Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, Synergy↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
1529- Ba,    Studies on the Inhibitory Mechanisms of Baicalein in B16F10 Melanoma Cell Proliferation
- in-vitro, Melanoma, B16-F10
ROS↑, eff↓, tumCV↓, Casp3↑, necrosis↑,
1533- Ba,    Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation
- in-vitro, BrCC, MCF7 - in-vitro, Nor, MCF10
tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, Var, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27/CDKN1B↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
1526- Ba,    Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, cl‑PARP↑, DNAdam↑, cl‑BID↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9?, H2O2↑, ROS↑,
1525- Ba,  almon,    Synergistic antitumor activity of baicalein combined with almonertinib in almonertinib-resistant non-small cell lung cancer cells through the reactive oxygen species-mediated PI3K/Akt pathway
- in-vitro, Lung, H1975 - in-vivo, Lung, NA
Synergy↑, TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp9↑, p‑PI3K↓, p‑Akt↓, ROS↑, eff↓,
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
1523- Ba,    Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,
1521- Ba,    Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells
- in-vitro, Bladder, 5637
TumCG↓, Apoptosis↑, IAP1↓, IAP2/BIRC3↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
2477- Ba,    Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells
- in-vitro, CRC, T24/HTB-9
TumCG↓, TumCCA↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, p‑Akt↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, 12LOX↓,
2478- Ba,    The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway
- in-vitro, BC, MDA-MB-231
Bcl-2↓, BAX↓, Cyt‑c↑, Casp3↑, Ca+2↓,
2606- Ba,    Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma
- Review, HCC, NA
ChemoSen↑, TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, MMPs↓, MAPK↓, TGF-β↓, ZFX↓, p‑MEK↓, ERK↓, MMP2↓, MMP9↓, uPA↓, TIMP1↓, TIMP2↓, NF-kB↓, p65↓, p‑IKKα↓, Fas↑, Casp2↑, Casp3↑, Casp8↑, Casp9↑, Bcl-xL↓, BAX↑, ER Stress↑, Ca+2↑, JNK↑, P53↑, ROS↑, H2O2↑, cMyc↓, CD24↓, 12LOX↓,
2600- Ba,    Baicalein Induces Apoptosis and Autophagy via Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Cells
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402
ER Stress↑, Bcl-2↓, Ca+2↑, JNK↑, CHOP/DDIT3↑, Casp9↑, Casp3↑, PARP↑, Apoptosis↑, UPR↑,
2618- Ba,    Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer
- in-vitro, Lung, H1299 - in-vivo, Lung, A549
TumCG↓, TumCP↓, Apoptosis↑, GLUT1↓, GLS↓, mTOR↓, *toxicity∅, cl‑Casp9↓, cl‑Casp3↓, GSH↓, GlutMet↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- in-vivo, Var, NA
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
5539- BBM,    Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway
- vitro+vivo, CRC, SW480
tumCV↓, TumCCA↑, MMP↓, P53↑, Casp3↑, Casp9↑, BAX↑, PARP↑, Bcl-2↓, TumVol↑,
5547- BBM,    Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Casp3↑, Casp9↑, Bax:Bcl2↑, ATG5↑, Beclin-1/ATG6↑, TumCP↓, MEK↓, ERK↓,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
1394- BBR,  DL,    Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803
- in-vitro, GC, MGC803
Synergy↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, TumCCA↑,
1393- BBR,  EPI,    Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest
- in-vitro, Bladder, T24/HTB-9
ChemoSen↑, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, P53↑, P21↑, Bcl-2↓, ROS↑,
1390- BBR,  Rad,    Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
- in-vitro, Pca, PC3
RadioS↑, Apoptosis↑, ROS↑, eff↑, BAX↑, Casp3↑, P53↑, p38↑, JNK↑, Bcl-2↓, ERK↓, HO-1↓,
1374- BBR,  PDT,    Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells
- in-vitro, RCC, 786-O - in-vitro, RCC, HK-2
ROS↑, TumAuto↑, Apoptosis↑, Casp3↑, eff↑,
1378- BBR,    Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway
- in-vitro, Lung, NA
Apoptosis↑, Casp3↑, Cyt‑c↑, MMP↓, p‑JNK↑, eff↓,
1382- BBR,    Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28
Apoptosis↑, necrosis↑, DNAdam↑, TumCCA↑, ROS↑, Casp3↑, p‑P53↑, ERK↑,
1402- BBR,    Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction
- in-vitro, GBM, T98G
tumCV↓, ROS↑, Ca+2↑, ER Stress↑, eff↓, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, cl‑PARP↑,
1404- BBR,    Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation
- in-vitro, Pca, PC3
Apoptosis↑, *Apoptosis∅, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, eff↓, Cyt‑c↑,
2700- BBR,    Cell-specific pattern of berberine pleiotropic effects on different human cell lines
- in-vitro, GBM, U343 - in-vitro, GBM, MIA PaCa-2 - in-vitro, Nor, HDFa
selectivity↑, TumCCA↑, Casp3↑, TumCI↓, TumCMig↓, N-cadherin?, DNMT1↑,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
2681- BBR,  PDT,    Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells
- in-vitro, Melanoma, NA
Apoptosis↑, cl‑Casp3↑, LC3s↑, ER Stress↑, ROS↑, CHOP/DDIT3↑,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
1030- BBR,    Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5
- in-vitro, Lung, H460
PD-L1↓, TumCG↓, Ki-67↓, cl‑Casp3↑,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, Synergy↑, chemoPv↑, BioAv↓,
5178- BBR,    Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,
5177- BBR,    Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
- in-vitro, Oral, HMC3
TumCCA↑, Apoptosis↑, TumCG↓, Casp3↑, TumCCA↑, ROS↑, Ca+2↑, MMP↓, ER Stress↑, Cyt‑c↑,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5636- BCA,    Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
- vitro+vivo, Lung, A549
tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, TumCG↓, P21↑, Casp3↑, Bcl-2↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
6500- BCP,    Beta-Caryophyllene Suppresses Ovarian Cancer Proliferation by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, Ovarian, NA
TumCP↓, TumCCA↑, Apoptosis↑, Casp3↑, cl‑PARP↑,

Showing Research Papers: 151 to 200 of 1195
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1195

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 3,   NA↑, 6,   NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 7,   antiOx↑, 16,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 17,   Catalase↑, 12,   Ceru↓, 1,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 4,   frataxin↑, 1,   GCLM↓, 1,   GPx↓, 8,   GPx↑, 9,   GPx4↓, 11,   GSH↓, 82,   GSH↑, 16,   mt-GSH↓, 1,   GSH/GSSG↓, 9,   GSR↓, 3,   GSR↑, 5,   GSS↑, 1,   GSSG↓, 1,   GSSG↑, 1,   GSTs↓, 4,   GSTs↑, 5,   H2O2↓, 1,   H2O2↑, 15,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 13,   HO-1↑, 22,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 1,   Iron↑, 5,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 11,   lipid-P↑, 22,   lipid-P↝, 1,   MDA↓, 8,   MDA↑, 20,   MPO↓, 4,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 3,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 32,   NRF2⇅, 1,   NRF2↝, 1,   NRF2∅, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   OSI↑, 2,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 5,   ROS↓, 48,   ROS↑, 523,   ROS⇅, 14,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 17,   RPM↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 14,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 6,   SOD2↑, 8,   TAC↓, 2,   TAC↑, 2,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   TOS↑, 2,   Trx↓, 3,   Trx1↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 12,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FTH1↓, 2,   IronCh↑, 4,   NCOA4↑, 1,   STEAP3↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 4,   CDC2↓, 9,   CDC2↑, 1,   CDC25↓, 23,   CDC25↑, 1,   p‑CDC25↑, 1,   compI↓, 3,   compII↓, 1,   compIII↓, 2,   compIV↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 8,   EGF↑, 1,   ETC↓, 9,   ETC↝, 1,   HSP60/HSPD1↑, 1,   MCU↓, 1,   MFN2↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 56,   OCR↓, 11,   OCR↑, 2,   OXPHOS↓, 7,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↓, 4,   PDH↓, 3,   PDH↑, 3,   PDH↝, 1,   p‑PDH↓, 1,   PINK1↑, 4,   SDH↓, 4,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 4,   ACC↑, 5,   p‑ACC↑, 1,   Acetyl-CoA↓, 1,   ACLY↓, 5,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALDOA↓, 2,   AMP↑, 2,   AMPK↓, 3,   AMPK↑, 39,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 39,   ATP↝, 1,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   citrate↓, 1,   CPT1A↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 8,   FASN↑, 2,   FBI-1↓, 1,   FBPase↑, 2,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   glucoNG↑, 2,   glucose↓, 1,   GlucoseCon↓, 24,   GlutaM↓, 1,   GlutMet↓, 2,   glyC↓, 1,   Glycolysis↓, 55,   GSK‐3β↓, 18,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 9,   p‑GSK‐3β↑, 1,   Histones↑, 1,   HK1↓, 2,   HK2↓, 33,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   IDO1↓, 1,   lactateProd↓, 26,   lactateProd↑, 1,   LDHA↓, 13,   LDL↓, 2,   lipidLev↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↝, 1,   NADPH↓, 5,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 10,   PDKs↓, 3,   PFK↓, 4,   PFK1↓, 2,   PFK2?, 1,   PFK2↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PGK1↓, 1,   PKM2↓, 19,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 12,   SIRT1↑, 7,   SREBP1/SREBF1↓, 3,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 6,   TCA↑, 2,   TS↓, 2,   TumCM/A↓, 1,   Warburg↓, 9,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 27,   APAF1↑, 19,   Apoptosis?, 4,   Apoptosis↓, 11,   Apoptosis↑, 587,   Apoptosis↝, 1,   mt-Apoptosis↑, 7,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 4,   BAD?, 1,   BAD↓, 5,   BAD↑, 32,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 23,   BAX?, 1,   BAX↓, 9,   BAX↑, 410,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 85,   Bcl-2↓, 421,   Bcl-2↑, 13,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 84,   Bcl-xL↑, 4,   Bcl-xL↝, 2,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 18,   p‑BID↓, 1,   cl‑BID↑, 4,   BIM↓, 1,   BIM↑, 14,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 1,   BOK↑, 2,   Casp↓, 1,   Casp↑, 28,   Casp1↓, 2,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 11,   Casp12↝, 1,   cl‑Casp12↑, 1,   Casp2↑, 5,   Casp3?, 4,   Casp3↓, 15,   Casp3↑, 833,   Casp3↝, 4,   Casp3∅, 2,   cl‑Casp3↓, 3,   cl‑Casp3↑, 204,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   proCasp3↓, 8,   proCasp3↑, 9,   pro‑Casp3↓, 1,   pro‑Casp3↑, 2,   pro‑Casp3↝, 1,   CASP4↑, 3,   Casp6↓, 1,   Casp6↑, 6,   Casp7?, 1,   Casp7↓, 1,   Casp7↑, 88,   cl‑Casp7↑, 11,   Casp8↓, 3,   Casp8↑, 144,   Casp8↝, 1,   Casp8∅, 3,   cl‑Casp8↑, 27,   proCasp8↓, 2,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9?, 2,   Casp9↓, 4,   Casp9↑, 380,   Casp9↝, 1,   Casp9∅, 1,   cl‑Casp9↓, 2,   cl‑Casp9↑, 64,   proCasp9↓, 4,   proCasp9↑, 5,   pro‑Casp9↑, 1,   CellShr↑, 1,   cFLIP↓, 16,   Cupro↑, 1,   Cyt‑c↓, 5,   Cyt‑c↑, 280,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 12,   DIDO1/DIO-1↑, 1,   DR5↑, 48,   Endon↑, 2,   FADD↑, 14,   Fap1↓, 2,   Fas↓, 3,   Fas↑, 45,   FasL↑, 28,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   GranB/GZMB↝, 1,   GRP58↓, 1,   GSDME↑, 2,   cl‑GSDME↑, 1,   GSDME-N↑, 2,   HEY1↓, 2,   IAP1↓, 15,   IAP2/BIRC3↓, 6,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 26,   iNOS↑, 1,   Mcl-1?, 1,   Mcl-1↓, 61,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 17,   MDM2↑, 2,   p‑MDM2↓, 2,   MLKL↑, 3,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 10,   NAIP↓, 2,   Necroptosis↑, 8,   necrosis↑, 6,   NOXA↑, 7,   p38↓, 7,   p38↑, 45,   p‑p38↓, 5,   p‑p38↑, 11,   Paraptosis↑, 1,   PDCD4↑, 1,   Perforin↝, 1,   PUMA↑, 12,   PUMA↝, 1,   Pyro↑, 9,   RIP3↓, 1,   RIP3↑, 5,   p‑RIP3↑, 3,   survivin↓, 107,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 3,   TRAIL↑, 11,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD↓, 5,   TumCD↑, 48,   TumCD∅, 1,   TUNEL↑, 2,   XIAP↓, 54,   XIAP↑, 1,   YAP/TEAD↓, 4,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 226,   Akt↑, 14,   Akt↝, 1,   p‑Akt↓, 87,   AKT1↓, 5,   Akt2↓, 2,   AMPKα↑, 2,   BRAF↓, 2,   BRAF↝, 1,   CaMKII ↓, 3,   CIP2A↓, 2,   CK2↓, 4,   cMET↓, 4,   p‑cMET↑, 2,   p‑CREB↓, 2,   CREB2↓, 1,   cSrc↓, 6,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 78,   ERK↑, 17,   ERK↝, 1,   p‑ERK↓, 30,   p‑ERK↑, 8,   e-ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↑, 1,   HRAS↓, 1,   IGF-1R↓, 8,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 9,   IKKα↑, 2,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   IκB↑, 3,   p‑IκB↓, 3,   JAK↓, 4,   JAK1?, 1,   JAK1↓, 11,   JAK1↑, 2,   p‑JAK1↓, 2,   JAK2↓, 21,   p‑JAK2↓, 5,   JNK↓, 9,   JNK↑, 55,   JNK↝, 1,   p‑JNK↓, 4,   p‑JNK↑, 12,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 47,   MAPK↑, 27,   MAPK↝, 3,   p‑MAPK↓, 3,   p‑MAPK↑, 3,   MARK4↓, 1,   MEK↓, 11,   p‑MEK↓, 4,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 111,   mTOR↑, 5,   mTOR↝, 2,   p‑mTOR↓, 27,   mTORC2↓, 4,   NIK↓, 1,   p70S6↓, 2,   P70S6K↓, 9,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 151,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 21,   PI3K/Akt↓, 5,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 4,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 3,   p‑PKA↓, 1,   PKCδ↓, 12,   p‑PKCδ↓, 1,   cl‑PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 4,   PTEN↑, 38,   PTEN↝, 2,   p‑PTEN↓, 2,   Raf↓, 7,   c-Raf↓, 1,   RAS↓, 12,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 2,   RIP1↑, 3,   RPS6KA1↓, 1,   p‑RSK↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   S6K↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 5,   Sp1/3/4↓, 13,   Src↓, 5,   Src↑, 1,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 2,   STAT3↓, 97,   STAT3↑, 5,   p‑STAT3↓, 27,   p‑STAT3↑, 2,   STAT5↓, 3,   p‑STAT5↓, 1,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF1↓, 1,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 24,   ATF4↝, 1,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 2,   cMyc↓, 59,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 12,   DNMT1↑, 1,   DNMT3A↓, 4,   DNMTs↓, 9,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 4,   FOXO3↓, 7,   FOXO3↑, 9,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↑, 2,   GATA3↑, 1,   H3↓, 5,   H3↑, 2,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 7,   HATs↑, 2,   HDAC↓, 33,   HDAC1↓, 7,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC8↓, 3,   HES1↓, 2,   HMTs↓, 2,   HOXB-AS1↓, 1,   KCNQ1OT1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 4,   miR-17↓, 2,   miR-195↑, 1,   miR-200b↑, 1,   miR-21↓, 10,   miR-21↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 2,   miR-27a-3p↑, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-340↓, 1,   miR-340↑, 1,   miR-34a↓, 2,   miR-34a↑, 5,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   miR-497↑, 1,   miR-590-3p↑, 1,   Myc↓, 6,   MYCN↓, 1,   n-MYC↓, 1,   NR1D2↓, 1,   OCT4↓, 17,   OCT4↑, 1,   other?, 1,   other↓, 5,   other↑, 10,   other↝, 13,   PhotoS↑, 2,   SALL4↓, 1,   sonoS↑, 2,   SOX2↓, 10,   SOX4↓, 1,   SOX4↑, 2,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 3,   TCF-4↓, 2,   TET3↑, 1,   tumCV?, 3,   tumCV↓, 196,   tumCV↑, 1,   tumCV∅, 1,   ZBTB10↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 6,   cl‑ATF6↑, 1,   c-ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 57,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 14,   p‑eIF2α↓, 1,   p‑eIF2α↑, 13,   ER Stress↓, 5,   ER Stress↑, 94,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 34,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 10,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 10,   HSP70/HSPA5↑, 4,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 16,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 9,   p‑IRE1↑, 1,   PDI↑, 1,   PERK↑, 17,   p‑PERK↑, 3,   SERPINH1/HSP47↓, 1,   UPR↑, 16,   XBP-1↓, 2,   XBP-1↑, 8,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 19,   ATG5↝, 1,   ATG7↑, 5,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 34,   Beclin-1/ATG6↝, 1,   CTSB↓, 2,   CTSD↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 9,   LC3A↑, 3,   LC3B↑, 6,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 2,   LC3II↓, 3,   LC3II↑, 29,   LC3s↓, 1,   LC3s↑, 3,   MitoP↑, 2,   p62↓, 13,   p62↑, 10,   PARK2↑, 4,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto↑, 93,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   APE1/APEX1↓, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 3,   ATR↑, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 2,   DFF45↑, 3,   DNA-PK↑, 2,   DNAdam↓, 4,   DNAdam↑, 154,   mt-DNAdam↑, 2,   DNArepair↓, 5,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 18,   Ku70/XRCC6↓, 2,   MGMT↓, 2,   NHEJ↓, 1,   p16↑, 6,   P53?, 1,   P53↓, 6,   P53↑, 204,   P53↝, 3,   P53∅, 2,   p‑P53↓, 1,   p‑P53↑, 12,   ac‑P53↑, 1,   p53 Wildtype↓, 2,   PARP↓, 11,   PARP↑, 65,   PARP↝, 2,   p‑PARP↑, 5,   cl‑PARP↓, 4,   cl‑PARP↑, 247,   cl‑PARP↝, 1,   cl‑PARP∅, 2,   proPARP↓, 2,   PARP1↓, 1,   PARP1↑, 9,   cl‑PARP1↑, 6,   PCNA↓, 52,   RAD51↓, 1,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 18,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 3,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 2,   γH2AX↓, 1,   γH2AX↑, 21,   γH2AX↝, 1,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CC(CDKs/cyclins)↓, 1,   CDK1↓, 31,   CDK1↑, 4,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 55,   CDK2↑, 5,   p‑CDK2↓, 1,   CDK4↓, 67,   CDK4↑, 6,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK6↓, 28,   CDK6↑, 5,   CDK8↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↓, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 50,   CycB/CCNB1↑, 6,   cycD1/CCND1↓, 150,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 33,   cycE/CCNE↑, 1,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 53,   MAD↓, 1,   mitA↑, 6,   p19↑, 2,   P21?, 2,   P21↓, 14,   P21↑, 129,   P21↝, 2,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 51,   pRB↓, 1,   pRB↑, 3,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 7,   Securin↓, 2,   TubPol↓, 1,   TumCCA?, 2,   TumCCA↓, 10,   TumCCA↑, 386,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 3,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 10,   CD24↓, 2,   CD34↓, 2,   CEBPA↑, 1,   cFos↓, 10,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 48,   Diff↓, 1,   Diff↑, 2,   EIF4E↓, 2,   FGF↓, 4,   Gli↓, 3,   Gli1↓, 13,   HH↓, 11,   IGF-1↓, 13,   p‑IGF-1↓, 1,   IGF-2↓, 2,   IGF-2↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 53,   Let-7↓, 1,   Let-7↑, 4,   MCM2↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 19,   NOTCH1↓, 17,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 5,   OGFr↑, 2,   PCLAF↓, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   PTCH2↓, 2,   SCF↓, 2,   Shh↓, 14,   Smo↓, 7,   STAT1↓, 2,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 188,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 300,   TumCP↑, 5,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 49,   Wnt↑, 1,   Wnt/(β-catenin)↓, 7,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 13,   AP-1↑, 1,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↑, 60,   Ca+2↝, 8,   i-Ca+2?, 1,   i-Ca+2↑, 6,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↓, 1,   cal2↑, 6,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 2,   COL3A1↓, 1,   DLC1↑, 2,   E-cadherin↓, 9,   E-cadherin↑, 64,   EM↑, 1,   EMT?, 1,   EMT↓, 89,   EMT↑, 3,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 23,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 5,   GIT1↓, 1,   GLI2↓, 6,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 3,   ITGB3↓, 2,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 4,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 127,   MMP2↝, 1,   proMMP2↓, 1,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 45,   MTA1↓, 2,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 46,   p44↓, 1,   p‑p44↓, 1,   PAI-1/SERPINE1↑, 1,   PAK1↓, 2,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   proline↓, 1,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 4,   Rho↑, 1,   ROCK1↓, 3,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 4,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 1,   p‑SMAD4↓, 2,   Snail?, 1,   Snail↓, 43,   TET1↑, 6,   TGF-β↓, 20,   TGF-β↑, 5,   TGF-β1↓, 1,   THBS1↑, 1,   TIMP1↓, 5,   TIMP1↑, 18,   TIMP2↓, 4,   TIMP2↑, 17,   TIMP3↑, 1,   TPM4↓, 1,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 4,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 124,   TumCI↑, 1,   TumCMig↓, 119,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 87,   TumMeta↑, 5,   TumPF↓, 4,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 26,   uPA↝, 1,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 49,   Vim↑, 1,   Zeb1↓, 15,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 62,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 117,   angioG↑, 2,   CD31/PECAM-1↓, 12,   EGR1↑, 1,   Endoglin↑, 3,   eNOS↓, 3,   eNOS↑, 1,   HIF-1↓, 4,   Hif1a↓, 90,   Hif1a↑, 2,   NO↓, 5,   NO↑, 4,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 151,   VEGF↑, 2,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 1,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 2,   CLDN2↑, 1,   CX43/GJA1↓, 1,   EPR↑, 6,   GLUT1↓, 18,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   IBI↑, 1,   KCNH2/hERG↓, 1,   memfluid↓, 1,   MMP?, 3,   MMP↓, 329,   MMP↑, 4,   MMP↝, 1,   MMP∅, 2,   MPT↑, 14,   NHE1↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↝, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 17,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 5,   p‑cDC2↓, 1,   p‑cDC2↑, 1,   COX1?, 1,   COX1↓, 2,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 110,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 3,   CXCR2↓, 1,   CXCR4↓, 16,   CXCR4↑, 1,   DCells↑, 1,   DR4↑, 12,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 6,   IFN-γ↓, 4,   IFN-γ↑, 4,   Igs↓, 1,   IL1↓, 5,   IL1↑, 2,   IL10↓, 8,   IL10↑, 2,   IL12↓, 2,   IL12↑, 1,   IL17↓, 2,   IL18↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 5,   IL2↓, 2,   IL2↑, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 2,   IL5↓, 1,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   IL8↓, 13,   Imm↑, 16,   Imm↝, 3,   Inflam↓, 47,   pol-M1↑, 1,   MCP1/CCL2↓, 6,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB↓, 211,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p50↓, 3,   p65↓, 11,   p‑p65↓, 3,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 26,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   RANTES?, 1,   SOCS-3↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   TCF↓, 2,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 11,   TLR4↝, 1,   TNF-α↓, 52,   TNF-α↑, 11,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GGT/CD224↑, 1,   IM↓, 1,   pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   PTN↓, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   ACE/ACE1↓, 1,   AhR↑, 1,   AR↓, 21,   AR↝, 1,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 5,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 4,   cl‑PPARα↓, 1,   PPARγ↓, 4,   PPARγ↑, 8,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 48,   BioAv↑, 56,   BioAv↝, 11,   BioEnh↑, 6,   ChemoSen?, 2,   ChemoSen↓, 3,   ChemoSen↑, 201,   ChemoSen↝, 1,   CompStab↓, 3,   CompStab↑, 5,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   CYP3A4↓, 2,   DDS↑, 2,   Dose?, 12,   Dose↓, 5,   Dose↑, 11,   Dose⇅, 1,   Dose↝, 92,   Dose∅, 18,   eff↓, 138,   eff↑, 136,   eff↝, 16,   eff∅, 5,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 12,   Half-Life↑, 2,   Half-Life↝, 12,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 5,   RadioS?, 1,   RadioS↑, 60,   selectivity?, 2,   selectivity↓, 1,   selectivity↑, 166,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 140,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 4,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 21,   AR↝, 1,   ascitic↓, 1,   AST↓, 5,   AST↑, 1,   AST↝, 1,   BG↓, 1,   BloodF↓, 1,   BRAF↓, 2,   BRAF↝, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 3,   E6↓, 5,   E7↓, 4,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   EZH2↓, 2,   Ferritin↓, 3,   FOXM1↓, 8,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 18,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   LDH?, 1,   LDH↓, 22,   LDH↑, 11,   LDH↝, 2,   i-LDH↓, 1,   Myc↓, 6,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↓, 3,   TP53↑, 3,   TRIB3↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 76,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 37,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 4,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 37,   chemoPv↑, 31,   ChemoSideEff↓, 11,   ChemoSideEff∅, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 11,   memory↑, 2,   neuroP↑, 11,   NP/CIPN↓, 1,   OS↑, 20,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 7,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 13,   Risk↓, 20,   Sleep↑, 1,   Strength↑, 4,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 8,   toxicity↝, 10,   toxicity∅, 2,   TumNum↓, 3,   TumVol↓, 58,   TumVol↑, 2,   TumW↓, 27,   Weight↓, 1,   Weight↑, 4,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 4,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 3,   Ingr↝, 9,  
Total Targets: 1449

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 1,   antiOx↓, 7,   antiOx↑, 133,   ARE↑, 2,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 70,   Copper↓, 1,   Fenton↓, 3,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 54,   GPx1↑, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 78,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 10,   GSTs↓, 3,   GSTs↑, 19,   H2O2↓, 6,   HDL↑, 4,   HO-1↓, 4,   HO-1↑, 35,   hyperG↝, 1,   Iron↓, 3,   Keap1↓, 3,   Keap1↑, 2,   Keap1↝, 2,   lipid-P↓, 50,   MDA?, 1,   MDA↓, 57,   MDA↑, 4,   MPO↓, 10,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 2,   NQO1↑, 5,   NQO1↝, 1,   NRF2↓, 2,   NRF2↑, 70,   Prx↑, 2,   RNS↓, 6,   ROS?, 1,   ROS↓, 180,   ROS↑, 9,   ROS⇅, 1,   ROS∅, 5,   mt-ROS?, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 91,   SOD1↑, 4,   SOD2↑, 3,   TAC↑, 9,   TBARS↓, 4,   Thiols↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 3,   IronCh↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   FIS1↓, 1,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 1,   mtDam↓, 5,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 3,   adiP↑, 1,   ALAT↓, 23,   AMPK↓, 1,   AMPK↑, 15,   ATP↓, 3,   ATP↑, 11,   cAMP↑, 2,   DGAT1↓, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 3,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HMG-CoA↓, 2,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 3,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 3,   NH3↓, 1,   PLA2↓, 2,   SIRT1↑, 11,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 2,   Apoptosis↓, 46,   Apoptosis∅, 1,   ASC↓, 1,   BAD↓, 3,   BAX↓, 47,   BAX↑, 4,   Bax:Bcl2↓, 8,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-2↑, 31,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 3,   Casp3?, 1,   Casp3↓, 104,   Casp3↑, 10,   Casp3∅, 2,   cl‑Casp3↓, 20,   cl‑Casp3↑, 1,   proCasp3↓, 2,   proCasp3↑, 1,   Casp7↓, 1,   Casp8↓, 5,   Casp8↑, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 27,   Casp9↑, 4,   Casp9∅, 1,   cl‑Casp9↓, 3,   cl‑Casp9↑, 1,   Cyt‑c↓, 17,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   GSDMD↓, 1,   iNOS↓, 26,   iNOS↑, 3,   MLKL↓, 1,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 10,   p‑Akt↓, 4,   p‑Akt↑, 9,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 4,   p‑CREB↑, 3,   EGFR↓, 1,   ERK↓, 6,   ERK↑, 5,   p‑ERK↓, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 6,   JNK↑, 3,   p‑JNK↓, 2,   MAPK↓, 19,   MAPK↑, 3,   Mst1↓, 1,   mTOR↓, 3,   mTOR↑, 4,   p‑mTOR↓, 4,   p‑mTOR↑, 2,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 8,   PI3K↑, 8,   PKCδ?, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↓, 2,   RAS↓, 1,   RIP1↓, 2,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 4,   p‑STAT3↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 6,   other↝, 12,   RUNX2↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   ER Stress↓, 8,   GRP78/BiP↓, 7,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 5,   HSP90↓, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 3,   PERK↓, 2,   UPR↓, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3II↓, 1,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 1,   p62↑, 4,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   p16↓, 1,   P53↓, 7,   P53↑, 2,   PARP↓, 2,   PARP∅, 1,   p‑PARP↓, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 2,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 2,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 4,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 2,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   neuroG↑, 3,   TumCG↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 9,   AP-1↓, 3,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 3,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 2,   COL1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 3,   MMP7↓, 1,   MMP9↓, 5,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 6,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   Hif1a↑, 1,   NO?, 1,   NO↓, 21,   NO↑, 5,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 2,   BBB↑, 19,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   CLDN5↓, 1,   GastroP↑, 6,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 6,   MMP↑, 23,   MMP∅, 1,   MUC5AC↓, 1,   OCLN↓, 2,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPM7⇅, 1,   TRPV1↑, 1,   ZO-1↓, 4,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 40,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 9,   IL10↑, 8,   IL12↓, 2,   IL13↑, 1,   IL17↓, 2,   IL18↓, 3,   IL1β↓, 51,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL33↓, 1,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 59,   IL6↑, 1,   IL8↓, 7,   Imm↓, 1,   Imm↑, 8,   Imm⇅, 1,   INF-γ↓, 2,   Inflam↓, 161,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 5,   NF-kB↓, 65,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 10,   p65↓, 2,   PAF↑, 1,   PGE2↓, 20,   PGE2↑, 3,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 9,   TNF-α↓, 85,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 6,   AChE↓, 25,   BChE↓, 6,   BDNF↓, 2,   BDNF↑, 24,   BDNF⇅, 1,   BDNF∅, 1,   ChAT↑, 4,   DA↑, 1,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 5,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 6,   BACE/β-secretase↓, 9,   IDE↑, 1,   tau↓, 7,   p‑tau↓, 7,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE/ACE1↑, 1,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Estro↓, 1,   FGF21↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 9,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 48,   BioAv↑, 47,   BioAv⇅, 1,   BioAv↝, 22,   BioAv∅, 1,   BioEnh↑, 2,   ChemoSen↑, 2,   CompStab↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 22,   Dose∅, 2,   eff↓, 5,   eff↑, 21,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 14,   Half-Life∅, 3,   MRP↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 3,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 23,   ALB↝, 1,   ALP↓, 6,   anemia↓, 1,   AST↓, 24,   BG↓, 1,   Bil↓, 1,   BloodF↑, 2,   BMD↑, 2,   BP↓, 5,   BUN?, 1,   BUN↓, 4,   CEA↓, 1,   colonLen↑, 1,   creat↓, 9,   CRP↓, 7,   EGFR↓, 1,   Ferritin↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 59,   IL6↑, 1,   IRes↝, 1,   LDH↓, 12,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 7,   antiAll↑, 22,   AntiArt↑, 12,   AntiCan↑, 26,   antiCG↑, 3,   antiD↓, 1,   AntiDiabetic↑, 35,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↓, 2,   AntiTum↑, 7,   cardioP?, 1,   cardioP↑, 55,   chemoP↑, 12,   chemoPv↑, 6,   cognitive↓, 1,   cognitive↑, 36,   diuretic↑, 3,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 53,   Learn↑, 4,   memory↑, 34,   Mood↑, 1,   motorD↑, 7,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 100,   Obesity↓, 12,   OS↑, 3,   Pain↓, 4,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 19,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 14,   toxicity?, 1,   toxicity↓, 60,   toxicity↑, 4,   toxicity↝, 8,   toxicity∅, 11,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 15,   Bacteria↓, 32,   Diar↓, 3,   GutMicro↑, 17,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 1,   Ingr↝, 6,   Phen↑, 1,   QC↑, 1,  
Total Targets: 616

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
38 Silver-NanoParticles
35 Quercetin
32 Curcumin
29 Thymoquinone
26 Apigenin (mainly Parsley)
23 Sulforaphane (mainly Broccoli)
22 Luteolin
21 Baicalein
21 Berberine
18 EGCG (Epigallocatechin Gallate)
18 Emodin
18 Fisetin
17 Shikonin
16 Cisplatin
16 Propolis -bee glue
16 Chrysin
16 Honokiol
14 Artemisinin
14 Magnetic Fields
14 Allicin (mainly Garlic)
14 Capsaicin
14 Licochalcone A
14 Magnolol
13 Ashwagandha(Withaferin A)
13 Radiotherapy/Radiation
13 Kaempferol
12 Betulinic acid
12 Benzyl isothiocyanate
12 Boron
12 Silymarin (Milk Thistle) silibinin
11 doxorubicin
11 Eugenol
11 Gambogic Acid
11 Hyperoside
11 Morin
10 Chlorogenic acid
10 Ginkgetin
10 Graviola
10 isoorientin
10 Juglone
10 Lycopene
10 Matrine
10 Resveratrol
9 Alpha-Lipoic-Acid
9 Carvacrol
9 Phenylbutyrate
8 5-fluorouracil
8 D-limonene
8 Phenethyl isothiocyanate
8 Citric Acid
8 Dandelion Root
8 Formononetin
8 Garcinol
8 Ivermectin
7 Allyl isothiocyanate
7 Melatonin
7 Gallic acid
7 Isobavachalcone
7 Vitexin
7 L-Theanine
7 mebendazole
7 Piperlongumine
7 Rosmarinic acid
6 Beta-Caryophyllene
6 Bufalin/Huachansu
6 chaetocin
6 chitosan
6 Ferulic acid
6 phytic acid, Inositol hexakisphosphate
6 Isoliquiritigenin
6 Licorice
6 Nimbolide
6 Selenite (Sodium)
6 Vitamin K2
5 Boswellia (frankincense)
5 α-Bisabolol / Chamomile oil
5 Caffeic acid
5 Chemotherapy
5 Centella asiatica / Gotu kola → asiaticoside
5 Crocetin
5 Ursolic acid
5 Dichloroacetate
5 salinomycin
5 Ellagic acid
5 Paclitaxel/Taxol
5 Evodiamine
5 Isorhamnetin
5 isoquercitrin
5 lambertianic acid
5 Linalool
5 Magnetic Field Rotating
5 Mangiferin
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Plumbagin
5 Aflavin-3,3′-digallate
4 3-bromopyruvate
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Anethole/trans-Anethole
4 Astaxanthin
4 Photodynamic Therapy
4 Bromelain
4 borneol
4 Carvone
4 Cucurbitacin
4 Geraniol
4 Isovitexin
4 Lemongrass Extract/Citral
4 Lutein
4 methylseleninic acid
4 Moringa oleifera
4 Naringin
4 Marjoram (Origanum majorana)
4 Propyl gallate
4 Piperine
4 VitK3,menadione
4 Urolithin
3 Açaí, Euterpe oleracea
3 Auranofin
3 Metformin
3 Berbamine
3 Biochanin A
3 Brucea javanica
3 Carnosic acid
3 Thymol-Thymus vulgaris
3 Celastrol
3 Cynaropicrin
3 Deguelin
3 Date Fruit Extract
3 Docetaxel
3 Echinacea
3 Fenbendazole
3 Fucoidan
3 Ginkgo biloba
3 Ginkgolide B
3 Gossypol/AT-101
3 Hydrogen Gas
3 Hydroxycinnamic-acid
3 Hibiscus sabdariffa
3 Helleborus niger extracts – Christmas Rose
3 Rutin
3 itraconazole
3 Laetrile B17 Amygdalin
3 Methylsulfonylmethane
3 Patchouli Oil (Pogostemon cablin)
3 Phycocyanin
3 Psoralidin
3 Pterostilbene
3 α-Santalol/Sandalwood oil
3 Vitamin C (Ascorbic Acid)
2 1,8-Cineole
2 Coenzyme Q10
2 Astragalus
2 SonoDynamic Therapy UltraSound
2 entinostat
2 Gemcitabine (Gemzar)
2 tamoxifen
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Aloe anthraquinones
2 brusatol
2 Bullatacin
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Cat’s Claw
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Citicoline, CDP-Choline
2 Copper and Cu NanoParticles
2 Oxaliplatin
2 Diclofenac
2 diet FMD Fasting Mimicking Diet
2 Ginkgo biloba-EGb 761
2 Electrical Pulses
2 Eurycomanone
2 Flaxseed/Linseed
2 carboplatin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 HydroxyTyrosol
2 Huperzine A/Huperzia serrata
2 Inositol
2 low dose naltrexone
2 Lactoferrin/Talactoferrin
2 Methyl Jasmonate
2 Magnesium
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Oleuropein
2 Parthenolide
2 Selenium
2 Selenium NanoParticles
2 Vitamin D3
2 Zyflamend
1 5-Aminolevulinic acid
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 2-DeoxyGlucose
1 Ascorbyl Palmitate
1 Trastuzumab
1 almonertinib
1 epirubicin
1 temozolomide
1 Bacopa monnieri
1 Beetroot
1 Black turtle bean
1 Butyrate
1 Mung Bean Sprouts
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 Polyphenols
1 CUSP9
1 Chlorella (Chlorella vulgaris)
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Cannabichromene
1 eicosapentaenoic acid
1 ferumoxytol
1 Geldanamycin
1 Radicicol/monorden
1 Bortezomib
1 Flaxseed Oil
1 Galloflavin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 hydrogen sulfide
1 Orlistat
1 Hyperthermia
1 Indole-3-carbinol
1 iodine
1 Inulin Prebiotic
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lapachol
1 Lasiodin
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Myricetin
1 nelfinavir/Viracept
1 sericin
1 Purple Corn / Purple Maize
1 topotecan
1 isoflavones
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Folic Acid, Vit B9
1 Sesamin
1 Lignans
1 Spirulina(Arthrospira/Limnospira)
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Turmerones
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:42  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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