Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
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The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
9155- MG, MIC-1,    The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo
- in-vivo, Mye, NA
NF-kB↓, Apoptosis↑, Casp↑, GSTA1↑, AntiTum↝,
8669- MLT,    Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities
- Review, Lung, NA
Apoptosis↑, ROS↑, Cyt‑c↑, Bcl-2↓, Casp↑, TumCP↓, TumCI↓, angioG↓, Inflam↓, ChemoSen↑, RadioS↑,
8685- MLT,    Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis
- vitro+vivo, RCC, 786-O
Synergy↑, Casp↑, LC3II↑, TumAuto↑, Apoptosis↑, MAPK↑, TumCG↓, MMP?, Bax:Bcl2↑,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
1762- MNPs,  Fe,    Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane
- in-vitro, RCC, NA
Dose∅, Apoptosis↑, Casp↑, tumCV↓, Casp3↑, Casp7↑, Ca+2↑, Cyt‑c↑,
8615- MO,    Melissa officinalis Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620
AntiCan↑, TumCP↓, TumCCA↑, Casp↑, TumCMig↓, EMT↓, other↑,
8911- MO,    Anticancer Potential of Moringa Oleifera in Lung Cancer: A Mini Review of In vitro and In vivo Evidence
- Review, Lung, NA
tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp↑, NF-kB↓, EGFR↓, STAT3↓, VEGF↓, eff↑, CD4+↑, CD8+↑,
8952- mushLions,    Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation
- vitro+vivo, CRC, DLD1
TNFR 1↑, Fas↑, FasL↑, Casp↑, Bcl-2↓, Bcl-xL↓, tumCV↓, selectivity↑, MMP2↓, MMP9↓, Apoptosis↑, Dose↝,
8957- mushLions,    Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
- Review, Nor, NA
*neuroP↑, *AntiTum↑, *antiOx↑, TumCP↓, *Inflam↓, TumCI↓, Casp↑, *GutMicro↑, *proBDNF↑, *BDNF↑, *Mood↑, *antiD↑, *ANXi↓, *Sleep↑, *cognitive↑, *Imm↑, *NGF↑, *AChE↓, *toxicity↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, Var, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4974- Nimb,    Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma
- in-vitro, OS, NA
Apoptosis↑, ER Stress↑, mtDam↑, ROS↑, Casp↑, TumCMig↓, TumMeta↓,
4975- Nimb,    Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma
- in-vitro, Oral, NA
Apoptosis↑, ROS↑, Ca+2↑, ER Stress↑, Casp↑, MMP↓, tumCV↓,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,
5183- PEITC,  Cisplatin,    Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, HaCaT
DNAdam↑, Apoptosis↑, ChemoSen↑, ROS↑, mt-ROS↑, Casp↑, Casp3↑, selectivity↑, TumCP↓, tumCV↓, eff↓,
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,
1989- PTL,    Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties
- Review, Var, NA
eff↑, NF-kB↓, STAT↓, ROS↑, Inflam↓, Wnt↓, TCF-4↓, LEF1↓, GSH↓, MMP↓, Casp↑, eff↓, CSCs↓,
1992- PTL,    Parthenolide induces ROS-dependent cell death in human gastric cancer cell
- in-vitro, BC, MGC803
TumCCA↑, Casp↑, Apoptosis↑, Necroptosis↑, RIP1↓, RIP3↑, MLKL↑, ROS↑, eff↓,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
- Review, Var, NA
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, Var, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
40- QC,    Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells
- in-vitro, lymphoma, U937
cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, CycB/CCNB1↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓,
7149- Rhe,    Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells
- in-vitro, PC, NA
TumCCA↑, Casp↑, mt-Apoptosis↑, PI3K↓, Akt↓, ChemoSen↑, ROS↑, eff↓,
1746- RosA,    Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells
- in-vitro, AML, U937
TNF-α↓, ROS↓, Casp↑, NF-kB↓, IκB↓, p50↓, p65↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Apoptosis↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
6449- SAO,    Skin cancer chemoprevention by α-santalol
- Review, Melanoma, A431
*chemoPv↑, Apoptosis↑, Casp↑, MMP↓, Cyt‑c↑, TumCCA↑, TumCG↓,
6451- SAO,    α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer
- vitro+vivo, BC, MDA-MB-231
TumCP↓, selectivity↑, Bcl-2↓, PLK1↓, BAD↑, Casp↑, BAX↑, Dose↝, TumCG↓,
4714- Se,  SSE,  SeNPs,    Selenium in cancer management: exploring the therapeutic potential
- Review, Var, NA
Risk↓, *BioAv↑, eff↝, *ROS↓, MMP↓, ROS↑, P53↑, *toxicity↓, TumCP↓, Casp↑, Apoptosis↑,
4734- SeNPs,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,
1465- SFN,    TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells
- in-vitro, Bladder, NA
Synergy↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,
1476- SFN,  PDT,    Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane
- in-vitro, HNSCC, NA
Synergy↑, tumCV↓, ROS↑, eff↓, Casp↑,
1733- SFN,    Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- in-vitro, PC, PanCSC - in-vitro, Nor, HPNE - in-vitro, Nor, HNPSC
CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3649- SIL,    Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis
- in-vitro, Nor, NA
*Inflam↓, *NF-kB↓, *cJun↓, *Casp↓, *ROS↓, *lipid-P↓,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2469- SK,    Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2
- in-vitro, Lung, H1975
Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, GSDME↑, ROS↑, COX2/PTGS2↓, PDK1 / PDPK1↓, Akt↓, ERK↓, eff↓, eff↓, eff↑,
2010- SK,    Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Nor, CCD19
EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,
5108- SSE,    Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis
- in-vitro, AML, U937
p‑P53↑, Beclin-1/ATG6↓, LC3I↓, Apoptosis↑, Casp↑,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
1929- TQ,    Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells
- in-vitro, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCI↓, Casp↑, ROS↑, PD-L1↓, EMT↓, MMP↓, eff↓,
1933- TQ,    Thymoquinone: potential cure for inflammatory disorders and cancer
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCCA↑, ROS↑, angioG↓, Apoptosis↑, Casp↑, ChemoSen↑, eff↝,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2129- TQ,  doxoR,    Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
- in-vitro, BC, MCF7
ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,
2094- TQ,    Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies
- Review, Var, NA
ROS↑, angioG↓, TumMeta↓, VEGF↓, MMPs↓, P53↑, BAX↑, Casp↑, Bcl-2↓, survivin↓, *ROS↓, ChemoSen↑, chemoP↑, MDR1↓, BioAv↓, BioAv↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3429- TQ,    Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
- in-vitro, AML, NA - in-vivo, NA, NA
DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2/PTGS2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, CompStab↝, TumCG↓,

Showing Research Papers: 151 to 200 of 205
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 205

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 1,   GPx4↓, 3,   GSH↓, 10,   GSH↑, 2,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 3,   Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA↓, 1,   MDA↑, 3,   NADH↓, 2,   mt-NADH↓, 1,   NQO1↓, 1,   NRF2↓, 7,   NRF2↑, 7,   ROS↓, 11,   ROS↑, 131,   ROS⇅, 3,   ROS↝, 1,   i-ROS?, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 1,   SOD↑, 2,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   Trx↓, 1,   Trx↑, 1,   TrxR↓, 2,   TrxR↑, 1,   TrxR1↓, 4,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IRP1↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   compI↓, 4,   compII↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC↓, 4,   mitResp↓, 3,   mtDam↑, 16,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 4,   PDH↑, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ACSL4↑, 1,   AMP↓, 1,   AMPK?, 1,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↓, 16,   mt-ATP↓, 1,   FASN↓, 5,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 11,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   H2S↑, 1,   HK2↓, 7,   HMG-CoA↓, 2,   lactateProd↓, 3,   lactateProd↑, 2,   LDHA↓, 3,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 10,   PDK3↑, 1,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 126,   mt-Apoptosis↑, 4,   BAD↑, 4,   Bak↑, 4,   BAX↑, 44,   Bax:Bcl2↑, 13,   Bcl-2↓, 56,   Bcl-2↑, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 19,   Bcl-xL↑, 2,   BID↑, 3,   BIM↓, 1,   BIM↑, 4,   BNIP3↓, 1,   BTG3↑, 1,   Casp↓, 5,   Casp↑, 184,   Casp↝, 3,   Casp∅, 1,   cl‑Casp↑, 6,   proCasp↑, 1,   Casp3↓, 1,   Casp3↑, 24,   cl‑Casp3↑, 5,   Casp6↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 3,   Casp8↑, 3,   cl‑Casp8↑, 3,   Casp9↑, 9,   cl‑Casp9↑, 6,   Cupro↑, 1,   Cyt‑c↑, 63,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↑, 9,   Endon↑, 1,   FADD↑, 2,   Fas?, 1,   Fas↓, 2,   Fas↑, 9,   FasL↑, 4,   Ferroptosis↑, 7,   GSDME↑, 1,   cl‑GSDME↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 6,   Mcl-1↓, 5,   MDM2↓, 3,   MLKL↑, 1,   MOMP↑, 3,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   p38↓, 5,   p38↑, 7,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP3↑, 1,   survivin↓, 25,   TNFR 1↑, 2,   TRAIL↑, 3,   TumCD↑, 8,   XIAP↓, 8,   XIAP↑, 1,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 55,   p‑Akt↓, 7,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 10,   ERK↓, 14,   ERK↑, 4,   p‑ERK↓, 4,   HCAR2↑, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   Hippo↓, 1,   IKKα↓, 2,   IκB↓, 1,   JAK1↓, 1,   JAK2↓, 8,   JAK3↓, 1,   JNK↓, 2,   JNK↑, 8,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK?, 1,   MAPK↓, 17,   MAPK↑, 9,   MEK↓, 3,   mTOR↓, 33,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 1,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   PDGFRA↓, 1,   PI3K↓, 38,   p‑PI3K↓, 1,   PI3K/Akt↓, 2,   PKCδ↓, 2,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 6,   Raf↓, 3,   e-Raf↓, 1,   RAS↓, 4,   RIP1↓, 1,   Sp1/3/4↓, 5,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3↓, 29,   p‑STAT3↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF4↑, 5,   cJun↓, 2,   cJun↑, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 4,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   p‑H3↓, 2,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 11,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC6↓, 1,   miR-148a↑, 1,   miR-203↑, 1,   miR-21↝, 1,   miR-34a↑, 1,   miR-375↑, 1,   NDRG1↑, 1,   OCT4↓, 4,   other↑, 3,   other↝, 5,   PhotoS↑, 1,   SOX2↓, 4,   TCF-4↓, 2,   TFAP2A↓, 1,   TFE3↑, 1,   tumCV↓, 30,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 17,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 2,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 2,   LC3I↓, 1,   LC3II↑, 5,   LC3s↑, 1,   lysoMP↑, 1,   p62↓, 4,   p62↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 15,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   DNAdam↓, 1,   DNAdam↑, 34,   DNArepair↓, 2,   hTERT/TERT↓, 4,   p16↑, 2,   P53↓, 2,   P53↑, 38,   P53↝, 2,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 6,   PARP↝, 1,   cl‑PARP↑, 36,   cl‑PARP1↑, 2,   PCNA↓, 8,   SIRT6↓, 1,   Telomerase↓, 6,   TOP1↓, 6,   TOP2↓, 4,   γH2AX↑, 4,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 11,   p‑CDK2↓, 1,   CDK4↓, 12,   CDK4↑, 1,   CDK6↓, 4,   CDK6↑, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   CycB/CCNB1↓, 4,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 23,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 10,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 8,   mitA↓, 1,   mitA↑, 2,   P21↑, 28,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 11,   PLK1↓, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 88,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH1A1↓, 1,   BMI1↓, 1,   CD133↓, 2,   cFos↓, 3,   CSCs↓, 13,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 2,   IGFBP3↑, 2,   Ki-67↓, 8,   mTORC1↓, 5,   Nanog↓, 4,   NOTCH↓, 2,   NOTCH1↓, 3,   NOTCH1↑, 1,   NOTCH2↑, 1,   SCF↓, 1,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 39,   TumCG↑, 2,   TumCP↓, 60,   TumCP↑, 3,   Wnt↓, 13,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 6,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 22,   cal2↑, 1,   CCN2/CTGF↓, 2,   COL1↓, 1,   E-cadherin↑, 13,   EMT↓, 19,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   GLI2↓, 1,   ITGB4↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 26,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 29,   MMP9↑, 2,   MMPs↓, 10,   MMPs↝, 1,   MUC4↓, 1,   N-cadherin↓, 7,   PAK1↑, 1,   PDGF↓, 2,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Slug↓, 1,   Snail↓, 2,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TSC1↑, 2,   TSP-1↑, 1,   TumCI↓, 23,   TumCI↑, 1,   TumCMig↓, 22,   TumCMig↑, 1,   TumMeta↓, 25,   TumMeta↑, 3,   Twist↓, 4,   uPA↓, 8,   Vim↓, 10,   Zeb1↓, 3,   β-catenin/ZEB1↓, 17,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 37,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 3,   HIF-1↓, 2,   Hif1a↓, 17,   Hif1a↑, 1,   NO↓, 1,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 41,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   EPR↑, 4,   GLUT1↓, 4,   GLUT4↓, 2,   MMP?, 2,   MMP↓, 78,   MMP↝, 1,   MPT↑, 10,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↑, 1,   CD44↓, 3,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 24,   COX2/PTGS2↑, 1,   CXCR2↓, 1,   CXCR4↓, 5,   DR4↑, 3,   Eos↑, 1,   HCAR2↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL12↑, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 10,   IL8↓, 1,   Imm↑, 8,   Inflam↓, 11,   M2 MC↓, 1,   MCT1↓, 1,   MDSCs↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 55,   NF-kB↑, 3,   NF-kB↝, 1,   NK cell↑, 1,   NLRP3↓, 2,   p50↓, 1,   p65↓, 3,   PD-1↝, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 5,   PSA↓, 2,   TCF↝, 1,   TLR4↓, 1,   TNF-α↓, 15,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 16,   BioAv↑, 16,   BioAv↝, 4,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 64,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↑, 2,   Dose↝, 25,   Dose∅, 5,   eff↓, 33,   eff↑, 37,   eff↝, 6,   eff∅, 1,   GSTA1↑, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 6,   Half-Life↝, 2,   MDR1↓, 4,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   P450↓, 2,   RadioS↑, 20,   RadioS↝, 1,   selectivity?, 1,   selectivity↑, 40,   selectivity↝, 1,   Synergy↑, 41,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 8,   BMD↑, 1,   BRCA1↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 10,   EZH2↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 4,   IL6↓, 10,   LDH↓, 1,   LDH↑, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 21,   AntiTum↑, 9,   AntiTum↝, 1,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 5,   ChemoSideEff↓, 1,   fatigue↓, 2,   hepatoP↑, 5,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 2,   NP/CIPN↑, 1,   Obesity↓, 1,   OS↑, 4,   Pain↓, 2,   QoL↑, 1,   radioP↑, 4,   Remission↑, 2,   RenoP↑, 1,   Risk↓, 7,   Sleep↑, 1,   toxicity↓, 12,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 2,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 629

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 23,   Catalase↑, 11,   GPx↑, 9,   GSH↑, 7,   GSR↑, 2,   GSTs↑, 2,   HO-1↑, 8,   Keap1↓, 2,   lipid-P↓, 6,   MDA↓, 4,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 14,   ROS↓, 27,   ROS↝, 1,   ROS∅, 2,   SOD↑, 12,   SOD2↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   ETC↑, 1,   Insulin↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↓, 1,   ALAT↓, 3,   AMPK↑, 2,   ATP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   glucose↓, 2,   glyC↓, 1,   NAD↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp↓, 5,   Ferroptosis↓, 1,   iNOS↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↑, 1,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 2,   PKCδ↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 1,   p‑cMyc↑, 1,   other↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   Ca+2↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   MMP↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   HMGB1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 3,   IL6↓, 8,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 33,   Inflam↑, 1,   NeuroI↓, 1,   NF-kB↓, 7,   NK cell↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   AChE∅, 1,   BChE∅, 1,   BDNF↑, 1,   proBDNF↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 5,   tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 2,   CompStab↑, 1,   Dose↝, 2,   eff↑, 2,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↝, 3,   Half-Life∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   CRP↓, 2,   IL6↓, 8,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 3,   AntiArt↑, 3,   AntiCan↑, 4,   antiD↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   ANXi↓, 1,   cardioP↑, 8,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 4,   hepatoP↑, 6,   memory↑, 3,   Mood↑, 1,   neuroP↑, 15,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 1,   Sleep↑, 1,   Stroke↓, 3,   toxicity?, 1,   toxicity↓, 5,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   GutMicro↑, 4,  
Total Targets: 149

Scientific Paper Hit Count for: Casp, caspase
7 Thymoquinone
6 Betulinic acid
6 Capsaicin
6 Fisetin
4 Silver-NanoParticles
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Carvacrol
4 Curcumin
4 Graviola
4 Sulforaphane (mainly Broccoli)
4 Shikonin
3 Allicin (mainly Garlic)
3 Alpha-Lipoic-Acid
3 Anethole/trans-Anethole
3 Cucurbitacin
3 Dichloroacetate
3 Gambogic Acid
3 Ginkgetin
3 Licochalcone A
3 Melatonin
3 Nimbolide
3 α-Santalol/Sandalwood oil
3 Selenite (Sodium)
3 Silymarin (Milk Thistle) silibinin
2 Berberine
2 Rosmarinic acid
2 Thymol-Thymus vulgaris
2 chaetocin
2 Selenium
2 Chrysin
2 Gemcitabine (Gemzar)
2 Chlorella (Chlorella vulgaris)
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Isoliquiritigenin
2 Garcinol
2 HydroxyTyrosol
2 Isobavachalcone
2 iodine
2 isoquercitrin
2 Phenethyl isothiocyanate
2 Kaempferol
2 Luteolin
2 Matrine
2 methylseleninic acid
2 Magnetic Fields
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Parthenolide
2 Quercetin
2 Selenium NanoParticles
2 Urolithin
1 3-bromopyruvate
1 Astragalus
1 alpha Linolenic acid
1 Isovitexin
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Cat’s Claw
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenate
1 Chlorophyllin
1 Cinnamon
1 Cranberry
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Indole-3-carbinol
1 Deguelin
1 Diindolylmethane
1 D-limonene
1 Docetaxel
1 Ellagic acid
1 Eugenol
1 Ferulic acid
1 Fenbendazole
1 Formononetin
1 Flaxseed Oil
1 Fucoidan
1 verapamil
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginseng
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperthermia
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Ivermectin
1 Geldanamycin
1 Licorice
1 Linalool
1 Methylene blue
1 Magnolol
1 mebendazole
1 Paclitaxel/Taxol
1 Metformin
1 Chemotherapy
1 Magnetic Field Rotating
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Naringin
1 Phenylbutyrate
1 Phycocyanin
1 Pterostilbene
1 Rhein
1 salinomycin
1 irinotecan
1 Photodynamic Therapy
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:443  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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