P21 Cancer Research Results

P21, P21/CDKN1A: Click to Expand ⟱
Source:
Type: Proapototic
cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli.
P21 is a cyclin-dependent kinase inhibitor that plays a crucial role in regulating the cell cycle. It is encoded by the CDKN1A gene and is a key player in the cellular response to stress, including DNA damage.
P21 is often considered a tumor suppressor because its expression is upregulated in response to p53 activation, a well-known tumor suppressor protein. When DNA damage occurs, p53 can activate the transcription of the CDKN1A gene, leading to increased levels of P21, which helps prevent the proliferation of damaged cells.
In many cancers, the p53 pathway is disrupted, leading to decreased levels of P21. p21 is a apoptotic marker protein.
Cell cycle arrest gene p21
Field Suggested Entry
Target CDKN1A / p21 / p21Cip1/Waf1
Full Name Cyclin-dependent kinase inhibitor 1A
Target Class CIP/KIP-family cyclin-dependent kinase inhibitor
Main Binding Partners CDK2, CDK1, CDK4/6, cyclin complexes, PCNA
Primary Biology p53-mediated cell-cycle arrest, DNA damage response, senescence, differentiation, CDK inhibition, RB/E2F pathway suppression, apoptosis regulation
Cancer Relevance High but context-dependent: p21 can suppress tumor growth through cell-cycle arrest and senescence, but can also support apoptosis resistance, senescent-cell survival, and therapy resistance in some tumors
AD Relevance Medium: indirect relevance through neuronal cell-cycle re-entry, senescence, p53 stress signaling, and aging-related cell-cycle dysregulation
Therapeutic Direction Context-dependent. Restore/activate p21 for tumor-suppressive arrest where appropriate; inhibit or bypass p21 where it promotes apoptosis resistance, senescent-cell survival, or treatment resistance.


Scientific Papers found: Click to Expand⟱
2859- FIS,    The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways
- in-vitro, Liver, HepG2 - NA, Colon, Caco-2
TumCG↓, other↝, Casp3↑, Casp7↑, PGE2↓, GSTs↓, Wnt↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, P53↑, P21↑, P450↓,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6980- Form,    The potential role of formononetin in cancer treatment: An updated review
- Review, Var, NA
TumCP↓, TumCI↓, TumMeta↓, Apoptosis↑, TumCCA↑, p‑Akt↑, p38↑, P21↑, P53↑, NF-kB↓, ERK↓, LAMs↓, JAK↓, STAT↓, Akt↓,
8308- FS,  lign,    The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1
- in-vivo, BPH, NA
*eff↑, *other↝, *GPER↑, *TumCCA↑, *P53↑, *P21↑, *cycD1/CCND1↓,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
1065- GA,    Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression
- vitro+vivo, Pca, NA
tumCV↓, MMP↓, DNAdam↑, HDAC1↓, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE1↓, P21↑, TumVol↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycB/CCNB1↓, p‑cJun↑,
803- GAR,    Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↑, CDK6↑, P21↑, p27/CDKN1B↑, ERK↓, MAPK↓,
7107- GEN,    Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
- Trial, Pca, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
COX2/PTGS2↓, P21↑, PGE2↓, other↑, Dose↝,
1504- GEN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, Var, NA
DNMTs↓, P21↑, p16↑, ac‑H3↑, ac‑H4↑, TumCCA↑, Casp↑, Apoptosis↑, hTERT/TERT↓, BTG3↑,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
7323- GSE,    Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity
- vitro+vivo, Lung, NA
miR-106b↓, P21↑, TumCG↓, Dose↝,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, Synergy↑, ChemoSen↑, *toxicity↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
2898- HNK,    Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism
- in-vitro, GC, AGS - in-vitro, GC, NCI-N87 - in-vitro, BC, MGC803 - in-vitro, GC, SGC-7901
TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, HER2/EBBR2↓, TumCCA↑, PI3K↓, Akt↓, MMP9↓, P21↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
7607- I3C,    Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
- in-vitro, AML, THP1
AhR↑, TumCP↓, selectivity↑, Bcl-2↓, Fas↑, P21↑, p27/CDKN1B↑, P53↓, CDK2↓,
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7593- I3C,    Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells
- Review, Pca, NA
Risk↓, TumCG↓, TumCCA↑, P21↑, p27/CDKN1B↑, CDK6↓, cl‑RB1↓, cl‑PARP↑, BAX↑, Bcl-2↓,
7718- IP6,    Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
- in-vitro, Pca, DU145
chemoPv↑, TumCG↓, TumCCA↑, P21↓, p27/CDKN1B↑, CDK2↓, CDK4↓, CDK6↓, cycE/CCNE↓, cycD1/CCND1↓, pRB↑, Apoptosis↑, cl‑PARP↑, Casp3↑,
7642- IP6,    Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, Apoptosis↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, AKT1↓, S6K↓, mTOR↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, Synergy↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
1293- IP6,    Inositol Hexaphosphate Inhibits Growth and Induces G1 Arrest and Apoptotic Death of Androgen-Dependent Human Prostate Carcinoma LNCaP Cells
- vitro+vivo, Pca, LNCaP
TumCG↓, TumCCA↑, P21↑, CDK4↓, cycD1/CCND1↓, RB1↑, E2Fs↓,
7748- ISL,  GEM,    Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis
- in-vitro, Lung, NA
Dose↝, Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, P21↑, selectivity↑, JAK2↓, STAT3↓,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7786- ISL,    Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function
- in-vitro, Var, NA
AntiTum↑, TumCP⇅, cycD1/CCND1↓, cycE/CCNE↓, P21↑,
9252- ISO, IH,    Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, mtDam↑, MMPs↓, VEGF↓, EMT↓, *antiOx↓, *Inflam↓, *ROS↓, MDR1↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, Ingr↝, TumCCA↑, CycB/CCNB1↓, CDK1↓, P21↑, ROS↑, AMPK↑, *Ferroptosis↓, *NRF2↑, *HO-1↑, *IronCh↑, *lipid-P↓, *GSH↑, *ACSL4↓, *COX2/PTGS2↓, VEGF↓, angioG↓, E-cadherin↑, N-cadherin↓, uPA↓, *NK cell↑, radioP↑, Imm↑, Neut↑, Eos↑,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
1923- JG,    Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells
- in-vitro, Endo, NA
TumCP↓, TumCCA↑, cycA1/CCNA1↓, ROS↑, P21↑, CDK2↓, CDK1↓, CDC25↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Cyt‑c↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8101- KAE,    Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
- vitro+vivo, ESCC, KYSE150 - vitro+vivo, ESCC, Eca109
TumCCA↑, TumCP↓, Glycolysis↓, HK2↓, GlucoseCon↓, lactateProd↓, EGFR↓, TumCG↓, P21↑, Dose↝, Ki-67↓,
8115- LA,    Inhibitory Effect of Vaginal Lactobacillus Supernatants on Cervical Cancer Cells
- in-vitro, Cerv, CaSki
TumCP↓, TumCCA↑, E6↓, E7↓, CDK2↓, cycA1/CCNA1↓, P21↑,
8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, *Bacteria↓, AR↓, PSA↓, TumCCA↑, CDK4↓, CDK6↓, cycD1/CCND1↓, P53↑, P21↑, p27/CDKN1B↓, Apoptosis↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Dose↝,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8253- LCA,    Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma
- in-vitro, SCC, HSC4
*AntiTum↑, *angioG↓, *AntiP↑, *antiOx↑, *Bacteria↓, *Inflam↓, tumCV↓, Sp1/3/4↓, p27/CDKN1B↑, P21↑, cycD1/CCND1↓, Mcl-1↓, survivin↓, Apoptosis↑,

Showing Research Papers: 151 to 200 of 349
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 349

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 4,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 7,   GPx1↓, 1,   GPx4↓, 2,   GSH↓, 21,   GSH↑, 9,   GSH/GSSG↓, 1,   GSR↑, 2,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 12,   HO-2↓, 1,   Iron↓, 1,   i-Iron↑, 1,   lipid-P↓, 6,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 4,   MPO↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 20,   NRF2↝, 1,   PAO↑, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 21,   ROS↑, 159,   ROS⇅, 8,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   SAM-e↝, 1,   SOD↓, 5,   SOD↑, 6,   SOD1↑, 2,   SOD2↓, 2,   SOD2↑, 1,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 3,   TrxR↑, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 8,   CDC2↑, 1,   CDC25↓, 19,   CDC25↑, 1,   compI↓, 1,   compIII↓, 1,   EGF↓, 3,   ETC↓, 3,   HSP60/HSPD1↓, 2,   Insulin↓, 2,   mitResp↓, 2,   mtDam↑, 14,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   PDH↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5-HETE↓, 1,   5LO↓, 4,   ACC↑, 2,   ALAT↓, 2,   ALAT↝, 1,   ALDOA↓, 1,   AMPK↓, 2,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↓, 9,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 5,   G6PD↓, 1,   GlucoseCon↓, 5,   GlucoseCon∅, 1,   Glycolysis↓, 17,   GSK‐3β↓, 11,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 4,   H2S↑, 1,   Histones↑, 1,   HK2↓, 12,   HMG-CoA↓, 1,   lactateProd↓, 5,   lactateProd∅, 1,   LDHA↓, 5,   LDL↓, 3,   MCT4↓, 1,   NAD↓, 1,   NAD↝, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PKM2↓, 9,   polyA↓, 1,   p‑S6↓, 1,   SIRT1↓, 6,   SIRT1↑, 3,   SIRT2↓, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 2,   SSAT↑, 1,   TCA↓, 1,   TS↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 14,   APAF1↑, 7,   Apoptosis?, 2,   Apoptosis↓, 6,   Apoptosis↑, 153,   Apoptosis↝, 1,   Apoptosis∅, 1,   mt-Apoptosis↑, 3,   ASK1↑, 1,   BAD↑, 11,   Bak↑, 8,   BAX↓, 5,   BAX↑, 106,   BAX⇅, 1,   BAX↝, 2,   BAX∅, 1,   Bax:Bcl2↑, 35,   Bcl-2↓, 95,   Bcl-2↑, 6,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 36,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   BIM↑, 5,   BNIP3↑, 1,   BTG3↑, 1,   Casp↑, 28,   Casp1↑, 3,   Casp10↑, 2,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 116,   Casp3↝, 2,   cl‑Casp3↑, 23,   proCasp3↓, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 15,   cl‑Casp7↑, 2,   Casp8↑, 29,   Casp8∅, 1,   cl‑Casp8↑, 6,   proCasp8↓, 1,   Casp9↑, 78,   cl‑Casp9↑, 10,   proCasp9↓, 2,   cFLIP↓, 3,   Cyt‑c↓, 2,   Cyt‑c↑, 67,   Cyt‑c↝, 4,   mt-Cyt‑c↓, 1,   Diablo↑, 9,   DR5↓, 1,   DR5↑, 16,   FADD↑, 3,   Fas?, 1,   Fas↓, 1,   Fas↑, 14,   FasL↑, 7,   Ferroptosis↑, 1,   HEY1↓, 1,   IAP1↓, 6,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 11,   iNOS↑, 1,   Mcl-1?, 1,   Mcl-1↓, 11,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 13,   MDM2↑, 1,   necrosis↑, 1,   NOXA↑, 3,   p38↓, 4,   p38↑, 17,   p‑p38↑, 4,   PUMA↓, 1,   PUMA↑, 7,   RIP3↑, 1,   survivin↓, 47,   survivin↝, 1,   TRAIL↑, 7,   TRAILR↑, 1,   TumCD↑, 13,   TUNEL↑, 1,   XIAP↓, 20,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 83,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 25,   p‑Akt↑, 1,   AKT1↓, 2,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CK2↓, 3,   cMET↓, 3,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 33,   ERK↑, 6,   p‑ERK↓, 8,   p‑ERK↑, 2,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IGF-1R↓, 2,   IKKα↓, 5,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 5,   p‑JAK2↓, 1,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 6,   JNK↑, 23,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 26,   MAPK↑, 10,   MAPK↝, 2,   MEK↓, 1,   p‑MEK↓, 1,   mTOR↓, 46,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 7,   mTORC2↓, 2,   p‑p42↓, 1,   p70S6↓, 2,   p70S6↑, 1,   P70S6K↓, 4,   P90RSK↓, 1,   PDGFR-BB↓, 2,   PI3K↓, 58,   PI3K↑, 1,   PI3K↝, 2,   p‑PI3K↓, 1,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PI3K/mTOR/ETS2↓, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKCδ↓, 7,   p‑PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 16,   PTEN↝, 2,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 11,   RIP1↓, 1,   RIP1↑, 1,   S6K↓, 1,   Sp1/3/4↓, 9,   Src↓, 2,   STAT↓, 2,   STAT3↓, 47,   STAT3↑, 2,   p‑STAT3↓, 6,   STAT5↓, 2,   STAT6↓, 1,   STK11/LKB1↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 9,   ATF4↝, 1,   CBP↑, 2,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 29,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 3,   DNMTs↓, 4,   EZH2↓, 1,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 4,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 3,   p‑H3↑, 1,   ac‑H3↑, 8,   H3K9↓, 1,   H4↑, 1,   ac‑H4↑, 6,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 31,   HDAC1↓, 8,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 6,   HDAC3↓, 5,   HDAC4↓, 2,   HDAC8↓, 3,   HES1↓, 1,   HMTs↓, 1,   IRF1↑, 1,   miR-106b↓, 1,   miR-130a↓, 1,   miR-133a-3p↑, 1,   miR-155↓, 1,   miR-192-5p↑, 1,   miR-203↑, 1,   miR-21↓, 3,   miR-29b↑, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 7,   MYCN↓, 1,   MYCN↑, 1,   OCT4↓, 9,   OCT4↑, 1,   OLIG2↓, 1,   other?, 1,   other↑, 1,   other↝, 6,   PAX2↓, 1,   SOX2↓, 6,   SOX4↓, 2,   SOX4↑, 2,   SOX9↓, 2,   SUV39H↓, 2,   TCF-4↓, 2,   TET3↑, 1,   tumCV↓, 41,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 30,   GRP78/BiP↓, 2,   GRP78/BiP↑, 10,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 4,   PERK↑, 4,   Proteasome↓, 1,   UPR↑, 3,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↓, 1,   ATG5↑, 3,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 2,   LC3I↓, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   p62↓, 3,   p62↑, 3,   TumAuto↓, 2,   TumAuto↑, 19,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6,   ATR↑, 3,   BRCA1↓, 1,   BRCA1↑, 4,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↓, 1,   DNAdam↓, 3,   DNAdam↑, 56,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 10,   MDMX↓, 1,   MSH2↑, 1,   p16↑, 6,   P53↓, 6,   P53↑, 134,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↓, 2,   PARP↑, 8,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 56,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 29,   PCNA↝, 1,   SIRT6↑, 1,   Telomerase↓, 10,   TOP1↓, 2,   TOP2↓, 7,   TP53↓, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 11,   p‑γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 21,   CDK1↑, 4,   p‑CDK1↓, 2,   CDK2↓, 61,   CDK2↑, 1,   CDK4↓, 71,   CDK4↑, 2,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 24,   CDK6↑, 3,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 2,   cellSen↑, 1,   CHK1↓, 4,   CHK1↑, 4,   Chk2↓, 4,   Chk2↑, 6,   p‑Chk2↑, 1,   Cyc↓, 6,   Cyc↝, 1,   cycA1/CCNA1↓, 22,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 40,   CycB/CCNB1↑, 4,   cycD1/CCND1↓, 116,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 45,   cycE/CCNE↑, 1,   cycE/CCNE↝, 1,   cycE1↓, 1,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 7,   E2Fs↑, 1,   GADD45A↑, 4,   Ki-67↓, 18,   mitA↑, 1,   p19↑, 1,   P21?, 2,   P21↓, 22,   P21↑, 316,   P21↝, 2,   p‑P21↑, 1,   p27/CDKN1B↓, 8,   p27/CDKN1B↑, 86,   pRB↓, 4,   pRB↑, 3,   p‑pRB↓, 3,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 8,   cl‑RB1↓, 1,   TumCCA?, 3,   TumCCA↓, 2,   TumCCA↑, 219,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 4,   ALDH1A1↓, 3,   BMPs↑, 1,   CD133↓, 6,   CD24↓, 2,   cFos↓, 7,   CSCs↓, 22,   Diff↑, 3,   EIF4E↓, 1,   EP300↑, 1,   EP4/PTGER4↑, 1,   Gli1↓, 3,   HH↓, 1,   HMGCR↓, 2,   IGF-1↓, 7,   IGFBP3↑, 3,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 18,   Let-7↑, 1,   mTORC1↓, 5,   Nanog↓, 10,   Nanog↑, 1,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 10,   NOTCH1↓, 8,   NOTCH2↑, 1,   NOTCH3↓, 2,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 2,   STAT1↓, 1,   p‑STAT1↓, 1,   TAZ↓, 1,   TOPflash↑, 1,   TumCG?, 2,   TumCG↓, 60,   TumCG↑, 1,   TumCP↓, 119,   TumCP↑, 1,   TumCP⇅, 1,   Wnt?, 1,   Wnt↓, 24,   Wnt↝, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 13,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 20,   Ca+2↝, 1,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↓, 1,   cal2↑, 2,   Cdc42↑, 1,   COL1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 4,   E-cadherin↑, 22,   EMT?, 1,   EMT↓, 39,   F-actin↓, 1,   FAK↓, 9,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 2,   ITGA5↓, 1,   ITGB4↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 2,   MMP1↓, 3,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 48,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 10,   MMP9↓, 61,   MMP9↑, 1,   MMPs↓, 17,   MUC4↓, 2,   N-cadherin↓, 13,   p44↓, 1,   p‑p44↓, 1,   PAK1↓, 1,   PDGF↓, 5,   Rho↑, 1,   ROCK1↓, 2,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 9,   SMAD3↓, 1,   SMAD3↑, 1,   SMAD4↑, 1,   Snail↓, 15,   TET1↑, 2,   TGF-β↓, 6,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 1,   TIMP2↑, 3,   TRIB3↑, 1,   TSC1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 46,   TumCI↑, 1,   TumCMig↓, 43,   TumMeta↓, 43,   TumMeta↑, 5,   Twist↓, 17,   TXNIP↑, 1,   uPA↓, 13,   uPAR↓, 1,   Vim↓, 22,   Zeb1↓, 9,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 28,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 44,   angioG↑, 2,   CD31/PECAM-1↓, 2,   Endoglin↑, 2,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 39,   Hif1a↑, 1,   LOX1↓, 2,   NO↓, 1,   NO↑, 4,   VCAM-1↓, 2,   VEGF↓, 62,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   EPR↑, 2,   GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 76,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   SVCT-2↝, 1,   TRPM7↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD44↓, 13,   CD59↑, 1,   CD8+↑, 1,   cDC2↓, 6,   COX1?, 1,   COX1↓, 3,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 54,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCR4↓, 8,   DCells↑, 1,   DR4↑, 4,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   Igs↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL4↑, 3,   IL6↓, 19,   IL6↝, 1,   IL7↓, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 7,   Imm↝, 1,   Inflam↓, 17,   Inflam↝, 1,   IRAK1↓, 1,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB↓, 103,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 2,   p50↓, 1,   p65↓, 8,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 5,   PGD2↓, 1,   PGE2↓, 13,   PSA↓, 12,   PSA↝, 1,   PSA∅, 1,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 20,   TNF-α↑, 5,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 2,   AR↓, 19,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ER(estro)↑, 1,   Estro↝, 1,   FGF21↓, 1,   GR↑, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 24,   BioAv↑, 19,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↓, 4,   ChemoSen↑, 90,   ChemoSen⇅, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 4,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↑, 4,   Dose↝, 32,   Dose∅, 10,   eff↓, 29,   eff↑, 44,   eff↝, 3,   eff∅, 1,   GSTA1↑, 2,   Half-Life↓, 7,   Half-Life↝, 9,   MDR1↓, 7,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 14,   P450↓, 5,   P450↝, 1,   RadioS↑, 30,   selectivity?, 1,   selectivity↑, 60,   selectivity↝, 1,   Synergy↑, 49,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 19,   AR↝, 1,   AST↓, 2,   AST↝, 1,   B2M↓, 1,   BRAF↝, 1,   BRCA1↓, 1,   BRCA1↑, 4,   p‑BRCA1↑, 1,   E6↓, 4,   E7↓, 4,   EGFR↓, 31,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 5,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 19,   IL6↝, 1,   LDH↓, 5,   LDH↑, 1,   Maspin↑, 2,   Myc↓, 7,   PD-L1↓, 5,   PSA↓, 12,   PSA↝, 1,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 35,   AntiTum↑, 10,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 13,   chemoPv↑, 11,   ChemoSideEff↓, 2,   fatigue↓, 1,   FTO↑, 1,   hepatoP↑, 10,   Mucositis↓, 1,   neuroP↑, 6,   OS?, 1,   OS↑, 10,   OS⇅, 1,   Pain↓, 2,   PFS↑, 1,   QoL↑, 5,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 7,   Risk↓, 10,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 18,   TumW↓, 8,   Weight↓, 1,   Weight↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 921

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 40,   Catalase↑, 16,   GPx↓, 1,   GPx↑, 14,   GSH↑, 23,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 5,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 5,   Iron∅, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 16,   MDA↓, 14,   MPO↓, 2,   MPO↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 19,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 39,   ROS↑, 3,   SOD↓, 1,   SOD↑, 20,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   Trx↓, 1,   Trx↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 7,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 1,   ATP↑, 2,   FASN↓, 1,   glucose↓, 2,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 3,   NAD↓, 1,   NADPH↑, 1,   PONs↓, 1,   SCFAs↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↓, 3,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 2,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 2,   Fas↓, 1,   Fas↑, 2,   Ferroptosis↓, 1,   iNOS↓, 8,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 1,   other↑, 1,   other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 4,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK5↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 6,   P21↑, 6,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 2,   Rho↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   E-sel↓, 1,   HIF2a↑, 1,   NO↓, 3,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT2↑, 1,   GLUT4↑, 1,   MMP↓, 3,   MMP↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 15,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 1,   IL10↓, 3,   IL17↓, 2,   IL1β↓, 7,   IL23↓, 1,   IL5↓, 1,   IL6↓, 10,   IL8↓, 3,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 38,   Inflam↑, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 15,   NK cell↑, 2,   NLRP3↓, 1,   PGE2↓, 6,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 4,   TNF-α↓, 13,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   AChE↑, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   FGF21↑, 1,   GPER↑, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 4,   BioAv⇅, 1,   BioAv↝, 5,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↝, 2,   eff↑, 2,   GSTA1↑, 2,   Half-Life↝, 2,   Half-Life∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 2,   AST↓, 7,   BMD↑, 1,   BP↓, 2,   BP↝, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 10,   LDH↓, 3,   LDH↑, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 8,   AntiArt↑, 5,   AntiCan↑, 5,   AntiDiabetic↑, 7,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 13,   chemoP↑, 5,   chemoPv↑, 3,   cognitive↑, 4,   hepatoP↑, 14,   Learn↑, 1,   memory↑, 7,   neuroP↑, 27,   Obesity↓, 3,   OS↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 14,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 2,   AntiViral↑, 1,   Bacteria↓, 7,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 270

Scientific Paper Hit Count for: P21, P21/CDKN1A
19 Thymoquinone
14 Curcumin
13 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Fisetin
9 Silver-NanoParticles
8 EGCG (Epigallocatechin Gallate)
8 Lycopene
8 Quercetin
7 Magnolol
7 Propolis -bee glue
7 Resveratrol
6 Eugenol
6 Phenethyl isothiocyanate
5 Berberine
5 Indole-3-carbinol
5 Emodin
5 phytic acid, Inositol hexakisphosphate
5 Luteolin
5 Phenylbutyrate
5 Piperlongumine
5 Urolithin
4 Gemcitabine (Gemzar)
4 Allicin (mainly Garlic)
4 Cisplatin
4 Biochanin A
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Cucurbitacin
4 Ursolic acid
4 Ellagic acid
4 Diindolylmethane
4 Gallic acid
4 Honokiol
4 Morin
4 Shikonin
3 Allyl isothiocyanate
3 Baicalein
3 Benzyl isothiocyanate
3 Capsaicin
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Ferulic acid
3 Isoliquiritigenin
3 Licochalcone A
3 Magnetic Fields
3 Melatonin
3 Naringin
3 Patchouli Oil (Pogostemon cablin)
3 salinomycin
3 Silymarin (Milk Thistle) silibinin
3 Zyflamend
2 Alpha-Lipoic-Acid
2 Anethole/trans-Anethole
2 Ashwagandha(Withaferin A)
2 Astaxanthin
2 Berbamine
2 Betulinic acid
2 Caffeic acid
2 Carnosic acid
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Chlorogenic acid
2 chaetocin
2 Crocetin
2 diet Methionine-Restricted Diet
2 Fenbendazole
2 Garcinol
2 Genistein (soy isoflavone)
2 HydroxyTyrosol
2 Kaempferol
2 lambertianic acid
2 Linalool
2 mebendazole
2 doxorubicin
2 Oleuropein
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Plumbagin
2 Rosmarinic acid
1 3-bromopyruvate
1 5-fluorouracil
1 Coenzyme Q10
1 Astragalus
1 Camptothecin
1 Acetyl-l-carnitine
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Artemisinin
1 Atorvastatin
1 epirubicin
1 Bufalin/Huachansu
1 Boron
1 brusatol
1 Bruteridin(bergamot juice)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Dihydrocaffeic Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 D-limonene
1 Docetaxel
1 Dandelion Root
1 Butyrate
1 Cinnamon
1 Formononetin
1 Flaxseed/Linseed
1 SDG/lignans
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inositol
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Juglone
1 Lactobacillus
1 Lactoferrin/Talactoferrin
1 Matrine
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 methylseleninic acid
1 Magnetic Field Rotating
1 Moringin
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Methylsulfonylmethane
1 Radiotherapy/Radiation
1 Nimbolide
1 Rutin
1 buckwheat sprouts
1 acetazolamide
1 Aflavin-3,3′-digallate
1 Oxaliplatin
1 Vitamin C (Ascorbic Acid)
1 Magnesium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:234  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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