VEGF Cancer Research Results

VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1 / PDPK1↓, Beclin-1/ATG6↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
TumCG↓, MDSCs↓, TLR4↓, NF-kB↓, IL6↓, IL1↓, PGE2↓, COX2/PTGS2↓, GM-CSF↓, angioG↓, VEGF↓, CD31/PECAM-1↓, GM-CSF↓, α-SMA↓, p‑IKKα↓, MyD88↓,
432- CUR,    Curcumin-Induced Global Profiling of Transcriptomes in Small Cell Lung Cancer Cells
- in-vitro, Lung, H446
Bcl-2↓, cycF↓, LOX1↓, VEGF↓, MRGPRF↓, BAX↑, Cyt‑c↑, miR-548ah-5p↑,
155- CUR,    Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
- in-vitro, Pca, PC3
p‑ERK↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, angioS↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2/PTGS2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
TRAILR↑, BAX↑, P21↑, p27/CDKN1B↑, NF-kB↓, cycD1/CCND1↓, VEGF↓, uPA↓, MMP2↓, MMP9↓, Bcl-2↓, Bcl-xL↓,
169- CUR,    Curcumin inhibits the expression of vascular endothelial growth factor and androgen-independent prostate cancer cell line PC-3 in vitro
- in-vitro, Pca, PC3
VEGF↓,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, Synergy↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
4675- CUR,    Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines
- in-vitro, NSCLC, A549
ChemoSen↑, CSCs↓, EpCAM↓, TumCCA↓, VEGF↓, MMP9↓, toxicity↓,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27/CDKN1B↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
1444- Deg,    Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
- in-vitro, GC, MKN-28
Casp9↑, Casp3↑, Hif1a↓, VEGF↓, TumCCA↑, TumCG↓, DNAdam↑, p‑Akt↓,
1445- Deg,    Deguelin--an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model
- in-vivo, lymphoma, NA - in-vitro, lymphoma, NA
Akt↓, TumCP↓, TumCMig↓, VEGF↓, TumCG↓, OS↑,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
6703- DFC,    Molecular docking of anti-inflammatory drug diclofenac with metabolic targets: Potential applications in cancer therapeutics.
- Analysis, Var, NA
*Inflam?, *COX1↓, *COX2/PTGS2↓, GLUT1↓, MCT4↓, LDHA↓, ABCG2↓, MDM2↓, MRP1/ABCC1↓, SOD2↓, Myc↓, β-catenin/ZEB1↓, VEGF↓, IKKα↓, cJun↓, E2Fs↓,
6692- DFC,    Diclofenac Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer by Modulation of VEGF Levels and Arginase Activity
- in-vivo, PC, Panc02
TumW↓, Apoptosis↑, VEGF↓, COX2/PTGS2↓, ARG1/2↑, TumCG↓, angioG↓, ARG↓, NO↓,
8840- DIM,    Inactivation of uPA and its receptor uPAR by 3, 3'-Diindolylmethane (DIM) leads to the inhibition of Prostate Cancer Cell growth and migration
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Pca, PC3
uPA↓, uPAR↓, TumCG↓, TumCMig↓, VEGF↓, MMP9↓,
8855- DIM,    A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78)
- vitro+vivo, Pca, PC3 - in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, COLO205 - in-vitro, Nor, HUVECs
angioG↓, GRP78/BiP↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓,
8853- DIM,    Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies
- Review, Var, NA
AhR↓, NRF2↑, *ROS↓, *p‑BRCA1↑, *COX2/PTGS2↓, CYP19↓, uPA↓, VEGF↓, MMP9↓, TumCMig↓, FOXM1↓, mTOR↓, Akt↓, radioP↑, ATM?, BioAv↑, BioAv↓, Dose↝, BioAv↑, Half-Life↝,
6271- DL,    D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
- in-vitro, Colon, SW480 - in-vitro, Colon, HT-29
TumCP↓, Apoptosis↑, Bax:Bcl2↑, VEGF↓, angioG↓, TumMeta↓, VEGFR1↓, MMP9↓,
6285- DL,    Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
VEGF↓, *STAT3↓, TumCP↓, TumMeta↓, p‑STAT3↓, MMP9↓, SHP1↑, angioG↓,
6280- DL,    Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs
- Review, Var, NA
BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, TGF-β↑, Bcl-2↓, VEGF↓, AntiTum↑, *Inflam↓, *Bacteria↓,
6283- DL,    D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects
- in-vivo, Nor, NA
*TGF-β1↓, *VEGF↓, *MDA↓, *GPx↑, *Catalase↑, *Inflam↓, *ROS↓, *angioG↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
- Review, Var, NA
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, Synergy↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
7230- EGb 761,    Ginkgo biloba extract (EGb 761) promotes peripheral nerve regeneration and neovascularization after acellular nerve allografts in a rat model
- in-vivo, Nor, NA
*Dose↝, *NGF↑, *angioG↑, *VEGF↑, *SOX18↑, *CD133↑, *IL6↑,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
3211- EGCG,    Antioxidation Function of EGCG by Activating Nrf2/HO-1 Pathway in Mice with Coronary Heart Disease
- in-vivo, CardioV, NA
*cardioP↑, *VEGF↓, *MMP2↓, *SOD↑, *ROS↓, *HO-1↑, *NQO1↑, *NRF2↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2/PTGS2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
1056- EGCG,    EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression
- vitro+vivo, BC, E0771
TumW↓, VEGF↓, Weight∅, Hif1a↓, NF-kB↓,
670- EGCG,    Epigallocatechin-3-gallate and its nanoformulation in cervical cancer therapy: the role of genes, MicroRNA and DNA methylation patterns
- Review, Cerv, NA
TumCCA↑, P53↑, ERK↓, EGFR↓, p‑ERK↑, VEGF↓, Hif1a↓, miR-203↓, miR-210↑,
666- EGCG,    The Role of EGCG in Breast Cancer Prevention and Therapy
- Review, BC, NA
ROMO1↑, VEGF↓, TumCG↓,
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, Lung, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2/PTGS2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,
691- EGCG,    Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer
- Review, Var, NA
Apoptosis↑, necrosis↑, TumAuto↑, ERK↓, p38↓, NF-kB↓, VEGF↓,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1/ATG6↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, Cerv, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27/CDKN1B↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
5228- EMD,    Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
OS↑, PKCδ↓, ERK5↓, MMP3↓, VEGF↓, NRF2↑, HO-1↑, MDA↓, AFP↓,
5225- EMD,    Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
STAT3↓, Akt↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCP↓, Casp3↑, cl‑PARP↑, ChemoSen↑, XIAP↓,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, Synergy↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6336- Eug,    Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG
- in-vivo, GC, NA
Apoptosis?, Bcl-2↓, Cyt‑c↝, Casp↑, TumCI↓, angioG↓, MMPs↓, VEGF↓, VEGFR1↓, TIMP2↑, RECK↑,

Showing Research Papers: 151 to 200 of 466
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 466

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 8,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 8,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 3,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 26,   GSH↑, 5,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 9,   HO-1↑, 15,   HO-2↓, 1,   Iron↑, 1,   Iron∅, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 5,   MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 24,   NRF2↑, 24,   NRF2↝, 1,   p‑NRF2↓, 1,   OSI↑, 1,   Prx4↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROMO1↑, 1,   ROS?, 1,   ROS↓, 16,   ROS↑, 175,   ROS⇅, 12,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 6,   SOD2↓, 4,   TAC↓, 3,   Thiols↓, 1,   TOS↑, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC2↓, 8,   CDC25↓, 8,   EGF↓, 6,   ETC↓, 2,   HSP60/HSPD1↓, 2,   mitResp↓, 4,   MKK7↓, 2,   Mortalin↓, 1,   mtDam↑, 10,   OCR↓, 3,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   AApath↓, 1,   ACC↑, 2,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 20,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ARG↓, 1,   ATP↓, 14,   ATP↑, 1,   ATP↝, 1,   i-ATP↓, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 7,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 10,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 7,   HK2↓, 12,   IDO1↓, 1,   lactateProd↓, 11,   lactateProd↑, 1,   e-lactateProd↓, 1,   LDHA↓, 9,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 11,   PKM2↑, 1,   p‑S6↓, 2,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 152,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 9,   Bak↑, 11,   BAX↓, 2,   BAX↑, 86,   BAX⇅, 1,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2↓, 116,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 41,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 4,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 33,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 118,   Casp3↝, 1,   cl‑Casp3↑, 17,   proCasp3↑, 1,   Casp6↑, 1,   Casp7?, 1,   Casp7↑, 16,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 29,   cl‑Casp8↑, 6,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 69,   cl‑Casp9↑, 9,   proCasp9↓, 1,   cFLIP↓, 5,   Cyt‑c↑, 67,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   Endon↑, 1,   FADD↑, 3,   Fas↑, 22,   FasL↑, 6,   Ferroptosis↑, 7,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICAD↑, 1,   iNOS↓, 21,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 29,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 2,   Necroptosis↑, 4,   necrosis↑, 3,   NOXA↑, 4,   oncosis↑, 1,   p38↓, 10,   p38↑, 16,   p‑p38↓, 3,   p‑p38↑, 3,   PUMA↑, 5,   Pyro↑, 3,   RIP1↑, 2,   RIP3↑, 2,   survivin↓, 68,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAIL⇅, 1,   TRAILR↑, 4,   TumCD?, 1,   TumCD↑, 6,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 35,   XIAP↑, 1,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 4,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 36,   BRAF↓, 1,   Brk/PTK6↓, 1,   CK2↓, 5,   cMET↓, 3,   p‑cMET↑, 2,   cSrc↓, 3,   DYRK1B↓, 1,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 52,   ERK↑, 7,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 16,   p‑ERK↑, 2,   ERK5↓, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 9,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 6,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 14,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 4,   p‑JAK1↓, 1,   JAK2↓, 17,   p‑JAK2↓, 3,   JNK↓, 6,   JNK↑, 20,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 29,   MAPK↑, 12,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 10,   MKK4↓, 2,   mTOR↓, 81,   mTOR↝, 1,   p‑mTOR↓, 9,   mTORC2↓, 1,   p‑p70S6↓, 2,   P70S6K↓, 5,   p‑P70S6K↓, 2,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 106,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 11,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 30,   PTEN↝, 1,   p‑PTEN↓, 1,   PTPN6↑, 1,   Raf↓, 7,   e-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 2,   SHP1↑, 4,   Sp1/3/4↓, 17,   Src↓, 4,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 3,   STAT3↓, 86,   p‑STAT3↓, 20,   p‑STAT3↑, 3,   STAT5↓, 4,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 46,   p‑cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 8,   EZH2↓, 2,   FOXM1↓, 6,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 5,   FOXO3↑, 5,   FOXO3↝, 1,   FOXO4↓, 2,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 27,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 2,   HOTAIR↓, 1,   KISS1↑, 1,   miR-10a-5p↝, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-21↝, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 3,   miR-34a↝, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-548ah-5p↑, 1,   Myc↓, 9,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NEAT1↓, 1,   OCT4↓, 7,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 6,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 1,   Prot↓, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFAP2A↓, 1,   tumCV↓, 29,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 24,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 2,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 29,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   HSP27↓, 3,   HSP27↑, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 7,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG5↝, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 14,   Beclin-1/ATG6↝, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3II↓, 2,   LC3II↑, 12,   LC3s↑, 1,   p62↓, 9,   p62↑, 3,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto⇅, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM?, 1,   ATM↑, 1,   p‑ATM↑, 2,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 45,   DNArepair↓, 3,   DNArepair↑, 2,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   p16↑, 5,   P53?, 1,   P53↓, 4,   P53↑, 74,   P53↝, 1,   p‑P53↓, 1,   p‑P53↑, 4,   PARP↓, 3,   PARP↑, 18,   PARP↝, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 57,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 28,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1↓, 9,   TOP2↓, 6,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 7,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 37,   CDK2↑, 1,   CDK4↓, 46,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 21,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 3,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 8,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 20,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 82,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 15,   cycE/CCNE↑, 2,   cycE1↓, 2,   cycF↓, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 24,   mitA↑, 2,   P21↓, 4,   P21↑, 55,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 27,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   TubPol↓, 1,   TumCCA↓, 6,   TumCCA↑, 151,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMP2↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 5,   CD133↑, 1,   CD24↓, 1,   CD34↓, 2,   cFos↓, 3,   cFos↑, 1,   cMYB↓, 2,   CSCs↓, 39,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 10,   HH↓, 7,   IGF-1?, 1,   IGF-1↓, 11,   IGF-2↓, 1,   IGFBP3↑, 5,   Jun↓, 1,   Ki-67↓, 24,   Let-7↑, 5,   MCM2↓, 1,   mTORC1↓, 2,   p‑mTORC1↓, 1,   Nanog↓, 6,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 17,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 3,   p300↓, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 2,   Shh↓, 11,   Smo↓, 6,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 79,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 115,   TumCP↑, 1,   tyrosinase↓, 2,   Wnt↓, 38,   Wnt↑, 2,   Wnt/(β-catenin)↓, 9,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   ANGPT2↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 14,   AP-1↝, 1,   ARG1/2↑, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 3,   Ca+2↓, 1,   Ca+2↑, 28,   Ca+2↝, 3,   CAFs/TAFs↓, 2,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 10,   E-cadherin↑, 45,   EM↑, 1,   EMT?, 1,   EMT↓, 72,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 22,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 4,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   LAMs↓, 3,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 8,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 1,   MMP2↓, 115,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 13,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 42,   MMPs↝, 1,   MRGPRF↓, 1,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 28,   NCAM↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 11,   Rac1↓, 3,   RECK↑, 2,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 5,   ROCK1↑, 2,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 24,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 24,   TGF-β↑, 2,   TGF-β1↓, 3,   TIMP1↓, 2,   TIMP1↑, 12,   TIMP2↓, 3,   TIMP2↑, 14,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 5,   TumCA↓, 2,   TumCI↓, 68,   TumCMig↓, 73,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 72,   TumMeta↑, 5,   Twist↓, 26,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 29,   uPAR↓, 4,   UroPA↓, 1,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 4,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 169,   angioG↑, 5,   angioS↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 14,   EGR1↑, 1,   Endoglin↓, 1,   Endoglin↑, 1,   eNOS↓, 4,   HIF-1↓, 11,   Hif1a↓, 141,   LOX1↓, 3,   NO↓, 8,   NO↑, 2,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 412,   VEGF↑, 5,   VEGF↝, 2,   VEGFR1↓, 7,   VEGFR2/KDR/Flk1↓, 29,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 4,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN2↑, 1,   CTR1↑, 2,   CX43/GJA1↓, 1,   EPR↑, 4,   EPR↝, 1,   GLUT1↓, 20,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 67,   MMP↑, 5,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 2,   CD44↓, 14,   CD8+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 96,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 4,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DR4↑, 6,   FOXP3↓, 2,   GM-CSF↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 12,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 10,   IL10↓, 8,   IL10↑, 3,   IL12↓, 4,   IL12↑, 1,   IL1α↓, 2,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 7,   IL4↓, 2,   IL4↑, 1,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IL8↓, 16,   Imm↑, 10,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 26,   LIF↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MDSCs↓, 2,   MIP2↓, 2,   mPGES-1↓, 3,   MyD88↓, 1,   MyD88↑, 1,   NF-kB↓, 157,   NF-kB↑, 1,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 9,   NLRP3↓, 4,   NLRP3↑, 2,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 11,   PGE2↓, 16,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 8,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 39,   TNF-α↑, 4,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↓, 1,   AChE↑, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AhR↓, 1,   AR↓, 18,   AR↝, 1,   CYP19↓, 2,   ER-α36↓, 2,   ER-α36↝, 1,   ER(estro)↓, 2,   Estro↝, 1,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 3,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 42,   BioAv↑, 48,   BioAv↝, 6,   BioEnh↑, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 128,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 1,   Dose↑, 9,   Dose↝, 33,   Dose∅, 7,   eff↓, 16,   eff↑, 54,   eff↝, 15,   eff∅, 1,   Half-Life↓, 13,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 2,   MDR1↓, 10,   MRP1/ABCC1↓, 6,   P-gp/ABCB1↓, 15,   P450↓, 4,   RadioS?, 1,   RadioS↑, 46,   selectivity↑, 50,   Synergy↑, 90,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 3,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 18,   AR↝, 1,   ascitic↓, 3,   AST↓, 4,   AST↑, 1,   AST↝, 1,   BloodF↓, 1,   BloodF↑, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 3,   E7↓, 3,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 6,   HER2/EBBR2↓, 9,   hTERT/TERT↓, 14,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   LDH↓, 2,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 9,   NSE↓, 1,   PD-L1↓, 11,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 40,   AntiCan∅, 1,   antiNeop↑, 7,   AntiTum↑, 14,   cachexia↓, 2,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 23,   chemoPv↑, 19,   ChemoSideEff↓, 7,   fatigue↓, 2,   hepatoP↑, 5,   Mucositis↓, 1,   neuroP↑, 7,   NP/CIPN↓, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 19,   Pain↓, 1,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 24,   TumW↓, 11,   Weight↓, 1,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 1080

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 1,   antiOx↑, 64,   Catalase↓, 1,   Catalase↑, 36,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 20,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 6,   GSTs↑, 9,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 18,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 22,   MPO↓, 4,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 40,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 93,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 37,   SOD1↑, 2,   SOD2↑, 3,   TBARS↓, 2,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PDH↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   ALAT↓, 15,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↑, 2,   cytoP450↓, 1,   glucose↓, 5,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   LDL↓, 4,   lipidLev↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↑, 8,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3?, 1,   Casp3↓, 14,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 2,   IAP1↓, 1,   iNOS↓, 10,   iNOS↑, 2,   p38↓, 3,   p38↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 6,   p‑Akt↑, 2,   AKT1↑, 1,   CREB↑, 1,   EGFR↓, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 2,   p‑LIMK1↑, 1,   MAPK↓, 8,   MAPK↑, 3,   mTOR↓, 4,   mTOR↑, 2,   P70S6K↓, 1,   PI3K↓, 8,   PI3K↑, 5,   PKA↑, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PTEN↑, 1,   Sp1/3/4↓, 1,   Sp1/3/4↑, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 2,   HDAC↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 6,   other↝, 4,   SOX18↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↑, 1,   HSPs↑, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 3,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↓, 1,   CD133↑, 1,   Diff↑, 2,   FGF↑, 2,   IGF-1↓, 1,   IGFBP3↑, 1,   MSCs↑, 1,   neuroG↑, 1,   TumCP↓, 3,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 4,   Ca+2↝, 1,   Cartilage↑, 2,   p‑Cofilin↑, 1,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   FAK↑, 1,   ITGB1↑, 1,   p‑MLC2/MYL9↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 3,   MMPs↑, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   N-cadherin↑, 2,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↑, 1,   SLIT2↑, 1,   SMAD4↑, 1,   SMAD5↑, 1,   TGF-β↓, 3,   TGF-β↑, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   uPA↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   angioG↑, 15,   angioG↝, 1,   CD31/PECAM-1↓, 2,   CD31/PECAM-1↑, 2,   E-sel↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   Hif1a↑, 6,   Hif1a∅, 1,   NO↓, 14,   NO↑, 3,   VCAM-1↓, 6,   VEGF↓, 22,   VEGF↑, 32,   VEGFR2/KDR/Flk1↓, 1,   VEGFR2/KDR/Flk1↑, 1,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 9,   BBB↝, 1,   GLUT2↑, 1,   GLUT3↑, 3,   GLUT4↑, 3,   MMP↑, 6,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OATPs↓, 1,   OCLN↓, 1,   TRPC1↓, 1,   VGCC↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 5,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 9,   IL12↓, 2,   IL13↓, 1,   IL17↓, 3,   IL18↓, 3,   IL1β↓, 20,   IL2↓, 3,   IL2↑, 1,   IL23↓, 1,   IL4↓, 6,   IL4↑, 1,   IL5↓, 3,   IL6↓, 31,   IL6↑, 1,   IL8↓, 4,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 89,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MyD88↓, 2,   NF-kB↓, 43,   NF-kB↑, 1,   NLRP3↓, 9,   p65↓, 1,   PGE2↓, 13,   PGE2↑, 2,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 5,   TLR4∅, 1,   TNF-α↓, 34,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 8,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 13,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 3,   p‑tau↓, 8,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   END↑, 1,   Estro↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 32,   BioAv↑, 24,   BioAv↝, 9,   BioEnh↑, 2,   CompStab↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↓, 1,   eff↑, 11,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 3,   P-gp/ABCB1↓, 1,   P450↓, 2,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 5,   ascitic↓, 1,   AST↓, 18,   BMD↑, 2,   BP↓, 2,   p‑BRCA1↑, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 4,   EGFR↓, 1,   IL6↓, 31,   IL6↑, 1,   LDH↓, 7,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 16,   AntiArt↑, 7,   AntiCan↓, 1,   AntiCan↑, 8,   antiD↓, 1,   AntiDiabetic↑, 14,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 32,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 18,   diuretic↑, 1,   hepatoP↑, 31,   Learn↑, 2,   memory↑, 21,   motorD↑, 4,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 58,   Obesity↓, 9,   OS↑, 2,   Pain↓, 5,   QoL↑, 1,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 8,   Stroke↓, 6,   toxicity↓, 22,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 9,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 3,   AntiViral↑, 10,   Bacteria↓, 16,   Bacteria↑, 1,   GutMicro↑, 13,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 437

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
17 Thymoquinone
16 Apigenin (mainly Parsley)
15 Curcumin
14 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
12 Resveratrol
11 Betulinic acid
11 Sulforaphane (mainly Broccoli)
10 Quercetin
10 Garcinol
9 Baicalein
9 Berberine
9 Chrysin
8 Silver-NanoParticles
8 Propolis -bee glue
8 Fisetin
8 Kaempferol
7 Artemisinin
7 Boswellia (frankincense)
7 Silymarin (Milk Thistle) silibinin
6 Radiotherapy/Radiation
6 Fucoidan
6 Luteolin
6 Melatonin
5 Beta-Caryophyllene
5 Chlorogenic acid
5 Ellagic acid
5 Emodin
5 Formononetin
5 Gambogic Acid
5 Hydrogen Gas
5 Honokiol
4 Cisplatin
4 Ashwagandha(Withaferin A)
4 Bevacizumab (brand Avastin)
4 Caffeic acid
4 Cinnamon
4 Deguelin
4 D-limonene
4 Ferulic acid
4 Isoliquiritigenin
4 Juglone
4 Lycopene
4 Matrine
4 methylseleninic acid
4 Methylsulfonylmethane
4 Nimbolide
4 Phenethyl isothiocyanate
3 Alpha-Lipoic-Acid
3 Chemotherapy
3 Boron
3 Capsaicin
3 Carvacrol
3 Crocetin
3 Diindolylmethane
3 Eugenol
3 Flaxseed/Linseed
3 Ginkgolide B
3 iodine
3 phytic acid, Inositol hexakisphosphate
3 Licochalcone A
3 Magnolol
3 mebendazole
3 Naringin
3 Piperine
3 Selenite (Sodium)
2 Biochanin A
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 chaetocin
2 Cucurbitacin
2 Ursolic acid
2 Diclofenac
2 Gallic acid
2 Gemcitabine (Gemzar)
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Proanthocyanidins
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Hyperoside
2 MCT, metronomic chemo
2 lambertianic acid
2 Licorice
2 SDG/lignans
2 Phenylbutyrate
2 Piperlongumine
2 Rosmarinic acid
2 Shikonin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Isovitexin
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Baicalin
1 Berbamine
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Coenzyme Q10
1 Vitamin E
1 Carvone
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 Docetaxel
1 Bortezomib
1 olaparib/LYNPARZA
1 Paclitaxel/Taxol
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Grapeseed extract
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Inositol
1 Extracorporeal Shock Wave Therapy
1 isoflavones
1 isoorientin
1 itraconazole
1 Lactoferrin/Talactoferrin
1 Methyl Jasmonate
1 vp16, etoposide
1 Moringa oleifera
1 tamoxifen
1 Mistletoe/Viscum album Extracts
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Niclosamide (Niclocide)
1 Neem
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Plumbagin
1 VitK3,menadione
1 Psoralidin
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Salvia miltiorrhiza
1 Theobromine
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitamin D3
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:334  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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