, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 24,   MCP1/CCL2↓, 1,   NF-kB↓, 11,   NLRP3↓, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   AChE↑, 1,   BDNF↑, 3,   GABA↑, 2,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↝, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 5,   BioAv↝, 2,   CompStab↝, 1,   Dose↑, 1,   Dose↝, 2,   GSTA1↑, 1,   Half-Life↑, 1,   P450↓, 1,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 4,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 3,   LDH↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 5,   AntiTum↓, 1,   cardioP↑, 9,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 6,   memory↑, 6,   Mucositis↓, 1,   neuroP↑, 18,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 1,   Risk↓, 1,   Stroke↓, 1,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 2,  
Total Targets: 177

Scientific Paper Hit Count for: CDK2, Cyclin-dependent kinase 2
16 Fisetin
5 Lycopene
5 Quercetin
4 Chrysin
4 Ellagic acid
4 Garcinol
4 Honokiol
4 Luteolin
3 Apigenin (mainly Parsley)
3 Artemisinin
3 Propolis -bee glue
3 Diindolylmethane
3 Ferulic acid
3 Sulforaphane (mainly Broccoli)
3 Magnolol
2 Silver-NanoParticles
2 Berberine
2 Boswellia (frankincense)
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Flaxseed/Linseed
2 HydroxyTyrosol
2 Indole-3-carbinol
2 Juglone
2 Thymoquinone
1 Allicin (mainly Garlic)
1 Cisplatin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Biochanin A
1 Betulinic acid
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Cinnamon
1 Hydroxycinnamic-acid
1 Crocetin
1 Cucurbitacin
1 Emodin
1 Eugenol
1 Gallic acid
1 Ginseng
1 5-fluorouracil
1 Inulin Prebiotic
1 phytic acid, Inositol hexakisphosphate
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Lactobacillus
1 Lapachol
1 Licochalcone A
1 Licorice
1 Metformin
1 Magnetic Fields
1 Chemotherapy
1 Lemon Balm/Melissa officinalis
1 Morin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Plumbagin
1 Pterostilbene
1 Resveratrol
1 Rosmarinic acid
1 Sesame seeds and Oil
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:467  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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