p27/CDKN1B Cancer Research Results

p27/CDKN1B, p27kip1: Click to Expand ⟱
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The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.

CDKN1B - Cyclin-Dependent Kinase Inhibitor 1B / p27

Abbreviation: CDKN1B, p27, p27Kip1

Type: Cyclin-dependent kinase inhibitor / cell-cycle regulator

Function: CDKN1B/p27 inhibits cyclin-CDK complexes, particularly cyclin E-CDK2 and cyclin A-CDK2, thereby restricting G1/S cell-cycle progression. It also regulates differentiation, transcription, cytoskeletal organization, cell migration, and cellular responses to growth-factor signaling.

Cancer: ↕ Context-dependent, but predominantly tumor-suppressive. Reduced nuclear p27 expression or functional loss can promote uncontrolled proliferation, tumor progression, and treatment resistance. However, cytoplasmic p27 can acquire CDK-independent pro-oncogenic functions that promote cell motility, invasion, and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,
5219- PG,    Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle
- in-vitro, Cerv, HeLa
TumCG↓, TumCCA↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, Casp8↑, cl‑PARP↑,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27/CDKN1B↑, P53↑, Casp9↑, Casp3↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27/CDKN1B↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27/CDKN1B↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27/CDKN1B↑, TumCCA↑, ChemoSen↑, COX2/PTGS2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27/CDKN1B↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
TumCCA↑, p27/CDKN1B↑, cycD1/CCND1↓, TumCP↓, IGF-1R↓, Akt↓, Wnt↓, P53↑, Apoptosis↑, Sp1/3/4↓, cl‑PARP↑, β-catenin/ZEB1↓, MDM2↓,
2982- RES,    The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1
- in-vitro, Melanoma, MSTO-211H
tumCV↓, Apoptosis↑, Sp1/3/4↓, p27/CDKN1B↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27/CDKN1B↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27/CDKN1B↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27/CDKN1B↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2/PTGS2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27/CDKN1B↑, ROS↑, DNAdam↑, MUC4↓,
3413- TQ,    Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, EGFR↓, ROS↑,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
6456- TUR,    Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCP↓, TumCCA↑, CTSB↓, cl‑p27/CDKN1B↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, Synergy↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, Synergy↑, Synergy↑,

Showing Research Papers: 101 to 123 of 123
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 123

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 2,   antiOx⇅, 1,   ARE↑, 2,   Catalase↓, 2,   Catalase↑, 3,   Copper↑, 1,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 4,   GSTs↑, 1,   HO-1↓, 5,   HO-1↑, 2,   i-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 1,   MDA↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NRF2↓, 7,   NRF2↑, 7,   ROS↓, 12,   ROS↑, 55,   ROS⇅, 4,   i-ROS↑, 1,   SOD↓, 3,   SOD↑, 3,   SOD2↓, 2,   TAC?, 1,   TAC↓, 1,   Trx↑, 1,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 3,   CDC25↓, 7,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 1,   ETC↓, 2,   Insulin↓, 2,   mitResp↓, 1,   mtDam↑, 3,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   PDH↑, 2,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   ACC↑, 1,   ALDOA↓, 1,   AMP↓, 1,   AMPK↑, 7,   ATP↓, 6,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FAO↓, 1,   FASN↓, 3,   GlucoseCon↓, 1,   Glycolysis↓, 6,   GSK‐3β↓, 7,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   Histones↑, 1,   HK2↓, 4,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDHA↓, 4,   LDL↓, 2,   MCT4↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 3,   PFK↓, 2,   PKM2↓, 3,   polyA↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TS↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 58,   mt-Apoptosis↑, 2,   BAD↓, 1,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 39,   BAX⇅, 1,   Bax:Bcl2↑, 15,   Bcl-2↓, 42,   Bcl-2↑, 1,   Bcl-xL↓, 15,   BID↓, 1,   BID↑, 3,   BIM↑, 3,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 12,   Casp1↑, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 45,   cl‑Casp3↑, 8,   Casp7↑, 4,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 33,   cl‑Casp9↑, 1,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 25,   Diablo↑, 4,   DR5↓, 1,   DR5↑, 7,   FADD↑, 2,   Fas↑, 7,   FasL↑, 1,   Ferroptosis↑, 2,   iNOS↓, 2,   Mcl-1?, 1,   Mcl-1↓, 8,   MDM2↓, 5,   MDM2↑, 1,   NAIP↓, 1,   necrosis↑, 1,   oncosis↑, 1,   p38↓, 1,   p38↑, 6,   p‑p38↑, 2,   PUMA↓, 2,   PUMA↑, 2,   survivin↓, 21,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↑, 4,   XIAP↓, 11,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 53,   Akt↑, 1,   p‑Akt↓, 8,   AKT1↓, 1,   AMPKα↑, 1,   CK2↓, 1,   cMET↓, 2,   EGFR↓, 15,   ERK↓, 23,   p‑ERK↓, 4,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IKKα↓, 3,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 1,   JAK2↓, 4,   JNK↓, 3,   JNK↑, 9,   p‑JNK↑, 1,   MAPK↓, 13,   MAPK↑, 4,   MEK↓, 1,   mTOR↓, 27,   p‑mTOR↓, 2,   p70S6↓, 1,   P70S6K↓, 3,   PI3K↓, 35,   p‑PI3K↓, 2,   PI3K/Akt↓, 2,   PKCδ↓, 3,   PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 3,   RAS↓, 8,   S6K↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 3,   STAT3↓, 22,   STAT3↑, 1,   p‑STAT3↓, 2,   STAT5↓, 2,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 2,   cJun↓, 2,   cJun↑, 1,   cMyc↓, 14,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 1,   EZH2↓, 3,   FOXM1↓, 4,   FOXO↑, 3,   FOXO1↓, 1,   FOXO3↓, 3,   FOXO3↑, 3,   H3↓, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 7,   HDAC1↓, 4,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 1,   IRF1↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   MTA2↓, 2,   Myc↓, 2,   n-MYC↓, 1,   OCT4↓, 3,   other↑, 1,   other↝, 4,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 2,   TCF-4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 10,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   IRE1↑, 3,   PERK↑, 2,   Proteasome↓, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↑, 1,   CTSB↓, 1,   LC3A↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   ATR↑, 1,   p‑ATR↑, 1,   BRCA1↑, 3,   BRCA2↑, 1,   DNAdam↑, 21,   DNArepair↑, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 5,   P53↓, 2,   P53↑, 38,   p‑P53↓, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 4,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 24,   PARP1↑, 1,   PCNA↓, 10,   RAD51↓, 1,   Telomerase↓, 5,   TOP1↓, 2,   TOP2↓, 4,   TP53↑, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 37,   CDK2↑, 2,   CDK4↓, 41,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 13,   CDK6↑, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 9,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 62,   cycD1/CCND1↑, 1,   CycD3↓, 4,   cycE/CCNE↓, 24,   cycE/CCNE↑, 2,   cycE1↓, 3,   E2F4↑, 1,   E2Fs↓, 4,   Ki-67↓, 4,   P21↓, 7,   P21↑, 88,   p27/CDKN1B↓, 11,   p27/CDKN1B↑, 111,   cl‑p27/CDKN1B↓, 1,   pRB↓, 3,   pRB↑, 2,   p‑pRB↓, 4,   RB1↑, 2,   cl‑RB1↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 84,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   BMPs↑, 1,   CD133↓, 3,   cFos↓, 2,   CSCs↓, 9,   Diff↓, 1,   Diff↑, 4,   EP4/PTGER4↑, 1,   Gli↓, 1,   Gli1↓, 3,   HMGCR↓, 2,   IGF-1↓, 5,   IGFBP3↑, 1,   p‑Jun↓, 1,   Ki-67↓, 4,   Let-7↓, 1,   Let-7↑, 1,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 8,   NOTCH⇅, 1,   NOTCH1↓, 4,   NOTCH2↓, 1,   NOTCH2↑, 1,   PTCH1↓, 2,   Smo↓, 2,   TumCG↓, 20,   TumCG↑, 1,   TumCP↓, 40,   TumCP↑, 1,   Wnt?, 1,   Wnt↓, 12,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   AP-1↓, 5,   CA↓, 1,   Ca+2↑, 7,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   Cdc42↑, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 13,   EMT↓, 15,   FAK↓, 6,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↑, 1,   LRP1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 27,   MMP3↓, 2,   MMP7↓, 4,   MMP9↓, 23,   MMP9↑, 1,   MMPs↓, 9,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 5,   NCAM↑, 1,   PDGF↓, 4,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 2,   ROCK1↑, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 6,   TGF-β↓, 2,   TIMP2↓, 1,   TIMP2↑, 3,   Trop2↓, 1,   TumCI↓, 12,   TumCMig↓, 15,   TumMeta↓, 14,   TumMeta↑, 2,   Twist↓, 8,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 9,   Zeb1↓, 7,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 10,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   angioG↑, 1,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 18,   LOX1↓, 2,   NO↓, 2,   NO↑, 3,   VEGF↓, 30,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 30,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 1,   CD44↓, 3,   COX2/PTGS2↓, 19,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR4↓, 3,   DR4↑, 3,   FOXP3↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IL1↓, 5,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↑, 1,   IL6↓, 10,   IL7↓, 1,   IL8↓, 6,   IL8↑, 1,   Imm↑, 2,   Inflam↓, 10,   IRAK1↓, 2,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 50,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 7,   PSA∅, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 2,   TNF-α↓, 11,   TNF-α↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AhR↑, 2,   AhR↓, 1,   AR↓, 10,   ER-α36↓, 1,   ER(estro)↓, 1,   GR↑, 1,   PPARα↑, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 8,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 3,   ChemoSen↑, 34,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 3,   Dose↝, 8,   Dose∅, 1,   eff↓, 7,   eff↑, 16,   eff↝, 3,   GSTA1↑, 1,   Half-Life↓, 5,   Half-Life↝, 4,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 3,   RadioS↑, 15,   selectivity↑, 24,   selectivity↝, 1,   Synergy↑, 22,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 10,   BRCA1↑, 3,   E6↓, 1,   E7↓, 1,   EGFR↓, 15,   EZH2↓, 3,   FOXM1↓, 4,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 4,   IL6↓, 10,   Maspin↑, 1,   Myc↓, 2,   PD-L1↓, 3,   PSA↓, 7,   PSA∅, 1,   TP53↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 23,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 4,   ChemoSideEff↓, 2,   FTO↑, 1,   hepatoP↑, 4,   neuroP↑, 2,   NKG2D↑, 1,   OS↑, 2,   QoL↑, 2,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 2,   TumVol↓, 5,   TumW↓, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 581

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 6,   GPx↑, 3,   GSH↑, 8,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 2,   Iron∅, 1,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NQO1↑, 2,   NRF2↑, 4,   RNS↓, 1,   ROS↓, 15,   SOD↓, 1,   SOD↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↑, 2,   CRM↑, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   glyC↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 1,   ERK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   MMP13↓, 1,   PAI-1/SERPINE1↓, 1,   Rho↓, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 2,   Inflam↓, 12,   NF-kB↓, 2,   NLRP3↓, 1,   PGE2↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 1,   BioAv↝, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   eff↑, 1,   GSTA1↑, 2,   Half-Life↓, 1,   Half-Life↝, 2,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   BUN↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 2,   antiD↓, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↓, 1,   cardioP↑, 6,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 3,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 1,   RenoP↑, 1,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 1,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   GutMicro↑, 1,   Sepsis↓, 1,  
Total Targets: 116

Scientific Paper Hit Count for: p27/CDKN1B, p27kip1
6 Thymoquinone
6 phytic acid, Inositol hexakisphosphate
6 Resveratrol
5 Diindolylmethane
5 Lycopene
4 Berberine
4 Indole-3-carbinol
4 Fisetin
3 Alpha-Lipoic-Acid
3 Curcumin
3 EGCG (Epigallocatechin Gallate)
3 Gallic acid
3 Sulforaphane (mainly Broccoli)
3 Propolis -bee glue
2 Silver-NanoParticles
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalein
2 Cucurbitacin
2 diet Methionine-Restricted Diet
2 Eugenol
2 HydroxyTyrosol
2 Inositol
2 Phenethyl isothiocyanate
2 lambertianic acid
2 Linalool
2 Luteolin
2 Silymarin (Milk Thistle) silibinin
1 3-bromopyruvate
1 5-fluorouracil
1 Coenzyme Q10
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Berbamine
1 Biochanin A
1 Betulinic acid
1 Brucea javanica
1 brusatol
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Cisplatin
1 Caffeic acid
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Deguelin
1 Emodin
1 Ferulic acid
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperoside
1 Isoliquiritigenin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Licochalcone A
1 Magnolol
1 mebendazole
1 Dordaviprone; Modeyso
1 methylseleninic acid
1 Metformin
1 Melatonin
1 Methylsulfonylmethane
1 Naringin
1 Oleuropein
1 Propyl gallate
1 Plumbagin
1 Quercetin
1 Rosmarinic acid
1 salinomycin
1 Turmerones
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:468  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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