TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
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Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
6301- Cro,    Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways
- vitro+vivo, Colon, HT29 - in-vitro, Colon, Caco-2
tumCV↓, selectivity↑, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, NF-kB↓, VEGF↓, TumMeta↓,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,
6211- CUR,    The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer
- Review, Var, NA
HIF-1↓, VEGF↓, angioG↓, RadioS↑, ChemoSen↑, other↝, Apoptosis↑, TumCG↓, TumMeta↓, BioAv↓, COX2↓, CD31↓, IL8↓, TGF-β↓, NF-kB↓, JAK2↓, STAT3↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6222- CUR,    Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials
- Review, Var, NA
RadioS↑, ChemoSen↑, MMPs↓, TumMeta↓, TumCI↓, Inflam↓, NF-kB↓, BioAv↓, BioAv↑, MAPK↓, PI3K↓, Akt↓, *ROS↓, *MDA↓, *lipid-P↓, *Half-Life↓, mTOR↓,
6218- CUR,    Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications
- Review, Var, NA
NF-kB↓, TrxR↓, ROS↑, TumMeta↓, TumCD↑, RadioS↑, BioAv↝, BioAv↑,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
4652- CUR,    Anticancer effect of curcumin on breast cancer and stem cells
- Review, BC, NA
TumCP↓, TumMeta↓, TumCCA↑, Apoptosis↑, CSCs↓, NF-kB↓, Telomerase↓, Cyt‑c↑, Casp9↑, Casp3↑, E-cadherin↑,
467- CUR,    Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling
- in-vitro, Liver, HepG2
TumCP↓, TumCI↓, TumMeta↓, Apoptosis↑, HSP70/HSPA5↓, e-HSP70/HSPA5↓, TLR4↓,
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓, AR↓, STAT3↓, p‑Akt↓, Mcl-1↓, Bcl-xL↓, cl‑PARP↑, miR-21↓, miR-205↑, TumCG↓, TumCP↓, TumCI↓, angioG↓, TumMeta↓,
153- CUR,    Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone Morphogenic Protein-7 in Vivo
- in-vivo, Pca, C4-2B
PSA↓, TGF-β↓, BMPs↑, TumMeta↓,
16- Cyc,  RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, N-cadherin↓, E-cadherin↑, Snail↓, TumCI↓, TumMeta↓,
6245- Cyc,    Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
- vitro+vivo, PC, NA
HH↓, Snail↓, E-cadherin↑, EMT↓, TumCI↓, ChemoSen↑, TumMeta↓, ALDH↓, eff↑,
6593- DAS,    Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors
TumCP↓, TumCI↓, TumMeta↓, eff↑, Src↓,
1446- Deg,    Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
- in-vitro, BC, 4T1
cMET↓, p‑ERK↓, p‑Akt↓, TumCMig↓, TumCG↓, Weight∅, *toxicity∅, Hif1a↓, TumMeta↓,
6676- Deg,    Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry
- Review, Var, NA
TumCP↓, Apoptosis↑, NF-kB↓, Wnt↓, TumCCA↑, TumMeta↑, antiOx↑, Inflam↓, angioG↓, Half-Life↑, MMP2↓, MMP9↓, Casp9↑, Casp3↑, EMT↓, PTEN↑, ChemoSen↑, toxicity↑, *BBB↑,
6704- DFC,    Diclofenac demonstrates notable anticancer properties
- Review, Var, NA
TumMeta↓, other↝,
6663- DFE,    Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, *AntiArt↑, *neuroP↑, *hepatoP↑, *GastroP↑, *other↝, *cardioP↑, *cognitive↑, *ROS↓, *memory↑, *other↝, *SOD↑, *Catalase↑, *GSH↑, *GA↑, *Catechins↑, *FA↑, *QC↑, Api↑, *CA↑, *Imm↑, *Phen↑, *IL1β↓, *TGF-β↓, *COX1↓, *COX2↓, TumCP↓, Casp3↑, TumMeta↓, *GutMicro↑,
1183- DHA,    Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo
- in-vitro, BC, 4T1 - in-vitro, BC, MCF7 - in-vivo, BC, NA
TumCG↓, TumCCA↑, β-catenin/ZEB1↓, TCF↓, LEF1↓, cMyc↓, cycD1/CCND1↓, Wnt/(β-catenin)↓, TumMeta↓,
6729- Dipy,    Dipyridamole prevents triple-negative breast-cancer progression
- Trial, BC, MDA-MB-231
TumCG↓, TumMeta↑, β-catenin/ZEB1↓, *AntiAg↑, TumCCA↑, Wnt↓, NF-kB↓,
6271- DL,    D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
- in-vitro, Colon, SW480 - in-vitro, Colon, HT-29
TumCP↓, Apoptosis↑, Bax:Bcl2↑, VEGF↓, angioG↓, TumMeta↓, VEGFR1↓, MMP9↓,
6285- DL,    Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
VEGF↓, *STAT3↓, TumCP↓, TumMeta↓, p‑STAT3↓, MMP9↓, SHP1↑, angioG↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
5012- DSF,  Cu,    Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
678- EGCG,    Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells
other↑, TumMeta↓, YMcells↑, CSCs↓,
4680- EGCG,    The Potential of Epigallocatechin Gallate in Targeting Cancer Stem Cells: A Comprehensive Review
- Review, Var, NA
CSCs↓, EMT↓, TumMeta↓, RadioS↑, ChemoSen↑, BioAv↓,
1503- EGCG,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2↓, NOS2↓, ac‑H3↑, ac‑H4↑, eff↑,
5490- EP,    Application of Pulsed Electric Fields to Cancer Therapy
- Review, Var, NA
CellMemb↑, Ca+2↑, Imm↑, TumMeta↓,
6384- Eug,    Eugenol modulates the NOD1-NF-κB signaling pathway via targeting NF-κB protein in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453
TumCG↓, TumMeta↓, NF-kB↓,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27↑, NF-kB↓, COX2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
6386- Eug,    A comprehensive and systematic review on potential anticancer activities of eugenol: From pre-clinical evidence to molecular mechanisms of action
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, Inflam↝, TumCI↓, TumMeta↓, cycD1/CCND1↓, CycB/CCNB1↓, PCNA↓, NF-kB↓, Bcl-2↓, BAX↑, AIF↑, P21↑, P53↑, ChemoSen↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *eff↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
1112- FA,    Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition
- in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA
tumCV↓, Apoptosis↑, AntiTum↑, TumMeta↓, EMT↓, TumVol↓, TumW↓,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
1773- GA,    Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action
- Review, Var, NA
antiOx↑, AntiCan↑, Inflam↑, GutMicro↑, BioAv↝, BioAv↓, BioAv↑, TumMeta↓,

Showing Research Papers: 101 to 150 of 273
Prev Page 3 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 273

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Fenton↑, 1,   Ferroptosis↑, 3,   GPx4↓, 1,   GSH↓, 3,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 2,   Iron↑, 1,   lipid-P↑, 3,   MAD↓, 1,   MDA↑, 1,   NADH↓, 1,   NRF2↓, 2,   NRF2↑, 2,   OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 19,   SOD↓, 1,   SOD1↓, 1,   Thiols↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 2,   EGF↓, 1,   ETC↓, 2,   MMP↓, 10,   MPT↑, 2,   mtDam↑, 1,   OCR↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↑, 5,   cMyc↓, 4,   CREB↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↑, 1,   LDH↓, 1,   LDH↑, 1,   LDHA↓, 1,   PDH↝, 1,   PDK1↓, 2,   PKM2↓, 1,   PPARα↝, 1,   SCD1↓, 1,   SIRT1↓, 1,   SREBP2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 15,   Akt↑, 1,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 23,   ATF2↓, 1,   BAD↓, 1,   BAD↑, 2,   Bak↑, 2,   BAX↑, 9,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-xL↓, 4,   BID↑, 1,   BIM↑, 3,   Casp↑, 5,   Casp3↑, 13,   cl‑Casp3↑, 1,   Casp6↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 9,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 1,   Ferroptosis↑, 3,   JNK↑, 1,   MAPK↓, 8,   Mcl-1↓, 4,   MCT1↓, 1,   Myc↓, 1,   NOXA↑, 1,   p27↑, 4,   p38↓, 1,   Proteasome↓, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 6,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 3,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   miR-205↑, 1,   miR-21↓, 1,   other↑, 1,   other↝, 2,   tumCV↓, 4,   YMcells↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   e-HSP70/HSPA5↓, 1,   IRE1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3II↑, 1,   LC3s↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 8,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 3,   P53?, 1,   P53↑, 10,   PARP↑, 3,   cl‑PARP↑, 8,   PCNA↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 5,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 10,   cycE/CCNE↓, 3,   E2Fs↓, 3,   P21↑, 6,   TumCCA↓, 1,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 6,   Axin2↑, 1,   CD133↑, 1,   CD24↓, 1,   CD44↓, 3,   cFos↓, 3,   CIP2A↓, 1,   cMET↓, 1,   CSCs↓, 10,   CTNNB1↓, 1,   EMT↓, 17,   EpCAM↓, 3,   ERK↓, 1,   p‑ERK↓, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   Gli1↓, 1,   GSK‐3β↓, 2,   HDAC↓, 3,   HDAC4↓, 1,   HH↓, 2,   mTOR↓, 8,   mTORC2↓, 1,   NOTCH↓, 4,   NOTCH1↓, 4,   NOTCH1↝, 1,   OCT4↓, 3,   PI3K↓, 11,   PTEN↑, 2,   SHP1↑, 1,   SOX2↓, 1,   Src↓, 2,   STAT↓, 1,   STAT3↓, 7,   p‑STAT3↓, 1,   TCF↓, 1,   TCF-4↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 14,   Wnt↓, 7,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AP-1↓, 3,   AP-1↝, 1,   Ca+2↑, 3,   CD31↓, 1,   E-cadherin↑, 11,   FAK↓, 2,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   LEF1↓, 1,   MET↓, 1,   MMP1↓, 2,   MMP2↓, 10,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 14,   MMPs↓, 7,   N-cadherin↓, 3,   NEDD9↓, 1,   PKCδ↓, 2,   RECK↑, 2,   Rho↓, 1,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 7,   TGF-β↓, 4,   TGF-β↑, 1,   TIMP1↑, 2,   TIMP2↑, 2,   TumCI↓, 18,   TumCI↑, 1,   TumCMig↓, 6,   TumCMig↑, 1,   TumCP↓, 15,   TumCP↑, 1,   TumMeta↓, 45,   TumMeta↑, 5,   Twist↓, 3,   uPA↓, 2,   VEGFR1↓, 2,   Vim↓, 5,   Zeb1↓, 2,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 24,   angioG↑, 1,   ATF4↓, 1,   ATF4↑, 1,   EGFR↓, 2,   eNOS↓, 1,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 3,   Hif1a↝, 1,   VEGF↓, 13,   VEGFR2↓, 3,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   GLUT1↓, 2,   P-gp↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 9,   IL1↓, 1,   IL12↓, 1,   IL2↓, 1,   IL6↓, 3,   IL8↓, 3,   Imm↑, 3,   Inflam↓, 3,   Inflam↑, 1,   Inflam↝, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 28,   NK cell↑, 1,   p65↓, 1,   PD-1↓, 1,   PGE2↓, 3,   PSA↓, 1,   TLR4↓, 1,   TLR4↝, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 8,   BioAv↝, 3,   ChemoSen↑, 19,   DDS↑, 1,   Dose↝, 3,   DrugR↓, 1,   eff↓, 1,   eff↑, 15,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 1,   RadioS↑, 8,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BMPs↑, 1,   EGFR↓, 2,   GutMicro↑, 2,   HER2/EBBR2↓, 2,   IL6↓, 3,   Ki-67↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   NOS2↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   antiNeop↑, 1,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   Remission↑, 1,   toxicity↓, 1,   toxicity↑, 2,   toxicity↝, 2,   TumVol↓, 3,   TumW↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 320

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 2,   AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Catalase↑, 5,   GPx↑, 1,   GPx1↑, 1,   GSH↑, 1,   GSTs↑, 4,   HO-1↑, 3,   lipid-P↓, 3,   MDA↓, 2,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 10,   SOD↓, 1,   SOD↑, 3,   SOD1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cytoP450↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   TGF-β↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 4,   CRP↓, 1,   IL1↓, 1,   IL1β↓, 1,   IL6↓, 4,   Imm↑, 1,   Inflam↓, 7,   Inflam↑, 1,   NF-kB↓, 2,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 1,   eff↑, 2,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 2,   neuroP↑, 6,   Pain↓, 1,   radioP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 76

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
15 Curcumin
11 Thymoquinone
9 Nimbolide
8 Eugenol
8 Quercetin
7 Resveratrol
7 Pterostilbene
6 Chrysin
6 Magnetic Fields
6 Bicarbonate(Sodium)
5 Artemisinin
5 Aspirin
5 chitosan
5 Honokiol
5 Phenethyl isothiocyanate
4 brusatol
4 Capsaicin
4 Celastrol
4 Magnetic Field Rotating
4 Piperlongumine
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Silver-NanoParticles
3 Melatonin
3 Baicalein
3 Berbamine
3 Biochanin A
3 Beta-Caryophyllene
3 Propolis -bee glue
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Cinnamon
3 Copper and Cu NanoParticles
3 Disulfiram
3 immunotherapy
3 EGCG (Epigallocatechin Gallate)
3 Gambogic Acid
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Astaxanthin
2 Betulinic acid
2 Brucea javanica
2 Bromelain
2 Boswellia (frankincense)
2 Bruteridin(bergamot juice)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Zinc
2 Coenzyme Q10
2 Vitamin K2
2 Cucurbitacin
2 Cyclopamine
2 Deguelin
2 D-limonene
2 Ellagic acid
2 Fisetin
2 Luteolin
2 Lycopene
2 Radiotherapy/Radiation
2 Rosmarinic acid
2 Selenium
2 Selenium NanoParticles
2 Urolithin
1 1,8-Cineole
1 3-bromopyruvate
1 Astragalus
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 almonertinib
1 Andrographis
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 beta-glucans
1 Berberine
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 urea
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Docetaxel
1 Chocolate
1 Metformin
1 Boron
1 Carica papaya leaf extract
1 Crocetin
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dipyridamole
1 Electrical Pulses
1 Ferulic acid
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Geraniol
1 Graviola
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Ivermectin
1 Sorafenib (brand name Nexavar)
1 Magnolol
1 nicotinamide adenine dinucleotide
1 Dichloroacetate
1 Oleuropein
1 Phenylbutyrate
1 Piperine
1 Sanguinarine
1 Psoralidin
1 salinomycin
1 Sulfasalazine
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Whole Body Vibration
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:604  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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